2025
The Implications of Oxygen-Dependent Chronic Obstructive Pulmonary Disease on Sac Growth and Mortality Following Endovascular Aneurysm Repair
Bellamkonda K, Suckow B, Columbo J, Upchurch G, Jacobs B, Ochoa Chaar C, Scully R, Goodney P, Scali S, Stone D. The Implications of Oxygen-Dependent Chronic Obstructive Pulmonary Disease on Sac Growth and Mortality Following Endovascular Aneurysm Repair. Annals Of Vascular Surgery 2025, 115: 98-106. PMID: 40081526, DOI: 10.1016/j.avsg.2025.02.019.Peer-Reviewed Original ResearchChronic obstructive pulmonary diseaseEndovascular AAA repairObstructive pulmonary diseaseSac growthImpact of chronic obstructive pulmonary diseaseOxygen-dependent chronic obstructive pulmonary diseaseEffect of COPD severityCox proportional hazards regressionElective endovascular AAA repairAAA-related mortalityPulmonary diseaseChronic obstructive pulmonary disease severityChronic obstructive pulmonary disease patientsLimited life expectancyIncreased reintervention rateAbdominal aortic aneurysm (AAAEndovascular aneurysm repairElevated mortality ratesPredictors of mortalityPrimary exposureHazards regressionInclusion criteriaIncreased reinterventionsLogistic regressionPost-EVARUsing Radiology as a Screening Tool to Identify Intimate Partner Violence
Lenehan P, Tang A, Watane G, Gujrathi R, Park H, Gosangi B, Thomas R, Franco F, Patel K, Warsofsky I, Rosner B, Khurana B. Using Radiology as a Screening Tool to Identify Intimate Partner Violence. Journal Of The American College Of Radiology 2025, 22: 395-404. PMID: 40044319, PMCID: PMC11887577, DOI: 10.1016/j.jacr.2025.01.003.Peer-Reviewed Original ResearchConceptsAdjusted incidence rate ratiosEmergency departmentRetrospective case-control studyImaging utilization patternsEvident injuriesCox proportional hazards regressionRace-matched controlsCase-control studyTime-to-event analysisProportional hazards regressionImaging utilizationIncidence rate ratiosCumulative incidenceAnatomical sitesScreening mammogramsHazards regressionOdds ratioImaging studiesIntimate partner violencePatientsInjury patternsLogistic regressionInjuryOrgan systemsPoisson regressionRacial/Ethnic Differences and Effects of Clinical/Socioeconomic Factors on Time from Diagnosis to Treatment in Pancreatic Cancer
Sridharan A, Dotan E, Dorta M, Vemula N, Handorf E, Deng M, Renning A, Sorice K, Laderman L, Whittington K, Cukierman E, Astsaturov I, Vijayvergia N, Meyer J, Reddy S, Lynch S. Racial/Ethnic Differences and Effects of Clinical/Socioeconomic Factors on Time from Diagnosis to Treatment in Pancreatic Cancer. Journal Of Gastrointestinal Cancer 2025, 56: 67. PMID: 39954184, PMCID: PMC11829832, DOI: 10.1007/s12029-025-01188-x.Peer-Reviewed Original ResearchConceptsSocioeconomic statusHazard ratioConfidence intervalsSocioeconomic status populationsCancer CenterComprehensive cancer centerDiagnosis to first treatmentPatient-level variablesAcademic cancer centerCox proportional hazards regressionReceipt of chemotherapyMultivariable Cox proportional hazards regressionProportional hazards regressionT2TCancer disparitiesNeighborhood deprivationRace/ethnic disparitiesDisparity indicatorsRacial/ethnic differencesHospital settingEffects of racePatient raceDiagnosis to treatmentUS CensusMetastatic PDACEvaluating the therapeutic role of lymph node dissection in variant histology bladder cancer.
Rahman S, Hesse D, Jalfon M, Kong V, Ghali F. Evaluating the therapeutic role of lymph node dissection in variant histology bladder cancer. Journal Of Clinical Oncology 2025, 43: 749-749. DOI: 10.1200/jco.2025.43.5_suppl.749.Peer-Reviewed Original ResearchLymph node dissectionVariant histology bladder cancerRadical cystectomyBladder cancerNodal dissectionNode dissectionSurvival benefit of lymph node dissectionAssociated with lymph node dissectionBenefit of lymph node dissectionImpact of lymph node dissectionLymph node dissection statusPathological nodal statusCox proportional hazards analysisNational Cancer DatabaseUrothelial bladder cancerKaplan Meier analysisCox proportional hazards regressionProportional hazards analysisProportional hazards regressionNo-LND groupDegree of therapeutic benefitNeuroendocrine subtypeSarcomatoid histologyT3/4 diseaseUC histologyIndustrial air emissions and breast cancer incidence in a United States-wide prospective cohort.
Ish J, Madrigal J, Pearce J, Keil A, Fisher J, Jones R, Sandler D, White A. Industrial air emissions and breast cancer incidence in a United States-wide prospective cohort. Epidemiology 2025 PMID: 39855262, DOI: 10.1097/ede.0000000000001837.Peer-Reviewed Original ResearchBreast cancer incidenceCancer incidenceBreast cancerIncidence of breast cancerEstimate adjusted hazard ratiosHazard ratioAssociated with breast cancerIncident breast cancerConfidence intervalsBreast cancer casesAdjusted hazard ratiosCox proportional hazards regressionProportional hazards regressionParticipating residentsCancer casesHazards regressionProspective cohortStudy enrollmentElevated associationIndustrial air emissionsIndustrial carcinogensCharacterized associationsBreastFollow-upPollutant mixturesHepatic Biomarker Abnormalities in the Cardiac Intensive Care Unit Proposed Criteria for Cardiohepatic Syndrome
Butt A, Padkins M, Crespo-Diaz R, Hillerson D, Katz J, Kamath P, Miller P, Rosenbaum A, Samsky M, Kashani K, Jentzer J. Hepatic Biomarker Abnormalities in the Cardiac Intensive Care Unit Proposed Criteria for Cardiohepatic Syndrome. JACC Advances 2025, 4: 101464. PMID: 39850044, PMCID: PMC11755386, DOI: 10.1016/j.jacadv.2024.101464.Peer-Reviewed Original ResearchCardiac intensive care unitLiver function testsIn-hospital mortalityLiver function test abnormalitiesAbnormal liver function testsCardiac intensive care unit patientsCardiac intensive care unit populationLFT valuesCardiohepatic syndromeCox proportional hazards regressionRisk prediction toolsAdmission liver function testsAssociated with higher in-hospital mortalityProportional hazards regressionAssociated with in-hospitalHistorical cohort studyHigher in-hospital mortalityEvaluate in-hospital mortalityOne-year mortalityPredictor of prognosisLiver synthetic dysfunctionIntensive care unitCohort studyHazards regressionLogistic regressionEarly life stress and pubertal predictors of subsequent substance use in a national diverse sample of adolescents: Sex and substance type matter
Donovan A, Assari S, Grella C, Shaheen M, Richter L, Friedman T. Early life stress and pubertal predictors of subsequent substance use in a national diverse sample of adolescents: Sex and substance type matter. Drug And Alcohol Dependence 2025, 268: 112551. PMID: 39848135, PMCID: PMC11849747, DOI: 10.1016/j.drugalcdep.2025.112551.Peer-Reviewed Original ResearchConceptsEarly life stressSubstance use disordersSubstance useSex differencesLife stressImpact of early life stressAdolescent Brain Cognitive Development StudyMeasures of early life stressAdult substance use disordersRisk of substance use disordersDiverse sample of adolescentsCognitive Development StudySample of adolescentsNationally diverse sampleTrauma ScoreSubstance use riskFamily-based preventionCox proportional hazards regressionUse disorderAssociated with riskProportional hazards regressionTotal scoreIn adulthoodIncreased aHRMarijuana useCardiohepatic Syndrome In The Cardiac Intensive Care Unit, One-year Mortality
Butt A, Padkins M, Crespo-Diaz R, Hillerson D, Katz J, Kamath P, Miller E, Rosenbaum A, Samsky M, Kashani K, Jentzer J. Cardiohepatic Syndrome In The Cardiac Intensive Care Unit, One-year Mortality. Journal Of Cardiac Failure 2025, 31: 196. DOI: 10.1016/j.cardfail.2024.10.045.Peer-Reviewed Original ResearchLiver function test abnormalitiesCardiac intensive care unitLiver function testsOne-year mortalityCardiac intensive care unit patientsAssociated with higher one-year mortalityCTCAE grade 1Cardiohepatic syndromeIntensive care unitTime of CICU admissionCICU patientsHazard ratioMultivariable adjustmentCTCAE gradeCICU admissionLFT valuesConfidence intervalsRisk of one-year mortalityPredictor of long-term prognosisAdmission liver function testsCox proportional hazards regressionCardiac intensive care unit admissionMeeting criteriaCare unitAbnormal liver function tests
2024
Ursodeoxycholic acid and severe COVID-19 outcomes in a cohort study using the OpenSAFELY platform
Costello R, Waller K, Smith R, Mells G, Wong A, Schultze A, Mahalingasivam V, Herrett E, Zheng B, Lin L, MacKenna B, Mehrkar A, Bacon S, Goldacre B, Tomlinson L, Tazare J, Rentsch C. Ursodeoxycholic acid and severe COVID-19 outcomes in a cohort study using the OpenSAFELY platform. Communications Medicine 2024, 4: 238. PMID: 39562612, PMCID: PMC11576861, DOI: 10.1038/s43856-024-00664-y.Peer-Reviewed Original ResearchCOVID-19 hospitalisationSevere COVID-19 outcomesCOVID-19 related hospitalisationCOVID-19 outcomesCohort studyPopulation-based cohort studyHazard ratioPrimary care recordsDeath registration dataOpenSAFELY-TPP platformApproval of NHS EnglandConfidence intervalsEstimate hazard ratiosCox proportional hazards regressionProportional hazards regressionPre-specified confoundersAbsolute risk reductionOpenSAFELY platformCare recordsNHS EnglandConfounder adjustmentEligible individualsRegistration dataHazards regressionHospital recordsHealth-Related Quality of Life of Luspatercept Versus Epoetin Alfa in Red Blood Cell Transfusion-Dependent Lower-Risk Myelodysplastic Syndromes: Results from the Final Datacut of the Phase 3 COMMANDS Study
Oliva E, Platzbecker U, Della Porta M, Garcia-Manero G, Santini V, Fenaux P, Shortt J, Komrokji R, Pelligra C, Guo S, Yucel A, Glassberg M, Eliason L, Hnoosh A, Miteva D, Rose S, Kreitz S, Sekeres M, Zeidan A. Health-Related Quality of Life of Luspatercept Versus Epoetin Alfa in Red Blood Cell Transfusion-Dependent Lower-Risk Myelodysplastic Syndromes: Results from the Final Datacut of the Phase 3 COMMANDS Study. Blood 2024, 144: 3216. DOI: 10.1182/blood-2024-198374.Peer-Reviewed Original ResearchLower-risk myelodysplastic syndromesReduction of red blood cellsFunctional Assessment of Cancer Therapy-AnemiaClinically important differenceEpoetin alfaMyelodysplastic syndromeRevised International Prognostic Scoring SystemInternational Prognostic Scoring SystemHealth-related qualityClinically important difference thresholdImprovement of cytopeniasMean haemoglobin increaseRBC transfusion independencePrognostic Scoring SystemPhase 3 studyStratified Cox proportional hazard regressionsFront-line treatmentOnset of improvementQLQ-C30Cox proportional hazards regressionEORTC QLQ-C30Treatment of anemiaProportional hazards regressionSuperior treatment effectsPost-baseline assessmentAsparaginase Treatment Patterns, Toxicity, and Outcomes Among Patients with Extranodal NK/T-Cell Lymphoma: A North American Multicenter Retrospective Cohort Study
Allen P, Bagley E, Graf K, Sethi T, Foss F, Dong N, Saeed H, Wang J, Dittus C, Paulino D, Wilcox R, Barta S, Carvajal V, Mehta-Shah N, Mou E, Ravindra A, Haverkos B, Mehta A, Shea L, Zain J, Reef D, Ayzman A, Greenwell I. Asparaginase Treatment Patterns, Toxicity, and Outcomes Among Patients with Extranodal NK/T-Cell Lymphoma: A North American Multicenter Retrospective Cohort Study. Blood 2024, 144: 1690. DOI: 10.1182/blood-2024-211424.Peer-Reviewed Original ResearchExtranodal NK/T-cell lymphomaNK/T-cell lymphomaAsparaginase useENKTL patientsResponse rateTreatment patternsDiscontinued due to toxicityMulticenter retrospective cohort studyNon-ASP groupAssociated with significant ratesTherapy related deathsEBV-associated lymphomasKaplan-Meier methodCox proportional hazards regressionRetrospective cohort studyQuarter of patientsProportional hazards regressionStatistically significant advantageHigh response rateLimitations of therapyAnalysis of outcomesAssociated lymphomaChemotherapy backboneNeutropenic feverAsparaginase dosesTranscatheter versus surgical aortic valve replacement in lower-risk patients: an updated meta-analysis of randomised controlled trials
Reddy R, Howard J, Reardon M, Thyregod H, Jorgensen T, Toff W, Forrest J, Leon M, Ahmad Y. Transcatheter versus surgical aortic valve replacement in lower-risk patients: an updated meta-analysis of randomised controlled trials. European Heart Journal 2024, 45: ehae666.2456. DOI: 10.1093/eurheartj/ehae666.2456.Peer-Reviewed Original ResearchLower-risk patientsIndividual patient dataFollow-upNo significant differenceClinical outcomesPairwise random-effects meta-analysesNew-onset atrial fibrillationLong-term clinical outcomesSurgical aortic valve replacementKaplan-Meier survival curvesMeta-analysis of randomised controlled trialsLow-surgical riskMeta-analysesAortic valve reinterventionReconstructed individual patient dataLow surgical riskAortic valve replacementFollow-up durationSevere aortic stenosisMeta-analysisSignificant differenceCox proportional hazards regressionComposite of deathKaplan-Meier plotsLonger-term follow-upInfluenza Vaccine Effectiveness Against Illness and Asymptomatic Infection in 2022–2023: A Prospective Cohort Study
White E, Grant L, Mak J, Olsho L, Edwards L, Naleway A, Burgess J, Ellingson K, Tyner H, Gaglani M, Lutrick K, Caban-Martinez A, Newes-Adeyi G, Duque J, Yoon S, Phillips A, Thompson M, Britton A, Flannery B, Fowlkes A. Influenza Vaccine Effectiveness Against Illness and Asymptomatic Infection in 2022–2023: A Prospective Cohort Study. Clinical Infectious Diseases 2024, ciae491. PMID: 39446477, DOI: 10.1093/cid/ciae491.Peer-Reviewed Original ResearchInfluenza virus infectionReverse transcription-polymerase chain reactionVirus infectionVaccine effectivenessIncidence of laboratory-confirmed influenza illnessLaboratory-confirmed influenza virus infectionLaboratory-confirmed influenza illnessInfluenza A virus infectionAsymptomatic infectionInfluenza season startsLaboratory-confirmed influenzaInfluenza A subtypesCox proportional hazards regressionProspective cohort studyUnvaccinated participantsProportional hazards regressionTranscription-polymerase chain reactionInfluenza illnessInfluenza testingA subtypeDate of infectionEstimates of vaccine effectivenessInfluenza exposureStudy withdrawalProspective cohortLong-term outcomes of elective endovascular vs open repair of popliteal artery aneurysms in the VISION database
Satam K, Brahmandam A, Zheng X, Mao J, Goodney P, Ochoa Chaar C. Long-term outcomes of elective endovascular vs open repair of popliteal artery aneurysms in the VISION database. Journal Of Vascular Surgery 2024, 81: 672-681.e2. PMID: 39454844, DOI: 10.1016/j.jvs.2024.10.026.Peer-Reviewed Original ResearchPopliteal artery aneurysm repairGreat saphenous veinLong-term outcomesVascular Quality InitiativeAneurysm repairAssociated with increased survivalShort hospital length of stayGreat saphenous vein bypassHospital length of stayRandomized multicenter studyCox proportional hazards regressionKaplan-Meier curvesAssociated with lower mortalityPopliteal aneurysm repairPopliteal artery aneurysmPeripheral vascular interventionsProportional hazards regressionLength of stayP2Y12 inhibitorsBaseline characteristicsMulticenter studyEndovascular therapyArtery aneurysmPropensity-matchedSubgroup analysisComplete vs. Incomplete Consolidative Radiotherapy in Patients with Extensive-Stage Small Cell Lung Cancer
Ninia J, Verma N, Laird J, Hayman T, Knowlton C, Peters G, Campbell A, Housri N, Feghali K, de Jong D, Park H. Complete vs. Incomplete Consolidative Radiotherapy in Patients with Extensive-Stage Small Cell Lung Cancer. International Journal Of Radiation Oncology • Biology • Physics 2024, 120: e51. DOI: 10.1016/j.ijrobp.2024.07.1890.Peer-Reviewed Original ResearchExtensive-stage small cell lung cancerProgression-free survivalSmall cell lung cancerOverall survivalCell lung cancerOligometastatic diseaseChemo-immunotherapyLung cancerSuperior progression-free survivalMedian follow-up timePatients treated with CCSites of disease involvementConsolidative thoracic radiotherapyAssociated with improved outcomesChemotherapy-based treatmentStratified Cox proportional hazard regressionsLog-rank testCox proportional hazards regressionDisease burdenTime of diagnosisKaplan-Meier estimatesProportional hazards regressionConsolidation radiotherapyPolymetastatic diseaseOligometastatic patientsAnticoagulation Alone vs Anticoagulation Plus Aspirin or DAPT Following Left Atrial Appendage Occlusion
Reinhardt S, Gibson D, Hsu J, Kapadia S, Yeh R, Price M, Piccini J, Nair D, Christen T, Allocco D, Freeman J. Anticoagulation Alone vs Anticoagulation Plus Aspirin or DAPT Following Left Atrial Appendage Occlusion. Journal Of The American College Of Cardiology 2024, 84: 889-900. PMID: 39197978, DOI: 10.1016/j.jacc.2024.05.067.Peer-Reviewed Original ResearchConceptsLeft atrial appendage occlusionRate of adverse eventsAdverse eventsLAA closure deviceAppendage occlusionAntithrombotic strategiesP2Y<sub>12</sub> inhibitorsDays of follow-upMultivariable Cox proportional hazards regressionClosure deviceRisk of adverse eventsCox proportional hazards regressionWatchman FLX deviceDual antiplatelet therapyDevice-related thrombusProportional hazards regressionStroke/transient ischemic attackAntithrombotic regimensFLX deviceAntiplatelet therapyDOACsGroup patientsFollow-upMultivariate analysisHazards regressionAssociation Between the Decipher Genomic Classifier and Prostate Cancer Outcome in the Real-world Setting
Leapman M, Ho J, Liu Y, Filson C, Zhao X, Hakansson A, Proudfoot J, Davicioni E, Martin D, An Y, Seibert T, Lin D, Spratt D, Cooperberg M, Sprenkle P, Ross A. Association Between the Decipher Genomic Classifier and Prostate Cancer Outcome in the Real-world Setting. European Urology Oncology 2024 PMID: 39098389, DOI: 10.1016/j.euo.2024.07.010.Peer-Reviewed Original ResearchDecipher genomic classifierRisk of metastasisBiochemical recurrenceRadical prostatectomyGenomic classifierDecipher testProstate cancerProstate Risk Assessment Postsurgical ScoreRisk of biochemical recurrencePatient's prostate cancerRisk of cancer recurrencePathological risk factorsProstate cancer outcomesCox proportional hazards regressionRetrospective cohort studyElectronic health record dataReal-world settingsProportional hazards regressionHealth record dataReal-world practice settingsProstate biopsyRP specimensOncological outcomesPrognostic significanceMedian agePancreatic Cancer Surveillance and Survival of High-Risk Individuals
Blackford A, Canto M, Dbouk M, Hruban R, Katona B, Chak A, Brand R, Syngal S, Farrell J, Kastrinos F, Stoffel E, Rustgi A, Klein A, Kamel I, Fishman E, He J, Burkhart R, Shin E, Lennon A, Goggins M. Pancreatic Cancer Surveillance and Survival of High-Risk Individuals. JAMA Oncology 2024, 10: 1087-1096. PMID: 38959011, PMCID: PMC11223057, DOI: 10.1001/jamaoncol.2024.1930.Peer-Reviewed Original ResearchHigh-risk individualsSurveillance of high-risk individualsScreening programPancreatic ductal adenocarcinomaScreening high-risk individualsPancreatic cancer surveillanceUS academic medical centersPopulation-based screeningConditional logistic regressionUS national dataCox proportional hazards regressionAcademic medical centerLead-time biasProportional hazards regressionYear of diagnosisControl patientsRisk regression modelCancer surveillanceComparative cohort studyMain OutcomesComparison cohortOverall survivalCohort studyHazards regressionNational dataPre‐diagnostic plasma advanced glycation end‐products and soluble receptor for advanced glycation end‐products and mortality in colorectal cancer patients
Li J, Baker J, Aglago E, Zhao Z, Jiao L, Freisling H, Hughes D, Eriksen A, Tjønneland A, Severi G, Katzke V, Kaaks R, Schulze M, Masala G, Pala V, Pasanisi F, Tumino R, Padroni L, Vermeulen R, Gram I, Braaten T, Jakszyn P, Sánchez M, Gómez‐Gómez J, Moreno‐Iribas C, Amiano P, Papier K, Weiderpass E, Huybrechts I, Heath A, Schalkwijk C, Jenab M, Fedirko V. Pre‐diagnostic plasma advanced glycation end‐products and soluble receptor for advanced glycation end‐products and mortality in colorectal cancer patients. International Journal Of Cancer 2024, 155: 1982-1995. PMID: 39057841, DOI: 10.1002/ijc.35114.Peer-Reviewed Original ResearchConceptsAssociated with CRC-specificAdvanced glycation end productsPlasma advanced glycation end productsColorectal cancerCRC-specificOverall mortalityGlycation end productsSoluble receptorCancer patientsIntracellular signaling alterationsMultivariable-adjusted Cox proportional hazards regressionCancer and NutritionCox proportional hazards regressionEuropean Prospective InvestigationFollow-up periodColorectal cancer casesColorectal cancer patientsProportional hazards regressionUltra-performance liquid chromatography mass spectrometryColorectal cancer diagnosisEnzyme-linked immunosorbent assayColorectal cancer survivalProspective InvestigationChronic inflammationSRAGEQuantifying the Association between Pump Use and Breastfeeding Duration
Nardella D, Canavan M, Sharifi M, Taylor S. Quantifying the Association between Pump Use and Breastfeeding Duration. The Journal Of Pediatrics 2024, 274: 114192. PMID: 39004167, PMCID: PMC11499033, DOI: 10.1016/j.jpeds.2024.114192.Peer-Reviewed Original ResearchNon-Hispanic blacksBreastfeeding durationBreastfeeding cessationPump usePregnancy Risk Assessment Monitoring System dataAssociated with longer breastfeeding durationNon-Hispanic whitesMagnitude of associationAssociated with breastfeeding durationLonger breastfeeding durationCox proportional hazards regressionCross-sectional analysisProportional hazards regressionNative American participantsBreastfeeding inequitiesBreastfeeding outcomesInitiate breastfeedingLive-born infantsNon-missing dataUnmarried statusSurvey completionMonitoring system dataLow-incomeStratified analysisHazards regression
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