2025
Resistance to tuberculin skin test/interferon-gamma release assay conversion among highly TB exposed, HIV infected goldminers in South Africa
Ntshiqa T, Velen K, Ginindza S, Nhlangulela L, Charalambous S, Hawn T, Churchyard G, Boom W, Chihota V, Wallis R. Resistance to tuberculin skin test/interferon-gamma release assay conversion among highly TB exposed, HIV infected goldminers in South Africa. PLOS ONE 2025, 20: e0318819. PMID: 40343976, PMCID: PMC12063869, DOI: 10.1371/journal.pone.0318819.Peer-Reviewed Original ResearchConceptsIsoniazid preventive therapyTuberculin skin testCD4 countQFT-PlusAssociated with lower CD4 countsTST responseQuantiFERON-TB Gold PlusBody mass index >Median CD4 countLow CD4 countExposure to TBRates of HIVLongitudinal cohort studyMedian ageTST/IGRAAntiretroviral treatmentMedian timePreventive therapySkin testFollow-upCohort studyLogistic regressionHIVMonthsAssay conversionHospital and Clinician Practice Variation in Cardiac Surgery and Postoperative Acute Kidney Injury
Mathis M, Mentz G, Cao J, Balczewski E, Janda A, Likosky D, Schonberger R, Hawkins R, Heung M, Ailawadi G, Ladhania R, Sjoding M, Kheterpal S, Singh K, Sundt T, Fitzsimons M, Shann K, Kumar V, Yarboro L, Naik B, Tibayan F, Aziz M, Mulligan M, Jelacic S, Kaneko T, Graetz T, Assi R, Mallidi H, Querejeta-Roca G, Shook D, Tsai C, Jewell E, Wanderer J, Freundlich R, Rock P, Douville N, Fisher C, Pace N, Domino K, Wagener G, King C, O'Reilly-Shah V, Bardia A, Clark D. Hospital and Clinician Practice Variation in Cardiac Surgery and Postoperative Acute Kidney Injury. JAMA Network Open 2025, 8: e258342. PMID: 40314957, PMCID: PMC12048843, DOI: 10.1001/jamanetworkopen.2025.8342.Peer-Reviewed Original ResearchConceptsAcute kidney injuryClinician-level variationAssociated with acute kidney injuryAcute kidney injury ratesCardiac surgeryIntraclass correlation coefficientAdult patientsKidney injuryCohort studyCohort study of adult patientsResuscitation practicesPostoperative acute kidney injuryOperating room practiceStudy of adult patientsAssociated with increased morbidityCardiac surgical proceduresCardiac surgical databasePractice variationRBC transfusion ratesFluid volume administrationHospital-level variationMultilevel mixed-effects modelsPatient-level characteristicsRisk-adjustment modelsHealth care costsConversion Therapy Exposure and Elevated Cardiovascular Disease Risk
Gibb J, Schrock J, Smith M, D’Aquila R, McDade T, Mustanski B. Conversion Therapy Exposure and Elevated Cardiovascular Disease Risk. JAMA Network Open 2025, 8: e258745. PMID: 40327341, DOI: 10.1001/jamanetworkopen.2025.8745.Peer-Reviewed Original ResearchConceptsHigh blood pressureSystolic blood pressureDiastolic blood pressureSelf-reported high blood pressureCohort studyCardiovascular health dataCardiovascular health indicatorsSelf-reported hypertensionSGM health disparitiesMental health impactsCardiovascular health consequencesCardiovascular disease riskBlood pressureElevated diastolic blood pressureHealth disparitiesCare approachElevated systolic blood pressureHealth indicatorsMain OutcomesIncreased DBPBehavioral covariatesHealth dataSGM individualsDisease riskHealth consequencesDiaphragm Dysfunction from Phrenic Nerve Injures During LVAD or Heart Transplant: Positive Role of Diaphragm Pacing
Boutros C, Elmo M, Carl N, Abu-Omar Y, Arora R, Elgudin Y, Gray K, Pelletier M, Onders R. Diaphragm Dysfunction from Phrenic Nerve Injures During LVAD or Heart Transplant: Positive Role of Diaphragm Pacing. JHLT Open 2025, 100281. DOI: 10.1016/j.jhlto.2025.100281.Peer-Reviewed Original ResearchNon-invasive ventilationLeft ventricular assist deviceDiaphragm pacingHeart transplantationMechanical ventilationNerve injurySingle-center cohort studyPhrenic nerve dysfunctionPhrenic nerve injuryLeft ventricular assist device recipientsPhrenic injuryDiaphragm dysfunctionDifficulty weaningNerve dysfunctionNerve injuresCase seriesDiaphragm functionMV weaningDP useAdverse eventsCohort studyVentricular assist deviceHTxExploratory case seriesTransplantationArtificial Intelligence–Enabled Prediction of Heart Failure Risk From Single-Lead Electrocardiograms
Dhingra L, Aminorroaya A, Pedroso A, Khunte A, Sangha V, McIntyre D, Chow C, Asselbergs F, Brant L, Barreto S, Ribeiro A, Krumholz H, Oikonomou E, Khera R. Artificial Intelligence–Enabled Prediction of Heart Failure Risk From Single-Lead Electrocardiograms. JAMA Cardiology 2025, 10 PMID: 40238120, PMCID: PMC12004248, DOI: 10.1001/jamacardio.2025.0492.Peer-Reviewed Original ResearchYale New Haven Health SystemELSA-BrasilPCP-HFNew-onset HFHarrell's C-statisticProspective population-based cohortUK Biobank (UKBBrazilian Longitudinal StudyELSA-Brasil participantsC-statisticPopulation-based cohortIntegrated discrimination improvementReclassification improvementRisk of deathUKB participantsHealth systemRetrospective cohort studyDiscrimination improvementMain OutcomesLeft ventricular systolic dysfunctionHF riskUKBCohort studySingle-lead ECGIndependent of ageCraniosynostosis among children with X-linked hypophosphatemia: A systematic review and meta-analysis
Fisch S, Tudor A, Benchekroun E, Landsberg W, Feldstein N, Lamb M, Carpenter T, Rundle A, Jacobson J, Neugut A, Freedberg D. Craniosynostosis among children with X-linked hypophosphatemia: A systematic review and meta-analysis. Bone 2025, 196: 117488. PMID: 40220947, DOI: 10.1016/j.bone.2025.117488.Peer-Reviewed Original ResearchX-linked hypophosphatemiaPrevalence of craniosynostosisPooled prevalenceSystematic reviewMeta-analysisRandom-effects modelWeb of SciencePediatric populationSkull abnormalitiesCohort studyImpaired phosphate reabsorptionElevated FGF23 levelsPrevalenceFemale predominanceCase seriesFGF23 levelsPhosphate reabsorptionGene variantsChildrenIncreased vigilanceCraniosynostosisAbnormal bone growthGenetic disordersHypophosphatemiaAbnormalitiesScreening History, Stage at Diagnosis, and Mortality in Screen-Detected Breast Cancer
Huang S, Westvold S, Soulos P, Fan J, Winer E, Zhan H, Lustberg M, Lewin J, Robinson T, Dinan M. Screening History, Stage at Diagnosis, and Mortality in Screen-Detected Breast Cancer. JAMA Network Open 2025, 8: e255322. PMID: 40232715, DOI: 10.1001/jamanetworkopen.2025.5322.Peer-Reviewed Original ResearchConceptsBreast cancer-specific mortalityBreast cancer mortalityBreast cancer diagnosisCancer-specific mortalityCancer mortalityCancer diagnosisScreening mammographyHazard of breast cancer-specific deathFee-for-service Medicare Parts AAssociated with reduced breast cancer mortalityLower breast cancer mortalityHazard of breast cancer-specific mortalityBreast cancerImprove breast cancer outcomesScreen-detected breast cancerCohort studyBreast cancer-specific deathStudy of older womenBreast cancer outcomesFee-for-serviceDetection of breast cancerMedicare Part ALater-stage diseaseCox proportional hazards modelsAssociated with early stagesIn the time of COVID-19: challenges, successes and lessons learned from studies in cancer patients
Mack P, Crawford J, Chang A, Yin A, Klein S, Shea P, Hirsch F, Zidar D, Simon V, Gleason C, McBride R, Cordon-Cardo C, VanOudenhove J, Halene S, Lee F, Mantis N, Kushi L, Weiskopf D, Merchant A, Reckamp K, Skarbinski J, Figueiredo J. In the time of COVID-19: challenges, successes and lessons learned from studies in cancer patients. Journal Of The National Cancer Institute 2025, djaf073. PMID: 40127178, DOI: 10.1093/jnci/djaf073.Peer-Reviewed Original ResearchChanging public health landscapePublic health landscapeEnrollment of participantsSARS-CoV-2National Cancer InstituteRisk of SARS-CoV-2 infectionU.S. National Cancer InstituteNational Institute of AllergyOverall healthHealth landscapeSelf-reportCohort studyStudy designBiospecimen collectionInstitute of AllergySARS-CoV-2 infectionCancer InstituteStandard serological testsData elementsStudy immune responsesHematologic malignanciesClinicopathological dataNational InstituteCancer patientsCOVID-19Moderate alcohol-associated hepatitis: A real-world multicenter study
Idalsoaga F, Díaz L, Dunn W, Mehta H, Muñoz K, Caldentey V, Arnold J, Ayares G, Mortuza R, Sarin S, Maiwall R, Zhang W, Qian S, Simonetto D, Singal A, Elfeki M, Ramirez-Cadiz C, Malhi G, Ahmed A, Homsi H, Abid Z, Cabezas J, Echavarría V, Poca M, Soriano G, Cuyas B, Cots M, La Tijera M, Ayala-Valverde M, Perez D, Gomez J, Abraldes J, Al-Karaghouli M, Jalal P, Ibrahim M, García-Tsao G, Goyes D, Skladaný L, Havaj D, Sulejova K, Selcanova S, Rincón D, Chacko K, Restrepo J, Yaquich P, Toro L, Shah V, Arrese M, Kamath P, Bataller R, Arab J. Moderate alcohol-associated hepatitis: A real-world multicenter study. Hepatology Communications 2025, 9: e0673. PMID: 40131003, PMCID: PMC11936654, DOI: 10.1097/hc9.0000000000000673.Peer-Reviewed Original ResearchConceptsSevere alcohol-associated hepatitisNeutrophil-to-lymphocyte ratioMaddrey's discriminant functionModerate AHMultiple organ failureOrgan failureMulticenter retrospective cohort studyAlcohol-associated hepatitisCumulative survival rateRetrospective cohort studyReceiver operating characteristic curveLong-term outcomesShort-term mortalityMortality scoring systemsPrognostic factorsSerum bilirubinMELD scoreWell-characterized diseaseClinical profileMedian MELDCohort studyCox regressionMultivariate analysisTherapeutic strategiesSurvival rateValidation of the Latin American and Caribbean Food Security Scale (ELSCA) for use in Samoa
Tanawattanacharoen V, Choy C, Anesi T, Hromi-Fiedler A, Naseri T, Reupena M, Duckham R, Wang D, Hawley N, Ulberg C. Validation of the Latin American and Caribbean Food Security Scale (ELSCA) for use in Samoa. Journal Of Nutrition 2025 PMID: 40127734, DOI: 10.1016/j.tjnut.2025.03.023.Peer-Reviewed Original ResearchCaribbean Food Security ScaleFood Security ScaleFood insecurityInternal consistencySecurity ScaleDegree of food insecurityChildren's dietary intakeLongitudinal cohort studyRasch modelProtective factorsItem infit statisticsFocus group discussionsObesity riskInfit statisticsContent validityMaternal educationConstruct validityHealthy foodSamoan mothersSamoan womenCohort studyDietary intakeHousehold incomeGroup discussionsCohort characteristicsIncidence of Dysphagia and Comorbidities in Patients with Cervical Dystonia, Analyzed by Botulinum Neurotoxin Treatment Exposure
Barbano R, Jabbari B, Sadeghi M, Ukah A, Yue E, Ifantides K, Huang N, Swope D. Incidence of Dysphagia and Comorbidities in Patients with Cervical Dystonia, Analyzed by Botulinum Neurotoxin Treatment Exposure. Toxins 2025, 17: 148. PMID: 40137921, PMCID: PMC11945862, DOI: 10.3390/toxins17030148.Peer-Reviewed Original ResearchConceptsIncidence of dysphagiaCervical dystoniaComorbid conditionsContinuous health plan enrollmentCohort entry dateRate of dysphagiaRetrospective cohort studyPre-existing dysphagiaHealth plan enrollmentRisk factors of dysphagiaFactors of dysphagiaReal-world studyPotential adverse eventsPotential risk factorsPatient-level dataReal-world analysisAdverse eventsCD patientsCohort studyComorbid neurological conditionsLongitudinal patient-level dataCD diagnosisDysphagiaDysphagia riskPatientsPerceived Discrimination, Trauma, Mental Health, and Blood Pressure Outcomes Among Young African American/Black Mothers in the InterGEN Study.
Nyembwe A, Zhao Y, Millender E, Hall K, Caceres B, Taylor B, Morrison M, Prescott L, Potts-Thompson S, Aziz A, Aruleba F, Crusto C, Taylor J. Perceived Discrimination, Trauma, Mental Health, and Blood Pressure Outcomes Among Young African American/Black Mothers in the InterGEN Study. The Journal Of Cardiovascular Nursing 2025 PMID: 40052829, DOI: 10.1097/jcn.0000000000001190.Peer-Reviewed Original ResearchDepressive symptomsSecondary data analysis of dataAssociation of discriminationPresentation of depressive symptomsFactors associated with BPLongitudinal cohort studySecondary data analysisAssociated with blood pressureBlood pressure outcomesExperiences of discriminationInfluence of discriminationChildren aged 3InterGEN StudyMother-child dyadsPsychosocial measuresAA womenBlood pressureMental healthPressure outcomesCohort studyLinear regression analysisCulturally sensitive screening toolsScreening toolMaternal BPSensitive screening toolDetectability of acute ischemic stroke with thin (3 mm) axial versus thin (3 mm) coronal diffusion-weighted imaging in patients presenting to the emergency department with acute dizziness
Lozano R, Shareef F, Neupane A, Siddique Z, Joshi R, Pasquini L, Tu L, Mahajan A. Detectability of acute ischemic stroke with thin (3 mm) axial versus thin (3 mm) coronal diffusion-weighted imaging in patients presenting to the emergency department with acute dizziness. Emergency Radiology 2025, 1-7. PMID: 40053160, DOI: 10.1007/s10140-025-02327-4.Peer-Reviewed Original ResearchAxial DWIIschemic lesionsMRI examinationsDetection of brain ischemiaEmergency departmentIschemic strokeMiddle cerebellar peduncleRetrospective cohort studyDiffusion-weighted imagingAcute ischemic strokeDetection of acute ischemic strokeDetection of ischemiaMethodsRetrospective studyPosterior circulationAxial MRIDWI sequencesAcute dizzinessCerebellar pedunclePurposeIschemic strokeCoronal sequencesCohort studyDiagnostic utilityMRI protocolMcNemar testBrain ischemiaPostoperative acute kidney injury is associated with persistent renal dysfunction: a multicentre propensity-matched cohort study
Stannard B, Epstein R, Gabel E, Nadkarni G, Ouyang Y, Lin H, Salari V, Hofer I. Postoperative acute kidney injury is associated with persistent renal dysfunction: a multicentre propensity-matched cohort study. BJA Open 2025, 14: 100384. PMID: 40129614, PMCID: PMC11930183, DOI: 10.1016/j.bjao.2025.100384.Peer-Reviewed Original ResearchPostoperative acute kidney injuryGlomerular filtration rateAcute kidney injuryRenal functionKidney injuryRates of postoperative acute kidney injuryOccurrence of postoperative acute kidney injuryAcute Kidney Injury Network classificationLong-term renal functionRetrospective propensity-matched studyCox modelPropensity-matched cohort studyPersistent renal dysfunctionIncreased hazardKaplan-Meier analysisFollow-up outpatient visitsFollow-up glomerular filtration ratePropensity-matched studyTertiary care hospitalHaemodialysis requirementRenal dysfunctionAdult patientsFiltration rateCohort studyHazard ratioThe Association of Gender in the Management and Prognosis of Vertebral and Sacral Chordoma: A SEER Analysis
Elsamadicy A, Sayeed S, Sherman J, Serrato P, Ghanekar S, Lo S, Sciubba D. The Association of Gender in the Management and Prognosis of Vertebral and Sacral Chordoma: A SEER Analysis. Journal Of Clinical Medicine 2025, 14: 1737. PMID: 40095791, PMCID: PMC11901273, DOI: 10.3390/jcm14051737.Peer-Reviewed Original ResearchFive-year survivalICD-O-3 codesNeo-adjuvant radiotherapyPredictors of survivalCancer Registry databaseRetrospective cohort studyAssociated with survivalICD-O-3SEER analysisTumor characteristicsSacral chordomaTumor sizeTumor locationMale patientsPatient demographicsSkull baseOsseous tumorsTreatment utilizationEnd ResultsRegistry databaseChordomaCohort studyTreatment characteristicsTumorPatientsGlobal estimates of rotavirus vaccine efficacy and effectiveness: a rapid review and meta-regression analysis
Prunas O, Asare E, Sajewski E, Li Y, Pithawala Z, Weinberger D, Warren J, Armah G, Cunliffe N, Iturriza-Gómara M, Lopman B, Pitzer V. Global estimates of rotavirus vaccine efficacy and effectiveness: a rapid review and meta-regression analysis. EClinicalMedicine 2025, 81: 103122. PMID: 40115174, PMCID: PMC11925534, DOI: 10.1016/j.eclinm.2025.103122.Peer-Reviewed Original ResearchRotavirus-associated gastroenteritisRotavirus vaccine efficacyPredicting vaccine efficacyVaccine efficacyVaccine effectivenessVaccine performanceNational rotavirus immunization programImpact of rotavirus vaccinationRotavirus immunization programAffecting young childrenBill &Meta-regression analysisRandomized controlled trialsSystematic review of studiesEstimates of vaccine effectivenessRotavirus morbidityMelinda Gates FoundationRotavirus vaccineCohort studyLicensed vaccinesVaccine trialsDecreased efficacyControlled trialsCase-controlLow-income settingsEpigenomic pathways from racism to preterm birth: secondary analysis of the Nulliparous Pregnancy Outcomes Study: monitoring Mothers-to-be (nuMoM2b) cohort study in the USA to examine how DNA methylation mediates the relationship between multilevel racism and preterm birth in black women: a study protocol
Barcelona V, Ray M, Zhao Y, Samari G, Wu H, Reho P, McNeil R, Reddy U. Epigenomic pathways from racism to preterm birth: secondary analysis of the Nulliparous Pregnancy Outcomes Study: monitoring Mothers-to-be (nuMoM2b) cohort study in the USA to examine how DNA methylation mediates the relationship between multilevel racism and preterm birth in black women: a study protocol. BMJ Open 2025, 15: e091801. PMID: 40037666, PMCID: PMC11881185, DOI: 10.1136/bmjopen-2024-091801.Peer-Reviewed Original ResearchConceptsNulliparous Pregnancy Outcomes StudyMonitoring Mothers-to-BeMothers-to-beBlack womenPregnancy Outcomes StudyParticipants' electronic health recordsPreterm birthSecondary analysisCohort studyGeocoded participant addressesSecondary analysis of dataStudy protocolElectronic health recordsStructural racism measuresUniversity Institutional Review BoardEffects of individual-Black pregnant womenOutcome studiesRacial residential segregationProspective cohort studyPregnancy-related morbidityParticipant's addressHealth recordsAdverse pregnancy outcomesWhite womenAssociations Between U.S. Women’s Toileting Behaviors and Lower Urinary Tract Symptoms: A Cross-Sectional Analysis of RISE for HEALTH Study Data
Berry A, Brady S, Burgio K, Cunningham S, Gahagan S, James A, Low L, LaCoursiere D, Lipman T, McGwin G, Mueller M, Palmer M, Rodriguez-Ponciano D, Smith A, Sutcliffe S, Williams B, Wyman J, Newman D. Associations Between U.S. Women’s Toileting Behaviors and Lower Urinary Tract Symptoms: A Cross-Sectional Analysis of RISE for HEALTH Study Data. Journal Of Women's Health 2025 PMID: 40029194, DOI: 10.1089/jwh.2024.0743.Peer-Reviewed Original ResearchLower urinary tract symptomsUrinary tract symptomsCross-sectional analysisDelayed voidingPremature voidingToileting behaviorsPopulation-based cohort studyYear old womanAssociated with urgencyCommunity-dwelling womenUnhealthy toileting behaviorsAge modified associationsUrgency incontinenceEmptying symptomsPostmicturition symptomsProportional odds logistic regressionCohort studyUrine storageBladder healthEducating young womenModified associationsYoung womenLogistic regressionAge groupsPrematurityEvaluating the effect of routine lethal means counseling in the emergency department on suicide mortality among mental health patients
Marcus S, Cullen S, Xie M, Bridge J, Caterino J, Schmutte T, Olfson M. Evaluating the effect of routine lethal means counseling in the emergency department on suicide mortality among mental health patients. AJPM Focus 2025, 100336. DOI: 10.1016/j.focus.2025.100336.Peer-Reviewed Original ResearchLethal means counselingMental health disordersEmergency departmentHealth disordersNational Medicaid claims dataSuicide deathsMental health patientsPeriod post-dischargeStorage of firearmsOdds ratio of deathMedicaid claims dataRisk of suicideHealth patientsObservational cohort studyRatio of deathED episodesED visitsSuicide mortalityPost-dischargeLethal meansOdds ratioED patientsStored firearmsCohort studyED management401 Prognostic Value of Pelvic Washing Cytology in Early-Stage Endometrial Cancer: A 10-Year Single-Institute Cohort Study
Wang M, Abi-Raad R, Krishnamurti U, Cai G, Adeniran A, Sun T. 401 Prognostic Value of Pelvic Washing Cytology in Early-Stage Endometrial Cancer: A 10-Year Single-Institute Cohort Study. Laboratory Investigation 2025, 105: 102628. DOI: 10.1016/j.labinv.2024.102628.Peer-Reviewed Original Research
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