2025
Artificial Intelligence-Enhanced Perfusion Scoring Improves the Diagnostic Accuracy of Myocardial Perfusion Imaging.
Miller R, Kavanagh P, Lemley M, Liang J, Sharir T, Einstein A, Fish M, Ruddy T, Kaufmann P, Sinusas A, Miller E, Bateman T, Dorbala S, Di Carli M, Hayes S, Friedman J, Berman D, Dey D, Slomka P. Artificial Intelligence-Enhanced Perfusion Scoring Improves the Diagnostic Accuracy of Myocardial Perfusion Imaging. Journal Of Nuclear Medicine 2025, jnumed.124.268079. PMID: 39978815, DOI: 10.2967/jnumed.124.268079.Peer-Reviewed Original ResearchObstructive coronary artery diseaseCoronary artery diseaseArea under the receiver operating characteristic curveMyocardial perfusion imagingPerfusion scoreDetection of obstructive coronary artery diseaseDiagnostic accuracy of myocardial perfusion imagingPerfusion imagingAccuracy of myocardial perfusion imagingInvasive coronary angiographyCohort of patientsHighest area under the receiver operating characteristic curveLeft main coronary arteryReceiver operating characteristic curveStress TPDDeep learningObstructive CADMedian ageCoronary angiographyArtificial intelligenceDiagnostic performanceDiagnostic accuracyArtery diseaseAI predictionsCoronary arteryIntegration and Potential Applications of Cardiovascular Computed Tomography in Cardio-Oncology
Erbay M, Manubolu V, Stein-Merlob A, Ferencik M, Mamas M, Lopez-Mattei J, Baldassarre L, Budoff M, Yang E. Integration and Potential Applications of Cardiovascular Computed Tomography in Cardio-Oncology. Current Cardiology Reports 2025, 27: 51. PMID: 39932640, PMCID: PMC11814013, DOI: 10.1007/s11886-025-02206-x.Peer-Reviewed Original ResearchConceptsRadiation-induced cardiovascular diseaseCoronary artery diseaseCardiovascular diseaseCardiac massComputed tomographyArtery diseaseChest CT scans of patientsCT scans of patientsIncreased risk of CVDInvasive coronary angiographyRisk of cardiovascular diseaseRisk of complicationsScans of patientsCardiovascular computed tomographySeverity of cardiovascular diseaseNon-invasive imaging toolMonitoring of disease progressionManifestations of diseaseAsymptomatic patientsCardiac deteriorationIschemia evaluationCoronary angiographyPericardial diseaseCardiac changesRisk stratification
2024
Automatic quantification of pressure waveform damping during cardiac catheterisation using artificial intelligence
Bahl R, Zahid A, Gustavo D, Almeida G, Rajkumar C, Ahmed-Jushuf F, Foley M, De Waard G, Echavarria-Pinto M, Sen S, Al-Lamee R, Francis D, Chamie D, Shun-Shin M, Petraco R. Automatic quantification of pressure waveform damping during cardiac catheterisation using artificial intelligence. European Heart Journal 2024, 45: ehae666.2330. DOI: 10.1093/eurheartj/ehae666.2330.Peer-Reviewed Original ResearchAortic pressure waveformPressure waveformCoronary angiographyAltman analysisPressure wire assessmentExpert consensusPatient safetyPhysiological assessmentWaveformCardiac catheterisationAortic pressure recordingsPracticing interventional cardiologistsImprove patient safetyNeural networkClinical consequencesCoronary ostiumIncrease patient safetySevere formVentricular fibrillationVessel injuryInterventional cardiologistsThe Updated Registry of Fast Myocardial Perfusion Imaging with Next-Generation SPECT (REFINE SPECT 2.0).
Miller R, Lemley M, Shanbhag A, Ramirez G, Liang J, Builoff V, Kavanagh P, Sharir T, Hauser M, Ruddy T, Fish M, Bateman T, Acampa W, Einstein A, Dorbala S, Di Carli M, Feher A, Miller E, Sinusas A, Halcox J, Martins M, Kaufmann P, Dey D, Berman D, Slomka P. The Updated Registry of Fast Myocardial Perfusion Imaging with Next-Generation SPECT (REFINE SPECT 2.0). Journal Of Nuclear Medicine 2024, 65: 1795-1801. PMID: 39362762, PMCID: PMC11533915, DOI: 10.2967/jnumed.124.268292.Peer-Reviewed Original ResearchCoronary artery calciumCT attenuation correction imagesStress total perfusion deficitMyocardial perfusion imagingTotal perfusion deficitAttenuation correction imagesPerfusion imagingREFINE SPECTImprove prediction of adverse outcomesPerfusion deficitsSPECT myocardial perfusion imagingIncreased risk of MACEPredictive of adverse outcomesMedian follow-upInvasive coronary angiographyRisk of MACEAdverse cardiovascular eventsCAC scoreExperience MACECoronary angiographyArtery calciumInternational registryCardiovascular eventsFollow-upClinical dataAssociation between 82Rb positron emission tomography-derived regional myocardial blood flow, severity of angiographic coronary artery stenosis, and mortality in patients with chest pain
Gallegos C, Paredes C, Hu J, Posada E, Saito Y, Lansky A, Shah S, Liu Y, Smolderen K, Mena-Hurtado C, Sinusas A, Miller E. Association between 82Rb positron emission tomography-derived regional myocardial blood flow, severity of angiographic coronary artery stenosis, and mortality in patients with chest pain. Advances In Radiotherapy & Nuclear Medicine 2024, 2: 3786. DOI: 10.36922/arnm.3786.Peer-Reviewed Original ResearchMyocardial flow reserveGlobal myocardial flow reserveQuantitative coronary angiographyAssociated with increased all-cause mortalityPositron emission tomographyCoronary artery stenosis severityMyocardial blood flowAll-cause mortalityCoronary angiographyChest painStenosis severityAngiographic coronary artery stenosisResting myocardial blood flowAcute chest painBlood flowInvasive coronary angiographyLeft circumflex arteryLeft descending arteryRight coronary arteryCoronary artery stenosisStress testCoronary stenosis severityCardiovascular eventsDescending arteryWeak correlationImpact of Time to Initiation of Targeted Temperature Management Among Patients with Out-of-Hospital Cardiac Arrest Undergoing Percutaneous Coronary Intervention
Kovach C, Leonard J, Messenger J, Waldo S, Perman S. Impact of Time to Initiation of Targeted Temperature Management Among Patients with Out-of-Hospital Cardiac Arrest Undergoing Percutaneous Coronary Intervention. Therapeutic Hypothermia And Temperature Management 2024 PMID: 39311798, DOI: 10.1089/ther.2024.0030.Peer-Reviewed Original ResearchOdds of neurologically favorable survivalOut-of-hospital cardiac arrestST-elevation myocardial infarctionNeurologically favorable survivalPercutaneous coronary interventionInitiation of targeted temperature managementTemperature management initiationFavorable survivalOverall survivalHospital dischargeVentricular tachycardiaTemperature managementSurvivors of ventricular tachycardiaVentricular fibrillationCoronary interventionAssociated with adverse clinical outcomesDelayed coronary angiographyProportion of patientsAdverse clinical outcomesPropensity-weighted analysisAssociated with decreased oddsAssociated with delayWithdrawal of life-sustaining careLife-sustaining careCoronary angiographyDiagnostic Yield and Clinical Utility of Coronary Angiography Versus Coronary Function Testing in Women With Angina and Nonobstructive Coronary Arteries
Cigarroa N, Latif N, Maayah M, Khokhar A, Kunnirickal S, Schwann A, Maciejewski K, Odanovic N, Mazure C, Spatz E, Pfau S, Lansky A, Shah S. Diagnostic Yield and Clinical Utility of Coronary Angiography Versus Coronary Function Testing in Women With Angina and Nonobstructive Coronary Arteries. Journal Of The American Heart Association 2024, 13: e035852. PMID: 39291500, PMCID: PMC11681466, DOI: 10.1161/jaha.124.035852.Peer-Reviewed Original ResearchCoronary function testingNonobstructive coronary arteriesInvasive coronary angiographyCoronary microvascular dysfunctionCoronary angiographyVasomotor disordersFunction testsCoronary arteryAntianginal therapyDiagnostic yieldVasospastic anginaMicrovascular dysfunctionDiagnostic yield of invasive coronary angiographyNonobstructive coronary artery diseaseSuspected ischemic heart diseaseCalcium channel blockersCoronary vasomotor disordersSymptomatic myocardial bridgingCoronary artery diseaseIschemic heart diseaseChannel blockersAnatomic diagnosisEndothelial dysfunctionArtery diseaseMyocardial bridgingPositron Emission Tomography in the Diagnosis and Management of Cardiac Allograft Vasculopathy
Csecs I, Yakkali S, Feher A. Positron Emission Tomography in the Diagnosis and Management of Cardiac Allograft Vasculopathy. Current Cardiovascular Imaging Reports 2024, 17: 85-92. DOI: 10.1007/s12410-024-09595-7.Peer-Reviewed Original ResearchManagement of CAVPositron emission tomography myocardial perfusion imagingCardiac allograft vasculopathyInvasive coronary angiographyMyocardial perfusion imagingMyocardial flow reservePositron emission tomographyHeart transplant recipientsMyocardial blood flowAllograft vasculopathyTransplant recipientsPET-derived MBFInternational Society for Heart and Lung Transplantation guidelinesCAV detectionAlternative to invasive coronary angiographyEfficacy of positron emission tomographyRoutine surveillance protocolEmission tomographyClass IIa indicationFrequent invasive proceduresReduce radiation exposurePositron emission tomography imagingPrognostic valueCoronary angiographyMulticenter studyMyocardial infarction with nonobstructive coronary arteries: a single-center retrospective study by sex and race
Hsueh C, Esin G, Breen T, Gitto M, Katz M, Gulati M, Capers Q, Reynolds H, Volgman A, Wenger N, Altin S. Myocardial infarction with nonobstructive coronary arteries: a single-center retrospective study by sex and race. Coronary Artery Disease 2024, 35: 684-691. PMID: 38989611, DOI: 10.1097/mca.0000000000001402.Peer-Reviewed Original ResearchRate of nonfatal MINonobstructive coronary arteriesMyocardial infarctionCerebrovascular accidentBlack patientsNonfatal MISecondary outcomesSingle-center retrospective studyCoronary arteryRate of cerebrovascular accidentsIncreased risk of readmissionAssociated with decreased oddsNonfatal cerebrovascular accidentAssociated with increased oddsAcute myocardial infarctionMINOCA patientsPatient-level dataRepeat angiographyCoronary angiographyRisk of readmissionBaseline demographicsRetrospective studyMINOCAFemale sexAngiographic reviewSelective Use of CT Fractional Flow at a Large Academic Medical Center: Insights from Clinical Implementation after 1 Year of Practice.
Randhawa M, Takigami A, Thondapu V, Ranganath P, Zhang E, Parakh A, Goiffon R, Baliyan V, Foldyna B, Lu M, Tower-Rader A, Meyersohn N, Hedgire S, Ghoshhajra B. Selective Use of CT Fractional Flow at a Large Academic Medical Center: Insights from Clinical Implementation after 1 Year of Practice. Radiology Cardiothoracic Imaging 2024, 6: e230073. PMID: 38573127, PMCID: PMC11056747, DOI: 10.1148/ryct.230073.Peer-Reviewed Original ResearchConceptsRate of invasive coronary angiographyCoronary CTAInvasive coronary angiographyCoronary CT angiographyCT-FFR analysisPercutaneous coronary interventionHeart rate controlCT-FFRRetrospective observational studyFractional flow reserveCT angiographyDual-source coronary CT angiographyCT fractional flow reserveFlow reserveObservational studyCoronary bypass graftingEarly diastolic periodBeats per minuteCoronary angiographyPhysician's discretionChart reviewClinical outcomesBypass graftingCTA acquisitionAcademic medical centerImpact of cardiac size on diagnostic performance of single-photon emission computed tomography myocardial perfusion imaging: insights from the REgistry of Fast Myocardial Perfusion Imaging with NExt generation single-photon emission computed tomography
Randazzo M, Elias P, Poterucha T, Sharir T, Fish M, Ruddy T, Kaufmann P, Sinusas A, Miller E, Bateman T, Dorbala S, Di Carli M, Castillo M, Liang J, Miller R, Dey D, Berman D, Slomka P, Einstein A. Impact of cardiac size on diagnostic performance of single-photon emission computed tomography myocardial perfusion imaging: insights from the REgistry of Fast Myocardial Perfusion Imaging with NExt generation single-photon emission computed tomography. European Heart Journal - Cardiovascular Imaging 2024, 25: 996-1006. PMID: 38445511, DOI: 10.1093/ehjci/jeae055.Peer-Reviewed Original ResearchSPECT myocardial perfusion imagingMyocardial perfusion imagingCoronary artery diseaseCardiac sizeDetect obstructive coronary artery diseasePerfusion imagingObstructive coronary artery diseaseDetection of coronary artery diseaseNegative predictive valueLeft ventricular volumeSolid-state scannersSmall cardiac sizeCoronary angiographyMale patientsYounger patientsElderly patientsMale sexDiagnostic performanceVentricular volumeArtery diseaseVisual assessmentPatientsPredictive valueElderly ageSPECT
2023
Multislice computerized tomography coronary angiography can be a comparable tool to intravascular ultrasound in evaluating “true” coronary artery bifurcations
Radunović A, Vidaković R, Timčić S, Odanović N, Stefanović M, Lipovac M, Krupniković K, Mandić A, Kojić D, Tomović M, Ilić I. Multislice computerized tomography coronary angiography can be a comparable tool to intravascular ultrasound in evaluating “true” coronary artery bifurcations. Frontiers In Cardiovascular Medicine 2023, 10: 1292517. PMID: 38028491, PMCID: PMC10657987, DOI: 10.3389/fcvm.2023.1292517.Peer-Reviewed Original ResearchCT coronary angiographyPercutaneous coronary interventionCoronary angiographyCoronary artery bifurcationsIntravascular ultrasoundBland-Altman analysisAtherosclerotic plaque characteristicsMB segmentLow incidenceCharacterization of atherosclerotic plaquesPlaque evaluationBifurcation percutaneous coronary interventionCoronary interventionPlaque characteristicsProvisional stentingCalcified plaqueSide branchesCircumferential plaquesAngiographyDistal MBSignificant correlationPlaqueCoronary bifurcationsLumen areaAtherosclerotic plaquesComprehensive Management of ANOCA, Part 1—Definition, Patient Population, and Diagnosis JACC State-of-the-Art Review
Samuels B, Shah S, Widmer R, Kobayashi Y, Miner S, Taqueti V, Jeremias A, Albadri A, Blair J, Kearney K, Wei J, Park K, El-Farra A, Holoshitz N, Janaszek K, Kesarwani M, Lerman A, Prasad M, Quesada O, Reynolds H, Savage M, Smilowitz N, Sutton N, Sweeny J, Toleva O, Henry T, Moses J, Fearon W, Tremmel J, Network M. Comprehensive Management of ANOCA, Part 1—Definition, Patient Population, and Diagnosis JACC State-of-the-Art Review. Journal Of The American College Of Cardiology 2023, 82: 1245-1263. PMID: 37704315, DOI: 10.1016/j.jacc.2023.06.043.Peer-Reviewed Original ResearchConceptsCoronary function testingMyocardial bridgingCoronary angiographyMultiple medical providersNonobstructive coronary arteriesCoronary microvascular dysfunctionDiagnostic coronary angiographyIschemic heart diseaseInvasive coronary angiographyCoronary flow reserveCardiac catheterization laboratoryCoronary abnormalitiesCoronary vasospasmEpicardial spasmMicrocirculatory resistanceEndothelial dysfunctionMicrovascular dysfunctionHemodynamic assessmentProvocative testingCoronary arteryFunction testingPatient populationHeart diseaseJACC StateFlow reserveComparison of intravascular ultrasound, optical coherence tomography, and conventional angiography‐guided percutaneous coronary interventions: A systematic review, network meta‐analysis, and meta‐regression
Park D, An S, Jolly N, Attanasio S, Yadav N, Gutierrez J, Nanna M, Rao S, Vij A. Comparison of intravascular ultrasound, optical coherence tomography, and conventional angiography‐guided percutaneous coronary interventions: A systematic review, network meta‐analysis, and meta‐regression. Catheterization And Cardiovascular Interventions 2023, 102: 440-450. PMID: 37483068, PMCID: PMC10908343, DOI: 10.1002/ccd.30784.Peer-Reviewed Original ResearchConceptsMajor adverse cardiovascular eventsPercutaneous coronary interventionOptical coherence tomographyCoronary angiographyIntravascular ultrasoundCoronary interventionCardiac deathClinical outcomesClinical efficacyConventional angiography-guided PCIAngiography-guided percutaneous coronary interventionCoherence tomographyUse of IVUSSuperiority of OCTAdverse cardiovascular eventsRandomized clinical trialsConventional coronary angiographyImaging modalitiesComparative clinical efficacyBest imaging modalityIntracoronary imaging modalityLesion revascularizationPCI guidanceCardiovascular eventsCause mortalityIllness Perception and the Impact of a Definitive Diagnosis on Women With Ischemia and No Obstructive Coronary Artery Disease: A Qualitative Study.
Tseng L, Göç N, Schwann A, Cherlin E, Kunnirickal S, Odanovic N, Curry L, Shah S, Spatz E. Illness Perception and the Impact of a Definitive Diagnosis on Women With Ischemia and No Obstructive Coronary Artery Disease: A Qualitative Study. Circulation Cardiovascular Quality And Outcomes 2023, 16: 521-529. PMID: 37476997, DOI: 10.1161/circoutcomes.122.009834.Peer-Reviewed Original ResearchConceptsObstructive coronary artery diseaseCoronary function testingCoronary artery diseaseInvasive coronary angiographyArtery diseaseCoronary angiographyFunction testingDefinitive diagnosisYale-New Haven HospitalNon-Hispanic blacksMore patient-centered careNew Haven HospitalPatient-centered careStructured telephone interviewQuality of lifeHealth care experiencesNon-Hispanic whitesGroup of womenCoronary functionIllness perceptionsMean ageINOCAUncertain causeMultidisciplinary teamPatient careAssociation of Beta-Blocker Therapy With Cardiovascular Outcomes in Patients With Stable Ischemic Heart Disease
Godoy L, Farkouh M, Austin P, Shah B, Qiu F, Jackevicius C, Wijeysundera H, Krumholz H, Ko D. Association of Beta-Blocker Therapy With Cardiovascular Outcomes in Patients With Stable Ischemic Heart Disease. Journal Of The American College Of Cardiology 2023, 81: 2299-2311. PMID: 37316110, DOI: 10.1016/j.jacc.2023.04.021.Peer-Reviewed Original ResearchConceptsStable coronary artery diseaseCoronary artery diseaseBeta-blocker groupRecent myocardial infarctionHeart failureMyocardial infarctionCardiovascular eventsCoronary angiographyPrescription claimsObstructive coronary artery diseaseIndex coronary angiographyBeta-blocker therapyBeta-blocker useHeart failure hospitalizationElective coronary angiographyNew-user designMyocardial infarction hospitalizationsCause deathCardiovascular outcomesCause mortalityFailure hospitalizationCardioprotective benefitsArtery diseasePrimary outcomeIschemic heart
2022
Variation in coronary angiography use in Out-of-Hospital cardiac arrest
Agusala V, Dale P, Khera R, Brown S, Idris A, Link M, Mody P. Variation in coronary angiography use in Out-of-Hospital cardiac arrest. Resuscitation 2022, 181: 79-85. PMID: 36332772, DOI: 10.1016/j.resuscitation.2022.10.020.Peer-Reviewed Original ResearchConceptsRates of CAGEarly coronary angiographyCoronary angiographyST elevationNon-shockable rhythmTrial clustersOHCA patientsShockable rhythmInitial non-shockable rhythmHospital cardiac arrest patientsUse of CAGCoronary angiography useInitial arrest rhythmInitial shockable rhythmPost-resuscitation electrocardiogramProportion of patientsOverall study populationCardiac arrest patientsHospital cardiac arrestArrest rhythmAngiography useHospital admissionArrest patientsCardiac arrestNational cohortCoronary artery disease and revascularization associated with immune checkpoint blocker myocarditis: Report from an international registry
Nowatzke J, Guedeney P, Palaskas N, Lehmann L, Ederhy S, Zhu H, Cautela J, Francis S, Courand PY, Deswal A, Ewer SM, Aras M, Arangalage D, Ghafourian K, Fenioux C, Finke D, Peretto G, Zaha V, Zadok O, Tajiri K, Akhter N, Levenson J, Baldassarre L, Power J, Huang S, Collet JP, Moslehi J, Salem JE, contributors I, Aghel N, Alexandre J, Aonuma K, Asnani A, Behling J, Bilen M, Bottinor W, Cariou E, Chahine J, Chan W, Chauhan A, Cohen M, Crusz S, Fernando S, Florido R, Frigeri M, Fukushima S, Gaughan E, Geisler B, Gilstrap L, Grohe C, Guha A, Habib M, Haegler-Laube E, Haydon A, Hayek S, Hughes A, Imai R, Katsume Y, Kimura H, Lin L, Lenneman C, Leong D, Makker V, Martinez-Calle N, Moey M, Mohri M, Morimoto R, Moritoki Y, Narezkina A, Nicol M, Nooka A, Orimoloye O, Patel M, Perl M, Piriou N, Raikhelkar J, Raza Y, Rao A, Reddy S, Seki N, Stangl K, Stewart A, Stringer B, Tamarappoo B, Tamura Y, Thuny F, Tierney S, Tresorier R, Ullah W, Von Hunolstein J, Warner E, Weppler A. Coronary artery disease and revascularization associated with immune checkpoint blocker myocarditis: Report from an international registry. European Journal Of Cancer 2022, 177: 197-205. PMID: 36030143, PMCID: PMC10165738, DOI: 10.1016/j.ejca.2022.07.018.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseImmune checkpoint blockersCoronary revascularizationArtery diseaseCAD groupInternational registryPrompt clinical diagnosisAcute coronary syndromeCoronary artery stenosisAdjustment of ageCause deathCoronary syndromeIndex hospitalisationSteroid administrationCheckpoint blockersCoronary angiographyArtery stenosisCoronary angiogramPoor outcomeSevere presentationRevascularizationPatientsCardiac pathologyClinical diagnosisMyocarditisAssociation of Opium Consumption and Coronary Artery Ectasia: A Propensity Score-Matched Study
Shafie M, Aminorroaya A, Vasheghani-Farahani A, Jalali A, Baradaran A. Association of Opium Consumption and Coronary Artery Ectasia: A Propensity Score-Matched Study. Archives Of Iranian Medicine 2022, 25: 542-546. PMID: 37543876, DOI: 10.34172/aim.2022.86.Peer-Reviewed Original ResearchConceptsCoronary artery ectasiaCoronary artery diseaseOpium consumptionArtery ectasiaArtery diseaseFamily history of coronary artery diseaseCoronary artery ectasia groupDevelopment of coronary artery ectasiaHistory of coronary artery diseasePrevalence of opium consumptionAssociated with increased riskAssociated with increased risk of atherosclerosisElective coronary angiographyIndependent risk factorControl groupScore-matched studyHyper-inflammatory stateTehran Heart CenterRisk of atherosclerosisNon-consumersFamily historyNo significant differenceCoronary angiographyControl patientsHeart CenterExplainable Deep Learning Improves Physician Interpretation of Myocardial Perfusion Imaging.
Miller RJH, Kuronuma K, Singh A, Otaki Y, Hayes S, Chareonthaitawee P, Kavanagh P, Parekh T, Tamarappoo BK, Sharir T, Einstein AJ, Fish MB, Ruddy TD, Kaufmann PA, Sinusas AJ, Miller EJ, Bateman TM, Dorbala S, Carli MD, Cadet S, Liang JX, Dey D, Berman DS, Slomka PJ. Explainable Deep Learning Improves Physician Interpretation of Myocardial Perfusion Imaging. Journal Of Nuclear Medicine 2022, 63: 1768-1774. PMID: 35512997, PMCID: PMC9635672, DOI: 10.2967/jnumed.121.263686.Peer-Reviewed Original ResearchConceptsMyocardial perfusion imagingCoronary artery diseaseObstructive coronary artery diseasePhysician interpretationDiagnostic accuracyPerfusion imagingLeft main arteryOverall net reclassification improvementInvasive coronary angiographyNet reclassification improvementTotal perfusion deficitArtery diseaseCoronary angiographyMedian agePhysician diagnosisReclassification improvementPerfusion deficitsClinical historyCoronary segmentsRepresentative cohortMeaningful improvementsMain arteryPatientsDL resultsQuantitative perfusion
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