2025
Hypersensitivity pneumonitis associated with home mold exposure: A retrospective cohort analysis
Adams T, Redlich C, Glazer C, Gulati M. Hypersensitivity pneumonitis associated with home mold exposure: A retrospective cohort analysis. PLOS ONE 2025, 20: e0323093. PMID: 40338891, PMCID: PMC12061107, DOI: 10.1371/journal.pone.0323093.Peer-Reviewed Original ResearchConceptsDiagnosis of HPHP patientsRetrospective cohort of patientsMold exposureTransplant free survivalCohort of patientsRetrospective cohort analysisMedical chart reviewDevelopment of HPHypersensitivity pneumonitis patientsHome moldFibrotic HPFree survivalAntigen exposureChart reviewConfident diagnosisRetrospective cohortPneumonic patientsInvasive proceduresHypersensitivity pneumonitisCohort analysisCulprit antigenPatientsImprove outcomesCohortAtrial Functional Tricuspid Regurgitation Contemporary Characteristics, Outcomes, and Novel Risk Score
Fava A, Nakhla M, Hajj Ali A, Akintoye E, Akyuz K, Arockiam A, Haroun E, El Dahdah J, Liao Y, Popovic Z, Gillinov M, Pettersson G, Griffin B, Desai M, Wang T. Atrial Functional Tricuspid Regurgitation Contemporary Characteristics, Outcomes, and Novel Risk Score. JACC Advances 2025, 4: 101623. PMID: 40009906, PMCID: PMC11908566, DOI: 10.1016/j.jacadv.2025.101623.Peer-Reviewed Original ResearchRegurgitant orifice areaRight atrial volumeAF-TRTricuspid regurgitationAtrial volumeOrifice areaAtrial functional tricuspid regurgitationAssociated with 1-year mortalityEffective regurgitant orifice areaRisk scoreFunctional tricuspid regurgitationSevere tricuspid regurgitationEffective regurgitant orificeRight heart failureCohort of patientsSystolic pressure ratioIncreasing clinical recognitionMultivariate logistic regressionMedian survivalAdverse prognosticatorEchocardiographic characteristicsConsecutive patientsValve lesionsPoor prognosisRisk stratificationArtificial Intelligence-Enhanced Perfusion Scoring Improves the Diagnostic Accuracy of Myocardial Perfusion Imaging.
Miller R, Kavanagh P, Lemley M, Liang J, Sharir T, Einstein A, Fish M, Ruddy T, Kaufmann P, Sinusas A, Miller E, Bateman T, Dorbala S, Di Carli M, Hayes S, Friedman J, Berman D, Dey D, Slomka P. Artificial Intelligence-Enhanced Perfusion Scoring Improves the Diagnostic Accuracy of Myocardial Perfusion Imaging. Journal Of Nuclear Medicine 2025, jnumed.124.268079. PMID: 39978815, DOI: 10.2967/jnumed.124.268079.Peer-Reviewed Original ResearchObstructive coronary artery diseaseCoronary artery diseaseArea under the receiver operating characteristic curveMyocardial perfusion imagingPerfusion scoreDetection of obstructive coronary artery diseaseDiagnostic accuracy of myocardial perfusion imagingPerfusion imagingAccuracy of myocardial perfusion imagingInvasive coronary angiographyCohort of patientsHighest area under the receiver operating characteristic curveLeft main coronary arteryReceiver operating characteristic curveStress TPDDeep learningObstructive CADMedian ageCoronary angiographyArtificial intelligenceDiagnostic performanceDiagnostic accuracyArtery diseaseAI predictionsCoronary arteryPredictors of Delayed Surgery After Distal Radius Fracture: A Large National Database Study.
Ratnasamy P, Allam O, Kammien A, Joo P, Luo X, Grauer J. Predictors of Delayed Surgery After Distal Radius Fracture: A Large National Database Study. Orthopedics 2025, 48: e75-e80. PMID: 39933104, DOI: 10.3928/01477447-20250204-01.Peer-Reviewed Original ResearchConceptsDistal radius fracturesDelayed surgeryRadius fracturesImmediate surgeryClinical factorsDistal radius fracture surgeryTime of surgeryCohort of patientsDemographics of patientsNon-clinical factorsFracture surgeryIndependent predictorsRetrospective studySurgical timeImpact patient outcomesMultivariate analysisSurgerySmoking statusComorbidity burdenPatientsWeek 0 to 2Patient outcomesWeek 3WeeksNon-clinicalUptake of Peritoneal Dialysis (PD) by Minoritized Patients: The Role of Modality Education.
Arnaoudova I, Wilson C, Rizzolo K, Shen J, Ehtesham N, Wilson J, Golestaneh L. Uptake of Peritoneal Dialysis (PD) by Minoritized Patients: The Role of Modality Education. Kidney360 2025 PMID: 39899379, DOI: 10.34067/kid.0000000702.Peer-Reviewed Original ResearchModality educationMinoritized patientsQualitative analysis of interviewsPeritoneal dialysisAnalysis of interviewsStructural barriersAssociation of patient characteristicsDialysis modality educationRacial ethnic minoritiesSemi-structured interviewsEducation sessionsMontefiore Medical CenterStudy of individualsCohort of patientsPatients' perceptionsQualitative analysisTailored contentPerception of usefulnessLessen anxietyMedical CenterEducationPatient characteristicsLate-stage kidney diseaseQuality of informationClinical comorbidityWorse clinical outcomes of TACE when liver function is decompensated in a cohort of patients with cirrhosis and HCC waiting for liver transplantation
Makarova E, Fan X, Farooqi I, Bakhl K, Murphy T, Stonesifer E, Faust A. Worse clinical outcomes of TACE when liver function is decompensated in a cohort of patients with cirrhosis and HCC waiting for liver transplantation. Journal Of Liver Transplantation 2025, 17: 100257. DOI: 10.1016/j.liver.2024.100257.Peer-Reviewed Original ResearchTrans arterial chemoembolizationDecompensated liver functionHepatocellular carcinomaLiver functionLiver transplantationClinical outcomesRetrospective cohort study of patientsClinical outcomes of patientsWorsening of liver functionCohort study of patientsCompensated liver functionOutcomes of patientsCohort of patientsRetrospective cohort studyStudy of patientsStatistically significant differenceLocoregional therapyArterial chemoembolizationDecompensated cirrhosisPoor outcomePrimary statistical analysisPatientsCirrhosisTransplantationSignificant differenceClinical outcomes and care for spontaneous bacterial peritonitis: A national cohort study.
Serper M, Tang H, Zhang S, McCullough A, Kaplan D, Taddei T, Mahmud N. Clinical outcomes and care for spontaneous bacterial peritonitis: A national cohort study. Hepatology 2025 PMID: 39879583, DOI: 10.1097/hep.0000000000001251.Peer-Reviewed Original ResearchIn-hospital mortalityImprove care outcomesPopulation-based studyNational cohort studyQuality measuresHazard of mortalityPost-discharge mortalityNational cohort of patientsCare outcomesSpontaneous bacterial peritonitisInformal careHealth systemPatient clinical factorsAcute kidney injuryBundle componentsRecurrent spontaneous bacterial peritonitisNational cohortCohort studyIncidence of stage 3In-hospitalClinical factorsStage 3Cohort of patientsCumulative incidenceBacterial peritonitisReal-world Rollout of Injectable Antiretrovirals for HIV Prevention and Treatment: Correlates of Early Adoption
Koshy L, Payne E, Barakat L, Hao R, Sureshanand S, Ornelas A, Dewan A, Meyer J. Real-world Rollout of Injectable Antiretrovirals for HIV Prevention and Treatment: Correlates of Early Adoption. Open Forum Infectious Diseases 2025, 12: ofaf029. DOI: 10.1093/ofid/ofaf029.Peer-Reviewed Original ResearchLAI-PrEPLAI-ARTSocial determinants of healthSubstance use disordersDeterminants of healthLong-actingRetrospective cohortRetrospective cohort of patientsSocial determinantsHIV preventionCohort of patientsFisher's exact testPre-exposure prophylaxisOvercome health inequitiesHealth equity lensPrEP patientsChi-square testUrban health systemMedian ageBivariate logistic regressionOral PrEPPublic health interventionsBackground DataExact testHIV treatmentAn update on botulinum toxin treatment of painful diabetic neuropathy, post-traumatic painful neuropathy/neuralgia, post-herpetic neuralgia and occipital neuralgia
Jabbari B, Tohidian A. An update on botulinum toxin treatment of painful diabetic neuropathy, post-traumatic painful neuropathy/neuralgia, post-herpetic neuralgia and occipital neuralgia. Toxicon 2025, 255: 108237. PMID: 39798899, DOI: 10.1016/j.toxicon.2025.108237.Peer-Reviewed Original ResearchConceptsPainful diabetic neuropathyPost-traumatic neuralgiaOccipital neuralgiaPostherpetic neuralgiaMode of treatmentBotulinum toxin treatmentDiabetic neuropathyTreatment of painful diabetic neuropathyPost-herpetic neuralgiaCohort of patientsPain disordersEfficacy criteriaNeuralgiaAmerican Academy of NeurologyLevel of efficacyToxin treatmentAmerican AcademyNeuropathyBotulinum therapyEfficacyPatientsTreatmentFamitinib plus camrelizumab in patients with advanced colorectal cancer: Data from a multicenter, basket study
Ai L, Li Q, Zhang S, Dong Y, Yang M, Li J, Pan Y, Yuan Y, Yi S, Wang J, Cheng Y, Feng J, Gao S, Wang X, Qu S, Zhang X, Lu J, Xiu P, Wang S, Yang X, Yu Y, Liu T. Famitinib plus camrelizumab in patients with advanced colorectal cancer: Data from a multicenter, basket study. The Innovation 2025, 6: 100745. PMID: 39872476, PMCID: PMC11763884, DOI: 10.1016/j.xinn.2024.100745.Peer-Reviewed Original ResearchProgression-free survivalDuration of responseAdvanced colorectal cancerOverall survivalColorectal cancerMedian duration of responseMedian progression-free survivalMetastatic colorectal cancer patientsTreatment-related adverse eventsMedian follow-up timeMedian overall survivalMetastatic solid tumorsPD-1 antagonistsFollow-up timeCohort of patientsAnti-angiogenic agentsColorectal cancer patientsInhibition of angiogenesisPD-1Immune checkpointsMetastatic diseaseBasket studyMedian durationPrimary endpointSystemic treatment
2024
Maternal Characteristics and Pregnancy Outcomes Associated with Delivery versus Expectant Management following Decreased Fetal Movement at Term
Ding J, Paoletti O, Culhane J, Lundsberg L, Partridge C, Cross S. Maternal Characteristics and Pregnancy Outcomes Associated with Delivery versus Expectant Management following Decreased Fetal Movement at Term. American Journal Of Perinatology 2024 PMID: 39708834, DOI: 10.1055/a-2486-7642.Peer-Reviewed Original ResearchDecreased fetal movementsBody mass indexNeonatal outcomesCohort of patientsCases of stillbirthGt;48 hoursAssociated with reduced oddsOdds of admissionMaternal characteristicsNeonatal demiseFetal movementsExpectant managementClinical variationNoncommercial insuranceRetrospective cohort studyCompare maternal characteristicsDelivery admissionPregnancy outcomesMultinomial logistic regressionMass indexCohort studyPregnancyImmediate deliveryPatientsCompared deliveryDiverse NKT cells regulate early inflammation and neurological outcomes after cardiac arrest and resuscitation
Tamura T, Cheng C, Villaseñor-Altamirano A, Yamada K, Ikeda K, Hayashida K, Menon J, Chen X, Chung H, Varon J, Chen J, Choi J, Cullen A, Guo J, Lin X, Olenchock B, Pinilla-Vera M, Manandhar R, Sheikh M, Hou P, Lawler P, Oldham W, Seethala R, Baron R, Bohula E, Morrow D, Blumberg R, Chen F, Merriam L, Weissman A, Brenner M, Chen X, Ichinose F, Kim E, Sohn H, Rolland T, Weil B. Diverse NKT cells regulate early inflammation and neurological outcomes after cardiac arrest and resuscitation. Science Translational Medicine 2024, 16: eadq5796. PMID: 39630883, PMCID: PMC11792709, DOI: 10.1126/scitranslmed.adq5796.Peer-Reviewed Original ResearchConceptsOut-of-hospital cardiac arrestCohort of patientsNeurological outcomeT cellsImmune cellsCardiac arrestNatural killer (NK) cellsAssociated with good neurological outcomesDiverse T cell receptor repertoireNeurological injuryT cell receptor repertoireAssociated with poor neurological outcomeIncreased inflammatory chemokineInnate T cellsPoor neurological outcomeWild-type micePost-cardiac arrestAccumulation of macrophagesIncreased neuronal injuryBrains of miceNKT cellsTreated miceReceptor repertoireInflammatory chemokinesCytokine expressionIdentification of Severe Acute Exacerbations of Chronic Obstructive Pulmonary Disease Subgroups by Machine Learning Implementation in Electronic Health Records.
Li H, Huston J, Zielonka J, Kay S, Sauler M, Gomez J. Identification of Severe Acute Exacerbations of Chronic Obstructive Pulmonary Disease Subgroups by Machine Learning Implementation in Electronic Health Records. Chronic Obstructive Pulmonary Diseases Journal Of The COPD Foundation 2024, 11: 611-623. PMID: 39423339, PMCID: PMC11703024, DOI: 10.15326/jcopdf.2024.0556.Peer-Reviewed Original ResearchElectronic health recordsMachine learningAcute exacerbation of COPDAdoption of electronic health recordsHealth recordsMachine learning implementationElectronic health record dataImplementation of MLEHR-derived dataML implementationChronic obstructive pulmonary disease subgroupCOVID-19 cohortSevere acute exacerbation of COPDClinical careExacerbation of COPDAcute exacerbationRetrospective cohort of patientsLearning implementationSeverity of acute exacerbations of COPDMachineRelevant subgroupsRetrospective cohortImplementationCohortCohort of patientsIntegrative multiomic analysis identifies distinct molecular subtypes of NAFLD in a Chinese population
Ding J, Liu H, Zhang X, Zhao N, Peng Y, Shi J, Chen J, Chi X, Li L, Zhang M, Liu W, Zhang L, Ouyang J, Yuan Q, Liao M, Tan Y, Li M, Xu Z, Tang W, Xie C, Li Y, Pan Q, Xu Y, Cai S, Byrne C, Targher G, Ouyang X, Zhang L, Jiang Z, Zheng M, Sun F, Chai J. Integrative multiomic analysis identifies distinct molecular subtypes of NAFLD in a Chinese population. Science Translational Medicine 2024, 16: eadh9940. PMID: 39504356, DOI: 10.1126/scitranslmed.adh9940.Peer-Reviewed Original ResearchConceptsNonalcoholic fatty liver diseaseWhole-genome sequencingHepatocellular carcinomaMolecular subtypesLiver cirrhosisChinese cohort of patientsInfiltration of M1Risk of liver cirrhosisSerum metabolic analysisClinical diagnosisSubtype of nonalcoholic fatty liver diseaseCohort of patientsDevelopment of liver cirrhosisHepatocellular carcinoma developmentIntegrative multiomic analysisHealth care burdenFatty liver diseaseExpression of CYP1A2Urine specimensTreatment strategiesChinese cohortImpaired outcomeM2 macrophagesIntegrative multiomicsLiver diseaseCharacterization of Newly Diagnosed Multiple Myeloma (NDMM) Patients with Early Progression Following Induction with Daratumumab, Lenalidomide, Bortezomib and Dexamethasone (D-RVd)
Gu L, Joseph N, Gupta V, Hofmeister C, Dhodapkar M, Lonial S, Nooka A, Kaufman J. Characterization of Newly Diagnosed Multiple Myeloma (NDMM) Patients with Early Progression Following Induction with Daratumumab, Lenalidomide, Bortezomib and Dexamethasone (D-RVd). Blood 2024, 144: 3780. DOI: 10.1182/blood-2024-211474.Peer-Reviewed Original ResearchNewly diagnosed myelomaProgression free survivalInternational Myeloma Working GroupD-RVdEarly progressionData cutoffMedian followMedian time to progressionYear progression free survivalNewly diagnosed multiple myelomaHigh riskEstimate 3-year survivalPresence of del(17pR-ISS-3Time to progressionEffective induction regimenFirst-line therapyStem cell transplantationDepth of responseDocumented disease progressionCohort of patientsAge of diagnosisLong-term outcomesAlternative treatment approachesMedian OSDevelopment of a prediction model for 30-day COVID-19 hospitalization and death in a national cohort of Veterans Health Administration patients–March 2022—April 2023
Bui D, Bajema K, Huang Y, Yan L, Li Y, Rajeevan N, Berry K, Rowneki M, Argraves S, Hynes D, Huang G, Aslan M, Ioannou G. Development of a prediction model for 30-day COVID-19 hospitalization and death in a national cohort of Veterans Health Administration patients–March 2022—April 2023. PLOS ONE 2024, 19: e0307235. PMID: 39365775, PMCID: PMC11451987, DOI: 10.1371/journal.pone.0307235.Peer-Reviewed Original ResearchConceptsVeterans Health AdministrationCOVID-19 hospitalizationArea under the receiver operating characteristic curveComprehensive electronic health recordNational cohortElectronic health recordsAll-cause mortalityNational cohort of patientsFull modelHealth recordsHealth AdministrationReceipt of COVID-19 vaccineMortality riskEpidemiology of COVID-19COVID-19High-risk patientsBrier scoreCohort of patientsAnti-SARS-CoV-2 treatmentCOVID-19 vaccineReceiver operating characteristic curveCalibration interceptHospitalAntiviral treatmentAvailability of effective vaccinesEfficacy and Safety of Ketamine/Esketamine in Bipolar Depression in a Clinical Setting.
Santucci M, Ansari M, Nikayin S, Radhakrishnan R, Rhee T, Wilkinson S. Efficacy and Safety of Ketamine/Esketamine in Bipolar Depression in a Clinical Setting. The Journal Of Clinical Psychiatry 2024, 85 PMID: 39361411, DOI: 10.4088/jcp.24m15376.Peer-Reviewed Original ResearchConceptsBipolar depressionAcute seriesRisk of affective switchDiagnosis of bipolar depressionRefractory bipolar depressionAcute phaseMADRS scoreAffective switchIntranasal esketamineManic episodesBipolar disorderCohort of patientsAttending psychiatristsSource of morbidityEsketamineSample of patientsIV ketamineMaintenance treatmentDepressionClinical responseHeightened riskClinical outcomesMania/hypomaniaKetamineKetamine/esketamineImproved technical outcomes with converting thrombectomy techniques after failed first pass recanalization
Matsukawa H, Matouk C, Uchida K, Al Kasab S, Sowlat M, Elawady S, Maier I, Jabbour P, Kim J, Wolfe S, T A, Starke R, Psychogios M, Samaniego E, Arthur A, Cuellar H, Howard B, Romano D, Tanweer O, Mascitelli J, Fragata I, Polifka A, Osbun J, Crosa R, Park M, Levitt M, Brinjikji W, Moss M, Williamson R, Navia P, Kan P, De Leacy R, Chowdhry S, Ezzeldin M, Spiotta A, Yoshimura S, Alawieh A. Improved technical outcomes with converting thrombectomy techniques after failed first pass recanalization. Journal Of NeuroInterventional Surgery 2024, jnis-2024-022071. PMID: 39304195, DOI: 10.1136/jnis-2024-022071.Peer-Reviewed Original ResearchEfficacy of endovascular thrombectomyFirst-pass recanalizationLarge vessel occlusionModified Rankin scoreClinical outcomesMatched cohortMatched cohort of patientsAcute ischemic stroke secondary to large vessel occlusionFirst-passIschemic stroke secondary to large vessel occlusionAnterior circulation large vessel occlusionRisk of symptomatic hemorrhagePropensity score matched cohortMulticenter international studyCohort of patientsScore-matched cohortAssociated with higher oddsPropensity score matchingMRS 0Symptomatic hemorrhagePostprocedural hemorrhageTechnical successRecanalization attemptsRankin scorePrimary outcome52875 Integrated cardiovascular safety analysis of ritlecitinib in patients with alopecia areata (AA) in the phase 2 and phase 3 ALLEGRO clinical trials, and contextualization with a US cohort of patients with AA
Sicco K, Soung J, Strober B, Irvine A, Wajsbrot D, Gromek K, Wolk R, Barnes D, Takiya L. 52875 Integrated cardiovascular safety analysis of ritlecitinib in patients with alopecia areata (AA) in the phase 2 and phase 3 ALLEGRO clinical trials, and contextualization with a US cohort of patients with AA. Journal Of The American Academy Of Dermatology 2024, 91: ab55. DOI: 10.1016/j.jaad.2024.07.228.Peer-Reviewed Original ResearchToll-like Receptor 9 Inhibition Mitigates Fibroproliferative Responses in Translational Models of Pulmonary Fibrosis.
Trujillo G, Regueiro-Ren A, Liu C, Hu B, Sun Y, Ahangari F, Fiorini V, Ishikawa G, Al Jumaily K, Khoury J, McGovern J, Lee C, Peng X, Pivarnik T, Sun H, Walia A, Woo S, Yu S, Antin-Ozerkis D, Sauler M, Kaminski N, Herzog E, Ryu C. Toll-like Receptor 9 Inhibition Mitigates Fibroproliferative Responses in Translational Models of Pulmonary Fibrosis. American Journal Of Respiratory And Critical Care Medicine 2024, 211: 91-102. PMID: 39189851, PMCID: PMC11755360, DOI: 10.1164/rccm.202401-0065oc.Peer-Reviewed Original ResearchToll-like receptor 9Model of pulmonary fibrosisIdiopathic pulmonary fibrosisPulmonary fibrosisFibroproliferative responseLung diseaseIdiopathic pulmonary fibrosis cohortsExpression of toll-like receptor 9Toll-like receptor 9 activationTransplant-free survivalExpression of MCP-1Cohort of patientsSlow clinical progressionFibrotic lung diseaseAccelerated disease courseFatal lung diseaseIP-10Pharmacodynamic endpointsPreclinical modelsDisease courseClinical progressionPlasma mtDNAMCP-1Receptor 9Mouse model
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