2025
Hypersensitivity pneumonitis associated with home mold exposure: A retrospective cohort analysis
Adams T, Redlich C, Glazer C, Gulati M. Hypersensitivity pneumonitis associated with home mold exposure: A retrospective cohort analysis. PLOS ONE 2025, 20: e0323093. PMID: 40338891, PMCID: PMC12061107, DOI: 10.1371/journal.pone.0323093.Peer-Reviewed Original ResearchConceptsDiagnosis of HPHP patientsRetrospective cohort of patientsMold exposureTransplant free survivalCohort of patientsRetrospective cohort analysisMedical chart reviewDevelopment of HPHypersensitivity pneumonitis patientsHome moldFibrotic HPFree survivalAntigen exposureChart reviewConfident diagnosisRetrospective cohortPneumonic patientsInvasive proceduresHypersensitivity pneumonitisCohort analysisCulprit antigenPatientsImprove outcomesCohortThe length of the popliteus on sagittal views correlates with high tibiofemoral rotations and patellar instability
Desroches S, Park N, Frumberg D, Fulkerson J, Sieberer J. The length of the popliteus on sagittal views correlates with high tibiofemoral rotations and patellar instability. The Knee 2025, 54: 128-135. PMID: 40036927, DOI: 10.1016/j.knee.2025.02.003.Peer-Reviewed Original ResearchIntraclass correlation coefficientTibiofemoral rotationPatellofemoral instabilitySagittal viewControl groupMann-Whitney U testInterrater reliabilityStatistically significant positive relationshipInstability patientsPatient groupPatellar instabilitySignificant positive relationshipMann-WhitneyU testPosterior tibiaPatientsSagittal slicesDegree of rotationRegression analysisPopliteusCondylar lineCorrelation coefficientSignificance levelCohortFemoral condyleFacial Determinants of Artificial Intelligence–Perceived Gender and Age Following Facial Feminization Surgery
Vassallo M, Ihnat J, Flores-Pérez P, Rancu A, Allam O, Alperovich M. Facial Determinants of Artificial Intelligence–Perceived Gender and Age Following Facial Feminization Surgery. Journal Of Craniofacial Surgery 2025, 36: 734-738. DOI: 10.1097/scs.0000000000011135.Peer-Reviewed Original ResearchFacial feminization surgeryFacial thirdFeminization surgeryUpper thirdPostoperative imagingPostoperative changesFacial recognition softwarePostoperative ageYounger cohortsArtificial intelligence evaluationArtificial intelligenceLower thirdCohortRecognition softwareIntelligent evaluationTransgender womenSurgeryAgeAge scoresScoresSpatial Correlates of Dementia and Disability After Intracerebral Hemorrhage.
Chen Y, Rivier C, Mora S, Torres Lopez V, Payabvash S, Sheth K, Harloff A, Falcone G, Rosand J, Mayerhofer E, Anderson C. Spatial Correlates of Dementia and Disability After Intracerebral Hemorrhage. Journal Of The American Heart Association 2025, 14: e037930. PMID: 39921496, DOI: 10.1161/jaha.124.037930.Peer-Reviewed Original ResearchConceptsFollow-up telephone interviewsElectronic health recordsAssociated with disabilityAssociated with dementiaDevelopment of dementiaDevelopment of disabilityIncident dementiaAssociated with intracerebral hemorrhageIntracerebral hemorrhageHealth recordsTelephone interviewsDementia conversionCohort studyDementiaDisabilityLobar intracerebral hemorrhageIntracerebral hemorrhage locationIntracerebral hemorrhagic lesionsFunctional outcomesNoncontrast computed tomography scanCohortMedian follow-up timeRight posterior limbOutcomesLeft temporo-occipital regionRisk factors for cut-throughs in intertrochanteric hip fracture fixation Tip-Apex Distance (TAD) <10 mm and Apex-to-Center <4 mm
Levine A, Klug T, Cross J, Salameh M, Riedel M, Leslie M. Risk factors for cut-throughs in intertrochanteric hip fracture fixation Tip-Apex Distance (TAD) <10 mm and Apex-to-Center <4 mm. Injury 2025, 56: 112205. PMID: 39954635, DOI: 10.1016/j.injury.2025.112205.Peer-Reviewed Original ResearchConceptsTip-apex distanceIntertrochanteric hip fracturesHip fractureRisk factorsAnterior-posteriorLevel 1 academic trauma centerSliding hip screwFracture reduction qualityNeck-shaft angleCut-out complicationsTrauma centerHip screwNeck-shaftIntramedullary nailingRetrospective reviewReduction qualityReduced riskIncreased riskFracture typeClinical outcomesRiskComplicationsCohortLateral viewFixation devicesInvestigative Approaches to Resilient Emotion Regulation Neurodevelopment in a South African Birth Cohort
Yates T, Sigwebela S, Seedat S, Milham M, du Plessis S, Abramson L, Niemiec E, Worthman C, Rotheram-Borus M, Salum G, Franco A, Zuanazzi A, Ahmed F, Gemmell K, Christodoulou J, Mhlaba N, Mqhele N, Ngalimane N, Sambudla A, Tottenham N, Tomlinson M. Investigative Approaches to Resilient Emotion Regulation Neurodevelopment in a South African Birth Cohort. Biological Psychiatry Global Open Science 2025, 5: 100457. PMID: 40144514, PMCID: PMC11938085, DOI: 10.1016/j.bpsgos.2025.100457.Peer-Reviewed Original ResearchSouth African birth cohortAfrican birth cohortEmotion regulationMiddle-income countriesBirth cohortNeurobiology of resilienceSelf-report measuresMagnetic resonance imagingMental health problemsNeurodevelopmental correlatesFunctional neurobiologyResonance imagingMental healthLongitudinal time pointsLow-incomeTime pointsHealth problemsDevelopmental historyAdolescent resilienceAnalytic planCohortNeurodevelopmentRegulate neurodevelopmentAdolescentsAdversityTrends of attrition and migration in academic radiology in U.S. medical schools
Malhotra A, Futela D, Ebrahimian S, Kandala K, Gandhi D, Payabvash S, Mohan S. Trends of attrition and migration in academic radiology in U.S. medical schools. Journal Of The American College Of Radiology 2025 PMID: 39892798, DOI: 10.1016/j.jacr.2025.01.013.Peer-Reviewed Original ResearchMedical schoolsPrimary cohortAttrition ratesUS medical schoolsU.S. medical schoolsWorkforce shortagesClinical facultyRetention rateAssess trendsFull-time facultyFaculty appointmentsLongitudinal trendsAcademic radiologySecondary cohortAcademic radiology departmentsEnd pointsCohortStudy periodAttritionWomenRadiology departmentRadiology facultyRadiologyProfessor rankIndependent variablesRisk factors affecting polygenic score performance across diverse cohorts
Hui D, Dudek S, Kiryluk K, Walunas T, Kullo I, Wei W, Tiwari H, Peterson J, Chung W, Davis B, Khan A, Kottyan L, Limdi N, Feng Q, Puckelwartz M, Weng C, Smith J, Karlson E, Center R, BioBank P, Jarvik G, Ritchie M. Risk factors affecting polygenic score performance across diverse cohorts. ELife 2025, 12: rp88149. PMID: 39851248, PMCID: PMC11771958, DOI: 10.7554/elife.88149.Peer-Reviewed Original ResearchConceptsBody mass indexPolygenic scoresAssociated with body mass indexPolygenic score performancePhysical activityStandard deviation changeAlcohol consumptionMass indexDiverse cohortInteraction effectsRisk factorsBlood lipidsDeviation changeQuintileScore performanceCohortCovariatesBinary covariateAncestryModel R<sup>2</sup>Continuous covariatesDifferencesRisk factors affecting polygenic score performance across diverse cohorts
Hui D, Dudek S, Kiryluk K, Walunas T, Kullo I, Wei W, Tiwari H, Peterson J, Chung W, Davis B, Khan A, Kottyan L, Limdi N, Feng Q, Puckelwartz M, Weng C, Smith J, Karlson E, Jarvik G, Ritchie M. Risk factors affecting polygenic score performance across diverse cohorts. ELife 2025, 12 DOI: 10.7554/elife.88149.3.Peer-Reviewed Original ResearchBody mass indexPolygenic scoresAssociated with body mass indexPolygenic score performancePhysical activityStandard deviation changeBMI effectsBMI individualsAlcohol consumptionDiverse cohortMass indexInteraction effectsRisk factorsBlood lipidsDeviation changeQuintileScore performanceCohortCovariatesBinary covariateAncestryContinuous covariatesModel R 2DifferencesScoresIdentifying Metabolic Dysfunction-Associated Steatotic Liver Disease Using Natural Language Processing in a US National Cohort.
John B, Bastaich D, Mezzacappa C, Ferreira R, Hentschel A, Samos A, Mahmud N, Taddei T, Kaplan D, Serper M, Dahman B. Identifying Metabolic Dysfunction-Associated Steatotic Liver Disease Using Natural Language Processing in a US National Cohort. The American Journal Of Gastroenterology 2025 PMID: 39950372, DOI: 10.14309/ajg.0000000000003321.Peer-Reviewed Original ResearchElectronic health recordsCardiometabolic risk factorsAlcohol useChart reviewRetrospective study of participantsStudy of participantsLiver diseaseSteatotic liver diseaseIncreased alcohol intakeEligible veteransICD-9/10 codesHealth recordsNational cohortAlcohol intakeEvidence of hepatic steatosisEpidemiological studiesNatural language processing algorithmsRisk factorsStudy cohortOutcome studiesVeteransCohortClinical entityRetrospective studyMetabolic dysfunctionAssociation between methyl-CpG-binding domain protein 5 gene and depressive symptoms in Mexican population: Results from MxGDAR/Encodat cohort.
Sanabrais-Jiménez M, Camarena B, Aguilar-García A, Genis-Mendoza A, Martínez-Magaña J, Nicolini H, Villatoro-Velá J, Bustos-Gamiño M, Gutiérrez-López M, Medina-Mora M. Association between methyl-CpG-binding domain protein 5 gene and depressive symptoms in Mexican population: Results from MxGDAR/Encodat cohort. Brazilian Journal Of Psychiatry 2025 PMID: 39787278, DOI: 10.47626/1516-4446-2024-3859.Peer-Reviewed Original ResearchDepressive symptomsAnxiety symptomsGenetic principal componentsMexican populationScreening questionnaireDepressive symptomatologyMexican cohortLogistic regression approachHealthy controlsAddiction researchDevelopment of DSDI padAnxietyCohortAssociationSymptomsMBD5Gene silencingGenesPopulationQuestionnairePLINKMYO1HSymptomatologySex
2024
A Hybrid Transformer-Convolutional Neural Network for Segmentation of Intracerebral Hemorrhage and Perihematomal Edema on Non-Contrast Head Computed Tomography (CT) with Uncertainty Quantification to Improve Confidence
Tran A, Desser D, Zeevi T, Abou Karam G, Dierksen F, Dell'Orco A, Kniep H, Hanning U, Fiehler J, Zietz J, Sanelli P, Malhotra A, Duncan J, Aneja S, Falcone G, Qureshi A, Sheth K, Nawabi J, Payabvash S. A Hybrid Transformer-Convolutional Neural Network for Segmentation of Intracerebral Hemorrhage and Perihematomal Edema on Non-Contrast Head Computed Tomography (CT) with Uncertainty Quantification to Improve Confidence. Bioengineering 2024, 11: 1274. PMID: 39768092, PMCID: PMC11672977, DOI: 10.3390/bioengineering11121274.Peer-Reviewed Original ResearchNon-contrast head computed tomographyPerihematomal edemaHead computed tomographyIntracerebral hemorrhageComputed tomographyVolume similarityUniversity Medical Center Hamburg-EppendorfSecondary brain injuryYale cohortInfratentorial locationMulticentre trialCT scanTreatment planningNon-contrastHamburg-EppendorfImaging markersHemorrhagic strokeHemorrhageEdemaCohortBrain injuryDice coefficientValidation of the NCCN/Yale criteria for the identification of CDH1 pathogenic variant carriers
Lerner B, Giner-Calabuig M, Carraway C, Richardson M, Krahn K, Susswein L, Nielsen S, Karam R, Xicola R, Llor X. Validation of the NCCN/Yale criteria for the identification of CDH1 pathogenic variant carriers. Journal Of Medical Genetics 2024, 62: 57-61. PMID: 39674581, PMCID: PMC11916899, DOI: 10.1136/jmg-2024-110446.Peer-Reviewed Original ResearchInternational Gastric Cancer Linkage ConsortiumInternational Gastric Cancer Linkage Consortium criteriaPV carriersLobular breast cancerGenetic tumor risk syndromesGenetic testingFamily membersEarly-onset diffuse gastric cancerPathogenic variant carriersGermline pathogenic variantsDiffuse gastric cancerPathogenic variantsEuropean Reference NetworkCancer geneticsRisk syndromeVariant carriersGenetics guidelinesEuropean cohortAutosomal-dominant syndromeBreast cancerCohortUS commercial laboratoryClinical dataGastric cancerCancerNon-alcohol-related cirrhosis leads to higher 6-week mortality after acute variceal bleeding than alcohol-related cirrhosis
Wong Y, Buckholz A, Sim A, Teng M, Wong R, Curry M, De Roza M, Baffy G, Teoh X, Chak E, Rustagi T, Chang J, Wong G, Tandon P, Garcia-Tsao G, Abraldes J, Mohanty A, Fortune B. Non-alcohol-related cirrhosis leads to higher 6-week mortality after acute variceal bleeding than alcohol-related cirrhosis. Clinical Gastroenterology And Hepatology 2024 PMID: 39675401, DOI: 10.1016/j.cgh.2024.10.022.Peer-Reviewed Original ResearchAcute variceal bleedingALD cirrhosisVariceal bleedingPrognostic scoreCirrhosis etiologyPrediction of 6-week mortalityAcute variceal bleeding patientsNon-alcohol-related cirrhosisSeverity of liver diseaseEtiology of liver cirrhosisPropensity-score matching analysisMultivariate logistic regressionMulti-center cohortAVB patientsOverall cohortRisk stratificationLiver cirrhosisPatient populationCirrhosisLiver diseasePatientsAggregate cohortCohortMatching analysisEtiologyMenopausal hormone therapy: assessing associations with breast and colorectal cancers by familial risk
Macinnis R, Jenkins M, Milne R, John E, Daly M, Andrulis I, Colonna S, Phillips K, Investigators K, Le Marchand L, Newcomb P, Phipps A, Schmit S, Macrae F, Buchanan D, Gallinger S, Pai R, Samadder N, Giles G, Southey M, Hopper J, Terry M. Menopausal hormone therapy: assessing associations with breast and colorectal cancers by familial risk. JNCI Cancer Spectrum 2024, 9: pkae121. PMID: 39673461, PMCID: PMC11700558, DOI: 10.1093/jncics/pkae121.Peer-Reviewed Original ResearchFamily risk scoreMenopausal hormone therapyFamilial riskHazard ratioColorectal cancerFamilial risk of BCBreast cancerFamily historyDecreased colorectal cancerCancer family historyRisk of BCIncreased breast cancerAssociated with breastIncident BCNever usersGeneral populationRisk scoreHarmonized dataWomenHormone therapyRiskAssociationCancerNeverCohortIdentification of Severe Acute Exacerbations of Chronic Obstructive Pulmonary Disease Subgroups by Machine Learning Implementation in Electronic Health Records.
Li H, Huston J, Zielonka J, Kay S, Sauler M, Gomez J. Identification of Severe Acute Exacerbations of Chronic Obstructive Pulmonary Disease Subgroups by Machine Learning Implementation in Electronic Health Records. Chronic Obstructive Pulmonary Diseases Journal Of The COPD Foundation 2024, 11: 611-623. PMID: 39423339, PMCID: PMC11703024, DOI: 10.15326/jcopdf.2024.0556.Peer-Reviewed Original ResearchElectronic health recordsMachine learningAcute exacerbation of COPDAdoption of electronic health recordsHealth recordsMachine learning implementationElectronic health record dataImplementation of MLEHR-derived dataML implementationChronic obstructive pulmonary disease subgroupCOVID-19 cohortSevere acute exacerbation of COPDClinical careExacerbation of COPDAcute exacerbationRetrospective cohort of patientsLearning implementationSeverity of acute exacerbations of COPDMachineRelevant subgroupsRetrospective cohortImplementationCohortCohort of patientsA Novel Machine Learning Model to Predict Revision ACL Reconstruction Failure in the MARS Cohort
Group M, Vasavada K, Vasavada V, Moran J, Devana S, Lee C, Hame S, Jazrawi L, Sherman O, Huston L, Haas A, Allen C, Cooper D, DeBerardino T, Spindler K, Stuart M, Amendola A, Annunziata C, Arciero R, Bach B, Baker C, Bartolozzi A, Baumgarten K, Berg J, Bernas G, Brockmeier S, Brophy R, Bush-Joseph C, Butler J, Carey J, Carpenter J, Cole B, Cooper J, Cox C, Creighton R, David T, Dunn W, Flanigan D, Frederick R, Ganley T, Gatt C, Gecha S, Giffin J, Hannafin J, Harris N, Hechtman K, Hershman E, Hoellrich R, Johnson D, Johnson T, Jones M, Kaeding C, Kamath G, Klootwyk T, Levy B, Benjamin C, Maiers G, Marx R, Matava M, Mathien G, McAllister D, McCarty E, McCormack R, Miller B, Nissen C, O’Neill D, Owens B, Parker R, Purnell M, Ramappa A, Rauh M, Rettig A, Sekiya J, Shea K, Slauterbeck J, Smith M, Spang J, Svoboda S, Taft T, Tenuta J, Tingstad E, Vidal A, Viskontas D, White R, Williams J, Wolcott M, Wolf B, Wright R, York J. A Novel Machine Learning Model to Predict Revision ACL Reconstruction Failure in the MARS Cohort. Orthopaedic Journal Of Sports Medicine 2024, 12: 23259671241291920. PMID: 39555321, PMCID: PMC11565622, DOI: 10.1177/23259671241291920.Peer-Reviewed Original ResearchRevision anterior cruciate ligament reconstructionMulticenter ACL Revision StudyGraft failureRisk of graft failureAnterior cruciate ligament reconstructionLogistic regressionFollow-up dataCruciate ligament reconstructionACL reconstruction failureLevel of evidencePatient-reported outcomesCohort dataIntraoperative findingsTibial tunnel sizesModerate predictive abilityReconstruction failureFollow-upGraft typeAllograft useCohort studyPreoperative radiographsLigament reconstructionRisk factorsCohortPatientsCorrigendum: The predictive validity of a Brain Care Score for late-life depression and a composite outcome of dementia, stroke, and late-life depression: data from the UK Biobank cohort
Singh S, Rivier C, Papier K, Chemali Z, Gutierrez-Martinez L, Parodi L, Mayerhofer E, Senff J, Clocchiatti-Tuozzo S, Nunley C, Newhouse A, Ouyang A, Westover M, Tanzi R, Lazar R, Pikula A, Ibrahim S, Brouwers H, Howard V, Howard G, Yechoor N, Littlejohns T, Sheth K, Rosand J, Fricchione G, Anderson C, Falcone G. Corrigendum: The predictive validity of a Brain Care Score for late-life depression and a composite outcome of dementia, stroke, and late-life depression: data from the UK Biobank cohort. Frontiers In Psychiatry 2024, 15: 1502482. PMID: 39600788, PMCID: PMC11589155, DOI: 10.3389/fpsyt.2024.1502482.Peer-Reviewed Original ResearchUpregulation vs. loss of function of NTRK2 in 44 affected individuals leads to two distinct neurodevelopmental disorders
Berger E, Jauss R, Ranells J, Zonic E, von Wintzingerode L, Wilson A, Wagner J, Tuttle A, Thomas-Wilson A, Schulte B, Rabin R, Pappas J, Odgis J, Muthaffar O, Mendez-Fadol A, Lynch M, Levy J, Lehalle D, Lake N, Krey I, Kozenko M, Knierim E, Jouret G, Jobanputra V, Isidor B, Hunt D, Hsieh T, Holtz A, Haack T, Gold N, Dunstheimer D, Donge M, Deb W, De La Rosa Poueriet K, Danyel M, Christodoulou J, Chopra S, Callewaert B, Busche A, Brick L, Bigay B, Arlt M, Anikar S, Almohammal M, Almanza D, Alhashem A, Bertoli-Avella A, Sticht H, Abou Jamra R. Upregulation vs. loss of function of NTRK2 in 44 affected individuals leads to two distinct neurodevelopmental disorders. Genetics In Medicine 2024, 101326. PMID: 39540377, DOI: 10.1016/j.gim.2024.101326.Peer-Reviewed Original ResearchDevelopmental delayHeterozygous pathogenic variantsTherapy-refractory epilepsyAffected individualsPhenotype of developmental delayDevelopmental delay/intellectual disabilityGlobal developmental delayRecurrent variant c.Associated with global developmental delayCholesterol-binding motifsTrkB activationVariant c.Pathogenic variantsMuscular hypotoniaFeeding difficultiesSevere phenotypeLoss of functionBinding motifVisual impairmentTransmembrane domainTruncating variantsNeurodevelopmental disordersNTRK2CohortVariantsCorrigendum: The predictive validity of a Brain Care Score for dementia and stroke: data from the UK Biobank cohort
Singh S, Oreskovic T, Carr S, Papier K, Conroy M, Senff J, Chemali Z, Gutierrez-Martinez L, Parodi L, Mayerhofer E, Marini S, Nunley C, Newhouse A, Ouyang A, Brouwers H, Westover B, Rivier C, Falcone G, Howard V, Howard G, Pikula A, Ibrahim S, Sheth K, Yechoor N, Lazar R, Anderson C, Tanzi R, Fricchione G, Littlejohns T, Rosand J. Corrigendum: The predictive validity of a Brain Care Score for dementia and stroke: data from the UK Biobank cohort. Frontiers In Neurology 2024, 15: 1501771. PMID: 39563774, PMCID: PMC11574342, DOI: 10.3389/fneur.2024.1501771.Peer-Reviewed Original Research
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