2025
Significance of Coronary Artery Calcifications and Ischemic Electrocardiographic Changes Among Patients Undergoing Myocardial Perfusion Imaging
Kokkinidis D, Kyriakoulis I, Chui P, Agarwal R, Liu Y, Khera R, Sinusas A, Velazquez E, Miller E, Feher A. Significance of Coronary Artery Calcifications and Ischemic Electrocardiographic Changes Among Patients Undergoing Myocardial Perfusion Imaging. JACC Advances 2025, 4: 101618. PMID: 39983619, PMCID: PMC11891677, DOI: 10.1016/j.jacadv.2025.101618.Peer-Reviewed Original ResearchCoronary artery calcificationMyocardial perfusion imagingIschemic ECG changesLow event ratesECG changesNormal perfusionArtery calcificationPerfusion imagingSingle-photon emission computed tomography/computed tomographyStress ECGCAC evaluationPresence of coronary artery calcificationSuspected coronary artery diseaseMedian follow-upEvent ratesIschemic electrocardiographic changesAnalysis to patientsComposite endpoint rateCoronary artery diseaseTomography/computed tomographyPrognostic informationMACE rateFollow-upSubgroup analysisAdverse outcomesLung Cancer Screening and Incidental Findings: A Research Agenda: An Official American Thoracic Society Research Statement.
Henderson L, Kim R, Tanner N, Tsai E, Begnaud A, Dako F, Gieske M, Kallianos K, Richman I, Sakoda L, Schwartz R, Yeboah J, Fong K, Lam S, Lee P, Pasquinelli M, Smith R, Triplette M, Tanoue L, Rivera M. Lung Cancer Screening and Incidental Findings: A Research Agenda: An Official American Thoracic Society Research Statement. American Journal Of Respiratory And Critical Care Medicine 2025, 211: 436-451. PMID: 39928329, PMCID: PMC11936151, DOI: 10.1164/rccm.202501-0011st.Peer-Reviewed Original ResearchConceptsLow-dose computed tomographyManagement of incidental findingsLung cancer screeningCancer screeningThree-round modified Delphi processReporting of incidental findingsClinically significant IFsPrioritized questionsDelphi processIncidental findingClinicians' effortsMultidisciplinary panelPatient anxietyResearch questionsPotential harmLDCT examinationsCoronary artery calcificationIncreased awarenessSignificant IFsExcess costsHarmPotential benefitsArtery calcificationKnowledge gapsComputed tomography
2024
Clonal hematopoiesis of indeterminate potential is associated with increased risk of immune checkpoint inhibitor myocarditis in a prospective study of a cardio-oncology cohort
Jaber Chehayeb R, Singh J, Matute-Martinez C, Chen N, Guajardo A, Lin D, Jayakrishnan R, Christofides A, Leveille E, Im Y, Biancon G, VanOudenhove J, Ibrahim E, Ardasheva A, Jha A, Hwa J, Halene S, Kwan J. Clonal hematopoiesis of indeterminate potential is associated with increased risk of immune checkpoint inhibitor myocarditis in a prospective study of a cardio-oncology cohort. Cardio-Oncology 2024, 10: 84. PMID: 39587635, PMCID: PMC11590368, DOI: 10.1186/s40959-024-00289-z.Peer-Reviewed Original ResearchImmune checkpoint inhibitor myocarditisImmune checkpoint inhibitorsImmune checkpoint inhibitor useICI-myocarditisIndeterminate potentialProspective studyImmune checkpoint inhibitor therapyCancer therapyClonal hematopoiesis of indeterminate potentialCancer treated with immunotherapyIncreased T cell activationObstructive coronary artery diseaseMultivariate competing risk analysisCardiotoxic cancer therapyRisks Cox regressionAssociated with increased riskIncreased all-cause mortalityPatient co-morbiditiesRisk of cardiomyopathyT cell activationCompeting risk analysisCoronary artery calcificationCoronary artery diseaseAll-cause mortalityHeart failure patientsEquity in Modifying Plaque of Women With Undertreated Calcified Coronary Artery Disease: Design and Rationale of EMPOWER CAD study
McEntegart M, Gonzalo N, Fendelander L, West N, Lansky A. Equity in Modifying Plaque of Women With Undertreated Calcified Coronary Artery Disease: Design and Rationale of EMPOWER CAD study. Journal Of The Society For Cardiovascular Angiography & Interventions 2024, 3: 102289. PMID: 39649816, PMCID: PMC11624350, DOI: 10.1016/j.jscai.2024.102289.Peer-Reviewed Original ResearchCoronary artery diseaseCalcified coronary artery diseasePercutaneous coronary interventionTarget lesion failureCoronary intravascular lithotripsyArtery diseaseFemale patientsIntravascular lithotripsySubcohort analysis of patientsPrevalence of coronary artery calcificationEnd pointsOptical coherence tomography imagesComposite of cardiac deathClinical events committeeSafety end pointAnalysis of patientsIndependent core laboratoryIncreased risk of mortalityIschemia-driven target lesion revascularizationTarget vessel myocardial infarctionTarget lesion revascularizationCoronary artery calcificationEffectiveness end pointCAD studiesCardiology clinical trialsRefining Cardiovascular Calcification in the Appraisal of Ischemic Heart
Nguyen V, Fan J, Hafeez I, Nguyen A, Mojibian H. Refining Cardiovascular Calcification in the Appraisal of Ischemic Heart. Cureus 2024, 16: e64328. PMID: 39130835, PMCID: PMC11316457, DOI: 10.7759/cureus.64328.Peer-Reviewed Original ResearchCoronary artery calcificationCardiovascular calcificationPositron emission tomographySuspected ischemiaPerfusion defectsArtery calcificationMedical historyPredictor of myocardial ischemiaNon-contrast computed tomographyRate of cardiovascular eventsAssociation of ischemiaCT attenuation correctionChest computed tomography imagesNegative predictive valueSignificant perfusion defectsAtherosclerotic coronary artery diseaseNuclear stress testingMyocardial perfusion defectsMyocardial perfusion imagingMyocardial perfusion scanCoronary artery diseaseFollow-up dataPatient's medical historyCoronary CTAInvasive angiographyAutomated vessel-specific coronary artery calcification quantification with deep learning in a large multi-centre registry
Williams M, Shanbhag A, Zhou J, Michalowska A, Lemley M, Miller R, Killekar A, Waechter P, Gransar H, Van Kriekinge S, Builoff V, Feher A, Miller E, Bateman T, Dey D, Berman D, Slomka P. Automated vessel-specific coronary artery calcification quantification with deep learning in a large multi-centre registry. European Heart Journal - Cardiovascular Imaging 2024, 25: 976-985. PMID: 38376471, DOI: 10.1093/ehjci/jeae045.Peer-Reviewed Original ResearchCoronary artery calcificationRight coronary arteryAttenuation correction CTGated CTAgatston unitsLeft circumflexHazard ratioCoronary artery calcification quantificationMulti-center registryAdverse cardiovascular eventsYear follow-upConfidence intervalsLinear weighted Cohen's kappaPrognostic implicationsMulticenter registryPrognostic assessmentCardiovascular eventsArtery calcificationCoronary arteryAttenuation correctionCohen's kappaLM/LADRegistry
2023
Whole-genome sequencing uncovers two loci for coronary artery calcification and identifies ARSE as a regulator of vascular calcification
de Vries P, Conomos M, Singh K, Nicholson C, Jain D, Hasbani N, Jiang W, Lee S, Lino Cardenas C, Lutz S, Wong D, Guo X, Yao J, Young E, Tcheandjieu C, Hilliard A, Bis J, Bielak L, Brown M, Musharoff S, Clarke S, Terry J, Palmer N, Yanek L, Xu H, Heard-Costa N, Wessel J, Selvaraj M, Li R, Sun X, Turner A, Stilp A, Khan A, Newman A, Rasheed A, Freedman B, Kral B, McHugh C, Hodonsky C, Saleheen D, Herrington D, Jacobs D, Nickerson D, Boerwinkle E, Wang F, Heiss G, Jun G, Kinney G, Sigurslid H, Doddapaneni H, Hall I, Bensenor I, Broome J, Crapo J, Wilson J, Smith J, Blangero J, Vargas J, Mosquera J, Smith J, Viaud-Martinez K, Ryan K, Young K, Taylor K, Lange L, Emery L, Bittencourt M, Budoff M, Montasser M, Yu M, Mahaney M, Mahamdeh M, Fornage M, Franceschini N, Lotufo P, Natarajan P, Wong Q, Mathias R, Gibbs R, Do R, Mehran R, Tracy R, Kim R, Nelson S, Damrauer S, Kardia S, Rich S, Fuster V, Napolioni V, Zhao W, Tian W, Yin X, Min Y, Manning A, Peloso G, Kelly T, O’Donnell C, Morrison A, Curran J, Zapol W, Bowden D, Becker L, Correa A, Mitchell B, Psaty B, Carr J, Pereira A, Assimes T, Stitziel N, Hokanson J, Laurie C, Rotter J, Vasan R, Post W, Peyser P, Miller C, Malhotra R. Whole-genome sequencing uncovers two loci for coronary artery calcification and identifies ARSE as a regulator of vascular calcification. Nature Cardiovascular Research 2023, 2: 1159-1172. PMID: 38817323, PMCID: PMC11138106, DOI: 10.1038/s44161-023-00375-y.Peer-Reviewed Original ResearchGenome-wide association studiesMultiple ancestral groupsWhole-genome sequencingPotential drug targetsNovel lociAncestral groupsLociCoronary artery calcificationVascular smooth muscle cellsDrug targetsFunctional assaysPhenotypic switchingCoronary artery diseaseVascular smooth muscle cell phenotypic switchingHuman vascular smooth muscle cellsARSEG alleleArtery calcificationVascular calcificationPredictor of coronary artery diseaseReplicate analysesRegulation of vascular calcificationSmooth muscle cellsCalcifiersSequenceComparison of the prognostic value between quantification and visual estimation of coronary calcification from attenuation CT in patients undergoing SPECT myocardial perfusion imaging
Feher A, Pieszko K, Shanbhag A, Lemley M, Miller R, Huang C, Miras L, Liu Y, Gerber J, Sinusas A, Miller E, Slomka P. Comparison of the prognostic value between quantification and visual estimation of coronary calcification from attenuation CT in patients undergoing SPECT myocardial perfusion imaging. The International Journal Of Cardiovascular Imaging 2023, 40: 185-193. PMID: 37845406, PMCID: PMC466934, DOI: 10.1007/s10554-023-02980-1.Peer-Reviewed Original ResearchConceptsMajor adverse cardiovascular eventsCoronary artery calcificationMyocardial perfusion imagingCT myocardial perfusion imagingSPECT/CT myocardial perfusion imagingArtery calcificationPrognostic valuePrior coronary stentingAdverse cardiovascular eventsSimilar prognostic valueSPECT myocardial perfusionREFINE SPECT registrySPECT/CTCardiovascular eventsCAC scoringCalcium scoreCoronary calcificationCoronary stentingPrognostic utilitySingle centerCoronary arteryLow doseMyocardial perfusionPerfusion imagingSurvival analysisCORONARY ARTERY CALCIFICATIONS ARE A BETTER PREDICTOR OF CARDIOVASCULAR OUTCOMES THAN ISCHEMIC ECG CHANGES IN PATIENTS WITH NORMAL PERFUSION ON EXERCISE SPECT
Shi T, Kokkinidis D, Agarwal R, Liu Y, Sinusas A, Miller E, Feher A. CORONARY ARTERY CALCIFICATIONS ARE A BETTER PREDICTOR OF CARDIOVASCULAR OUTCOMES THAN ISCHEMIC ECG CHANGES IN PATIENTS WITH NORMAL PERFUSION ON EXERCISE SPECT. Journal Of The American College Of Cardiology 2023, 81: 1498. DOI: 10.1016/s0735-1097(23)01942-3.Peer-Reviewed Original Research
2022
Next Generation Risk Markers in Preventive Cardio-oncology
Lamberg M, Rossman A, Bennett A, Painter S, Goodman R, MacLeod J, Maddula R, Rayan D, Doshi K, Bick A, Bailey S, Brown S. Next Generation Risk Markers in Preventive Cardio-oncology. Current Atherosclerosis Reports 2022, 24: 443-456. PMID: 35441347, PMCID: PMC10026729, DOI: 10.1007/s11883-022-01021-x.Peer-Reviewed Original ResearchConceptsClonal hematopoiesis of indeterminate potentialBreast arterial calcificationCoronary artery calcificationPurpose of reviewCardiovascular diseaseCoronary artery diseaseRisk stratificationRisk markersCVD risk assessmentCancer treatmentArtery calcificationImprove CV risk stratificationPresence of clonal hematopoiesis of indeterminate potentialAtherosclerotic CVDIndependent of traditional CV risk factorsLong-term CVD outcomesIncreased risk of CVDTraditional CV risk factorsCV risk markersPrediction of coronary artery diseaseCardio-oncology practiceLung cancer screeningCV risk factorsCVD risk calculatorsCV risk stratificationCoronary artery stenosisSex-Specific Outcomes After Coronary Intravascular Lithotripsy: A Patient-Level Analysis of the Disrupt CAD Studies
Hussain Y, Kearney K, Abbott J, Kereiakes D, Di Mario C, Saito S, Cristea E, Riley R, Fajadet J, Shlofmitz R, Ali Z, Klein A, Price M, Hill J, Stone G, Lansky A. Sex-Specific Outcomes After Coronary Intravascular Lithotripsy: A Patient-Level Analysis of the Disrupt CAD Studies. Journal Of The Society For Cardiovascular Angiography & Interventions 2022, 1: 100011. PMID: 39130137, PMCID: PMC11307712, DOI: 10.1016/j.jscai.2021.100011.Peer-Reviewed Original ResearchPrimary efficacy end pointPrimary safety end pointMajor adverse cardiovascular eventsAdverse cardiovascular eventsEfficacy end pointSafety end pointIntravascular lithotripsyEnd pointCardiovascular eventsMyocardial infarctionHospital major adverse cardiovascular eventsMean reference vessel diameterCoronary intravascular lithotripsySevere coronary calcificationCoronary artery calcificationReference vessel diameterPercutaneous coronary interventionPrior myocardial infarctionSex-based outcomesSex-specific outcomesSide branch involvementPatient-level analysisSmall vessel sizeAngiographic complicationsLesion predilatation
2019
Absence of Coronary Artery Calcification in Middle-Aged Familial Hypercholesterolemia Patients Without Atherosclerotic Cardiovascular Disease
Mszar R, Grandhi GR, Valero-Elizondo J, Virani SS, Blankstein R, Blaha M, Mata P, Miname MH, Al Rasadi K, Krumholz HM, Santos RD, Nasir K. Absence of Coronary Artery Calcification in Middle-Aged Familial Hypercholesterolemia Patients Without Atherosclerotic Cardiovascular Disease. JACC Cardiovascular Imaging 2019, 13: 1090-1092. PMID: 31843585, DOI: 10.1016/j.jcmg.2019.11.001.Peer-Reviewed Original ResearchSafety and Effectiveness of Coronary Intravascular Lithotripsy for Treatment of Severely Calcified Coronary Stenoses
Ali ZA, Nef H, Escaned J, Werner N, Banning AP, Hill JM, De Bruyne B, Montorfano M, Lefevre T, Stone GW, Crowley A, Matsumura M, Maehara A, Lansky AJ, Fajadet J, Di Mario C. Safety and Effectiveness of Coronary Intravascular Lithotripsy for Treatment of Severely Calcified Coronary Stenoses. Circulation Cardiovascular Interventions 2019, 12: e008434. PMID: 31553205, DOI: 10.1161/circinterventions.119.008434.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCardiac CatheterizationCoronary AngiographyCoronary StenosisEuropeFemaleHumansLithotripsyMaleMiddle AgedPatient SafetyPercutaneous Coronary InterventionProspective StudiesRisk FactorsSeverity of Illness IndexStentsTime FactorsTomography, Optical CoherenceTreatment OutcomeUnited StatesVascular CalcificationConceptsSevere coronary artery calcificationCoronary artery calcificationMajor adverse cardiac eventsAdverse cardiac eventsPrimary end pointIntravascular lithotripsyOptical coherence tomographyCardiac eventsStent implantationPlaque fractureHospital major adverse cardiac eventsNon-Q-wave myocardial infarctionOptical coherence tomography substudyIndependent clinical events committeeCoherence tomographyDrug-eluting stent implantationEnd pointCoronary intravascular lithotripsyClinical events committeeHigh procedural successIndependent core laboratoryAcute luminal gainPost-approval studiesMechanism of actionCalcium fractureReclassification of coronary heart disease risk in a primary prevention setting: traditional risk factor assessment vs . coronary artery calcium scoring
Alashi A, Lang R, Seballos R, Feinleib S, Sukol R, Cho L, Schoenhagen P, Griffin BP, Flamm SD, Desai MY. Reclassification of coronary heart disease risk in a primary prevention setting: traditional risk factor assessment vs . coronary artery calcium scoring. Cardiovascular Diagnosis And Therapy 2019, 9: 214-220. PMID: 31275811, PMCID: PMC6603493, DOI: 10.21037/cdt.2019.04.05.Peer-Reviewed Original ResearchReynolds Risk ScoreC-reactive proteinCoronary heart disease riskHeart disease riskPrimary preventionCHD riskAsymptomatic middle-aged patientsAsymptomatic middle-aged subjectsAtherosclerotic cardiovascular disease (ASCVD) scoreTraditional risk factor assessmentDisease riskMean C-reactive proteinCoronary artery calcium scoringConsecutive asymptomatic subjectsSignificant risk reclassificationCoronary artery calcificationMiddle-aged patientsRisk factor assessmentMiddle-aged subjectsStandard risk factorsASCVD scorePrevention clinicArtery calcificationCAC scoringAsymptomatic subjects
2018
Lipoprotein Sub-Fractions by Ion-Mobility Analysis and Its Association with Subclinical Coronary Atherosclerosis in High-Risk Individuals
Aneni EC, Osondu CU, De La Cruz J, Martin SS, Blaha MJ, Younus A, Feldman T, Agatston AS, Veledar E, Nasir K. Lipoprotein Sub-Fractions by Ion-Mobility Analysis and Its Association with Subclinical Coronary Atherosclerosis in High-Risk Individuals. Journal Of Atherosclerosis And Thrombosis 2018, 26: 50-63. PMID: 30224606, PMCID: PMC6308270, DOI: 10.5551/jat.40741.Peer-Reviewed Original ResearchConceptsCoronary artery calcificationLipoprotein subfractionsCoronary atherosclerosisRisk of CACLipoprotein particlesLipoprotein subfraction analysisSubclinical coronary atherosclerosisBaptist Health South FloridaLarge LDL particlesHigh-risk personsHigh-risk populationHigh-risk individualsTriglyceride-rich lipoproteinsHigh-risk workersArtery calcificationIDL particlesMetabolic syndromeLipoprotein profileHDL lipoproteinsMean ageLipoprotein subclassesMedium LDLStudy populationRisk individualsVLDL particlesMultifactorial Analysis of Mortality in Screening Detected Lung Cancer
Digumarthy SR, De Man R, Canellas R, Otrakji A, Wang G, Kalra MK. Multifactorial Analysis of Mortality in Screening Detected Lung Cancer. Journal Of Oncology 2018, 2018: 1296246. PMID: 29861726, PMCID: PMC5976935, DOI: 10.1155/2018/1296246.Peer-Reviewed Original ResearchCoronary artery calcificationNational Lung Screening TrialLow-dose CTBody mass indexLung cancerFat attenuationMuscle massLow-dose chest CTLung cancer mortalitySeverity of emphysemaLung cancer stageNLST trialNonsurvivor groupArtery calcificationSmoking historyMass indexCancer mortalityChest CTCancer stageSurvivor groupScreening TrialSurvival timeEmphysemaPatientsCancer
2017
The relationship of erectile dysfunction and subclinical cardiovascular disease: A systematic review and meta-analysis
Osondu CU, Vo B, Oni ET, Blaha MJ, Veledar E, Feldman T, Agatston AS, Nasir K, Aneni EC. The relationship of erectile dysfunction and subclinical cardiovascular disease: A systematic review and meta-analysis. Vascular Medicine 2017, 23: 9-20. PMID: 29243995, DOI: 10.1177/1358863x17725809.Peer-Reviewed Original ResearchConceptsCarotid intima-media thicknessAssociation of EDFlow-mediated dilationSubclinical cardiovascular diseaseCoronary artery calcificationErectile dysfunctionCardiovascular diseaseHigher carotid intima-media thicknessAnkle-brachial indexToe-brachial indexCVD risk assessmentIntima-media thicknessPulse wave velocityArtery calcificationEndothelial dysfunctionCVD mortalityMean ageVascular functionStudy qualityStudy populationAssessment QuestionnaireSystematic reviewDysfunctionPercentage point reductionMultiple databases
2016
Association of Fitness in Young Adulthood With Survival and Cardiovascular Risk: The Coronary Artery Risk Development in Young Adults (CARDIA) Study
Shah R, Murthy V, Colangelo L, Reis J, Venkatesh B, Sharma R, Abbasi S, Goff D, Carr J, Rana J, Terry J, Bouchard C, Sarzynski M, Eisman A, Neilan T, Das S, Jerosch-Herold M, Lewis C, Carnethon M, Lewis G, Lima J. Association of Fitness in Young Adulthood With Survival and Cardiovascular Risk: The Coronary Artery Risk Development in Young Adults (CARDIA) Study. JAMA Internal Medicine 2016, 176: 1-9. PMID: 26618471, PMCID: PMC5292201, DOI: 10.1001/jamainternmed.2015.6309.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAsymptomatic DiseasesCardiovascular DiseasesCoronary Artery DiseaseExercise TestFemaleHeart VentriclesHumansHypertrophy, Left VentricularLongitudinal StudiesMaleMiddle AgedMortalityObesityPhysical FitnessProportional Hazards ModelsProspective StudiesTomography, X-Ray ComputedUltrasonographyUnited StatesVascular CalcificationYoung AdultConceptsCardiorespiratory fitnessIncident cardiovascular diseaseCoronary artery calcificationCardiovascular diseaseEffects of cardiorespiratory fitnessHazard of cardiovascular diseaseCoronary Artery Risk DevelopmentHigher level of fitnessImprove cardiorespiratory fitnessAssociation of fitnessBaseline cardiorespiratory fitnessExercise test durationAssessment of obesityAssociated with lower riskFollow-upLevel of fitnessTreadmill exercise testBaseline study visitCardiovascular disease eventsYoung adultsLeft ventricular massSubclinical cardiovascular diseasePresence of coronary artery calcificationYoung adulthoodAssociated with coronary artery calcification
2015
Coronary artery calcification score is an independent predictor of the no-reflow phenomenon after reperfusion therapy in acute myocardial infarction
Modolo R, Figueiredo V, Moura F, Almeida B, Quinaglia e Silva J, Nadruz W, Lemos P, Coelho O, Blaha M, Sposito A. Coronary artery calcification score is an independent predictor of the no-reflow phenomenon after reperfusion therapy in acute myocardial infarction. Coronary Artery Disease 2015, 26: 562-566. PMID: 26010531, DOI: 10.1097/mca.0000000000000269.Peer-Reviewed Original ResearchConceptsCoronary artery calcification scoreST-elevation myocardial infarctionCoronary artery calcificationMyocardial blush gradeTIMI flowAssociated with impaired reperfusionST-elevation myocardial infarction patientsCoronary angiographic severityCardiac computed tomographyConsecutive STEMI patientsTIMI flow ratesNonculprit coronary arteryCoronary thrombus burdenArtery calcification scoreAcute coronary syndromeNo-reflow phenomenonHigher heart rateCoronary blood flowCAC scoreOptimal reperfusionCalcification scoreClinical characteristicsAngiographic severityBlush gradeSTEMI patientsElevated serum uric acid is associated with vascular inflammation but not coronary artery calcification in the healthy octogenarians: the Brazilian study on healthy aging
Malik R, Aneni EC, Shahrayar S, Freitas WM, Ali SS, Veledar E, Latif MA, Aziz M, Ahmed R, Khan SA, Joseph J, Feiz H, Sposito A, Nasir K. Elevated serum uric acid is associated with vascular inflammation but not coronary artery calcification in the healthy octogenarians: the Brazilian study on healthy aging. Aging Clinical And Experimental Research 2015, 28: 359-362. PMID: 26084248, DOI: 10.1007/s40520-015-0395-3.Peer-Reviewed Original ResearchConceptsSerum uric acidElevated hs-CRPCoronary artery calcificationHs-CRPSUA tertilesCardiovascular diseaseCoronary atherosclerosisHealthy octogenariansArtery calcificationVascular inflammationAssociation of SUATertiles of SUAElevated serum uric acidSensitive C-reactive proteinMedian hs-CRPClinical cardiovascular diseaseHigher SUA levelsC-reactive proteinSubclinical cardiovascular diseaseUric acidCAC burdenCAC presenceSUA levelsOverall prevalenceElderly population
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