2025
Uric Acid Stroke Cerebroprotection Transcended Sex, Age, and Comorbidities in a Multicenter Preclinical Trial
Patel R, Kumskova M, Kodali H, Budnik I, Kuznetsov V, Jain A, Jha A, Thedens D, Dhanesha N, Sutariya B, Nagarkatti K, Lamb J, Kamat P, Shi Y, Avery B, Imai T, Jin X, Chauhan A, Boisserand L, Khan M, Dhandapani K, Sanganahalli B, Sansing L, Hess D, Koehler R, McCullough L, Aronowski J, Ayata C, Diniz M, Lyden P, Planas A, Chamorro A, Chauhan A, Leira E, Investigators O. Uric Acid Stroke Cerebroprotection Transcended Sex, Age, and Comorbidities in a Multicenter Preclinical Trial. Stroke 2025, 56: 965-973. PMID: 40091742, PMCID: PMC11932773, DOI: 10.1161/strokeaha.124.048748.Peer-Reviewed Original ResearchConceptsUA-treated animalsPrimary functional outcomeFunctional outcomesMiddle cerebral artery filament occlusionModified intention-to-treat populationIntention-to-treat populationUric acidHuman clinical trialsImprove functional outcomesStudy drugIntravenous salineEffects of UARelevant to patientsClinical trialsPrimary outcomeSaline controlsSecondary outcomesPreclinical trialsDay 2Survival rateDay 7Filament occlusionGroups of animalsComorbiditiesDiverse comorbiditiesCardiovascular Event Prevalence in Type 1 Versus Type 2 Diabetes: Veradigm Metabolic Registry Insights
Goldsweig A, Knee A, Tak H, Desai N, Bradley S, Lotfi A, Spertus J, Goldsweig B. Cardiovascular Event Prevalence in Type 1 Versus Type 2 Diabetes: Veradigm Metabolic Registry Insights. Journal Of The Society For Cardiovascular Angiography & Interventions 2025, 4: 102502. DOI: 10.1016/j.jscai.2024.102502.Peer-Reviewed Original ResearchIncident cardiovascular eventsPrevalence ratiosDiabetes mellitus type 1Risk of incident cardiovascular eventsCardiovascular diseaseCardiovascular eventsPrimary carePercutaneous coronary interventionMyocardial infarctionType 2 diabetesOutpatient facilitiesEvent prevalenceLimb ischemiaCoronary interventionAge categoriesStudy populationDM2 patientsRisk factorsHemoglobin A1cCarePrevalencePeripheral revascularizationInterventionComorbiditiesDM2Pain Management in the Older Adults A Narrative Review
Rajput K, Ng J, Zwolinski N, Chow R. Pain Management in the Older Adults A Narrative Review. Clinics In Geriatric Medicine 2025, 41: 131-151. PMID: 39551538, DOI: 10.1016/j.cger.2024.03.011.Peer-Reviewed Original ResearchConceptsPain managementOlder adult populationOlder adult patientsOlder adultsAdult populationMultiple medicationsLife expectancyClinical practiceAdult patientsMedical managementPreexisting comorbiditiesPainUnited StatesDegenerative processPracticeNonagenariansMedicationAdultsComorbiditiesReviewManagementOctogenariansPatients
2024
Müllerian anomalies and endometriosis: associations and phenotypic variations
Bhamidipaty-Pelosi S, Kyei-Barffour I, Volpert M, O’Neill N, Grimshaw A, Eriksson L, Vash-Margita A, Pelosi E. Müllerian anomalies and endometriosis: associations and phenotypic variations. Reproductive Biology And Endocrinology 2024, 22: 157. PMID: 39702195, PMCID: PMC11656925, DOI: 10.1186/s12958-024-01336-1.Peer-Reviewed Original ResearchConceptsMullerian anomaliesObstructive Mullerian anomaliesAdverse pregnancy outcomesDevelopment of endometriosisAbsence of obstructionFemale reproductive tractHeterogeneity of phenotypesPregnancy outcomesRetrograde menstruationSurgical correctionCongenital conditionEndometriosisAnatomical variationsHigh riskReproductive tractCardiovascular systemVariable comorbiditiesClinical researchIncomplete developmentLack of genetic informationMalformationsComorbiditiesObstructionInfertilityMenstruationTransverse tibial bone transport for non-healing heel wound: A case report
Yang A, Park N, Gazes M, Samchukov M, Frumberg D. Transverse tibial bone transport for non-healing heel wound: A case report. International Journal Of Surgery Case Reports 2024, 124: 110400. PMID: 39369454, PMCID: PMC11490725, DOI: 10.1016/j.ijscr.2024.110400.Peer-Reviewed Original ResearchDiabetic foot ulcersFoot ulcersTransverse tibial bone transportTreatment of diabetic foot ulcersRefractory diabetic foot ulcersLongstanding insulin-dependent diabetes mellitusTibial bone transportWound interventionHeel ulcersHeel woundsMedical comorbiditiesDiabetes mellitusInsulin-dependent diabetes mellitusDistraction histogenesisInduce vascular regenerationCase reportUlcersTreatment optionsAmputationInterventionSoft tissueVascular regenerationTreat various disordersBlood vesselsComorbiditiesAmerican Radium Society Appropriate Use Criteria on Cardiac Toxicity Prevention and Management After Thoracic Radiotherapy
Amini A, Zaha V, Hamad E, Woodard P, Rimner A, Chang J, Chun S, Donington J, Edelman M, Gubens M, Higgins K, Iyengar P, Juloori A, Movsas B, Ning M, Park H, Rodrigues G, Wolf A, Simone C. American Radium Society Appropriate Use Criteria on Cardiac Toxicity Prevention and Management After Thoracic Radiotherapy. Journal Of Thoracic Oncology 2024, 19: 1654-1667. PMID: 39313150, PMCID: PMC11665043, DOI: 10.1016/j.jtho.2024.09.1433.Peer-Reviewed Original ResearchConceptsCardiac toxicityCardiac comorbiditiesThoracic radiotherapyToxicity preventionAmerican Radium Society Appropriate Use CriteriaAbsence of cardiovascular risk factorsLow riskHigh riskMultidisciplinary consensus guidelinesTreatment-related risksAppropriate Use CriteriaCardiovascular risk factorsVariants of patientsThoracic malignanciesModified Delphi methodologyCardiac substructuresConsensus guidelinesRadiotherapyRisk factorsCardiac imagingComorbiditiesDose exposurePatientsSystematic reviewThoracicInternal Tremors and Vibrations in Long COVID: A Cross-Sectional Study
Zhou T, Sawano M, Arun A, Caraballo C, Michelsen T, McAlpine L, Bhattacharjee B, Lu Y, Khera R, Huang C, Warner F, Herrin J, Iwasaki A, Krumholz H. Internal Tremors and Vibrations in Long COVID: A Cross-Sectional Study. The American Journal Of Medicine 2024, 138: 1010-1018.e14. PMID: 39069199, PMCID: PMC12023347, DOI: 10.1016/j.amjmed.2024.07.008.Peer-Reviewed Original ResearchNew-onset conditionsInternal tremorLong COVID symptomsCOVID symptomsNon-Hispanic whitesCross-sectional studyQuality of lifeVisual analogue scaleWorse healthHealth statusStudy participantsDemographic characteristicsAnalogue scaleOutcome variablesNeurological conditionsLong COVIDMast cell disordersTreatment experienceHealthComorbiditiesSymptomsMedian agePeopleCell disordersManaging Cluster Headache in Patients with Medical, Psychiatric, and Surgical Comorbidities
Burish M, Guirguis A, Schindler E. Managing Cluster Headache in Patients with Medical, Psychiatric, and Surgical Comorbidities. Current Neurology And Neuroscience Reports 2024, 24: 439-452. PMID: 39017830, DOI: 10.1007/s11910-024-01362-x.Peer-Reviewed Original ResearchAdults With Spina Bifida Fare Worse Than Young Adults: A Systemic Vulnerability in Urinary Tract Infection–Related Hospital Care
Huen K, Davis-Dao C, Sayrs L, Ehwerhemuepha L, Martin-King C, Kain Z. Adults With Spina Bifida Fare Worse Than Young Adults: A Systemic Vulnerability in Urinary Tract Infection–Related Hospital Care. Journal Of Urology 2024, 212: 749-756. PMID: 38950379, DOI: 10.1097/ju.0000000000004130.Peer-Reviewed Original ResearchSB patientsSpina bifidaAdult SB patientsRetrospective cohort analysisGender-matched controlsLogistic regression analysisCohort analysisHospital carePatientsSB casesOddsCerner Real World DataRegression analysisHealth care utilizationYoung adultsAdolescentsAdultsCare utilizationReal World DataAgeYearsUTICareUrinaryComorbiditiesIntegrated Safety and Efficacy Analyses of Phase 3 Trials of a Microbiome Therapeutic for Recurrent CDI
Kraft C, Sims M, Silverman M, Louie T, Feuerstadt P, Huang E, Khanna S, Berenson C, Wang E, Cohen S, Korman L, Lee C, Kelly C, Odio A, Cook P, Lashner B, Ramesh M, Kumar P, De A, Memisoglu A, Lombardi D, Hasson B, McGovern B, von Moltke L, Pardi D. Integrated Safety and Efficacy Analyses of Phase 3 Trials of a Microbiome Therapeutic for Recurrent CDI. Infectious Diseases And Therapy 2024, 13: 2105-2121. PMID: 38941068, PMCID: PMC11416444, DOI: 10.1007/s40121-024-01007-z.Peer-Reviewed Original ResearchTreatment-emergent adverse eventsPhase 3 trialRCDI rateAnalysis of treatment-emergent adverse eventsTreatment-related treatment-emergent adverse eventsStandard-of-care antibioticsHigh-risk patientsClostridioides difficile infectionPreventing rCDIRenal impairment/failureAbdominal painRecurrent CDIEfficacy analysisAdverse eventsTreatment-relatedPrevent recurrencePrevalent comorbiditiesRCDIWeeksAntibioticsPatientsComorbiditiesEfficacyPlaceboMicrobiomeComorbid Chronic Pain and Post-traumatic Stress Disorder: Current Rates and Psychiatric Comorbidities Among U.S. Military Veterans
Hadlandsmyth K, Zhuang C, Driscoll M, Lund B. Comorbid Chronic Pain and Post-traumatic Stress Disorder: Current Rates and Psychiatric Comorbidities Among U.S. Military Veterans. Military Medicine 2024, 189: 2303-2306. PMID: 38869274, PMCID: PMC11536323, DOI: 10.1093/milmed/usae313.Peer-Reviewed Original ResearchComorbid chronic painChronic painPost-traumatic stress disorderVeterans AffairsU.S. military veteransPsychiatric comorbiditiesPsychiatric comorbidityMultivariate logistic regression modelRates of psychiatric comorbiditiesNational Veterans AffairsMilitary veteransLogistic regression modelsPainStress disorderComorbiditiesComorbidityService usersStudy reports ratesAdministrative dataVeteransDemographic variablesRegression modelsDisordersUrban dwellingPatientsCharacterization of time toxicity in older patients with metastatic breast cancer
Atre S, Soulos P, Kuderer N, Gross C, Baum L, Dinan M, Lustberg M. Characterization of time toxicity in older patients with metastatic breast cancer. Breast Cancer Research And Treatment 2024, 207: 541-550. PMID: 38816556, DOI: 10.1007/s10549-024-07379-7.Peer-Reviewed Original ResearchMetastatic breast cancerBone-modifying agentsComorbid medical conditionsOlder patientsBreast cancerRetrospective cohort studySEER-Medicare databaseTreatment typeCancer treatment modalityTreatment modalitiesSEER-MedicareCohort studyUnadjusted analysisPatientsAge-related impactCancer treatmentComorbiditiesDay patientsCancerRadiotherapyOlder ageMedical conditionsToxicityTreatmentSociodemographic factorsAssessment of Days Alive Out of Hospital as a Possible End Point in Trials of Stroke Prevention for Atrial Fibrillation: A ROCKET AF Analysis
Harrington J, Hellkamp A, Mahaffey K, Breithardt G, Halperin J, Hankey G, Becker R, Nessel C, Berkowitz S, Fox K, Singer D, Goodman S, Patel M, Piccini J. Assessment of Days Alive Out of Hospital as a Possible End Point in Trials of Stroke Prevention for Atrial Fibrillation: A ROCKET AF Analysis. Journal Of The American Heart Association 2024, 13: e028951. PMID: 38780169, PMCID: PMC11255646, DOI: 10.1161/jaha.122.028951.Peer-Reviewed Original ResearchAtrial fibrillationROCKET AFClinical trialsEnd pointsLow overall event ratesInternational double-blindClinical trials of interventionsRandomized clinical trialsAssessment of dayOverall event rateDouble-blindAnticoagulation trialsTreatment armsIncreased riskWarfarinTrials of interventionsClinical utilityTreatment groupsEvent ratesPatientsDAOHPoisson regressionComorbiditiesFibrillationTrialsUnited States Veterans with comorbid chronic fatigue syndrome and chronic pain: do women differ from men?
Adamowicz J, Thomas E, Lund B, Driscoll M, Hadlandsmyth K. United States Veterans with comorbid chronic fatigue syndrome and chronic pain: do women differ from men? Fatigue Biomedicine Health & Behavior 2024, 12: 238-245. DOI: 10.1080/21641846.2024.2350301.Peer-Reviewed Original ResearchWomen veteransChronic fatigue syndromeChronic painVA Corporate Data WarehouseCorporate Data WarehousePsychiatric comorbiditiesFatigue syndromeGroup differencesEffect size differencesUnited States veteransPain clusterExamined group differencesHealthcare utilizationSociodemographic characteristicsPeriod prevalenceAdministrative dataClinical offeringsVeteransMenstrual painStates veteransPainWomenGroup comparisonsMenComorbidities1087 Recognizing Sleep Disorders in the US Military Health System: Differences Between On-base and Private Sector Care
Capaldi V, Williams S, Thomas C, Herrin J, Hong A, Funk W, Collen J, Stryckman B, Albrecht J, Wickwire E. 1087 Recognizing Sleep Disorders in the US Military Health System: Differences Between On-base and Private Sector Care. Sleep 2024, 47: a467-a467. DOI: 10.1093/sleep/zsae067.01087.Peer-Reviewed Original ResearchObstructive sleep apneaMilitary Data RepositoryMilitary Health System beneficiariesSleep disordersMilitary Health SystemBetween-group differencesUS Military Health SystemSleep carePsychiatric comorbiditiesPrivate sector careRecognize sleep disordersComorbid sleep disordersICD-10 diagnostic codesSleep apneaClinical characteristicsDiagnosis of insomniaDiagnostic codesBetween-groupDirect careComorbiditiesInsomniaDisordersSleepICD-10Active duty personnelComorbidity clusters in patients with rheumatoid arthritis identify a patient phenotype with a favourable prognosis
Crowson C, Atkinson E, Kronzer V, Kimbrough B, Arment C, Peterson L, Wright K, Mason T, Bekele D, Davis J, Myasoedova E. Comorbidity clusters in patients with rheumatoid arthritis identify a patient phenotype with a favourable prognosis. Annals Of The Rheumatic Diseases 2024, 83: 556-563. PMID: 38331589, PMCID: PMC11017091, DOI: 10.1136/ard-2023-225093.Peer-Reviewed Original ResearchRA disease activityStandardised mortality ratioPrevalence of depressionRheumatoid arthritisPopulation-based studyEight-county regionDisease activityComorbidity patternsMortality ratioDisease-modifying antirheumatic drugsPrevalence dateVital statusCluster patientsLatent class analysisComorbidity clustersAssess mortalityGeneral populationRA prognosisOlder patientsAntirheumatic drugsComorbiditiesPatient phenotypesClass analysisComorbidityPatientsT cell-mediated skin-brain axis: Bridging the gap between psoriasis and psychiatric comorbidities
Yang J, Zhang S, Wu Q, Chen P, Dai Y, Long J, Wu Y, Lin Y. T cell-mediated skin-brain axis: Bridging the gap between psoriasis and psychiatric comorbidities. Journal Of Autoimmunity 2024, 144: 103176. PMID: 38364575, DOI: 10.1016/j.jaut.2024.103176.Peer-Reviewed Original ResearchPsychiatric comorbiditiesMental disordersHypothalamic-pituitary-adrenal axisT cellsSuicidal ideationHPA axisPsychological disordersSympathetic nervous systemPsychiatric diseasesBlood-brain barrierDisordersMechanisms of T cellsChronic inflammatory skin conditionSkin diseasesEfficacy of treatmentPathogenesis of psoriasisInflammatory skin conditionProgression of psoriasisSecrete cytokinesIdeationPsoriasisComorbiditiesAnxietyDepressionNervous system
2023
Research Priorities in Critical Care Cardiology JACC Expert Panel
Miller P, Huber K, Bohula E, Krychtiuk K, Pöss J, Roswell R, Tavazzi G, Solomon M, Kristensen S, Morrow D, Care A. Research Priorities in Critical Care Cardiology JACC Expert Panel. Journal Of The American College Of Cardiology 2023, 82: 2329-2337. PMID: 38057075, PMCID: PMC10752230, DOI: 10.1016/j.jacc.2023.09.828.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCardiac intensive care unitCritical care cardiologyHigh-quality evidencePatient populationIntensive care unitCritical care researchCare unitIll patientsSociety guidelinesClinical trialsPractice patternsCare researchExpert panelDiagnosisResearch prioritiesComorbiditiesPatientsPopulationLimited guidanceCliniciansCardiologyTrialsCareAssessing and managing frailty in advanced heart failure: An International Society for Heart and Lung Transplantation consensus statement
Denfeld Q, Jha S, Fung E, Jaarsma T, Maurer M, Reeves G, Afilalo J, Beerli N, Bellumkonda L, De Geest S, Gorodeski E, Joyce E, Kobashigawa J, Mauthner O, McDonagh J, Uchmanowicz I, Dickson V, Lindenfeld J, Macdonald P. Assessing and managing frailty in advanced heart failure: An International Society for Heart and Lung Transplantation consensus statement. The Journal Of Heart And Lung Transplantation 2023, 43: 1-27. PMID: 38099896, DOI: 10.1016/j.healun.2023.09.013.Peer-Reviewed Original ResearchAdvanced heart failureDefinition of frailtyHeart failureConsensus statementOverview of frailtyAssessment of frailtyMeasurement of frailtyCritical evidence gapsHF cliniciansFrailty assessmentGeriatric conditionsNonsurgical interventionsClinical practiceEvidence gapsFrailtyPsychological impairmentPhysical performanceClinical implementationPatientsInternational SocietyComorbiditiesPrevious studiesSarcopeniaAssessmentFailureAre We Ready For “Triplet” Therapy in Higher-Risk MDS?
Brunner A, Platzbecker U, DeZern A, Zeidan A. Are We Ready For “Triplet” Therapy in Higher-Risk MDS? Clinical Hematology International 2023, 5: 23-32. PMID: 37933301, PMCID: PMC10625655, DOI: 10.46989/001c.88301.Peer-Reviewed Original ResearchAcute myeloid leukemiaCombination chemotherapyPatient populationOnly disease-modifying therapyNovel combination chemotherapyOngoing therapeutic challengeOlder patient populationUnique patient populationDisease-modifying therapiesCurrent treatment paradigmsTherapeutic challengeTreatment paradigmEffective therapyMyeloid leukemiaNew therapiesAppropriate endpointsTherapyChemotherapyComorbiditiesPatientsTransplantNeoplasmsLeukemiaPopulationDecitabine
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