2025
Dynamic Contrast-enhanced MRI Processing Comparison for Distinguishing True Progression From Pseudoprogression in High-grade Glioma.
Amer A, Ansari S, Krayyem A, Kundu S, Khose S, Pokhylevych H, Calle S, Patel C, Yang Z, Liu H, Johnson J. Dynamic Contrast-enhanced MRI Processing Comparison for Distinguishing True Progression From Pseudoprogression in High-grade Glioma. Journal Of Computer Assisted Tomography 2025 PMID: 39876523, DOI: 10.1097/rct.0000000000001716.Peer-Reviewed Original ResearchHigh-grade gliomasBlood-brain barrierDCE-MRIPeak contrast enhancementQuantify BBB permeabilityTreatment-related changesFollow-up subjectsKtrans mapsTrue progressionTumor progressionClinical dataConventional MRIPseudoprogressionBBB permeabilityCombined pathologyKtransContrast enhancementT1 enhancementStandard processing methodologyStatistically significant resultsClinical data setsPathologyPatientsGliomaSSS technique
2024
NIMG-30. DEUTERIUM METABOLIC IMAGING (DMI) SHOWS A STRONG RELATION BETWEEN TUMOR GRADE AND GLUCOSE METABOLISM IN PRIMARY BRAIN TUMORS
Thaw-Poon S, Blondin N, Liu Y, Corbin Z, Baehring J, Omuro A, Moliterno J, Omay S, Fulbright R, de Graaf R, De Feyter H. NIMG-30. DEUTERIUM METABOLIC IMAGING (DMI) SHOWS A STRONG RELATION BETWEEN TUMOR GRADE AND GLUCOSE METABOLISM IN PRIMARY BRAIN TUMORS. Neuro-Oncology 2024, 26: viii201-viii201. PMCID: PMC11553074, DOI: 10.1093/neuonc/noae165.0795.Peer-Reviewed Original ResearchGrade 2 lesionsTumor gradeDeuterium metabolic imagingMetabolic imagingNon-enhancing tumor regionsBrain tumorsTumor-to-brain contrastTumour-specific valuesActive tumor tissueImage contrastVOI-based analysisGrade 4Evaluate disease progressionTesla MRI scannerFDG-PETGrade 3Lesion gradeTumor tissuesDisease progressionDisease stageOral administrationTumorObservational studyNormal brainContrast enhancementSkin Thickening and Vascular Lesions
Andrejeva L, Lanjewar S, Woolf G, Killelea B, Brownson K, Podany P, Harigopal M. Skin Thickening and Vascular Lesions. 2024, 297-323. DOI: 10.1007/978-3-031-65711-5_11.Peer-Reviewed Original ResearchRare group of neoplasmsInflammatory breast carcinomaInvasive lobular carcinomaMalignant vascular tumorsGroup of neoplasmsIll-defined marginsLobular carcinomaBreast carcinomaBenign tumorsClinical presentationBenign lesionsVascular tumorsBreast parenchymaClinical historyWell-circumscribedSkin thickeningMalignant processVascular lesionsRare groupImaging appearanceSubcutaneous tissueContrast enhancementBreastCarcinomaTumorJS07.4.A A PHASE 0/IA STUDY OF BRIGIMADLIN CONCENTRATION IN BRAIN TISSUE AND A DOSE ESCALATION STUDY OF BRIGIMADLIN PLUS RADIOTHERAPY IN PATIENTS WITH NEWLY DIAGNOSED GLIOBLASTOMA
Sarkaria J, Mrugala M, Jaeckle K, Burns T, Vaubel R, Parney I, Chaichana K, Clement P, Martínez-García M, Sanchez J, Omuro A, Pronk L, Ross H, Teufel M, Hesse R, Grempler R, Galanis E. JS07.4.A A PHASE 0/IA STUDY OF BRIGIMADLIN CONCENTRATION IN BRAIN TISSUE AND A DOSE ESCALATION STUDY OF BRIGIMADLIN PLUS RADIOTHERAPY IN PATIENTS WITH NEWLY DIAGNOSED GLIOBLASTOMA. Neuro-Oncology 2024, 26: v13-v13. PMCID: PMC11485993, DOI: 10.1093/neuonc/noae144.036.Peer-Reviewed Original ResearchNon-contrast-enhancedMouse double minute 2Contrast enhancementMGMT promoter unmethylated glioblastomaPatient-derived xenograft modelsUnbound concentrationsCalculated unbound concentrationsNewly diagnosed GBMMaximum tolerated doseNewly diagnosed glioblastomaTumor cell apoptosisSingle-arm trialMDM2-p53 antagonistsDouble minute 2Restore wild-typeBrain tissueBrain tumor tissueTP53 WTUnmethylated glioblastomaPhase 0Diagnosed glioblastomaTolerated doseOpen-labelP53 target gene expressionIDH-wtA phase (Ph) 0/Ia study of brigimadlin concentration in brain tissue and a non-randomized, open-label, dose escalation study of brigimadlin in combination with radiotherapy (RT) in patients (pts) with newly diagnosed glioblastoma (GBM).
Sarkaria J, Mrugala M, Jaeckle K, Burns T, Vaubel R, Parney I, Chaichana K, Clement P, Martinez-Garcia M, Sepulveda Sanchez J, Omuro A, Pronk L, Ross H, Teufel M, Hesse R, Grempler R, Galanis E. A phase (Ph) 0/Ia study of brigimadlin concentration in brain tissue and a non-randomized, open-label, dose escalation study of brigimadlin in combination with radiotherapy (RT) in patients (pts) with newly diagnosed glioblastoma (GBM). Journal Of Clinical Oncology 2024, 42: 2017-2017. DOI: 10.1200/jco.2024.42.16_suppl.2017.Peer-Reviewed Original ResearchNon-contrast-enhancedOpen-labelContrast enhancementMGMT promoter unmethylated glioblastomaUnbound concentrationsCalculated unbound concentrationsNewly diagnosed GBMDose-escalation studyMaximum tolerated doseTumor cell apoptosisSingle-arm trialMDM2-p53 antagonistsRestore wild-typeBrain tissueUnmethylated glioblastomaBrain tumor tissueEscalation studyDiagnosed glioblastomaTolerated doseP53 target gene expressionPrimary endpointIDH-wtSolid tumorsTumor tissuesXenograft modelImplementation of a high-resolution, high-contrast magnetic resonance imaging protocol with extended delayed phases for peritoneal mesothelioma
Medved M, Witmer H, Dhiman A, Berger Y, Sherman S, Hindi E, Armato S, Reiser I, Oto A, Engelmann R, Kindler H, Oren N, Harmath C, Turaga K. Implementation of a high-resolution, high-contrast magnetic resonance imaging protocol with extended delayed phases for peritoneal mesothelioma. Quantitative Imaging In Medicine And Surgery 2024, 14: 2580589-2582589. PMID: 38545076, PMCID: PMC10963817, DOI: 10.21037/qims-23-13.Peer-Reviewed Original ResearchMalignant peritoneal mesotheliomaMagnetic resonance imagingPeritoneal mesotheliomaPost-contrast imagesDelayed phaseDelayed post-contrast imagesT2-weighted single-shot fast spin-echoHigh-contrast magnetic resonance imagingLow grade tumorsLesion contrast enhancementContrast enhancementSingle-shot fast spin-echoGrade of diseaseDose of contrast agentMagnetic resonance imaging examsMagnetic resonance imaging protocolNovel MRI protocolFeasibility of high-resolutionDefinitive surgeryGrade tumorsPeritoneal malignancyBlinded radiologistsTumor gradeAnalysis of contrast enhancementCross-sectional imagingA large open access dataset of brain metastasis 3D segmentations on MRI with clinical and imaging information
Ramakrishnan D, Jekel L, Chadha S, Janas A, Moy H, Maleki N, Sala M, Kaur M, Petersen G, Merkaj S, von Reppert M, Baid U, Bakas S, Kirsch C, Davis M, Bousabarah K, Holler W, Lin M, Westerhoff M, Aneja S, Memon F, Aboian M. A large open access dataset of brain metastasis 3D segmentations on MRI with clinical and imaging information. Scientific Data 2024, 11: 254. PMID: 38424079, PMCID: PMC10904366, DOI: 10.1038/s41597-024-03021-9.Peer-Reviewed Original ResearchConceptsWhole-brain radiotherapyStereotactic radiosurgeryT1 post-contrastBrain metastasesPost-contrastSide effectsImage informationArtificial intelligenceAssociated with cognitive side effectsContrast-enhancing lesionsQuality of datasetsCognitive side effectsFLAIR MR imagesValidation of AI modelsBrain radiotherapyLimitations of algorithmsStandard treatmentAI modelsMR imagingAI networksContrast enhancementClinical settingSegmentation workflowDatasetClinical adoption
2019
The feasibility of contrast echocardiography in the assessment of right ventricular size and function
Pereira JB, Essa M, Ugonabo I, Hur DJ, Crandall I, Vaccarelli M, Sugeng L. The feasibility of contrast echocardiography in the assessment of right ventricular size and function. Echocardiography 2019, 36: 1979-1988. PMID: 31633241, DOI: 10.1111/echo.14504.Peer-Reviewed Original ResearchConceptsRight ventricular evaluationRight ventricular sizeSegmental wall motionRight ventricular imagingRV-focused viewWall motionRight ventricle evaluationContrast enhancementWilcoxon signed-rank testInter-observer agreementRV dimensionsEchocardiography studyIntra-observer reproducibilityVentricular sizeSigned-rank testContrast echocardiographyRV imagingAnatomical assessmentVentricular imagingPatientsPercent agreementIrregular rhythmTotal segmentsIndependent observersSample t-test
2018
Real-time computerized video enhancement for minimally invasive fetoscopic surgery
Sadda P, Onofrey J, Imamoglu M, Papademetris X, Qarni B, Bahtiyar MO. Real-time computerized video enhancement for minimally invasive fetoscopic surgery. Laparoscopic Endoscopic And Robotic Surgery 2018, 1: 27-32. PMID: 31080936, PMCID: PMC6508886, DOI: 10.1016/j.lers.2018.06.001.Peer-Reviewed Original ResearchFetoscopic surgeryInvasive fetoscopic surgeryBlood vesselsOnly definitive treatmentTwin transfusion syndromePlacental blood vesselsTransfusion syndromeDefinitive treatmentVideo framesContrast Limited Adaptive Histogram EqualizationUterine environmentFetoscopic videosSurgeryChallenging operationContrast enhancementMedical traineesSubjectsVesselsSubset of imagesMarkersSelective coagulationLimited Adaptive Histogram EqualizationPoor lighting conditionsLower mean accuracyAdaptive histogram equalization
2017
NIMG-36. DELINEATION OF IMMUNE RESPONSES AFTER IMMUNOTHERAPY IN GLIOBLASTOMA USING PET AND MRI
Soto H, Antonios J, Everson R, Moughon D, Wang A, Orpilla J, Radu C, Ellingson B, Lee J, Cloughesy T, Phelps M, Czernin J, Liau L, Prins R. NIMG-36. DELINEATION OF IMMUNE RESPONSES AFTER IMMUNOTHERAPY IN GLIOBLASTOMA USING PET AND MRI. Neuro-Oncology 2017, 19: vi149-vi150. PMCID: PMC5692246, DOI: 10.1093/neuonc/nox168.611.Peer-Reviewed Original ResearchPD-1Dendritic cellsMAb blockadeContrast enhancementHost anti-tumor immune responseTreated with dendritic cellsAnti-tumor immune responseInflammatory responseClinical management of patientsDendritic cell vaccinesTumor-infiltrating lymphocytesSyngeneic immunocompetent miceTreated with immunotherapyCo-registration of PETSecondary lymphoid organsContrast-enhanced MRIManagement of patientsProbe uptakePET probeImmune inflammatory responseNon-invasive modalityNon-invasive imaging techniqueImmunocompetent micePre-contrast T1Cell vaccineDetection of immune responses after immunotherapy in glioblastoma using PET and MRI
Antonios J, Soto H, Everson R, Moughon D, Wang A, Orpilla J, Radu C, Ellingson B, Lee J, Cloughesy T, Phelps M, Czernin J, Liau L, Prins R. Detection of immune responses after immunotherapy in glioblastoma using PET and MRI. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 10220-10225. PMID: 28874539, PMCID: PMC5617282, DOI: 10.1073/pnas.1706689114.Peer-Reviewed Original ResearchConceptsPD-1Dendritic cellsMAb blockadeTumor lysate-pulsed DC vaccineHost antitumor immune responseTreated with dendritic cellsImmune responseDetection of immune responsesClinical management of patientsPET probeAntitumor immune responseTumor-infiltrating lymphocytesSyngeneic immunocompetent miceContrast enhancementSecondary lymphoid organsContrast-enhanced MRIManagement of patientsProbe uptakeNoninvasive imaging techniquesImmune inflammatory responseDC vaccinesImmunocompetent miceIntracranial tumorsImaging techniquesMalignant gliomasClinical Significance of Optic Nerve Enhancement on Magnetic Resonance Imaging in Enucleated Retinoblastoma Patients
Kim JW, Madi I, Lee R, Zolfaghari E, Jubran R, Lee TC, Murphree AL, Berry JL. Clinical Significance of Optic Nerve Enhancement on Magnetic Resonance Imaging in Enucleated Retinoblastoma Patients. Ophthalmology Retina 2017, 1: 369-374. PMID: 31047563, PMCID: PMC7448757, DOI: 10.1016/j.oret.2017.03.013.Peer-Reviewed Original ResearchOptic nerve enhancementAbnormal MRI findingsOptic nerve invasionNerve enhancementOptic nerveMRI scansNerve invasionMRI findingsClinical significanceRetinoblastoma patientsMagnetic resonance imaging (MRI) findingsPostoperative contrast enhancementTransected optic nerveContrast enhancementAbnormal contrast enhancementRetrospective chart reviewPostoperative MRI scansPrimary outcome measureResonance Imaging FindingsLast clinical followRadiographic grading systemMagnetic resonance imagingPostoperative enhancementPreoperative chemotherapyChart review
2016
Planning TTFields treatment using the NovoTAL system-clinical case series beyond the use of MRI contrast enhancement
Connelly J, Hormigo A, Mohilie N, Hu J, Chaudhry A, Blondin N. Planning TTFields treatment using the NovoTAL system-clinical case series beyond the use of MRI contrast enhancement. BMC Cancer 2016, 16: 842. PMID: 27809808, PMCID: PMC5096303, DOI: 10.1186/s12885-016-2890-0.Peer-Reviewed Original ResearchConceptsCase seriesAdvanced imagingTreatment planningCommon primary brain tumorNon-contrast enhancementPostcontrast MRI scansStandard care pathwayRecent clinical studiesPrimary brain tumorsContrast enhancementMagnetic resonance imaging (MRI) measurementsTumor Treating FieldsStandard treatment planningPrior therapyDisease activityNonmeasurable diseaseStandard therapySurvival benefitTumor burdenPoor prognosisTumor locationCare pathwayClinical evaluationClinical trialsPatient outcomesPresynaptic GABA Receptors Mediate Temporal Contrast Enhancement in Drosophila Olfactory Sensory Neurons and Modulate Odor-Driven Behavioral Kinetics
Raccuglia D, McCurdy LY, Demir M, Gorur-Shandilya S, Kunst M, Emonet T, Nitabach MN. Presynaptic GABA Receptors Mediate Temporal Contrast Enhancement in Drosophila Olfactory Sensory Neurons and Modulate Odor-Driven Behavioral Kinetics. ENeuro 2016, 3: eneuro.0080-16.2016. PMID: 27588305, PMCID: PMC4994068, DOI: 10.1523/eneuro.0080-16.2016.Peer-Reviewed Original ResearchConceptsOlfactory sensory neuronsPeripheral responsesGABA receptorsSensory neuronsContrast enhancementOSN axon terminalsInhibitory GABA receptorsPresynaptic GABAAxon terminalsDrosophila olfactory sensory neuronsPresynaptic terminalsNervous systemAuditory stimuliTemporal edgeOlfactory systemTime courseNeuronsInnate behavioral responsesReceptorsOptical electrophysiologyTemporal contrast enhancementBehavioral responsesLateral inhibitionResponseGABATRUS Biopsy: Is There Still a Role?
Leapman M, Shinohara K. TRUS Biopsy: Is There Still a Role? 2016, 53-67. DOI: 10.1007/978-3-319-21485-6_4.Peer-Reviewed Original ResearchProstate biopsyLateral peripheral zoneTRUS prostate biopsyInitial negative biopsyBiopsy-related complicationsCancer detection rateNovel serum biomarkersNegative predictive valueTRUS-BxPower Doppler imagingClinical parametersNegative biopsySextant biopsyGleason scoreSerum biomarkersUltrasonographic parametersPrognostic informationSuspicious lesionsBiopsy strategyBiopsyDoppler imagingPredictive valueBenign tissueContrast enhancementPeripheral zone
2012
Cine computed tomography angiography evaluation of blood flow for full face transplant surgical planning.
Sisk G, Kumamaru K, Schultz K, Bueno E, Diaz-Siso J, George E, Redjaee M, Mitsouras D, Steigner M, Pomahac B, Rybicki F. Cine computed tomography angiography evaluation of blood flow for full face transplant surgical planning. Eplasty 2012, 12: e57. PMID: 23308304, PMCID: PMC3531245.Peer-Reviewed Original ResearchVascular mappingBlood flowComprehensive vascular assessmentTomography angiography evaluationPreoperative vascular mappingCine loopsFull face transplantationAngiography evaluationCarotid distributionTransplantation candidatesVascular assessmentArterial fillingVenous anastomosisDiagnostic findingsVenous phaseMajor vesselsPreoperative planningSurgical planningFace transplantationPlastic surgeonsSmall vesselsContrast enhancementCineTomographic imagingVessels
2011
FLAIR, T1 contrast enhancement, MR perfusion, and FDG PET following hypofractionated stereotactic radiotherapy (HFSRT), bevacizumab (BEV), and temozolomide (TMZ) for glioblastoma (GBM).
Grommes C, Karimi S, Beal K, Chan T, Abrey L, Gutin P, Omuro A. FLAIR, T1 contrast enhancement, MR perfusion, and FDG PET following hypofractionated stereotactic radiotherapy (HFSRT), bevacizumab (BEV), and temozolomide (TMZ) for glioblastoma (GBM). Journal Of Clinical Oncology 2011, 29: 2048-2048. DOI: 10.1200/jco.2011.29.15_suppl.2048.Peer-Reviewed Original Research
2010
Optimization of on‐resonant magnetization transfer contrast in coronary vein MRI
Stoeck CT, Hu P, Peters DC, Kissinger KV, Goddu B, Goepfert L, Ngo L, Manning WJ, Kozerke S, Nezafat R. Optimization of on‐resonant magnetization transfer contrast in coronary vein MRI. Magnetic Resonance In Medicine 2010, 64: 1849-1854. PMID: 20938974, PMCID: PMC2992077, DOI: 10.1002/mrm.22581.Peer-Reviewed Original ResearchNitrosourea-based chemotherapy for low grade gliomas failing initial treatment with temozolomide
Kaloshi G, Sierra del Rio M, Ducray F, Psimaras D, Idbaih A, Laigle-Donadey F, Taillibert S, Houillier C, Dehais C, Omuro A, Sanson M, Delattre JY, Hoang-Xuan K. Nitrosourea-based chemotherapy for low grade gliomas failing initial treatment with temozolomide. Journal Of Neuro-Oncology 2010, 100: 439-441. PMID: 20464625, DOI: 10.1007/s11060-010-0197-6.Peer-Reviewed Original ResearchConceptsLow-grade gliomasGrade gliomasProgressive low-grade gliomaTerms of PFSContrast enhancementEfficacy of nitrosoureasBetter PFSMedian PFSMedian OSObjective responseSalvage treatmentUpfront therapyMedian ageBetter prognosisInitial treatmentConventional radiotherapyChromosome 1p/19q codeletionNon-enhancing tumorResponse ratePatientsTemozolomidePure oligodendrogliomasPFSGliomasDisappointing results
2006
Quantification of Regional Left Ventricular Wall Motion from Real-time 3-Dimensional Echocardiography in Patients with Poor Acoustic Windows: Effects of Contrast Enhancement Tested Against Cardiac Magnetic Resonance
Corsi C, Coon P, Goonewardena S, Weinert L, Sugeng L, Polonsky T, Veronesi F, Caiani E, Lamberti C, Bardo D, Lang R, Mor-Avi V. Quantification of Regional Left Ventricular Wall Motion from Real-time 3-Dimensional Echocardiography in Patients with Poor Acoustic Windows: Effects of Contrast Enhancement Tested Against Cardiac Magnetic Resonance. Journal Of The American Society Of Echocardiography 2006, 19: 886-893. PMID: 16824998, DOI: 10.1016/j.echo.2006.02.010.Peer-Reviewed Original ResearchMeSH KeywordsComputer SystemsEchocardiographyEchocardiography, Three-DimensionalFeasibility StudiesFemaleHumansImage Interpretation, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedMovementMyocardial ContractionMyocardiumReproducibility of ResultsSensitivity and SpecificityVentricular Dysfunction, LeftConceptsCardiac magnetic resonanceReal-time 3-dimensional echocardiographyCardiac magnetic resonance imagingRT3DE datasetsEndocardial definitionAcoustic windowCMR valuesRegional left ventricular functionPoor acoustic windowsLeft ventricular wall motionRT3DE image qualityRegional wall motionRegional left ventricular wall motionVentricular wall motionIntravenous contrastVentricular functionEndocardial visualizationWall motionRT3DE imagingEnd-diastolicEnd-systolePatientsContrast enhancementMagnetic resonanceImage quality
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply