2025
Correlation of Milestone Ratings and Family Physicians' Early Diabetes Management.
Hogan S, Yamazaki K, Holmboe E. Correlation of Milestone Ratings and Family Physicians' Early Diabetes Management. Family Medicine 2025, 57: 83-90. PMID: 39954237, PMCID: PMC11922144, DOI: 10.22454/fammed.2025.980357.Peer-Reviewed Original ResearchConceptsFamily physiciansUnsupervised practiceEarly-career family physiciansDiabetes managementEarly career family physiciansManagement of chronic diseasesChronic disease managementCommercial insurance claimsDiabetic patientsDoctor careChronic illnessPatient needsEye examType 2 diabetes mellitusTreatment of patientsMilestone ratingsChronic diseasesMilestone evaluationsResidency programsFunctional examPhysiciansDisease managementDoctorsProvider identification numberAdministration of standardized tests
2024
Targeting hypoxia and thrombospondin‐2 in diabetic wound healing
Huang Y, Xing H, Naud S, Kyriakides T. Targeting hypoxia and thrombospondin‐2 in diabetic wound healing. The FASEB Journal 2024, 38: e70091. PMID: 39383062, PMCID: PMC11486302, DOI: 10.1096/fj.202302429rrr.Peer-Reviewed Original ResearchConceptsThrombospondin-2Diabetic miceWound healingHIF-1aMatricellular protein thrombospondin-2Diabetic woundsImpaired wound healingWounds of diabetic miceDimethyloxalylglycine treatmentTargeting hypoxiaSustained hypoxiaDiabetic patientsTSP2 expressionCell dysfunctionIncreased neovascularizationDiabetic wound healingGenetic ablationDiabetic fibroblastsElevated glucoseReduced hypoxiaImprove healingImmunofluorescence analysisHIF-1a activationHypoxiaWestern blottingLetter to the Editor: “Silent myocardial infarction fatty scars detected by coronary calcium score CT scan in diabetic patients without a history of coronary heart disease”
Bader A, Haramati L. Letter to the Editor: “Silent myocardial infarction fatty scars detected by coronary calcium score CT scan in diabetic patients without a history of coronary heart disease”. European Radiology 2024, 35: 215-217. PMID: 38995379, DOI: 10.1007/s00330-024-10912-3.Peer-Reviewed Original Research
2023
Deriving Schwann cells from hPSCs enables disease modeling and drug discovery for diabetic peripheral neuropathy
Majd H, Amin S, Ghazizadeh Z, Cesiulis A, Arroyo E, Lankford K, Majd A, Farahvashi S, Chemel A, Okoye M, Scantlen M, Tchieu J, Calder E, Le Rouzic V, Shibata B, Arab A, Goodarzi H, Pasternak G, Kocsis J, Chen S, Studer L, Fattahi F. Deriving Schwann cells from hPSCs enables disease modeling and drug discovery for diabetic peripheral neuropathy. Cell Stem Cell 2023, 30: 632-647.e10. PMID: 37146583, PMCID: PMC10249419, DOI: 10.1016/j.stem.2023.04.006.Peer-Reviewed Original ResearchConceptsDiabetic peripheral neuropathySchwann cellsPeripheral neuropathyPeripheral nervous systemPrimary Schwann cellsBupropion treatmentDiabetic patientsMyelin damageSensory dysfunctionPrimary gliaSelective vulnerabilityAntidepressant drugsHyperglycemic miceLower incidenceRetrospective analysisHuman pluripotent stem cellsSC deathNervous systemTherapeutic candidateHigh glucoseNeuropathyHealth recordsMolecular featuresStem cellsPluripotent stem cells
2022
Safety and efficacy of intensive systolic blood pressure lowering after successful endovascular therapy: a post hoc analysis of the BP TARGET trial
Anadani M, Maier B, Escalard S, Labreuche J, de Havenon A, Sabben C, Lapergue B, Mistry EA, Gory B, Spiotta AM, Richard S, Sibon I, Desilles JP, Blanc R, Piotin M, Mazighi M. Safety and efficacy of intensive systolic blood pressure lowering after successful endovascular therapy: a post hoc analysis of the BP TARGET trial. Journal Of NeuroInterventional Surgery 2022, 15: e142-e147. PMID: 36220337, DOI: 10.1136/jnis-2022-019130.Peer-Reviewed Original ResearchConceptsIntensive SBP treatmentHistory of hypertensionBlood pressure treatmentSuccessful endovascular therapyIntravenous thrombolysisLocation of occlusionEndovascular therapySBP treatmentAdmission SBPDiabetic patientsIntensive blood pressure loweringIntensive systolic blood pressureAcute ischemic stroke trialsTarget trialsEffect of SBPBlood pressure loweringNon-diabetic patientsFavorable functional outcomeSystolic blood pressureIschemic stroke trialsSite of occlusionIntensive SBPRecanalization statusSuccessful reperfusionBlood pressureRacial/Ethnic Variation in White Matter Hyperintensity Progression in the ACCORDION MIND Study
Herman AL, de Havenon A, Falcone GJ, Prabhakaran S, Sheth KN. Racial/Ethnic Variation in White Matter Hyperintensity Progression in the ACCORDION MIND Study. The Neurologist 2022, 28: 157-159. PMID: 35834785, DOI: 10.1097/nrl.0000000000000454.Peer-Reviewed Original ResearchConceptsWMH progressionWhite matter hyperintensitiesLow-density lipoproteinCardiovascular riskWhite patientsBlack patientsWMH volumeSystolic blood pressure levelsWhite matter hyperintensity progressionBlack diabetic patientsBlood pressure levelsExclusion of patientsMagnetic resonance imagingDiabetes (ACCORD) trialDiabetic patientsMean SBPPrimary outcomePatient raceMultivariate regression modelMatter hyperintensitiesA1c measurementHigh riskPatientsNormal rangeCognitive declineAutomated versus conventional perioperative glycemic control in adult diabetic patients undergoing open heart surgery
Kaddoum R, Khalili A, Shebbo F, Ghanem N, Daher L, Ali A, Chehade N, Maroun P, Aouad M. Automated versus conventional perioperative glycemic control in adult diabetic patients undergoing open heart surgery. BMC Anesthesiology 2022, 22: 184. PMID: 35710339, PMCID: PMC9202201, DOI: 10.1186/s12871-022-01721-6.Peer-Reviewed Original ResearchConceptsOpen heart surgeryPercentage of patientsDiabetic patientsHeart surgeryControl groupGlucose controlHypoglycemic eventsGlucose control systemGlucose levelsPerioperative blood glucose levelsHyperglycemic eventsExperimental groupPerioperative glycemic controlAdult diabetic patientsIncidence of hyperglycemiaProportion of patientsRisk of mortalityTight glucose controlBlood glucose levelsCardiac surgeryGlycemic controlGlycemic variabilityLonger surgeryLower incidenceHigh riskIL18 signaling causes islet β cell development and insulin secretion via different receptors on acinar and β cells
Zhang X, Luo S, Wang M, Huang Q, Fang W, Li J, Liu T, Zhang Y, Deng Z, Liu CL, Guan S, Ayala JE, Flavell RA, Kulkarni RN, Libby P, Guo J, Liu Z, Shi GP. IL18 signaling causes islet β cell development and insulin secretion via different receptors on acinar and β cells. Developmental Cell 2022, 57: 1496-1511.e6. PMID: 35675813, PMCID: PMC9233156, DOI: 10.1016/j.devcel.2022.05.013.Peer-Reviewed Original ResearchConceptsGlucagon-like peptide-1Β-cell proliferationInsulin secretionΒ-cellsMacrophage expansionDiet-induced glucose intoleranceCell apoptosisIslet β-cell functionAcinar cellsCell proliferationΒ-cell functionIslet α-cellsCell developmentIL18 receptorΒ-cell apoptosisΒ-cell developmentDiabetic patientsGlucose intoleranceGlucose toleranceMacrophage accumulationInsulin sensitivityGLP1 receptorIslet sizePeptide-1Mouse pancreasesA glucose-like metabolite deficient in diabetes inhibits cellular entry of SARS-CoV-2
Tong L, Xiao X, Li M, Fang S, Ma E, Yu X, Zhu Y, Wu C, Tian D, Yang F, Sun J, Qu J, Zheng N, Liao S, Tai W, Feng S, Zhang L, Li Y, Wang L, Han X, Sun S, Yang L, Zhong H, Zhao J, Liu W, Liu X, Wang P, Li L, Zhao G, Zhang R, Cheng G. A glucose-like metabolite deficient in diabetes inhibits cellular entry of SARS-CoV-2. Nature Metabolism 2022, 4: 547-558. PMID: 35534727, DOI: 10.1038/s42255-022-00567-z.Peer-Reviewed Original ResearchConceptsSARS-CoV-2Diabetes mellitusDiabetic micePre-existing medical comorbiditiesSARS-CoV-2 infectionSARS-CoV-2 replicationRespiratory tissue damageSevere COVID-19COVID-19 pathogenesisHigh viral loadWild-type miceSARS-CoV-2 loadSARS-CoV-2 spike proteinCOVID-19Effective antiviral activityMedical comorbiditiesDiabetic populationDiabetic patientsNondiabetic miceViral loadAG supplementationSustained supplementationAg levelsHealthy individualsViral infectionRelationship Between Glucose Time in Range in Diabetic and Non-Diabetic Patients and Mortality in Critically Ill Patients
Ammar MA, Ammar AA, Wee T, Deshpande R, Band M, Akhtar S. Relationship Between Glucose Time in Range in Diabetic and Non-Diabetic Patients and Mortality in Critically Ill Patients. Journal Of Intensive Care Medicine 2022, 37: 1625-1633. PMID: 35491687, DOI: 10.1177/08850666221098383.Peer-Reviewed Original ResearchConceptsNon-diabetic patientsBlood glucose rangeDiabetic patientsIll patientsGlucose rangeTIR 70Hospital mortalityMortality rateHospital mortality rateNon-diabetic cohortLower mortality rateAdult patientsCohort studyMortality benefitSingle centerGlucose timePercentage of timeHigh incidencePatientsMortalityDlLtDiabeticsICUHyperglycemiaWait List And Transplant Outcomes Of Diabetic Patients With Listed For Heart Transplantation: A Propensity-matched Analysis
Akintoye E, Alvarez P, Salih M, Briasoulis A. Wait List And Transplant Outcomes Of Diabetic Patients With Listed For Heart Transplantation: A Propensity-matched Analysis. Journal Of Cardiac Failure 2022, 28: s64. DOI: 10.1016/j.cardfail.2022.03.163.Peer-Reviewed Original ResearchDiabetic patientsWaitlist mortalityHeart transplantPost-transplant graft survivalEnd-stage heart failurePropensity-matched cohortHeart failure patientsGraft survivalAdult patientsFailure patientsGraft failureHeart failureUnited NetworkRisk factorsOrgan SharingPatientsStudy periodTransplantMortalityFailureCohortWaitlistDoes presence of diabetes mellitus impact patient oncological outcomes in renal cell carcinoma: A multicenter analysis.
Saidian A, Walia A, Patil D, Saito K, Patel D, Nguyen M, Chakoumakos M, Ghali F, Narasimhan R, Perry J, Meagher M, Yasuda Y, Fujii Y, Master V. Does presence of diabetes mellitus impact patient oncological outcomes in renal cell carcinoma: A multicenter analysis. Journal Of Clinical Oncology 2022, 40: 325-325. DOI: 10.1200/jco.2022.40.6_suppl.325.Peer-Reviewed Original ResearchRenal cell carcinomaProgression-free survivalKaplan-Meier analysisCancer-specific survivalIndependent risk factorMultivariable analysisDiabetes mellitusRisk factorsOverall survivalCell carcinomaStage ICox regression multivariable analysisImpact of DMPatients' oncological outcomesNon-diabetic patientsRegression multivariable analysisOncologic effectCause mortalityOncological outcomesDiabetic patientsMulticenter analysisMeier analysisMale sexRCC patientsStage subgroupsPostoperative Urinary Incontinence in Diabetic Patients Undergoing Pelvic Reconstructive Surgery
Siddique M, Ringel N, de Winter K, Marczak T, Kisby C, Rutledge E, Soriano A, Samimi P, Schroeder M, Handler S, Chou J, Gutman R. Postoperative Urinary Incontinence in Diabetic Patients Undergoing Pelvic Reconstructive Surgery. Urogynecology 2022, 28: 372-378. PMID: 35113049, DOI: 10.1097/spv.0000000000001137.Peer-Reviewed Original ResearchConceptsStress urinary incontinencePelvic organ prolapsePelvic reconstructive surgeryUrgency urinary incontinencePostoperative urinary incontinenceAnti-incontinence surgeryUrinary incontinenceReconstructive surgeryDe novo urgency urinary incontinenceMulticenter retrospective cohort studyPostoperative stress urinary incontinencePersistent stress urinary incontinenceMixed urinary incontinenceRetrospective cohort studyHemoglobin A1c levelsIndependent risk factorCohort of womenDiverse medical centersPostoperative incontinenceSUI surgeryCohort studyIncontinence proceduresA1c levelsDiabetes mellitusDiabetic patientsOutcomes of diabetic patients with end‐stage heart failure listed for heart transplantation: A propensity‐matched analysis
Akintoye E, Alvarez P, Salih M, Sellke F, Briasoulis A. Outcomes of diabetic patients with end‐stage heart failure listed for heart transplantation: A propensity‐matched analysis. Clinical Transplantation 2022, 36: e14590. PMID: 35018661, DOI: 10.1111/ctr.14590.Peer-Reviewed Original ResearchConceptsDiabetic patientsWaitlist mortalityHeart transplantPost-transplant graft survivalEnd-stage heart failurePropensity-matched cohortHeart failure patientsGraft survivalAdult patientsFailure patientsGraft failureHeart failureUnited NetworkRisk factorsOrgan SharingPatientsStudy periodTransplantMortalityFailureCohortWaitlistThe Enhanced Cardiac Outcome of Conjugated SGLT2 Inhibitors and GLP-1RA Therapy in Diabetic Patients
Fadah K, Alashi A, Deoker A. The Enhanced Cardiac Outcome of Conjugated SGLT2 Inhibitors and GLP-1RA Therapy in Diabetic Patients. Current Cardiology Reports 2022, 24: 17-22. PMID: 35000149, DOI: 10.1007/s11886-021-01619-8.Peer-Reviewed Original ResearchConceptsDiabetic populationDiabetic patientsSGLT2 inhibitorsGlucagon-like peptide-1 receptor agonistsSodium-glucose cotransporter 2 inhibitorsMajor adverse cardiovascular eventsReal-world cohort studyPeptide-1 receptor agonistsAdditional cardiovascular benefitsGLP-1RA therapyAdverse cardiovascular eventsCotransporter 2 inhibitorsMechanism of actionGLP-1RAsAntihyperglycemic therapyCardiac complicationsCardiac mortalityCardiovascular eventsCardiac outcomesCardiovascular benefitsCohort studyDrug therapyReceptor agonistCardioprotective processesReviewCardiovascular diseaseWhen nerves fail: A cause of respiratory failure in a diabetic patient
Ayub M, Ayub T, Rasool W, Khan M, Ishaq M, Mba B. When nerves fail: A cause of respiratory failure in a diabetic patient. Caspian Journal Of Internal Medicine 2022, 13: 436-438. PMID: 35919641, PMCID: PMC9301228, DOI: 10.22088/cjim.13.2.436.Peer-Reviewed Original ResearchRespiratory failurePhrenic neuropathyDiabetes mellitusDiabetic patientsCompound action potential amplitudeLong-term respiratory supportUncommon clinical scenarioNerve conduction studiesAction potential amplitudeDiaphragmatic paresisRespiratory supportPhrenic nerveConduction studiesMechanical ventilationUnexplained shortnessPotential amplitudeClinical scenariosPatientsNeuropathyNerveFailureMellitusParesisShortnessSuspicion
2021
Failure to Upregulate the RNA Binding Protein ZBP After Injury Leads to Impaired Regeneration in a Rodent Model of Diabetic Peripheral Neuropathy
Jones J, Costa C, Cooney C, Goldberg D, Ponticiello M, Cohen M, Mellado W, C. T, Willis D. Failure to Upregulate the RNA Binding Protein ZBP After Injury Leads to Impaired Regeneration in a Rodent Model of Diabetic Peripheral Neuropathy. Frontiers In Molecular Neuroscience 2021, 14: 728163. PMID: 34949989, PMCID: PMC8688773, DOI: 10.3389/fnmol.2021.728163.Peer-Reviewed Original ResearchDiabetic peripheral neuropathyResponse to injuryPeripheral neuropathyDorsal root ganglion neuronsModel of type I diabetesInjured dorsal root ganglion neuronsSciatic nerve injuryRegeneration of peripheral axonsNeuronal response to injuryPeripheral nerve degenerationType I diabetesNerve injuryGanglion neuronsImpaired regenerationDecreased axonal regenerationNerve degenerationDiabetic patientsDiabetic rodentsRodent modelsPeripheral axonsTherapeutic opportunitiesPeripheral nervesAxonal regenerationInjured axonsDecreased levelsOutcomes of diabetic patients with end-stage heart failure listed for heart transplantation: a propensity-matched analysis
Akintoye E, Alvarez P, Briasoulis A. Outcomes of diabetic patients with end-stage heart failure listed for heart transplantation: a propensity-matched analysis. European Heart Journal 2021, 42: ehab724.0967. DOI: 10.1093/eurheartj/ehab724.0967.Peer-Reviewed Original ResearchHeart transplantWaitlist mortalityPost-transplant graft survivalEnd-stage heart failureOutcomes of patientsPropensity-matched cohortHeart failure patientsGraft survivalAdult patientsFailure patientsGraft failureDiabetic patientsHeart failureDiabetic cohortPoor outcomeUnited NetworkRisk factorsOrgan SharingPatientsTransplantStudy periodCohortMortalityOutcomesRiskA Rare Case of Invasive Mucormycosis in a Diabetic Patient Treated with a Short Course of Dexamethasone
Randhawa G, Hagaman S, Tootkaboni M, Kundal S, Oli S, Alrassi J, Schild S, Abu-Ghanem S, Brejt S. A Rare Case of Invasive Mucormycosis in a Diabetic Patient Treated with a Short Course of Dexamethasone. American Journal Of Case Reports 2021, 22: e932129-1-e932129-5. PMID: 34310559, PMCID: PMC8323743, DOI: 10.12659/ajcr.932129.Peer-Reviewed Original ResearchConceptsInvasive mucormycosisDiabetes mellitusShort courseAtypical presentationSubsequent magnetic resonance imagingSmall cell lung cancerMethicillin-susceptible Staphylococcus aureusLeft eyelid swellingUrgent medical managementHyperosmolar hyperglycemic stateCell lung cancerLife-threatening infectionsSurgical pathology reportsInferior frontal lobeLeft inferior frontal lobeMagnetic resonance imagingDexamethasone useCerebral edemaRare complicationClinical courseDiabetic patientsEyelid swellingMedical managementEmergency departmentCase reportSurgical Outcomes in Urogynecology—Assessment of Perioperative and Postoperative Complications Relative to Preoperative Hemoglobin A1c—A Fellows Pelvic Research Network Study
Ringel NE, de Winter KL, Siddique M, Marczak T, Kisby C, Rutledge E, Soriano A, Samimi P, Schroeder M, Handler S, Zeymo A, Gutman RE. Surgical Outcomes in Urogynecology—Assessment of Perioperative and Postoperative Complications Relative to Preoperative Hemoglobin A1c—A Fellows Pelvic Research Network Study. Urogynecology 2021, 28: 7-13. PMID: 33886510, DOI: 10.1097/spv.0000000000001057.Peer-Reviewed Original ResearchConceptsPelvic reconstructive surgeryMultivariate logistic regressionPostoperative complicationsOverall complicationsSevere complicationsReconstructive surgeryMulticenter retrospective cohort studyLogistic regressionUrinary incontinence surgeryRetrospective cohort studyResearch Network StudyFemale pelvic medicineReconstructive surgery programsHbA1c thresholdPreoperative HbA1cPreoperative hemoglobinUrogynecology populationAverage HbA1cIncontinence surgeryCohort studyMesh exposureDiabetes mellitusDiabetic patientsSurgery typeDiabetic cohort
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