2025
Clinical characteristics and outcomes of disseminated intravascular coagulation in patients with severe fever with thrombocytopenia syndrome
Zhang Z, Hu X, Du Q, Mo P, Chen X, Luo M, Jiang Q, Deng L, Xiong Y. Clinical characteristics and outcomes of disseminated intravascular coagulation in patients with severe fever with thrombocytopenia syndrome. BMC Infectious Diseases 2025, 25: 508. PMID: 40217170, DOI: 10.1186/s12879-025-10900-y.Peer-Reviewed Original ResearchConceptsDisseminated intravascular coagulationOutcomes of disseminated intravascular coagulationPresence of disseminated intravascular coagulationNon-DIC groupIndependent risk factorIntravascular coagulationClinical characteristicsRisk factorsDisseminated intravascular coagulation groupThrombocytopenia syndromeMultivariate logistic regression analysisAssociated with high mortalityIn-hospital mortality of patientsCumulative survival rateZhongnan Hospital of Wuhan UniversityMortality of patientsIn-hospital mortalitySevere feverLogistic regression analysisConsecutive patientsFerritin levelsD-dimerViral loadClinical dataCystatin CVoxel-Wise Map of Intracerebral Hemorrhage Locations Associated With Worse Outcomes
Karam G, Chen M, Zeevi D, Harms B, Berson E, Torres-Lopez V, Rivier C, Malhotra A, Qureshi A, Falcone G, Sheth K, Payabvash S. Voxel-Wise Map of Intracerebral Hemorrhage Locations Associated With Worse Outcomes. Stroke 2025, 56: 868-877. PMID: 40052269, DOI: 10.1161/strokeaha.124.048453.Peer-Reviewed Original ResearchConceptsImpact of intracerebral hemorrhageAssociated with worse outcomesClinical risk factorsVoxel-wise mapsMapping of brain regionsBaseline hematomaVoxel-wise analysisHematoma volumeICH locationBrain regionsValidation cohortWorse outcomesPresence of intraventricular hemorrhageRisk factorsBaseline hematoma volumeModified Rankin Scale scorePoor scan qualityMulticenter clinical trialRankin Scale scoreDeep white matterLow-risk categoryComprehensive stroke centerIntraventricular hemorrhageConsecutive patientsPatient ageHigh Risk of Persistence and Risk of Dysplasia after Ultrashort Barrett's Diagnosis.
Skef W, Haydel J, Rao A, Allencherril R, George R, Ketwaroo G, Thrift A, El-Serag H, Wenker T. High Risk of Persistence and Risk of Dysplasia after Ultrashort Barrett's Diagnosis. The American Journal Of Gastroenterology 2025 PMID: 40052679, DOI: 10.14309/ajg.0000000000003383.Peer-Reviewed Original ResearchFollow-up EGDRisk of dysplasiaBody mass indexBarrett's esophagusPersistent BEFollow-upCohort of United States veteransWhite raceLong segment BEUnited States veteransHispanic ethnicityPredictor of dysplasiaFollow-up endoscopyClinical risk factorsRetrospective cohort studyNon-Hispanic Black patientsNon-HispanicRisk of persistenceProportion of non-HispanicChi-square testConsecutive patientsStates veteransPathology databaseHighest risk of persistenceBE diagnosisComparison of prognostic accuracy of HCC staging systems in patients undergoing TACE
Kasolowsky V, Gross M, Madoff D, Duncan J, Taddei T, Strazzabosco M, Jaffe A, Chapiro J. Comparison of prognostic accuracy of HCC staging systems in patients undergoing TACE. Clinical Imaging 2025, 120: 110438. PMID: 40049074, DOI: 10.1016/j.clinimag.2025.110438.Peer-Reviewed Original ResearchConceptsOverall survival of patientsBCLC staging systemTransarterial chemoembolizationOverall survivalStaging systemHepatocellular carcinomaStaging systems of hepatocellular carcinomaHepatocellular carcinoma staging systemsRetrospective single center studyKaplan Meier survival analysisInternational Staging SystemSingle center studyLog-rank testTertiary care centerPredicting overall survivalMeier survival analysisConsecutive patientsPrognostic stratificationStudy endpointPrognostic accuracyCenter studyPrognostic powerStratify outcomesMultivariate analysisPatientsAtrial Functional Tricuspid Regurgitation Contemporary Characteristics, Outcomes, and Novel Risk Score
Fava A, Nakhla M, Hajj Ali A, Akintoye E, Akyuz K, Arockiam A, Haroun E, El Dahdah J, Liao Y, Popovic Z, Gillinov M, Pettersson G, Griffin B, Desai M, Wang T. Atrial Functional Tricuspid Regurgitation Contemporary Characteristics, Outcomes, and Novel Risk Score. JACC Advances 2025, 4: 101623. PMID: 40009906, PMCID: PMC11908566, DOI: 10.1016/j.jacadv.2025.101623.Peer-Reviewed Original ResearchRegurgitant orifice areaRight atrial volumeAF-TRTricuspid regurgitationAtrial volumeOrifice areaAtrial functional tricuspid regurgitationAssociated with 1-year mortalityEffective regurgitant orifice areaRisk scoreFunctional tricuspid regurgitationSevere tricuspid regurgitationEffective regurgitant orificeRight heart failureCohort of patientsSystolic pressure ratioIncreasing clinical recognitionMultivariate logistic regressionMedian survivalAdverse prognosticatorEchocardiographic characteristicsConsecutive patientsValve lesionsPoor prognosisRisk stratificationPrognosis of p16 and Human Papillomavirus Discordant Oropharyngeal Cancers and the Exploration of Using Natural Language Processing to Analyze Free-Text Pathology Reports
Shin E, Choi J, Hung T, Poon C, Riaz N, Yu Y, Kang J. Prognosis of p16 and Human Papillomavirus Discordant Oropharyngeal Cancers and the Exploration of Using Natural Language Processing to Analyze Free-Text Pathology Reports. JCO Clinical Cancer Informatics 2025, 9: e2400177. PMID: 39965177, DOI: 10.1200/cci-24-00177.Peer-Reviewed Original ResearchConceptsProgression-free survivalCancer-specific survivalOropharyngeal cancerHPV testingPathology reportsTreatment de-escalationCurative radiation therapyHPV+ oropharyngeal cancerPrimary end pointMinority of patientsPositive predictive valueStandard-of-careCancer-related deathsIn situ hybridizationStatistically significant differenceP16 statusP16-negativeHPV statusRadiation therapyInferior prognosisOverall survivalConsecutive patientsAcademic cancer centerDiscordant tumorsTreatment deintensification
2024
Evaluating fatigue and excessive daytime sleepiness: a comparative analysis of prevalence and correlating factors in interstitial lung disease patients and healthy controls
Ouyang X, Shen Q, Zhou S, Zhou P, Song M, Guo T, Guo W, Zhang Y, Peng H. Evaluating fatigue and excessive daytime sleepiness: a comparative analysis of prevalence and correlating factors in interstitial lung disease patients and healthy controls. Annals Of Medicine 2024, 56: 2398729. PMID: 39624966, PMCID: PMC11616753, DOI: 10.1080/07853890.2024.2398729.Peer-Reviewed Original ResearchInterstitial lung disease patientsInterstitial lung diseaseDiminished exercise capacityExcessive daytime sleepinessHealthy volunteersExercise capacityDaytime sleepinessEpworth Sleepiness Scale scoreQuality of lifePulmonary diffusion functionSleepiness Scale scoreFactors associated with excessive daytime sleepinessSecond Xiangya HospitalLogistic regressionLung disease patientsMultivariate logistic regressionDecreased quality of lifeCentral South UniversityCross-sectional studyPrevalence of fatigueChest painConsecutive patientsClinical characteristicsNon-ED patientsLung diseaseArtificial Intelligence–Driven Patient Selection for Preoperative Portal Vein Embolization for Patients with Colorectal Cancer Liver Metastases
Kuhn T, Engelhardt W, Kahl V, Alkukhun A, Gross M, Iseke S, Onofrey J, Covey A, Camacho J, Kawaguchi Y, Hasegawa K, Odisio B, Vauthey J, Antoch G, Chapiro J, Madoff D. Artificial Intelligence–Driven Patient Selection for Preoperative Portal Vein Embolization for Patients with Colorectal Cancer Liver Metastases. Journal Of Vascular And Interventional Radiology 2024, 36: 477-488. PMID: 39638087, DOI: 10.1016/j.jvir.2024.11.025.Peer-Reviewed Original ResearchTotal liver volumeMetastatic colorectal cancer patientsPreoperative portal vein embolizationColorectal cancer liver metastasesPortal vein embolizationCancer liver metastasesMulticenter retrospective studyColorectal cancer patientsStudent's t-testBoard-certified radiologistsVein embolizationConsecutive patientsLiver metastasesLiver volumePatient selectionRetrospective studyCancer patientsRadiomic featuresInclusion criteriaPatientsSemi-automatic segmentationLab valuesT-testSDAUCRhabdomyolysis in Severe Fever With Thrombocytopenia Syndrome: Associations With Acute Kidney Injury and Mortality
Zhang Z, Hu X, Du Q, Liu J, Chen X, Mo P, Luo M, Jiang Q, Deng L, Xiong Y. Rhabdomyolysis in Severe Fever With Thrombocytopenia Syndrome: Associations With Acute Kidney Injury and Mortality. Journal Of Medical Virology 2024, 96: e70095. PMID: 39624019, DOI: 10.1002/jmv.70095.Peer-Reviewed Original ResearchConceptsAcute kidney injuryKidney injuryRhabdomyolysis groupLaboratory parametersClinical characteristicsLevels of laboratory parametersThrombocytopenia syndromeMultivariate binary logistic regression analysisCumulative survival rateHigh viral loadMortality of patientsSevere feverBinary logistic regression analysisLogistic regression analysisAbdominal painConsecutive patientsSFTS patientsSerum levelsViral loadChest distressAdverse outcomesRhabdomyolysisSurvival ratePatientsSystem injuryOutcomes and Recurrence Rates Among Patients With Provoked and Cryptogenic Cerebral Venous Thrombosis
Al Kasab S, Almallouhi E, Shu L, Kicielinski K, Salehi Omran S, Liebeskind D, Zubair A, Vedovati M, Paciaroni M, Antonenko K, Heldner M, de Havenon A, Henninger N, Yaghi S. Outcomes and Recurrence Rates Among Patients With Provoked and Cryptogenic Cerebral Venous Thrombosis. Neurology Clinical Practice 2024, 15: e200381. PMID: 39399562, PMCID: PMC11464219, DOI: 10.1212/cpj.0000000000200381.Peer-Reviewed Original ResearchRisk of recurrent venous thromboembolismRecurrent venous thromboembolismCerebral venous thrombosisVenous thromboembolismFemale patientsVenous thrombosisBaseline characteristicsOutcome of cerebral venous thrombosisRate of recurrent venous thromboembolismProvoking factorsRare cause of strokeTransient provoking factorsKaplan-Meier survival analysisDuration of anticoagulationOutcomes of patientsMann-Whitney <i>Cause of strokeConsecutive patientsRare causeRecurrence rateMale patientsMulticenter studyRetrospective databaseStandard treatmentCox regression6620 Serum Steroid Profiling For The Diagnosis Of Adrenocortical Carcinoma: A Prospective Cross-Sectional Study From A Tertiary Center
Yu K, Athimulam S, Saini J, Kaur R, Singh R, Grebe S, Xue Q, Bancos I. 6620 Serum Steroid Profiling For The Diagnosis Of Adrenocortical Carcinoma: A Prospective Cross-Sectional Study From A Tertiary Center. Journal Of The Endocrine Society 2024, 8: bvae163.290. PMCID: PMC11454475, DOI: 10.1210/jendso/bvae163.290.Peer-Reviewed Original ResearchDiagnosing ACCDiagnosis of adrenocortical carcinomaArea under receiver operating curveAdrenocortical carcinomaUrine steroid profileAdrenocortical adenomaHounsfield unit measurementsSteroid profileAdrenal malignancyAdrenal massProspective cross-sectional studyExogenous glucocorticoid useCongenital adrenal hyperplasiaMeasurement of 11-deoxycortisolFasting serum samplesSerum steroid profilesNon-ACC groupsReceiver operating curveCross-sectional studyAdrenal tumorsAdrenal hyperplasiaConsecutive patientsGlucocorticoid useTertiary centerSerum steroidsDocetaxel Versus Androgen-Receptor Signaling Inhibitors (ARSI) as Second-Line Therapy After Failure of First-Line Alternative ARSI for the Elderly ≥ 75 Years Old With Metastatic Castration-Resistant Prostate Cancer (mCRPC): A SPARTACUSS—Meet-URO 26 Real-World Study
Patrikidou A, Saieva C, Lee-Ying R, Nuzzo P, Zarif T, McClure H, Davidsohn M, Eid M, Spinelli G, Catalano F, Cremante M, Fotia G, Rossetti S, Valenca L, Vauchier C, Ottanelli C, Andrade L, Gennusa V, Mestre R, Fornarini G, Pignata S, Procopio G, Santini D, Ravi P, Sweeney C, Heng D, De Giorgi U, Fizazi K, Russo A, Francini E, Group S. Docetaxel Versus Androgen-Receptor Signaling Inhibitors (ARSI) as Second-Line Therapy After Failure of First-Line Alternative ARSI for the Elderly ≥ 75 Years Old With Metastatic Castration-Resistant Prostate Cancer (mCRPC): A SPARTACUSS—Meet-URO 26 Real-World Study. Clinical Genitourinary Cancer 2024, 22: 102230. PMID: 39461026, DOI: 10.1016/j.clgc.2024.102230.Peer-Reviewed Original ResearchConceptsMetastatic castration-resistant prostate cancerAndrogen receptor signaling inhibitorsCastration-resistant prostate cancerAbiraterone acetateOverall survivalProstate cancerElderly patientsSignaling inhibitorsCohort of consecutive patientsSecond-line therapyStandard first-lineReal-world studySecond-lineConsecutive patientsTreatment toxicityFirst-lineD. CONCLUSIONSPatient comorbiditiesIdentified patientsRetrospective designToxicity outcomesD groupInternational cohortPatientsNo differenceRelative Cerebral Blood Flow as an Indirect Imaging Surrogate in Patients With Anterior Circulation Large Vessel Occlusion and Association of Baseline Characteristics With Poor Collateral Status.
Salim H, Hamam O, Parilday G, Moustafa R, Ghandour S, Rutgers M, Sharara M, Cho A, Mazumdar I, Radmard M, Shin C, Montes D, Malhotra A, Romero J, Yedavalli V. Relative Cerebral Blood Flow as an Indirect Imaging Surrogate in Patients With Anterior Circulation Large Vessel Occlusion and Association of Baseline Characteristics With Poor Collateral Status. Journal Of The American Heart Association 2024, 13: e034581. PMID: 39158542, DOI: 10.1161/jaha.124.034581.Peer-Reviewed Original ResearchConceptsAnterior circulation large vessel occlusionAcute ischemic strokeLarge vessel occlusionCollateral statusAdmission laboratory valuesChronic kidney diseaseBaseline characteristicsCerebral blood flowVessel occlusionPoor CSConsecutive patientsMale sexLaboratory valuesComputed tomography perfusion dataPretreatment computed tomography perfusionKidney diseasePredictors of favorable outcomeAssociation of baseline characteristicsRetrospective multicenter studyBlood flowPoor collateral statusIndications of CSCerebral perfusion parametersPatient baseline characteristicsRelative cerebral blood flowHypoperfusion Intensity Ratio as an Indirect Imaging Surrogate in Patients With Anterior Circulation Large-Vessel Occlusion and Association of Baseline Characteristics With Poor Collateral Status.
Hamam O, Gudenkauf J, Moustafa R, Cho A, Montes D, Sharara M, Moustafa A, Radmard M, Nabi M, Chen K, Sepehri S, Shin C, Mazumdar I, Kim M, Mohseni A, Malhotra A, Romero J, Yedavalli V. Hypoperfusion Intensity Ratio as an Indirect Imaging Surrogate in Patients With Anterior Circulation Large-Vessel Occlusion and Association of Baseline Characteristics With Poor Collateral Status. Journal Of The American Heart Association 2024, 13: e030897. PMID: 39158547, DOI: 10.1161/jaha.123.030897.Peer-Reviewed Original ResearchConceptsAnterior circulation large-vessel occlusionHypoperfusion intensity ratioLarge-vessel occlusionAcute ischemic strokeAdmission laboratory findingsCollateral statusAIS-LVOAdmission National InstitutesBaseline characteristicsLaboratory findingsConsecutive patientsPoor CSCryptogenic causeComputed tomography perfusion dataPretreatment computed tomography perfusionAssociation of baseline characteristicsPoor collateral statusPatient baseline characteristicsComputed tomography perfusionMultivariate logistic regressionInfarct growth rateMale patientsRetrospective studyClinical outcomesLogistic regression modelsDeep-Transfer-Learning–Based Natural Language Processing of Serial Free-Text Computed Tomography Reports for Predicting Survival of Patients With Pancreatic Cancer
Kim S, Kim S, Kim E, Cecchini M, Park M, Choi J, Kim S, Hwang H, Kang C, Choi H, Shin S, Kang J, Lee C. Deep-Transfer-Learning–Based Natural Language Processing of Serial Free-Text Computed Tomography Reports for Predicting Survival of Patients With Pancreatic Cancer. JCO Clinical Cancer Informatics 2024, 8: e2400021. PMID: 39151114, DOI: 10.1200/cci.24.00021.Peer-Reviewed Original ResearchConceptsArea under the receiver operating characteristic curveSurvival of patientsCT reportsPancreatic cancerNatural language processingC-indexPredicting survivalOverall survival of patientsTertiary hospitalPredicting 1-year survivalPredicting survival of patientsImproved C-indexSurvival informationPancreatic cancer survivalReceiver operating characteristic curveInternal test data setNLP modelsComputed tomography reportsLanguage processingKorean tertiary hospitalOverall survivalConsecutive patientsActual survivalConcordance indexPatientsPresentation and patterns of reinterventions after revascularization in patients with premature peripheral arterial disease
Sivakumar A, Satam K, Wu Z, Alameddine D, Aboian E, Chaer R, Schermerhorn M, Moreira C, Guzman R, Ochoa Chaar C. Presentation and patterns of reinterventions after revascularization in patients with premature peripheral arterial disease. Journal Of Vascular Surgery 2024, 80: 1776-1785.e1. PMID: 39002606, DOI: 10.1016/j.jvs.2024.07.021.Peer-Reviewed Original ResearchPremature peripheral arterial diseaseLower extremity revascularizationOlder patientsPeripheral arterial diseaseArtery diseaseRetrospective review of consecutive patientsReview of consecutive patientsDistressed Communities IndexAge of presentationFrequency of reinterventionsEnd-stage renal diseaseKaplan-Meier curvesOutcomes of lower extremity revascularizationLong-term outcomesCoronary artery diseaseMALE-free survivalAdverse limb eventsOverall survivalReintervention rateConsecutive patientsFrequent reinterventionsPerioperative complicationsRetrospective reviewNo significant differenceInstitutional experienceThe Predictive Value of Qanadli and Miller Index Scores in Patients with Intermediate-High–Risk and High-Risk Pulmonary Emboli Undergoing Aspiration Thrombectomy
Fish A, Knight E, Mutonga M, Moulton J, Gathagan R, Andreca M, Sare A, Cornman-Homonoff J. The Predictive Value of Qanadli and Miller Index Scores in Patients with Intermediate-High–Risk and High-Risk Pulmonary Emboli Undergoing Aspiration Thrombectomy. Journal Of Vascular And Interventional Radiology 2024, 35: 1457-1463. PMID: 38969337, DOI: 10.1016/j.jvir.2024.06.031.Peer-Reviewed Original ResearchPulmonary artery pressureIntensive care unitMiller scoreHigh-risk patientsArterial pressureInstitutional review boardPulmonary pressureClot burdenB-type natriuretic peptideIntensive care unit length of stayAssociated with ICU lengthIntensive care unit lengthLength of stayFlowTriever SystemConsecutive patientsEchocardiographic findingsPulmonary emboliCreatinine levelsPulmonary embolismNatriuretic peptideStratify patientsRetrospective studyClinical outcomesAspiration thrombectomyICU lengthCerebral venous sinus thrombosis associated with cancer: analysis of the ACTION-CVT study
Vedovati M, Shu L, Henninger N, Zubair A, Heldner M, Al Kasab S, Siegler J, Liebeskind D, Antonenko K, Yaghi S, Paciaroni M. Cerebral venous sinus thrombosis associated with cancer: analysis of the ACTION-CVT study. Journal Of Thrombosis And Thrombolysis 2024, 57: 1008-1017. PMID: 38824485, PMCID: PMC11315801, DOI: 10.1007/s11239-024-02997-w.Peer-Reviewed Original ResearchCases of cerebral vein thrombosisVenous thromboembolismRisk of recurrent venous thromboembolismRadiological characteristics of patientsCerebral vein thrombosisRecurrent venous thromboembolismKaplan-Meier methodLog-rank testAbsence of headacheAll-cause-deathLogistic regression analysisCharacteristics of patientsCancer statusCohort studyPropensity score matchingConsecutive patientsAssociated with cancerRadiological characteristicsVein thrombosisStudy outcomesRecanalization rateOlder ageRisk factorsMultivariate analysisPatient managementHematuria Cancer Risk Score with Ultrasound Informs Cystoscopy Use in Patients with Hematuria
Tan W, Ahmad A, Zhou Y, Nathan A, Ogunbo A, Gbolahan O, Kallam N, Smith R, Khalifeh M, Tan W, Cohen D, Volanis D, Walter F, Sasieni P, Kamat A, Kelly J. Hematuria Cancer Risk Score with Ultrasound Informs Cystoscopy Use in Patients with Hematuria. European Urology Oncology 2024, 8: 87-93. PMID: 38811250, DOI: 10.1016/j.euo.2024.05.005.Peer-Reviewed Original ResearchCancer risk scoreRenal bladder ultrasoundTa bladder cancerUrinary tract cancerRisk scoreValidation cohortBladder cancerHealth care cost savingsBladder ultrasoundDiagnosis of urinary tract cancerInvasive proceduresDevelopment cohortIdentification of cancerSuspicion of bladder cancerSecondary careIndependent validation cohortReceiver operating characteristic curveUK hospitalsArea under the receiver operating characteristic curveOutcome measuresTriage of patientsConsecutive patientsPatient cohortCystoscopyHematuriaHigh- versus low-gradient aortic stenosis: Is our evaluation limited by aorto-mitral angle on cardiovascular CT?
See C, Kim Y, Park J, Wang Y, Reinhardt S, Shkolnik E, Faridi K, Lombo B, Bellumkonda L, McNamara R, Sugeng L, Hur D. High- versus low-gradient aortic stenosis: Is our evaluation limited by aorto-mitral angle on cardiovascular CT? International Journal Of Cardiology 2024, 409: 132174. PMID: 38754590, DOI: 10.1016/j.ijcard.2024.132174.Peer-Reviewed Original ResearchNormal-flow low-gradientAortic valve areaTranscatheter AV replacementParadoxical low-flow low-gradientCardiovascular CTTransthoracic echocardiogramCalcium scoreAS patientsDiagnosis of severe ASLow-gradient aortic stenosisHG-AS patientsLG-AS patientsLow-flow low-gradientAorto-mitral angleAortic valve (AV) stenosisLG-ASPLFLG-ASAV replacementSevere ASConsecutive patientsAortic stenosisValve areaAS phenotypeClinical managementEchocardiogram
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