2024
Neuroimaging Correlates of the NIH-Toolbox-Driven Cognitive Metrics in Children
Acosta-Rodriguez H, Yuan C, Bobba P, Stephan A, Zeevi T, Malhotra A, Tran A, Kaltenhauser S, Payabvash S. Neuroimaging Correlates of the NIH-Toolbox-Driven Cognitive Metrics in Children. Journal Of Integrative Neuroscience 2024, 23: 217. PMID: 39735971, PMCID: PMC11851640, DOI: 10.31083/j.jin2312217.Peer-Reviewed Original ResearchConceptsCognitive composite scoreAdolescent Brain Cognitive DevelopmentFluid cognition composite scoresStructural magnetic resonance imagingComposite scoreDiffusion tensor imagingNeuroimaging correlatesCognitive functionRs-fMRINational Institutes of Health (NIH) Toolbox Cognition BatteryCognitive scoresMicrostructural integrityResting-state functional connectivityCrystallized cognition composite scoreCortical surface areaTotal cognitive scoreWM microstructural integrityCognitive batteryCrystallized cognitionNeuroanatomical correlatesWhite matterCognitive performanceNeuroimaging metricsFunctional connectivityNeuroimaging dataSPPADE symptom prevalence and severity in a diverse sample of patients living with metastatic cancers.
Pachman D, Ruddy K, Grzegorczyk V, Kroenke K, Griffin J, Ridgeway J, Chlan L, Tofthagen C, Leventakos K, Strand J, Austin J, Smith A, Mitchell S, Herrin J, Cheville A. SPPADE symptom prevalence and severity in a diverse sample of patients living with metastatic cancers. Journal Of Clinical Oncology 2024, 42: 11108-11108. DOI: 10.1200/jco.2024.42.16_suppl.11108.Peer-Reviewed Original ResearchSymptom burdenHigh school educationDiverse sample of patientsAmerican Indian/Alaska Native (AI/ANSymptom management interventionsHigh symptom burdenPhysical function impairmentComposite scoreCancer symptom controlTotal symptom burdenSchool educationComposite mean scoresSymptom interventionMetastatic diseaseMetastatic cancerSymptom prevalenceSample of patientsSymptom surveyEmployment statusDisability statusMean scoreICD codesCancer typesManagement interventionsSymptom controlNeural Correlates of Novelty-Evoked Distress in 4-Month-Old Infants: A Synthetic Cohort Study
Filippi C, Winkler A, Kanel D, Elison J, Hardiman H, Sylvester C, Pine D, Fox N. Neural Correlates of Novelty-Evoked Distress in 4-Month-Old Infants: A Synthetic Cohort Study. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2024, 9: 905-914. PMID: 38641209, PMCID: PMC11381178, DOI: 10.1016/j.bpsc.2024.03.008.Peer-Reviewed Original ResearchBrain-behavior associationsParent-report measuresInfant temperamentNetwork pairsDorsal attention network connectivityAssessment of infant temperamentParent-reported temperamentAttention network connectivityControl network connectivitySocial anxietyFMRI studyNeural correlatesNeural basisFunctional connectivityParent reportNeuroimaging dataTemperamentAttention-controlComposite scoreDistressNetwork connectivityObservational assessmentNegative associationBehavior estimationDorsal
2023
Changes in Older Adult Trauma Quality When Evaluated Using Longer-Term Outcomes vs In-Hospital Mortality
Zogg C, Cooper Z, Peduzzi P, Falvey J, Castillo-Angeles M, Kodadek L, Staudenmayer K, Davis K, Tinetti M, Lichtman J. Changes in Older Adult Trauma Quality When Evaluated Using Longer-Term Outcomes vs In-Hospital Mortality. JAMA Surgery 2023, 158: e234856. PMID: 37792354, PMCID: PMC10551815, DOI: 10.1001/jamasurg.2023.4856.Peer-Reviewed Original ResearchConceptsHospital-level factorsTraumatic brain injurySevere traumatic brain injuryHospital mortalityTrauma QualityOlder adultsHip fractureComposite scoreHigher risk-adjusted oddsLevel 1 trauma centerIn-Hospital MortalityRisk-adjusted oddsLong-term outcomesMultivariable logistic regressionNontrauma centersTrauma patientsTerm outcomesTrauma centerPrimary diagnosisBrain injuryTrauma systemMAIN OUTCOMEMedicare feeService claimsForms of traumaImprovement of Patient-Reported Outcomes Among Heavily Pretreated Patients with Lower-Risk Myelodysplastic Syndromes and High Transfusion Burden Treated with Imetelstat on the IMerge Phase 3 Trial
Sekeres M, Diez-Campelo M, Zeidan A, Platzbecker U, Regnault A, Creel K, Sengupta N, Wan Y, Sun L, Xia Q, Berry T, Dougherty S, Shah S, Navada S, Santini V, Valcárcel D. Improvement of Patient-Reported Outcomes Among Heavily Pretreated Patients with Lower-Risk Myelodysplastic Syndromes and High Transfusion Burden Treated with Imetelstat on the IMerge Phase 3 Trial. Blood 2023, 142: 6479. DOI: 10.1182/blood-2023-181103.Peer-Reviewed Original ResearchLower-risk myelodysplastic syndromesPatient-reported outcomesHigh transfusion burdenTransfusion burdenPlacebo groupMyelodysplastic syndromeTreatment groupsFunctional assessmentCancer Therapy-AnemiaPatient-reported fatigueTransfusion independence rateChronic Illness TherapyPhase 3 trialInferior overall survivalTransfusion-dependent anemiaLeast square meansImprovement of patientsPRO end pointsComposite scorePositive mean changesQuality of lifeFACT-AnTreat populationDyspnea scoreOverall survivalTHU606 Cognitive Impairment In Patients With Mild Autonomous Cortisol Secretion: A Cross-sectional Study
Saini J, Nathani R, Singh S, Thangamuthu K, Suresh M, Zhang C, Ebbehøj A, Thomas M, Fell V, Atkinson E, Achenbach S, Stricker N, Bancos I. THU606 Cognitive Impairment In Patients With Mild Autonomous Cortisol Secretion: A Cross-sectional Study. Journal Of The Endocrine Society 2023, 7: bvad114.136. PMCID: PMC10553766, DOI: 10.1210/jendso/bvad114.136.Peer-Reviewed Original ResearchComposite T-scoreDexamethasone suppression testPost-DST cortisolFluid cognitionCrystallized cognitionCognitive performanceCognitive impairmentNIH Toolbox Cognition BatteryPattern of cognitive impairmentCrystallized composite scoresComposite scoreReference subjectsT-scoreCognitive batterySubgroup analysisCognitive agingComposite cognitionMild autonomous cortisol secretionCognitive domainsNIH ToolboxSubgroup analysis of patientsImpaired cognitionCognitive functionSingle-center cross-sectional studyCompared to reference subjectsA comparison of below-knee vs above-knee endovenous ablation of varicose veins
Bai H, Gokani V, Storch J, Kibrik P, Aziz F, Sachdev U, Fukaya E, Chaar C, T. A, Ting W. A comparison of below-knee vs above-knee endovenous ablation of varicose veins. Journal Of Vascular Surgery Venous And Lymphatic Disorders 2023, 12: 101679. PMID: 37708939, PMCID: PMC11523341, DOI: 10.1016/j.jvsv.2023.08.018.Peer-Reviewed Original ResearchVenous Clinical Severity ScorePatient-reported outcomesKnee treatmentKnee interventionsComposite scoreVascular Quality Initiative Varicose Vein RegistryMultivariable logistic regression analysisClinical severity scoreDeep vein thrombosisMultivariable logistic regressionOdds of improvementLogistic regression analysisQuality of lifeVein ablationVein thrombosisAnatomic distributionSeverity scoreMultivariable modelTreatment outcomesVaricose veinsHigher oddsVein treatmentPatientsLogistic regressionCategorical variablesImmune-Inflammatory Response And Compensatory Immune-Regulatory Reflex Systems And White Matter Integrity in Schizophrenia
Gou M, Chen W, Li Y, Chen S, Feng W, Pan S, Luo X, Tan S, Tian B, Li W, Tong J, Zhou Y, Li H, Yu T, Wang Z, Zhang P, Huang J, Kochunov P, Tian L, Li C, Hong L, Tan Y. Immune-Inflammatory Response And Compensatory Immune-Regulatory Reflex Systems And White Matter Integrity in Schizophrenia. Schizophrenia Bulletin 2023, 50: 199-209. PMID: 37540273, PMCID: PMC10754202, DOI: 10.1093/schbul/sbad114.Peer-Reviewed Original ResearchConceptsImmune-inflammatory response systemWhite matter integrityNegative symptom scoresFractional anisotropySymptom scoresAffected white matter tractsImmune inflammatory responsePanel of cytokinesWhite matter impairmentEnzyme-linked immunosorbentWhite matter tractsAverage fractional anisotropyWhite matter componentsPeripheral inflammationNeuroinflammatory conditionsPathophysiological mechanismsHealthy controlsCorpus callosumNegative symptomsReflex systemSchizophreniaOligodendrocyte differentiationConsistent findingComposite scoreUnderlying mechanismFusion of Multi-Modal Neuroimaging Data and Association With Cognitive Data
LoPresto M, Akhonda M, Calhoun V, Adali T. Fusion of Multi-Modal Neuroimaging Data and Association With Cognitive Data. 2023, 00: 1-5. DOI: 10.1109/icasspw59220.2023.10193147.Peer-Reviewed Original ResearchHopkins Verbal Learning TestNeuropsychological assessment batteryCognitive dataNeuroimaging modalitiesBrief Assessment of CognitionSchizophrenia composite scoreVerbal Learning TestAssessment of CognitionMultiple neuroimaging modalitiesBrief AssessmentCross-modal connectionsLearning TestAssessment batteryCross-modal relationshipsNeuroimaging dataBrain benefitsCognitive scoresComposite scoreCognitionData-driven analysisIndependent vector analysisSchizophreniaNeuropsychologyFusion frameworkScoresUsing Behavioral Measures to Assess Suicide Risk in the Psychiatric Emergency Department for Youth
Shin K, Baroni A, Gerson R, Bell K, Pollak O, Tezanos K, Spirito A, Cha C. Using Behavioral Measures to Assess Suicide Risk in the Psychiatric Emergency Department for Youth. Child Psychiatry & Human Development 2023, 55: 1475-1486. PMID: 36821015, DOI: 10.1007/s10578-023-01507-y.Peer-Reviewed Original ResearchConceptsImplicit Association TestMeasures of suicide riskSuicide stroop taskBehavioral measuresSuicide riskStroop taskSuicidal ideationSuicide attemptsAttempted suicideWithin-person effectsAssess suicide riskLevels of distressSuicide-related reasonsBehavioral tasksSuicidal thoughtsPsychiatric EDIncreased distressSelf-reportSuicide screeningAssociation TestSuicideComposite scoreDemographic covariatesIdeationYouthPrevalence, Severity, and Co-Occurrence of SPPADE Symptoms in 31,866 Patients With Cancer
Kroenke K, Lam V, Ruddy K, Pachman D, Herrin J, Rahman P, Griffin J, Cheville A. Prevalence, Severity, and Co-Occurrence of SPPADE Symptoms in 31,866 Patients With Cancer. Journal Of Pain And Symptom Management 2023, 65: 367-377. PMID: 36738867, PMCID: PMC10106386, DOI: 10.1016/j.jpainsymman.2023.01.020.Peer-Reviewed Original ResearchConceptsProportion of patientsRelevant symptomsPatient characteristicsCancer typesNumeric rating scaleComposite scoreMost sociodemographic characteristicsSymptom Management ModelTypes of cancerDistribution-based methodsSymptom burdenClinical symptomsSymptom prevalenceClinical trialsHigh prevalenceMID estimatesPatientsClinical approachSociodemographic characteristicsSymptom dataSymptomsOncology encountersPrevalenceRating ScaleGood internal reliabilityWhen the Whole Is the Sum of Its Parts: Validation of the Heart Failure Collaboratory Medication Composite Score in Denmark
Ahmad F, Ahmad T, Allen L. When the Whole Is the Sum of Its Parts: Validation of the Heart Failure Collaboratory Medication Composite Score in Denmark. Circulation Heart Failure 2023, 16: e010309. PMID: 36695188, PMCID: PMC9974734, DOI: 10.1161/circheartfailure.122.010309.Peer-Reviewed Original ResearchConceptsComposite score
2022
Childhood trauma and cognitive deficits in patients with schizophrenia: mediation by orbitofrontal cortex H-shaped sulci volume
Wang L, Yin Y, Feng W, Zhou Y, Huang J, Zhang P, Chen S, Fan H, Cui Y, Luo X, Tan S, Wang Z, Tian B, Tian L, Li CR, Tan Y. Childhood trauma and cognitive deficits in patients with schizophrenia: mediation by orbitofrontal cortex H-shaped sulci volume. Journal Of Psychiatry And Neuroscience 2022, 47: e209-e217. PMID: 35654451, PMCID: PMC9177195, DOI: 10.1503/jpn.210178.Peer-Reviewed Original ResearchConceptsFirst-episode schizophreniaCTQ total scoresHealthy controlsCognitive functionChildhood Trauma QuestionnaireTotal scoreCognitive deficitsChildhood trauma experiencesMATRICS Consensus Cognitive BatteryChildhood traumaOrbitofrontal cortexWorse cognitive functionTrauma experiencesHigh-resolution MRIRetrospective designPatientsConsensus Cognitive BatterySchizophreniaTraumaSubscoresSmall sample sizeTrauma QuestionnaireComposite scoreLines of evidenceScores
2021
Detecting change in psychiatric functioning in clinical trials for cocaine use disorder: sensitivity of the Addiction Severity Index and Brief Symptom Inventory
Kiluk BD, Roos CR, Aslan M, Gueorguieva R, Nich C, Babuscio TA, Carroll KM. Detecting change in psychiatric functioning in clinical trials for cocaine use disorder: sensitivity of the Addiction Severity Index and Brief Symptom Inventory. Drug And Alcohol Dependence 2021, 228: 109070. PMID: 34600247, PMCID: PMC8595796, DOI: 10.1016/j.drugalcdep.2021.109070.Peer-Reviewed Original ResearchConceptsAddiction Severity IndexGlobal Severity IndexPsychiatric composite scoreClinical trialsCocaine useCocaine use disorderPsychiatric functioningBrief Symptom InventorySeverity IndexUse disordersASI psychiatric composite scoreSymptom InventoryEffect sizeStart of treatmentComposite scoreClinical trial participantsWeek 12Functional outcomeTreatment periodTrial participantsPsychiatric problemsDrug usePotential functional benefitsMedium effect sizeSubstance usersClinical Characteristics, Management, and In-Hospital Outcomes in Patients With Stroke or Transient Ischemic Attack in China
Gu H, Yang X, Wang C, Zhao X, Wang Y, Liu L, Meng X, Jiang Y, Li H, Liu C, Wangqin R, Fonarow G, Schwamm L, Xian Y, Li Z, Wang Y. Clinical Characteristics, Management, and In-Hospital Outcomes in Patients With Stroke or Transient Ischemic Attack in China. JAMA Network Open 2021, 4: e2120745. PMID: 34387677, PMCID: PMC8363916, DOI: 10.1001/jamanetworkopen.2021.20745.Peer-Reviewed Original ResearchConceptsTransient ischemic attackChinese Stroke Center AllianceMajor adverse cardiovascular eventsHospital clinical outcomesQuality improvement studyIschemic strokeIntracerebral hemorrhageIschemic attackClinical characteristicsClinical outcomesPoor outcomeIntravenous recombinant tissue plasminogen activatorTemporal improvementRecombinant tissue plasminogen activatorAdverse cardiovascular eventsIn-Hospital OutcomesUse of anticoagulantsComposite scoreImprovement studyTissue plasminogen activatorMean composite scoreHealth care systemHospital complicationsTIA admissionsTIA careThe Association Between Smoking Abstinence and Pain Trajectory Among Veterans Engaged in U.S. Department of Veterans Affairs Mental Health Care
Hammett PJ, Businelle MS, Taylor BC, Erbes CR, Bastian L, Doran N, Sherman SE, Rogers ES, Burgess DJ, Fu SS. The Association Between Smoking Abstinence and Pain Trajectory Among Veterans Engaged in U.S. Department of Veterans Affairs Mental Health Care. Pain Medicine 2021, 22: 1793-1803. PMID: 33502511, DOI: 10.1093/pm/pnab009.Peer-Reviewed Original ResearchConceptsLower pain scoresPain scoresPain groupMental health careSmoking abstinenceVeteran smokersProactive outreachPoint prevalence smoking abstinenceVA mental health careOverall sampleBaseline pain scoresModerate pain groupSevere pain groupVA mental healthSelf-reported abstinenceHealth careNicotine abstinenceMental health servicesMental healthPain trajectoriesSevere painComposite scoreAbstinenceProspective analysisInteraction test
2020
Access to Pain Care From Compensation Clinics: A Relational Coordination Perspective.
Rosen MI, Martino S, Sellinger J, Lazar CM, Fenton BT, Mattocks K. Access to Pain Care From Compensation Clinics: A Relational Coordination Perspective. Federal Practitioner 2020, 37: 336-342. PMID: 32908339, PMCID: PMC7473717, DOI: 10.12788/fp.0017.Peer-Reviewed Original ResearchRelational coordination surveyVeterans Health AdministrationVHA staffPain treatmentPain careMedical CenterCompensation examinationsVHA medical centersSemistructured interviewsPain managementVHA carePrimary careReferral practicesSpecific treatmentMusculoskeletal disordersHealth AdministrationTreatment engagementMeasure of coordinationClinicCareComposite scoreVeteransTreatmentAdministrationExaminationOptimizing High-risk Infant Follow-up in Nonresearch-based Paradigms: The New England Follow-up Network
Litt JS, Edwards EM, Lainwala S, Mercier C, Montgomery A, O’Reilly D, Rhein L, Woythaler M, Hartman T. Optimizing High-risk Infant Follow-up in Nonresearch-based Paradigms: The New England Follow-up Network. Pediatric Quality And Safety 2020, 5: e287. PMID: 32656462, PMCID: PMC7297406, DOI: 10.1097/pq9.0000000000000287.Peer-Reviewed Original ResearchHigh-risk infantsNICU dischargeNeonatal intensive care unit dischargeIntensive care unit dischargeLow birth weightRegional quality improvementQuality of followEligible infantsPostdischarge followRehospitalization ratesCerebral palsyGestational ageRespiratory illnessBirth weightThird percentileComparative outcomesBayley ScalesHealth statusDemographic dataInfantsFollowInfant developmentUnit dischargeComposite scoreQuality Initiative
2019
Short and long-term improvements in psychiatric symptomatology to validate clinically meaningful treatment outcomes for cocaine use disorders
Miguel AQC, Kiluk BD, Babuscio TA, Nich C, Mari JJ, Carroll KM. Short and long-term improvements in psychiatric symptomatology to validate clinically meaningful treatment outcomes for cocaine use disorders. Drug And Alcohol Dependence 2019, 198: 126-132. PMID: 30921648, PMCID: PMC6487863, DOI: 10.1016/j.drugalcdep.2019.01.046.Peer-Reviewed Original ResearchConceptsCocaine use disorderBrief Symptom InventoryCocaine use outcomesPsychiatric symptomatologyUse outcomesUse disordersPositive Symptom TotalDrug use outcomesMeaningful treatment outcomesInterpersonal sensitivityUse outcome measuresParanoid ideationSymptom TotalLong-term functional improvementSymptom InventoryLong-term associationPsychoticism dimensionOutcome effectsComposite scoreOutcome measuresSymptomatologyNegative urinalysis resultsGlobal indexComplete abstinenceLong-term improvementFour Approaches for Determining Composite Scores for the Measurement of Transition in Cancer Scale
Jeon S, Schulman-Green D, McCorkle R, Dixon JK. Four Approaches for Determining Composite Scores for the Measurement of Transition in Cancer Scale. Nursing Research 2019, 68: 57-64. PMID: 30247334, DOI: 10.1097/nnr.0000000000000318.Peer-Reviewed Original Research
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