2025
PTEN mutations impair CSF dynamics and cortical networks by dysregulating periventricular neural progenitors
DeSpenza T, Kiziltug E, Allington G, Barson D, McGee S, O’Connor D, Robert S, Mekbib K, Nanda P, Greenberg A, Singh A, Duy P, Mandino F, Zhao S, Lynn A, Reeves B, Marlier A, Getz S, Nelson-Williams C, Shimelis H, Walsh L, Zhang J, Wang W, Prina M, OuYang A, Abdulkareem A, Smith H, Shohfi J, Mehta N, Dennis E, Reduron L, Hong J, Butler W, Carter B, Deniz E, Lake E, Constable R, Sahin M, Srivastava S, Winden K, Hoffman E, Carlson M, Gunel M, Lifton R, Alper S, Jin S, Crair M, Moreno-De-Luca A, Luikart B, Kahle K. PTEN mutations impair CSF dynamics and cortical networks by dysregulating periventricular neural progenitors. Nature Neuroscience 2025, 28: 536-557. PMID: 39994410, DOI: 10.1038/s41593-024-01865-3.Peer-Reviewed Original ResearchConceptsNeural progenitor cellsCongenital hydrocephalusCSF dynamicsIncreased CSF productionDe novo mutationsFrequent monogenic causeEverolimus treatmentCSF shuntingNonsurgical treatmentPTEN mutationsAqueductal stenosisInhibitory interneuronsVentriculomegalyProgenitor cellsChoroid plexusMonogenic causeCortical networksIncreased survivalBrain ventriclesCortical deficitsNeural progenitorsGene PTENCSF productionNkx2.1PTEN
2024
Stepwise pathways from the olfactory cortex to central hub regions in the human brain
Menelaou G, Diez I, Zelano C, Zhou G, Persson J, Sepulcre J, Olofsson J. Stepwise pathways from the olfactory cortex to central hub regions in the human brain. Human Brain Mapping 2024, 45: e26760. PMID: 39688149, PMCID: PMC11651219, DOI: 10.1002/hbm.26760.Peer-Reviewed Original ResearchConceptsDefault-mode networkCortical hubsHuman brainDefault-mode network regionsAnterior olfactory nucleusFunctional connectivity researchProcessing rewardOrbitofrontal cortexAnterior insulaOlfactory tubercleFrontal sulcusPiriform cortexOlfactory cortexCortical subregionsOlfactory nucleusAssociation cortexLanguage acquisitionParietal operculumNeural activityTemporal regionsCortical networksSynchronous neural activityOlfactory pathwaySensory cortexOlfactory systemEarly‐ and Late‐Stage Auditory Processing of Speech Versus Non‐Speech Sounds in Children With Autism Spectrum Disorder: An ERP and Oscillatory Activity Study
Edgar E, McGuire K, Pelphrey K, Ventola P, van Noordt S, Crowley M. Early‐ and Late‐Stage Auditory Processing of Speech Versus Non‐Speech Sounds in Children With Autism Spectrum Disorder: An ERP and Oscillatory Activity Study. Developmental Psychobiology 2024, 66: e22552. PMID: 39508446, DOI: 10.1002/dev.22552.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderNon-speech soundsSpeech soundsTD childrenSpectrum disorderCortical activityResponses to speech soundsProcessing stagesSensitivity to speechAtypical auditory processingTheta phase coherenceAuditory speech processingP3a amplitudeAuditory speechIntra-individual variabilityDevelopment of cortical networksASD childrenCortical networksSpeech processingAuditory processingElectroencephalography sessionLanguage processingCortical responsesAutismSpeechManifold learning uncovers nonlinear interactions between the adolescent brain and environment that predict emotional and behavioral problems
Busch E, Conley M, Baskin-Sommers A. Manifold learning uncovers nonlinear interactions between the adolescent brain and environment that predict emotional and behavioral problems. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2024 PMID: 39009136, PMCID: PMC11729530, DOI: 10.1016/j.bpsc.2024.07.001.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingParticipants' brain activityBehavior problemsAdolescent brainBrain activityModerate-to-large associationsLarge-scale cortical networksCognitive Development StudyMental health researchBrain-environment interactionsCognitive processesLongitudinal predictionSubcortical regionsAdolescent mental health researchInternalizing problemsDevelopmental theoryBrain functionCortical networksEnvironmental experiencesLatent structureAttention networkEnvironmental risk factorsModerating effectBrainMagnetic resonance imagingBrain-state mediated modulation of inter-laminar dependencies in visual cortex
Das A, Sheffield A, Nandy A, Jadi M. Brain-state mediated modulation of inter-laminar dependencies in visual cortex. Nature Communications 2024, 15: 5105. PMID: 38877026, PMCID: PMC11178935, DOI: 10.1038/s41467-024-49144-w.Peer-Reviewed Original ResearchConceptsBrain state fluctuationsUnique dependenceSpatial attentionBehavioral outcomesState fluctuationsDeployment of spatial attentionDeployment of attentionBehaviorally relevant objectsComputational goalCluttered environmentsVisual cortexObject recognitionExcitatory populationHierarchical computationVisual area V4Internal fluctuationsDependenceRelevant objectsModulation patternsTask demandsEnhance information transferCortical networksNeural activityInformation transferArea V4
2023
Rapid fluctuations in functional connectivity of cortical networks encode spontaneous behavior
Benisty H, Barson D, Moberly A, Lohani S, Tang L, Coifman R, Crair M, Mishne G, Cardin J, Higley M. Rapid fluctuations in functional connectivity of cortical networks encode spontaneous behavior. Nature Neuroscience 2023, 27: 148-158. PMID: 38036743, PMCID: PMC11316935, DOI: 10.1038/s41593-023-01498-y.Peer-Reviewed Original ResearchConceptsFunctional connectivitySpontaneous behaviorCortical networksCortical network activityTime-varying functional connectivityFunctional magnetic resonanceCerebral cortexAwake miceDynamic functional connectivityAwake animalsNeighboring neuronsPatterned activityDistinct behavioral statesTwo-photon microscopyNeural activityCortical signalsBehavioral statesCortexNetwork activityCortical dynamicsMagnetic resonanceLaminar mechanisms of saccadic suppression in primate visual cortex
Denagamage S, Morton M, Hudson N, Reynolds J, Jadi M, Nandy A. Laminar mechanisms of saccadic suppression in primate visual cortex. Cell Reports 2023, 42: 112720. PMID: 37392385, PMCID: PMC10528056, DOI: 10.1016/j.celrep.2023.112720.Peer-Reviewed Original ResearchConceptsSaccadic suppressionFiring rateInter-neuronal correlationsLocal inhibitory activityCortical firing ratesEye movementsSaccadic eye movementsPutative inhibitory interneuronsDistinct neural subpopulationsVisual cortical networkPrimate visual cortexVisual area V4Inhibitory interneuronsCortical circuitryVisual cortexSaccade onsetArea V4Single neuronsCortical networksNeural subpopulationsVisual stabilityNeuronsInhibitory activityTemporary reductionVisual sensitivityTwo different brain networks underlying picture naming with familiar pre-existing native words and new vocabulary
Palomar-García M, Villar-Rodríguez E, Pérez-Lozano C, Sanjuán A, Bueichekú E, Miró-Padilla A, Costumero V, Adrián-Ventura J, Parcet M, Ávila C. Two different brain networks underlying picture naming with familiar pre-existing native words and new vocabulary. Brain And Language 2023, 237: 105231. PMID: 36716643, DOI: 10.1016/j.bandl.2023.105231.Peer-Reviewed Original ResearchConceptsLanguage control networkPicture naming taskOld wordsNaming taskMeasured BOLD signal changesControl networkBOLD signal changesNative wordsPicture namingBrain networksSpanish wordsParietal regionsCortical networksCortical/subcortical networksHealthy participantsActivity patternsFunctional circuitsWordsSignal changesVocabularyTaskCognitive purposesFMRILanguageHippocampus
2022
Spatiotemporally heterogeneous coordination of cholinergic and neocortical activity
Lohani S, Moberly A, Benisty H, Landa B, Jing M, Li Y, Higley M, Cardin J. Spatiotemporally heterogeneous coordination of cholinergic and neocortical activity. Nature Neuroscience 2022, 25: 1706-1713. PMID: 36443609, PMCID: PMC10661869, DOI: 10.1038/s41593-022-01202-6.Peer-Reviewed Original ResearchConceptsCortical network activityBehavioral statesCholinergic modulationAnimal's behavioral stateCholinergic signalingAwake miceCortical functionFunctional reorganizationNeuromodulatory influencesDifferent motor behaviorsNeocortical activityAcetylcholineMotor behaviorCortical networksRecent evidenceBrain activityFunctional segregationNeocortexMesoscopic imagingHeterogeneous signalsNetwork activityBehavioral markersBehavioral variablesCircuit dynamicsCholinergic
2021
An altered balance of integrated and segregated brain activity is a marker of cognitive deficits following sleep deprivation
Cross NE, Pomares FB, Nguyen A, Perrault AA, Jegou A, Uji M, Lee K, Razavipour F, Bin Ka’b Ali O, Aydin U, Benali H, Grova C, Dang-Vu TT. An altered balance of integrated and segregated brain activity is a marker of cognitive deficits following sleep deprivation. PLOS Biology 2021, 19: e3001232. PMID: 34735431, PMCID: PMC8568176, DOI: 10.1371/journal.pbio.3001232.Peer-Reviewed Original ResearchConceptsSleep-deprived stateSleep deprivationCortical networksFunctional magnetic resonance imaging (fMRI) scansLarge-scale cortical networksCognitive impairmentSleep-deprived brainNight of SDHomeostatic sleep pressureExecutive tasksCognitive performanceTask performanceCognitive changesRegular nightBrain activityCognitive functionCognitive deficitsNetwork integrationInformation processingSleep pressureCortical activityBidirectional effectsConnectivity changesInterindividual differencesNonrapid eye movement sleepCortical Networks of Creative Ability Trace Gene Expression Profiles of Synaptic Plasticity in the Human Brain
Orwig W, Diez I, Bueichekú E, Vannini P, Beaty R, Sepulcre J. Cortical Networks of Creative Ability Trace Gene Expression Profiles of Synaptic Plasticity in the Human Brain. Frontiers In Human Neuroscience 2021, 15: 694274. PMID: 34381343, PMCID: PMC8350487, DOI: 10.3389/fnhum.2021.694274.Peer-Reviewed Original ResearchSynaptic plasticityOrganization of brain networksFunctional neuroimaging dataHuman brainCreative abilitiesBrain networksFunctional connectivityNeuroimaging phenotypesGraph theory approachNeuroimaging dataNeural plasticityCortical networksBiological basisCortical distributionConnectivity mapsDistributed connectivityCreative thinkingDistribution of genesGene expression distributionSets of genesGene expression informationBrainSynaptic assemblyGene expression profilesNeuroimaging
2020
NMDAR-Dependent Emergence of Behavioral Representation in Primary Visual Cortex
Puścian A, Benisty H, Higley MJ. NMDAR-Dependent Emergence of Behavioral Representation in Primary Visual Cortex. Cell Reports 2020, 32: 107970. PMID: 32726633, PMCID: PMC7431963, DOI: 10.1016/j.celrep.2020.107970.Peer-Reviewed Original ResearchConceptsPrimary visual cortexVisual cortexNMDA-type glutamate receptorsNeocortical sensory areasFunctional plasticityConsiderable functional plasticityPyramidal cellsGlutamate receptorsCell-autonomous expressionV1 neuronsVisual task performanceSensory areasExperience-dependent emergenceCortical networksBehavioral outputCortexVisual inputBehavioral demandsMiceNeuronsReceptorsNeural correlates of non-specific skin conductance responses during resting state fMRI
Gertler J, Novotny S, Poppe A, Chung YS, Gross JJ, Pearlson G, Stevens MC. Neural correlates of non-specific skin conductance responses during resting state fMRI. NeuroImage 2020, 214: 116721. PMID: 32184189, PMCID: PMC7263940, DOI: 10.1016/j.neuroimage.2020.116721.Peer-Reviewed Original ResearchConceptsNon-specific skin conductance responsesSkin conductance responsesNeural correlatesConductance responsesBrain activitySpontaneous skin conductance responsesBrain regionsState fMRI scansEvent-related responsesIndividual differencesFMRI scansCingulate cortexCortical networksFMRI modelState fMRIParietal lobeProcessing areasNeuronal impulsesCorrelatesExternal stimulationExploratory analysisPossible homeostatic mechanismReplication studyCortexResponse profiles
2019
Assemblies of Perisomatic GABAergic Neurons in the Developing Barrel Cortex
Modol L, Bollmann Y, Tressard T, Baude A, Che A, Duan Z, Babij R, De Marco García N, Cossart R. Assemblies of Perisomatic GABAergic Neurons in the Developing Barrel Cortex. Neuron 2019, 105: 93-105.e4. PMID: 31780328, PMCID: PMC7537946, DOI: 10.1016/j.neuron.2019.10.007.Peer-Reviewed Original ResearchConceptsGABAergic neuronsBarrel cortexMouse barrel cortexParvalbumin-expressing cellsEarly postnatal periodGABAergic networkNeonatal periodGABAergic activityGABAergic cellsCalcium imagingPostnatal periodThalamic inputMigration arrestProgrammed cell deathCell deathNeuronsMiceCortexCortical networksCellsSimultaneous mesoscopic and two-photon imaging of neuronal activity in cortical circuits
Barson D, Hamodi AS, Shen X, Lur G, Constable RT, Cardin JA, Crair MC, Higley MJ. Simultaneous mesoscopic and two-photon imaging of neuronal activity in cortical circuits. Nature Methods 2019, 17: 107-113. PMID: 31686040, PMCID: PMC6946863, DOI: 10.1038/s41592-019-0625-2.Peer-Reviewed Original ResearchConceptsVasoactive intestinal peptide-expressing interneuronsBrain-wide network dynamicsTwo-photon calcium imagingEntire cortical mantleLocal neuronal circuitsLong-range cortical networksWidespread gene deliveryWidefield calciumPyramidal neuronsAwake miceCortical circuitsNeuronal activityCortical mantleTwo-photon imagingViral transduction methodsNeuronal circuitsCalcium imagingMouse brainFunctional connectivityLocal microcircuitsMammalian cortexCortical architectureCortical networksBrainActivity propagatesNeurofilament-lysosomal genetic intersections in the cortical network of stuttering
Benito-Aragón C, Gonzalez-Sarmiento R, Liddell T, Diez I, d'Oleire Uquillas F, Ortiz-Terán L, Bueichekú E, Chow H, Chang S, Sepulcre J. Neurofilament-lysosomal genetic intersections in the cortical network of stuttering. Progress In Neurobiology 2019, 184: 101718. PMID: 31669185, PMCID: PMC6938554, DOI: 10.1016/j.pneurobio.2019.101718.Peer-Reviewed Original ResearchConceptsCytoskeleton organizationNeurofilament genesCortical networksGenetic expression levelsMannose-6-phosphateGenetic interactomesInteractome networkTranscriptome dataLarge-scale cortical networksLysosomal pathwayAllen Human Brain AtlasPresence of stutteringGenetic intersectionFunctional connectivity MRIBiological functionsNeuronal circuitsSpatial similarity analysisGenesHuman Brain AtlasTarget pathwaysFunctional linkInteractomeNeurobiological underpinningsCo-localizationLysosomal dysfunctionRethinking Food Reward
de Araujo IE, Schatzker M, Small DM. Rethinking Food Reward. Annual Review Of Psychology 2019, 71: 1-26. PMID: 31561741, DOI: 10.1146/annurev-psych-122216-011643.Peer-Reviewed Original ResearchConceptsFood rewardReward regionsHedonic qualityBrain neural pathwaysSubliminal signalsCognitive processesBrain reward regionsConscious perceptionDietary decisionsCortical networksFlavor perceptionCaloric foodNeural pathwaysFood reinforcementRewardUncontrolled desirePerceptionDietary choicesOvereatingRecent animalHuman studiesTraditional modelsSensory receptorsDesireFindingsLongitudinal cortical network reorganization in early relapsing–remitting multiple sclerosis
Fleischer V, Koirala N, Droby A, Gracien R, Deichmann R, Ziemann U, Meuth S, Muthuraman M, Zipp F, Groppa S. Longitudinal cortical network reorganization in early relapsing–remitting multiple sclerosis. Therapeutic Advances In Neurological Disorders 2019, 12: 1756286419838673. PMID: 31040880, PMCID: PMC6482642, DOI: 10.1177/1756286419838673.Peer-Reviewed Original ResearchRelapsing-remitting MSEarly relapsing-remitting MSHealthy controlsDisease activityEarly relapsing-remitting multiple sclerosisLongitudinal brain volume changesRelapsing-remitting multiple sclerosisCortical atrophy patternsStructural cortical networksPatients' disease activityNetwork reorganizationBrain volume changesClinical disease manifestationsDetectable atrophyMultiple sclerosisAtrophy patternsDisease manifestationsAtrophy measurementsCortical responsesGray matter networksBrain functionPatientsT MRICortical networksGraph theoretical analysis
2018
Sparse recurrent excitatory connectivity in the microcircuit of the adult mouse and human cortex
Seeman SC, Campagnola L, Davoudian PA, Hoggarth A, Hage TA, Bosma-Moody A, Baker CA, Lee JH, Mihalas S, Teeter C, Ko AL, Ojemann JG, Gwinn RP, Silbergeld DL, Cobbs C, Phillips J, Lein E, Murphy G, Koch C, Zeng H, Jarsky T. Sparse recurrent excitatory connectivity in the microcircuit of the adult mouse and human cortex. ELife 2018, 7: e37349. PMID: 30256194, PMCID: PMC6158007, DOI: 10.7554/elife.37349.Peer-Reviewed Original ResearchConceptsRecurrent excitatory connectivityExcitatory connectivityAdult mouse primary visual cortexMouse primary visual cortexHuman cortexLayer 2/3 neuronsClasses of neuronsPrimary visual cortexShort-term depressionBody of evidenceExcitatory neuronsAdult miceVisual cortexSynaptic signalingTwo-photon optogeneticsCell classesCortical networksCortical microcircuitsCortexNeuronsFuture studiesMiceMicrocircuitsSynapses
2017
Impaired Tuning of Neural Ensembles and the Pathophysiology of Schizophrenia: A Translational and Computational Neuroscience Perspective
Krystal JH, Anticevic A, Yang GJ, Dragoi G, Driesen NR, Wang XJ, Murray JD. Impaired Tuning of Neural Ensembles and the Pathophysiology of Schizophrenia: A Translational and Computational Neuroscience Perspective. Biological Psychiatry 2017, 81: 874-885. PMID: 28434616, PMCID: PMC5407407, DOI: 10.1016/j.biopsych.2017.01.004.Peer-Reviewed Original ResearchConceptsNeural activityNeural ensemblesComputational neuroscience perspectiveHigher cognitive functionsNeuroscience perspectiveDevelopmental perspectiveDevelopmental correlatesCognitive functionNegative functional consequencesCortical networksComputational neuroscienceNeural codeCortical activityCognitive impairmentNeural dysfunctionAspartate glutamate receptor antagonistTemporal tuningSpatial tuningGlutamate receptor antagonistsPathophysiology of schizophreniaNeural network functionSchizophreniaPsychiatric disordersBalance of excitationInput-output curves
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