2024
Fetal behavior and gestational serotonin reuptake inhibitor exposure: relationships between behavior, drug dosage, plasma drug level, and a measure of drug bioeffect
Salisbury A, Anderson G, Yang A, Stika C, Rasmussen-Torvik L, Gollan J, Wisner K. Fetal behavior and gestational serotonin reuptake inhibitor exposure: relationships between behavior, drug dosage, plasma drug level, and a measure of drug bioeffect. Neuropsychopharmacology 2024, 49: 1968-1977. PMID: 39127823, PMCID: PMC11480508, DOI: 10.1038/s41386-024-01923-1.Peer-Reviewed Original ResearchConceptsPlatelet 5-HT levelsSerotonin reuptake inhibitorsPlasma drug concentrationsDEP groupPresence of maternal depressionSerotonin reuptake inhibitor exposureDrug exposureSRI groupDrug dosageMeasure of drug exposureDrug concentrationsPlasma drug levelsMother-infant pairsGroups of mother-infant pairsReuptake inhibitorsMaternal depressionFetal behaviorCord bloodFetal movementsPlatelet serotoninDrug levelsInhibitor exposureDepressionSerotoninCord1965-LB: Metabolomic and Transcriptomic Signatures of Gestational Diabetes Mellitus (GDM) Suggest Nutritional and Inflammatory Pathways in Intergenerational Transfer of Risk
THAKER V, FIRESTEIN M, MASSON C, LIU Z, REDDY U, GALLAGHER D, LEDUC C. 1965-LB: Metabolomic and Transcriptomic Signatures of Gestational Diabetes Mellitus (GDM) Suggest Nutritional and Inflammatory Pathways in Intergenerational Transfer of Risk. Diabetes 2024, 73 DOI: 10.2337/db24-1965-lb.Peer-Reviewed Original ResearchGestational diabetes mellitusMetabolic riskC-peptideCord blood C-peptideCord blood metabolitesBlood C-peptideMother-baby dyadsCord plasmaCord bloodSteroid hormone signalingMaternal milieuTransport abnormalitiesPlacental tissuePregnancy ageDiabetes mellitusOffspring birthweightPlacental transcriptomePlasma fructosamineInflammatory pathwaysInflammatory processPlacenta tissueINSR expressionCordMetabolite profilesObesityTotal spine MRI for the preoperative evaluation of adolescent idiopathic scoliosis: Part 2 – spinal cord tumors, dysraphisms, diastematomyelia, and vertebral anomalies
Lee H, Janjua F, Ragab A, Moran J, Haims A, Rubio D, Tuason D, Porrino J. Total spine MRI for the preoperative evaluation of adolescent idiopathic scoliosis: Part 2 – spinal cord tumors, dysraphisms, diastematomyelia, and vertebral anomalies. Current Problems In Diagnostic Radiology 2024, 53: 415-421. PMID: 38262798, DOI: 10.1067/j.cpradiol.2024.01.017.Peer-Reviewed Original ResearchTotal spine MRISpinal cord tumorsAdolescent idiopathic scoliosisCord tumorsSpine MRIIdiopathic scoliosisEvaluation of adolescent idiopathic scoliosisVertebral anomaliesNeural axis abnormalitiesArnold-Chiari malformationTime of diagnosisTethered cordAxis abnormalitiesChiari malformationPreoperative evaluationScreening examinationDiastematomyeliaDysraphismTumorScoliosisAbnormalitiesMRIMalformationsSyringomyeliaCord
2022
Genitofemoral Nerve Block
Wood M, Rajput K, Chow R. Genitofemoral Nerve Block. 2022, 449-455. DOI: 10.1007/978-3-031-11188-4_46.ChaptersGenitofemoral nerve blockNerve blockTransversus abdominis plane blockInguinal hernia repairAnterior scrotumPlane blockRound ligamentSensory innervationTherapeutic injectionsHernia repairSpermatic cordLabia majoraVisceral componentsMons pubisPainExtensive manipulationInnervationPatientsSurgeryCordScrotumGroinAdjunctMajoraBedsideDevelopment of paravertebral pseudoaneurysms following vertebral augmentation: a report of two cases
Nam D, Johnson MH, Mojibian H, Hebert RM, Cornman-Homonoff J. Development of paravertebral pseudoaneurysms following vertebral augmentation: a report of two cases. Clinical Imaging 2022, 90: 39-43. PMID: 35914342, DOI: 10.1016/j.clinimag.2022.07.004.Peer-Reviewed Original ResearchConceptsPoor medical statusVertebral augmentationDirect puncture embolizationTrans-arterial embolizationArterial anatomyVascular injuryArterial supplySegmental arteriesRadiofrequency ablationSpinal cordAnastomotic veinsL4 levelMedical statusPseudoaneurysmAssociated anatomyEmbolizationAugmentationDistinct manifestationsAnatomyComplicationsKyphoplastyArteryCordInjuryFeasibility of imaging synaptic density in the human spinal cord using [11C]UCB-J PET
Rossano S, Toyonaga T, Bini J, Nabulsi N, Ropchan J, Cai Z, Huang Y, Carson RE. Feasibility of imaging synaptic density in the human spinal cord using [11C]UCB-J PET. EJNMMI Physics 2022, 9: 32. PMID: 35503134, PMCID: PMC9065222, DOI: 10.1186/s40658-022-00464-0.Peer-Reviewed Original ResearchFull spinal cordSpinal cord injuryHuman spinal cordSpinal cordAmyotrophic lateral sclerosisDistribution volume ratioCervical SCSynaptic densitySynaptic vesicle protein 2ACervical spinal cordBrain gray matterUse of PETBaseline VTWhole-body imagesSynapse lossCord injuryLateral sclerosisInjury severityGray matterNeurodegenerative disordersCordProtein 2AHuman dataDVR valuesCurrent standardFetal Death
Oliver E, Reddy U. Fetal Death. 2022, 564-571. DOI: 10.1201/9781003099062-57.Peer-Reviewed Original Research
2021
iPSCs and DRGs: stepping stones to new pain therapies
Alsaloum M, Waxman SG. iPSCs and DRGs: stepping stones to new pain therapies. Trends In Molecular Medicine 2021, 28: 110-122. PMID: 34933815, PMCID: PMC8810720, DOI: 10.1016/j.molmed.2021.11.005.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsHuman DRG neuronsDRG neuronsDorsal root ganglion neuronsTreatment of painNovel pain therapeuticsNew pain therapiesVoltage-gated sodium channelsPain therapyPain therapeuticsGanglion neuronsTreatment optionsPain signalsSpinal cordPreclinical resultsPreclinical platformSensory neuronsPainNeuronsSodium channelsClinical translationIPSCsBlockadeCordTherapyExcitabilityPragmatic Approach to Neuraxial Anesthesia in Obstetric Patients With Disorders of the Vertebral Column, Spinal Cord, and Neuromuscular System
Walsh E, Zhang Y, Madden H, Lehrich J, Leffert L. Pragmatic Approach to Neuraxial Anesthesia in Obstetric Patients With Disorders of the Vertebral Column, Spinal Cord, and Neuromuscular System. Obstetric Anesthesia Digest 2021, 41: 164-165. DOI: 10.1097/01.aoa.0000796068.53863.3d.Peer-Reviewed Original ResearchUnilateral vocal cord paralysis due to meningoencephalitis in a pediatric patient
Hall R, Maurrasse S, Jaju A, Johnston D. Unilateral vocal cord paralysis due to meningoencephalitis in a pediatric patient. Otolaryngology Case Reports 2021, 21: 100366. DOI: 10.1016/j.xocr.2021.100366.Peer-Reviewed Original ResearchVocal cord paralysisUnilateral vocal cord paralysisCord paralysisMagnetic resonance imagingViral meningoencephalitisPost-extubation stridorPediatric vocal cord paralysisAirway protectionDorsal medullaPediatric patientsAssociated inflammationNerve nucleiVocal cordsResonance imagingMeningoencephalitisParalysisMedullaEpilepticusStridorHoarsenessInflammationPatientsHyperintensityCordHypermutated phenotype in gliosarcoma of the spinal cord
Hong CS, Kuzmik GA, Kundishora AJ, Elsamadicy AA, Koo AB, McGuone D, Blondin NA, DiLuna ML, Erson-Omay EZ. Hypermutated phenotype in gliosarcoma of the spinal cord. Npj Precision Oncology 2021, 5: 8. PMID: 33580181, PMCID: PMC7881101, DOI: 10.1038/s41698-021-00143-w.Peer-Reviewed Original ResearchSpinal cordWhole-exome sequencingLow-grade brain gliomasVariant of glioblastomaLow-grade gliomasTumor anteriorAdjuvant radiationNeurological deficitsSomatic single nucleotide variationsPoor prognosisGrade gliomasTemozolomide treatmentBrain gliomasGliosarcomaMicrosatellite stabilityCordSomatic mutationsHypermutator phenotypeGliomasComprehensive genetic characterizationGenomic mechanismsSingle nucleotide variationsPhenotypeFirst reportPathway genes
2020
Race and All-cause Mortality in Patients with a Primary Malignant or Nonmalignant Tumor of the Spinal Cord or Spinal Meninges
Elsamadicy A, Freedman I, Koo A, David W, Reeves B, Antonios J, Laurans M, Kolb L, Sciubba D. Race and All-cause Mortality in Patients with a Primary Malignant or Nonmalignant Tumor of the Spinal Cord or Spinal Meninges. Neurosurgery 2020, 67 DOI: 10.1093/neuros/nyaa447_203.Peer-Reviewed Original ResearchUmbilical Cord Abnormalities and Stillbirth
Hammad I, Blue N, Allshouse A, Silver R, Gibbins K, Page J, Goldenberg R, Reddy U, Saade G, Dudley D, Thorsten V, Conway D, Pinar H, Pysher T. Umbilical Cord Abnormalities and Stillbirth. Obstetric Anesthesia Digest 2020, 40: 200-200. DOI: 10.1097/01.aoa.0000719564.10175.ff.Peer-Reviewed Original ResearchReply to: “Is the spinal cord truly affected in half of the patients with Kearns-Sayre syndrome?” and “Spinal cord and heart involvement in Kearns Sayre Syndrome: which link?”
Pasquini L, Guarnera A, Rossi-Espagnet M, Napolitano A, Diodato D, Martinelli D, Longo D. Reply to: “Is the spinal cord truly affected in half of the patients with Kearns-Sayre syndrome?” and “Spinal cord and heart involvement in Kearns Sayre Syndrome: which link?”. Neuroradiology 2020, 63: 9-10. PMID: 33145628, DOI: 10.1007/s00234-020-02593-8.Peer-Reviewed Original ResearchPragmatic approach to neuraxial anesthesia in obstetric patients with disorders of the vertebral column, spinal cord and neuromuscular system
Walsh E, Zhang Y, Madden H, Lehrich J, Leffert L. Pragmatic approach to neuraxial anesthesia in obstetric patients with disorders of the vertebral column, spinal cord and neuromuscular system. Regional Anesthesia & Pain Medicine 2020, 46: 258-267. PMID: 33115718, DOI: 10.1136/rapm-2020-101792.Peer-Reviewed Original ResearchConceptsNeuraxial anesthesiaObstetric patientsSpinal cordCesarean delivery anesthesiaCesarean deliveryLabor analgesiaNeuraxial analgesiaVertebral columnCase seriesGeneral anesthesiaObstetrical patientsRetrospective studyDelivery anesthesiaPatient injuryAnesthesiaPatient harmPatientsNarrative reviewAvailable evidenceUnwarranted fearsNeuromuscular systemAdditional riskPresent unique challengesAnalgesiaCord
2019
A Case Study Evaluating the Diagnosis and Treatment of a Rare Mesenchymal Tumor
Shinder B, Sack J, Sadimin E, Tunuguntla H. A Case Study Evaluating the Diagnosis and Treatment of a Rare Mesenchymal Tumor. Urology 2019, 131: e1-e2. PMID: 31247212, DOI: 10.1016/j.urology.2019.06.019.Peer-Reviewed Case Reports and Technical NotesConceptsCellular angiofibromaPainless right inguinal massRare mesenchymal tumorRight inguinal massBenign mesenchymal neoplasmLimited treatment optionsOval-shaped massSurgical excisionInguinal massMesenchymal tumorsMesenchymal neoplasmsCT scanTreatment optionsSpermatic cordImmunohistochemical analysisRadiographic featuresImaging modalitiesAngiofibromaDiagnostic casesCD34NeoplasmsTumorExcisionDesminCordExternal validation of postnatal gestational age estimation using newborn metabolic profiles in Matlab, Bangladesh
Murphy MS, Hawken S, Cheng W, Wilson LA, Lamoureux M, Henderson M, Pervin J, Chowdhury A, Gravett C, Lackritz E, Potter BK, Walker M, Little J, Rahman A, Chakraborty P, Wilson K. External validation of postnatal gestational age estimation using newborn metabolic profiles in Matlab, Bangladesh. ELife 2019, 8: e42627. PMID: 30887951, PMCID: PMC6424558, DOI: 10.7554/elife.42627.Peer-Reviewed Original ResearchConceptsGestational ageGestational age estimationCord bloodNewborn metabolic profilesHeel prick samplesLow-resource settingsTerm infantsPreterm birthHeel prickPopulation-level estimatesPostnatal gestational age estimationBlood spotsMetabolic profileExternal validationInfantsScreening facilityAgeBloodFeasible optionMajority of samplesNewbornsPrickCordWeeks
2018
Detection of local and remote cellular damage caused by spinal cord and peripheral nerve injury using a heat shock signaling reporter system
Hashimoto-Torii K, Sasaki M, Chang YW, Hwang H, Waxman SG, Kocsis JD, Rakic P, Torii M. Detection of local and remote cellular damage caused by spinal cord and peripheral nerve injury using a heat shock signaling reporter system. IBRO Neuroscience Reports 2018, 5: 91-98. PMID: 30480161, PMCID: PMC6240805, DOI: 10.1016/j.ibror.2018.11.003.Peer-Reviewed Original ResearchPeripheral nerve injurySpinal cordNerve injuryPeripheral nerve injury resultsAltered electrophysiological propertiesNerve injury resultsSecondary damageHeat shock factor 1Neuropathic painInjury resultsInjury siteClinical abnormalitiesShock factor 1Mouse modelMemory dysfunctionElectrophysiological propertiesCordFactor 1Cellular damageFurther deteriorationInjuryReporter systemAbnormalitiesImmediate stress responseCellsNeuroanesthesia and Coexisting Respiratory Problems
Gruenbaum S, Sandhu M, Bilotta F, Kurup V. Neuroanesthesia and Coexisting Respiratory Problems. 2018, 63-82. DOI: 10.1007/978-981-13-2086-6_5.Peer-Reviewed Original ResearchNeurosurgical patientsRespiratory dysfunctionPerioperative respiratory complicationsPerioperative complicationsRespiratory complicationsPerioperative considerationsPerioperative managementPostoperative outcomesPerioperative carePreoperative workupSpinal cordRespiratory diseaseRespiratory problemsNervous systemPatientsRelevant anatomyComplicationsRespiratory systemNumerous physiological processesDysfunctionPhysiology principlesPhysiological processesNeuroanesthesiaCordWorkupPkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature
Sternberg JR, Prendergast AE, Brosse L, Cantaut-Belarif Y, Thouvenin O, Orts-Del’Immagine A, Castillo L, Djenoune L, Kurisu S, McDearmid JR, Bardet PL, Boccara C, Okamoto H, Delmas P, Wyart C. Pkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature. Nature Communications 2018, 9: 3804. PMID: 30228263, PMCID: PMC6143598, DOI: 10.1038/s41467-018-06225-x.Peer-Reviewed Original ResearchConceptsCentral canalCSF-cNsSpontaneous activityCSF flowCerebrospinal fluid-contacting neuronsSpine curvatureCSF-contacting neuronsCerebrospinal fluid flowSpinal cordIdiopathic scoliosisSingle-channel openingsCalcium activityPKD2L1 channelPKD2L1Mechanosensory cellsNeuronsCanalChannel openingMechanoceptionKyphosisCilia motilityCord
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