2025
Connectome-based predictive modeling of early and chronic psychosis symptoms
Foster M, Ye J, Powers A, Dvornek N, Scheinost D. Connectome-based predictive modeling of early and chronic psychosis symptoms. Neuropsychopharmacology 2025, 1-9. PMID: 40016363, DOI: 10.1038/s41386-025-02064-9.Peer-Reviewed Original ResearchConnectome-based predictive modelingPositive and Negative Syndrome ScalePsychosis symptomsSymptom networksSymptom severityBrain networksNeural correlates of CPResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingNegative Syndrome ScaleIdentified group differencesPredicted effect sizeCorrelates of CPGeneral psychopathologyNegative symptomsPositive symptomsSyndrome ScaleFrontoparietal networkNeural correlatesVirtual lesion analysisGroup differencesConnectivity changesEffect sizeLesion analysisLongitudinal study
2024
Sex‐specific topological structure associated with dementia via latent space estimation
Wang S, Wang Y, Xu F, Tian X, Fredericks C, Shen L, Zhao Y, Initiative F. Sex‐specific topological structure associated with dementia via latent space estimation. Alzheimer's & Dementia 2024, 20: 8387-8401. PMID: 39530632, PMCID: PMC11667551, DOI: 10.1002/alz.14266.Peer-Reviewed Original ResearchNeural mechanisms of psychedelic visual imagery
Stoliker D, Preller K, Novelli L, Anticevic A, Egan G, Vollenweider F, Razi A. Neural mechanisms of psychedelic visual imagery. Molecular Psychiatry 2024, 30: 1259-1266. PMID: 38862674, PMCID: PMC11919690, DOI: 10.1038/s41380-024-02632-3.Peer-Reviewed Original ResearchVisual association regionsVisual imageryConsistent with preclinical findingsInferior frontal gyrusSerotonergic psychedelic drugTop-down feedback connectionsFunctional MRI scansVisual areasDynamic causal modelingEffective connectivity modelsTop-down connectionsEarly visual areasFusiform gyrusFrontal gyrusClassic psychedelicsIntraparietal sulcusBehavioral measuresNeural mechanismsPsychedelic experiencePsychedelic drugsConnectivity changesAffect balancePlacebo-controlledPreclinical findingsCausal model74. Functional Connectivity Changes as a Result of a Novel Executive Working Memory Training in Adolescents With ADHD
Sullivan A, Anderson J, Beatty M, Choi J, Jaccard J, Pearlson G, Stevens M. 74. Functional Connectivity Changes as a Result of a Novel Executive Working Memory Training in Adolescents With ADHD. Biological Psychiatry 2024, 95: s129-s130. DOI: 10.1016/j.biopsych.2024.02.309.Peer-Reviewed Original ResearchNeuroimaging alterations and relapse in early-stage psychosis
Mihaljevic M, Nagpal A, Etyemez S, Narita Z, Ross A, Schaub R, Cascella N, Coughlin J, Nestadt G, Nucifora F, Sedlak T, Calhoun V, Faria A, Yang K, Sawa A. Neuroimaging alterations and relapse in early-stage psychosis. Journal Of Psychiatry And Neuroscience 2024, 49: e135-e142. PMID: 38569725, PMCID: PMC10980532, DOI: 10.1503/jpn.230115.Peer-Reviewed Original ResearchConceptsEarly-stage psychosisNeuroimaging alterationsResting-state functional MRI dataNo-relapse groupFunctional connectivity changesFunctional MRI dataHealthy controlsMagnetic resonance imagingRelapse groupPsychotic disordersFunctional connectivity estimatesBrain changesPsychotic eventsPsychosisConnectivity changesSymptom exacerbationConnectivity estimatesComparison correctionNo relapseLongitudinal studyThalamusNeuroimagingMRI dataClinical confounding factorsControl groupTraumatic brain injury disrupts state-dependent functional cortical connectivity in a mouse model
Bottom-Tanzer S, Corella S, Meyer J, Sommer M, Bolaños L, Murphy T, Quiñones S, Heiney S, Shtrahman M, Whalen M, Oren R, Higley M, Cardin J, Noubary F, Armbruster M, Dulla C. Traumatic brain injury disrupts state-dependent functional cortical connectivity in a mouse model. Cerebral Cortex 2024, 34: bhae038. PMID: 38365273, PMCID: PMC11486687, DOI: 10.1093/cercor/bhae038.Peer-Reviewed Original ResearchConceptsControlled cortical impactTraumatic brain injuryFunctional connectivityDisrupted functional connectivityAssociated with improved cognitionReduced theta powerBrain injuryHuman TBI patientsModel of traumatic brain injuryBehavioral state-dependent changesNetwork connectivity changesFunctional cortical connectivityBrain regionsTheta powerConnectivity changesState-dependent changesCortical impactPeriods of locomotionCortical connectivityTBI patientsRodent modelsECoG activityMotor dysfunctionCortexInjured cortex
2023
Delayed effective connectivity characterizes the epileptogenic zone during stereo-EEG
Feys O, Wens V, Rovai A, Schuind S, Rikir E, Legros B, De Tiège X, Gaspard N. Delayed effective connectivity characterizes the epileptogenic zone during stereo-EEG. Clinical Neurophysiology 2023, 158: 59-68. PMID: 38183887, DOI: 10.1016/j.clinph.2023.12.013.Peer-Reviewed Original ResearchSingle-pulse electrical stimulationEpileptogenic zoneRefractory focal epilepsyEffective connectivityEffective connectivity changesResection limitsEpileptogenic networksFocal epilepsyAbnormal responseCortico-subcorticoCortical levelElectrical stimulationStereo-EEGPatientsDepth electrodesConnectivity changesStereoelectroencephalographyAnalysis of varianceCharacteristic curveOccurrence of spikesCCEPsStimulationHigh-frequency oscillationsAssociationResponseInvestigating functional brain connectivity patterns associated with two hypnotic states
de Matos N, Staempfli P, Seifritz E, Preller K, Bruegger M. Investigating functional brain connectivity patterns associated with two hypnotic states. Frontiers In Human Neuroscience 2023, 17: 1286336. PMID: 38192504, PMCID: PMC10773817, DOI: 10.3389/fnhum.2023.1286336.Peer-Reviewed Original ResearchLingual gyrusFunctional brain connectivity patternsConnectivity changesUnbiased whole-brain analysesFunctional connectivity changesRegion-specific increaseFunctional connectivity patternsWhole-brain analysisBrain connectivity patternsConnectivity patternsHypnotic stateOccipital cortexOccipital poleClinical successTemporal areaNeural hubPlanum temporaleSupramarginal gyrusVoxel analysisGyrusFMRI studyNeurobiological underpinningsControl conditionHypnosis stateHypnosisLongitudinal resting-state network connectivity changes in electroconvulsive therapy patients compared to healthy controls
Verdijk J, van de Mortel L, Doesschate F, Pottkämper J, Stuiver S, Bruin W, Abbott C, Argyelan M, Ousdal O, Bartsch H, Narr K, Tendolkar I, Calhoun V, Lukemire J, Guo Y, Oltedal L, van Wingen G, van Waarde J. Longitudinal resting-state network connectivity changes in electroconvulsive therapy patients compared to healthy controls. Brain Stimulation 2023, 17: 140-147. PMID: 38101469, PMCID: PMC11145948, DOI: 10.1016/j.brs.2023.12.005.Peer-Reviewed Original ResearchDefault mode networkElectroconvulsive therapyHealthy controlsECT patientsResting-state networksTreatment effectivenessSalience networkElectroconvulsive therapy patientsWhole-brain voxel-wise analysisMajor depressive episodeCanonical resting-state networksRight frontoparietal networkVoxel-wise changesHigh treatment effectivenessVoxel-wise analysisNetwork connectivity changesTest-retest variabilityMulticenter studyDepressive episodeDepressed patientsTherapy patientsMagnetic resonance imaging dataDMN connectivityPatientsConnectivity changesBrain developmental and cortical connectivity changes in transgenic monkeys carrying the human-specific duplicated gene SRGAP2C
Meng X, Lin Q, Zeng X, Jiang J, Li M, Luo X, Chen K, Wu H, Hu Y, Liu C, Su B. Brain developmental and cortical connectivity changes in transgenic monkeys carrying the human-specific duplicated gene SRGAP2C. National Science Review 2023, 10: nwad281. PMID: 38090550, PMCID: PMC10712708, DOI: 10.1093/nsr/nwad281.Peer-Reviewed Original ResearchTransgenic monkeysDeep layer neuronsFetal neurogenesisMyelination levelsSynaptic maturationLongitudinal MRITransgenic miceSynaptic connectionsBrain developmentConnectivity changesBrain connectivityOccipital regionMolecular pathwaysBrainMotor planningMonkeysEnergy metabolismHuman brainCellular levelEnlarged brainExtracellular matrixPrior studiesHumansNeurogenesisGenesLongitudinal Evaluation of Brain Plasticity in Low-Grade Gliomas: fMRI and Graph-Theory Provide Insights on Language Reorganization
Pasquini L, Peck K, Tao A, Del Ferraro G, Correa D, Jenabi M, Kobylarz E, Zhang Z, Brennan C, Tabar V, Makse H, Holodny A. Longitudinal Evaluation of Brain Plasticity in Low-Grade Gliomas: fMRI and Graph-Theory Provide Insights on Language Reorganization. Cancers 2023, 15: 836. PMID: 36765795, PMCID: PMC9913404, DOI: 10.3390/cancers15030836.Peer-Reviewed Original ResearchLanguage reorganizationLaterality indexLanguage performanceLanguage assessmentTask-based functional MRIStandardized language assessmentsRight hemisphere participationEvaluating language functionInter-hemisphericFunctional networksLanguage dominanceLanguage plasticityLanguage functionFunctional MRIDominant hemisphereFMRI mapsHemispheric connectivityBrain plasticityConnectivity changesTb-fMRIFMRIFunctional plasticityLanguageFunctional changesLow-grade gliomas
2022
Sex differences in default mode network connectivity in healthy aging adults
Ficek-Tani B, Horien C, Ju S, Xu W, Li N, Lacadie C, Shen X, Scheinost D, Constable T, Fredericks C. Sex differences in default mode network connectivity in healthy aging adults. Cerebral Cortex 2022, 33: 6139-6151. PMID: 36563018, PMCID: PMC10183749, DOI: 10.1093/cercor/bhac491.Peer-Reviewed Original ResearchConceptsDefault mode networkPreclinical Alzheimer's diseaseAlzheimer's diseaseSex differencesBrain connectivity changesDefault mode network connectivityIntrinsic connectivity distributionSeed-based analysisMode network connectivityMedial prefrontal cortexPosterior DMN nodesHealthy aging adultsImpact of sexLifetime riskDMN connectivityWhole brainPosterior cingulateDMN nodesSignificant sex differencesPrefrontal cortexConnectivity changesAging AdultsHealthy participantsDMN functionMode networkMental imagery content is associated with disease severity and specific brain functional connectivity changes in patients with Parkinson’s disease
Cherry J, Kamel S, Elfil M, Aravala S, Bayoumi A, Patel A, Sinha R, Tinaz S. Mental imagery content is associated with disease severity and specific brain functional connectivity changes in patients with Parkinson’s disease. Brain Imaging And Behavior 2022, 17: 161-171. PMID: 36434490, PMCID: PMC10050121, DOI: 10.1007/s11682-022-00749-z.Peer-Reviewed Original ResearchConceptsImagery trainingFunctional connectivity changesMild Parkinson's diseaseVisual imagery trainingMental imagery trainingComplex cognitive processesConnectivity changesMotor imagery trainingBrain functional connectivity changesFunctional connectivity characteristicsExecutive processesMental imageryCognitive processesPerceptual experienceNeural correlatesBrain mechanismsImagery practiceImagery contentSensorimotor processesNeuropsychiatric patient populationsMotor functionMotor actsMotor enhancementBrain areasParkinson's disease
2021
An altered balance of integrated and segregated brain activity is a marker of cognitive deficits following sleep deprivation
Cross NE, Pomares FB, Nguyen A, Perrault AA, Jegou A, Uji M, Lee K, Razavipour F, Bin Ka’b Ali O, Aydin U, Benali H, Grova C, Dang-Vu TT. An altered balance of integrated and segregated brain activity is a marker of cognitive deficits following sleep deprivation. PLOS Biology 2021, 19: e3001232. PMID: 34735431, PMCID: PMC8568176, DOI: 10.1371/journal.pbio.3001232.Peer-Reviewed Original ResearchConceptsSleep-deprived stateSleep deprivationCortical networksFunctional magnetic resonance imaging (fMRI) scansLarge-scale cortical networksCognitive impairmentSleep-deprived brainNight of SDHomeostatic sleep pressureExecutive tasksCognitive performanceTask performanceCognitive changesRegular nightBrain activityCognitive functionCognitive deficitsNetwork integrationInformation processingSleep pressureCortical activityBidirectional effectsConnectivity changesInterindividual differencesNonrapid eye movement sleepWithin node connectivity changes, not simply edge changes, influence graph theory measures in functional connectivity studies of the brain
Luo W, Greene AS, Constable RT. Within node connectivity changes, not simply edge changes, influence graph theory measures in functional connectivity studies of the brain. NeuroImage 2021, 240: 118332. PMID: 34224851, PMCID: PMC8493952, DOI: 10.1016/j.neuroimage.2021.118332.Peer-Reviewed Original ResearchFunctional Network Development in Sagittal Craniosynostosis Treated With Whole Vault Cranioplasty
Cabrejo R, Lacadie C, Sun A, Chuang C, Yang J, Brooks E, Beckett J, Eilbott J, Gabrick K, Steinbacher D, Duncan C, DiLuna M, Alperovich M, Pelphrey K, Ventola P, Constable T, Persing JA. Functional Network Development in Sagittal Craniosynostosis Treated With Whole Vault Cranioplasty. Journal Of Craniofacial Surgery 2021, 32: 1721-1726. PMID: 33534301, DOI: 10.1097/scs.0000000000007505.Peer-Reviewed Original ResearchConceptsWhole-vault cranioplastySagittal craniosynostosisFunctional MRICase-control study designFunctional MRI scansControl study designAbnormal network connectionsFunctional network developmentNeurological changesIndividual patientsMRI scansFunctional brain networksCerebral networksFunctional connectivityVisual networkConnectivity changesPatientsStudy designSurgeryAdolescent controlsBrain networksCraniosynostosisWVC groupInfantsExecutive functionReduced functional connectivity of default mode network subsystems in depression: Meta-analytic evidence and relationship with trait rumination
Tozzi L, Zhang X, Chesnut M, Holt-Gosselin B, Ramirez CA, Williams LM. Reduced functional connectivity of default mode network subsystems in depression: Meta-analytic evidence and relationship with trait rumination. NeuroImage Clinical 2021, 30: 102570. PMID: 33540370, PMCID: PMC7856327, DOI: 10.1016/j.nicl.2021.102570.Peer-Reviewed Original ResearchConceptsMajor depressive disorderDefault mode networkFunctional connectivityDMPFC subsystemResting-state functional connectivity changesDiagnosis of MDDDMN subsystemsDiagnostic categoriesDefault mode network subsystemsResting-state functional connectivityFunctional connectivity changesDorsal medial prefrontal cortex (dMPFC) subsystemAnxiety/depressionMedial temporal lobe (MTL) subsystemSubgroup of individualsIllness durationDepressive disorderPrognostic markerDMN connectivityUnmedicated participantsConnectivity changesMidline coreMode networkMeta-analytic evidenceSymptoms
2020
Association Between Magnetic Resonance Imaging-Based Spinal Morphometry and Sensorimotor Behavior in a Hemicontusion Model of Incomplete Cervical Spinal Cord Injury in Rats
Chitturi J, Sanganahalli BG, Herman P, Hyder F, Ni L, Elkabes S, Heary R, Kannurpatti SS. Association Between Magnetic Resonance Imaging-Based Spinal Morphometry and Sensorimotor Behavior in a Hemicontusion Model of Incomplete Cervical Spinal Cord Injury in Rats. Brain Connectivity 2020, 10: 479-489. PMID: 32981350, PMCID: PMC7698856, DOI: 10.1089/brain.2020.0812.Peer-Reviewed Original ResearchConceptsNeurological outcomeFunctional connectivity changesSpinal cordMagnetic resonance imagingComplete neural axisNeural axisCervical SCIMorphometric changesIncomplete cervical spinal cord injuryC4/C5 levelResonance imagingCervical spinal cord injurySpinal cord injury patientsFunctional connectivityConnectivity changesCord injury patientsT2-weighted lesionsCervical spinal cordSpinal cord injuryYoung adult ratsFunctional connectivity assessmentC5 levelSCI ratsInjury patientsSham rats
2019
Distance disintegration delineates the brain connectivity failure of Alzheimer's disease
Costumero V, d'Oleire Uquillas F, Diez I, Andorrà M, Basaia S, Bueichekú E, Ortiz-Terán L, Belloch V, Escudero J, Ávila C, Sepulcre J. Distance disintegration delineates the brain connectivity failure of Alzheimer's disease. Neurobiology Of Aging 2019, 88: 51-60. PMID: 31941578, PMCID: PMC7085436, DOI: 10.1016/j.neurobiolaging.2019.12.005.Peer-Reviewed Original ResearchConceptsAssociated with lower global cognitionCognitive impairmentAlzheimer's diseaseBrain network dysfunctionAD-related changesMild cognitive impairmentFrontoparietal networkSalience networkMode networkStrength of connectionsNetwork-based investigationsGlobal cognitionNetwork dysfunctionAD-related conditionsBrain connectivityConnectivity changesCortical regionsConnection distanceInvestigation of brain connectivityAD spectrumVoxel levelHealthy controlsDistance of connectionBrainPathways of connectivity
2018
Intrinsic connectivity networks in posterior cortical atrophy: A role for the pulvinar?
Fredericks CA, Brown JA, Deng J, Kramer A, Ossenkoppele R, Rankin K, Kramer JH, Miller BL, Rabinovici GD, Seeley WW. Intrinsic connectivity networks in posterior cortical atrophy: A role for the pulvinar? NeuroImage Clinical 2018, 21: 101628. PMID: 30528957, PMCID: PMC6411779, DOI: 10.1016/j.nicl.2018.101628.Peer-Reviewed Original ResearchConceptsPosterior cortical atrophyVisuospatial networkAlzheimer's diseaseClinical featuresCortical atrophyPulvinar nucleusSN connectivityConnectivity changesPulvinar thalamic nucleiPatients' clinical featuresAmnestic Alzheimer's diseaseMedial pulvinar nucleusLateral pulvinar nucleusDefault mode network connectivitySalience network connectivityMore depressive symptomsMode network connectivityStandardized neuropsychological batteryTask-free fMRIIntrinsic connectivity networksDirect anatomical connectionsVisuospatial symptomsConnectivity increasesBrain atrophyPCa patients
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