2025
Exposure to School Racial Segregation and Late-Life Cognitive Outcomes
Lin Z, Wang Y, Gill T, Chen X. Exposure to School Racial Segregation and Late-Life Cognitive Outcomes. JAMA Network Open 2025, 8: e2452713. PMID: 39752159, PMCID: PMC11699536, DOI: 10.1001/jamanetworkopen.2024.52713.Peer-Reviewed Original ResearchConceptsCross-sectional studyCognitive scoresOlder adultsTelephone Interview for Cognitive StatusBlack participantsLate-life cognitive outcomesWhite participantsSchool racial segregationCognitive impairmentHealth and Retirement StudyNon-Hispanic whitePrevalence of cognitive impairmentAssociated with late-life cognitionEducational attainmentUS older adultsLikelihood of cognitive impairmentNon-Hispanic blacksLate-life cognitionCognitive outcomesNationally representative sampleLater-life cognitionMultilevel regression analysisStudy of BlackDementia occurrenceHealth inequalities
2024
Neuroimaging Correlates of the NIH-Toolbox-Driven Cognitive Metrics in Children
Acosta-Rodriguez H, Yuan C, Bobba P, Stephan A, Zeevi T, Malhotra A, Tran A, Kaltenhauser S, Payabvash S. Neuroimaging Correlates of the NIH-Toolbox-Driven Cognitive Metrics in Children. Journal Of Integrative Neuroscience 2024, 23: 217. PMID: 39735971, PMCID: PMC11851640, DOI: 10.31083/j.jin2312217.Peer-Reviewed Original ResearchConceptsCognitive composite scoreAdolescent Brain Cognitive DevelopmentFluid cognition composite scoresStructural magnetic resonance imagingComposite scoreDiffusion tensor imagingNeuroimaging correlatesCognitive functionRs-fMRINational Institutes of Health (NIH) Toolbox Cognition BatteryCognitive scoresMicrostructural integrityResting-state functional connectivityCrystallized cognition composite scoreCortical surface areaTotal cognitive scoreWM microstructural integrityCognitive batteryCrystallized cognitionNeuroanatomical correlatesWhite matterCognitive performanceNeuroimaging metricsFunctional connectivityNeuroimaging dataCorrelation between changes in apathy and cognition in Alzheimer’s disease associated apathy: Analysis of the Apathy in Dementia Methylphenidate Trial 2 (ADMET 2)
Sankhe K, Tumati S, Perin J, Rivet L, Vieira D, Rosenberg P, Herrmann N, Shade D, Lerner A, Padala P, Brawman-Mintzer O, van Dyck C, Porsteinsson A, Craft S, Levey A, Mintzer J, Lanctôt K. Correlation between changes in apathy and cognition in Alzheimer’s disease associated apathy: Analysis of the Apathy in Dementia Methylphenidate Trial 2 (ADMET 2). International Psychogeriatrics 2024, 37: 100012. PMID: 40086910, DOI: 10.1016/j.inpsyc.2024.100012.Peer-Reviewed Original ResearchBoston Naming TestMini-Mental State ExamCategory fluencyMild-to-moderate AD patientsClinically significant apathyCognitive change scoresModerate AD patientsHopkins Verbal LearningVerbal learningDigit spanNaming TestVerbal fluencySignificant apathyTrail MakingCognitive changesMeasure apathyMethylphenidateCognitionCognitive scoresState ExamMini-MentalChange scoresApathyAD patientsTrial 2Reasons for screening failure in the evoke and evoke+ trials of semaglutide for early AD
Sano M, Cummings J, Feldman H, Hansson O, van der Flier W, Bardtrum L, Jeppesen R, Johannsen P, Léon T, Hansen C, Scheltens P. Reasons for screening failure in the evoke and evoke+ trials of semaglutide for early AD. Alzheimer's & Dementia 2024, 20: e088735. PMCID: PMC11713595, DOI: 10.1002/alz.088735.Peer-Reviewed Original ResearchMini-Mental State ExaminationAmyloid positivityStrategic infarctsMild AD dementiaRepeatable BatteryPsychiatric disordersCognitive Assessment scoreMild cognitive impairment due to ADInclusion of participantsCognitive impairment due to ADCognitive scoresMini-MentalState ExaminationCDR scoreNeurological disordersScreening failureDisordersEvidence of neurologic disordersAD dementiaScreening failure rateSmall vessel pathologyEvokedScoresCentral nervous systemHierarchical screening procedureRegional differences in baseline demographic and clinical characteristics from the evoke and evoke+ trials of semaglutide for early Alzheimer’s disease
van der Flier W, Scheltens P, Feldman H, Hansson O, Sano M, Bardtrum L, Johannsen P, Jeppesen R, Hansen C, Leon T, Cummings J. Regional differences in baseline demographic and clinical characteristics from the evoke and evoke+ trials of semaglutide for early Alzheimer’s disease. Alzheimer's & Dementia 2024, 20: e088793. PMCID: PMC11713752, DOI: 10.1002/alz.088793.Peer-Reviewed Original ResearchMini-Mental State Examination scoreBaseline dataCognitive scoresClinical Dementia Rating-SumAlzheimer's diseaseApolipoprotein E4 carrier statusClinical Dementia Rating-Sum of Boxes scoresInclusion of participantsMild cognitive impairmentScreening failure rateProportion of individualsMild dementiaGeographic regionsType 2 diabetesBox scoresAD medicationsClinical characteristicsInclusion criteriaCarrier statusNorth AmericaExamination scoresClinical trial populationsPatient characteristicsCognitive impairmentSmall vessel pathologyMedical comorbidities and lower myelin content are associated with poor cognition in young adults with perinatally acquired HIV
Patel P, Prince D, Bolenzius J, Ch’en P, Chiarella J, Kolind S, Vavasour I, Pedersen T, Levendovszky S, Spudich S, Marra C, Paul R. Medical comorbidities and lower myelin content are associated with poor cognition in young adults with perinatally acquired HIV. AIDS 2024, 38: 1932-1939. PMID: 39110577, PMCID: PMC11524773, DOI: 10.1097/qad.0000000000003989.Peer-Reviewed Original ResearchPoor cognitionCognitive impairmentHorizontally acquired HIVMarkers of cognitive reserveAssociated with poorer cognitionRisk factorsCross-sectional studyYoung adultsLower cognitive scoresYears of educationMultiple cognitive domainsExperience cognitive deficitsCognitive domain scoresHIV-uninfected controlsOlder adultsCorticospinal tractCognitive batteryDomain scoresMedical comorbidityCognitive deficitsCognitive domainsMyelin contentCognitive reserveNeuroimaging dataCognitive scoresEarly-Life Circumstances and Racial Disparities in Cognition Among Older Adults in the US
Lin Z, Ye J, Allore H, Gill T, Chen X. Early-Life Circumstances and Racial Disparities in Cognition Among Older Adults in the US. JAMA Internal Medicine 2024, 184: 904-914. PMID: 38805197, PMCID: PMC11134283, DOI: 10.1001/jamainternmed.2024.1132.Peer-Reviewed Original ResearchEarly-life circumstancesLate-life cognitionRacial disparitiesCross-sectional studyBlack participantsWhite participantsCognitive scoresCognitive impairmentRacial differencesTelephone Interview for Cognitive StatusHealth and Retirement StudyAssociated with racial disparitiesPromote health equityPrevalence of cognitive impairmentIntervention of cognitive impairmentNon-Hispanic blacksSurvey of US adultsNon-Hispanic whitesReduce racial disparitiesPrimary explanatory variableSubstantial racial differencesHealth equityRetirement StudyOlder AdultsUS adultsA Method to Estimate Longitudinal Change Patterns in Functional Network Connectivity of the Developing Brain Relevant to Psychiatric Problems, Cognition, and Age
Saha R, Saha D, Rahaman A, Fu Z, Liu J, Calhoun V. A Method to Estimate Longitudinal Change Patterns in Functional Network Connectivity of the Developing Brain Relevant to Psychiatric Problems, Cognition, and Age. Brain Connectivity 2024, 14: 130-140. PMID: 38308475, PMCID: PMC10954605, DOI: 10.1089/brain.2023.0040.Peer-Reviewed Original ResearchFunctional network connectivityFunctional connectivityPsychiatric problemsFunctional network connectivity matricesNetwork connectivityMultivariate patternsWhole-brain functional networksIntrinsic functional connectivityPattern of functional changesBrain functional connectivityIntrinsic functional relationshipLongitudinal changesAdolescent brainAge-related changesBrain networksStudy developmental changesScanning sessionBrain functionAssociated with longitudinal changesCognitive scoresDevelopmental changesBrain developmentFunctional changesCognitionLongitudinal change patternsAssociation between experiencing low healthcare quality and developing dementia
Aravena J, Chen X, Levy B. Association between experiencing low healthcare quality and developing dementia. Journal Of The American Geriatrics Society 2024, 72: 2126-2132. PMID: 38415796, DOI: 10.1111/jgs.18842.Peer-Reviewed Original ResearchAssociated with increased dementia riskHealthcare qualityDementia riskHealthcare discriminationAssociated with greater dementia riskHazard ratioHealth and Retirement StudyDeterminants of dementiaCases of dementiaDementia prevalenceReducing dementiaPhysician diagnosisRetirement StudyHealthcare servicesOlder personsOlder adultsSocioeconomic factorsDementiaHealthcareImplement structural changesCognitive scoresCox regressionParticipantsHealthIndividual-level behavior
2023
A brain‐wide risk score of Alzheimer’s disease based on multimodal neuroimaging predicts cognition in large N>37000 population data
Zendehrouh E, Sendi M, Calhoun V. A brain‐wide risk score of Alzheimer’s disease based on multimodal neuroimaging predicts cognition in large N>37000 population data. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.077591.Peer-Reviewed Original ResearchMild cognitive impairmentAD riskGenetic risk of ADCognitive scoresRisk of ADFunctional network connectivityUK BiobankAlzheimer's diseaseGenetic riskRisk scoreBackground Alzheimer’s diseaseFI scoreFluid intelligenceCognitive impairmentPopulation dataEvaluate individualsGray matterScoresRiskReaction timeBiotypesEARLY-LIFE CIRCUMSTANCES AND RACIAL DISPARITIES IN COGNITION AMONG US OLDER ADULTS
Lin Z, Ye J, Allore H, Gill T, Chen X. EARLY-LIFE CIRCUMSTANCES AND RACIAL DISPARITIES IN COGNITION AMONG US OLDER ADULTS. Innovation In Aging 2023, 7: 304-304. PMCID: PMC10735771, DOI: 10.1093/geroni/igad104.1011.Peer-Reviewed Original ResearchSpatiotemporal Correlation between Amyloid and Tau Accumulations Underlies Cognitive Changes in Aging
Kim C, Diez I, Bueichekú E, Ahn S, Montal V, Sepulcre J. Spatiotemporal Correlation between Amyloid and Tau Accumulations Underlies Cognitive Changes in Aging. Journal Of Neuroscience 2023, 44: e0488232023. PMID: 38123362, PMCID: PMC10869152, DOI: 10.1523/jneurosci.0488-23.2023.Peer-Reviewed Original ResearchConceptsHarvard Aging Brain StudyCognitive changesCognitive declineAssociated with cognitive changesAssociated with early cognitive declineAging Brain StudyEarly cognitive declineTau depositionCognitive scoresBrain studiesHuman brainTau pathologyOlder adultsTau accumulationTau associationImpaired associationAD symptomsClinical trajectoryCortical patternsTauBraak stageSpatiotemporal levelsTemporal accumulationBraakFuture increasesEpigenetic associations with adolescent grey matter maturation and cognitive development
Jensen D, Chen J, Turner J, Stephen J, Wang Y, Wilson T, Calhoun V, Liu J. Epigenetic associations with adolescent grey matter maturation and cognitive development. Frontiers In Genetics 2023, 14: 1222619. PMID: 37529779, PMCID: PMC10390095, DOI: 10.3389/fgene.2023.1222619.Peer-Reviewed Original ResearchGM volume increaseGray matter maturationPatterns of brain maturationImprove cognitive performanceGray matterExecutive functionEpisodic memoryCognitive performanceCognitive testsBrain structuresProcessing speedBrain maturationCognitive AssessmentCognitive scoresBrain imagingAged 9BrainEpigenetic associationsAdolescentsLongitudinal cohortDNA methylationHuman neurodevelopmentDNA methylation of genesCytosine-phosphate-guanine (CpG) sitesBrain tissueTowards a multimodal neuroimaging-based risk score for Alzheimer’s disease by combining clinical and large N>37000 population data
Zendehrouh E, Sendi M, Calhoun V. Towards a multimodal neuroimaging-based risk score for Alzheimer’s disease by combining clinical and large N>37000 population data. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2023, 00: 1-4. PMID: 38083709, DOI: 10.1109/embc40787.2023.10340414.Peer-Reviewed Original ResearchResting‐state dynamic functional network connectivity predicts cognition in 37,784 participants of UK Biobank
Sendi M, Zendehrouh E, Miller R, Salat D, Calhoun V. Resting‐state dynamic functional network connectivity predicts cognition in 37,784 participants of UK Biobank. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.065832.Peer-Reviewed Original ResearchFunctional network connectivityDynamic FNCDynamic functional network connectivityCognitive scoresFluid intelligenceCognitive declineAge-related cognitive declineGroup independent component analysisResting-state functional MRIBrain functional changesResting-state fMRIBrain functional network connectivityReaction timeParticipants of UK BiobankRT taskFunctional MRIRs-fMRIPairing taskCognitionIndependent component analysisUK BiobankBrainNetwork connectivityHealthy adultsData-driven componentsFusion of Multi-Modal Neuroimaging Data and Association With Cognitive Data
LoPresto M, Akhonda M, Calhoun V, Adali T. Fusion of Multi-Modal Neuroimaging Data and Association With Cognitive Data. 2023, 00: 1-5. DOI: 10.1109/icasspw59220.2023.10193147.Peer-Reviewed Original ResearchHopkins Verbal Learning TestNeuropsychological assessment batteryCognitive dataNeuroimaging modalitiesBrief Assessment of CognitionSchizophrenia composite scoreVerbal Learning TestAssessment of CognitionMultiple neuroimaging modalitiesBrief AssessmentCross-modal connectionsLearning TestAssessment batteryCross-modal relationshipsNeuroimaging dataBrain benefitsCognitive scoresComposite scoreCognitionData-driven analysisIndependent vector analysisSchizophreniaNeuropsychologyFusion frameworkScores0522 CPAP Improves Cognition in Brain-Healthy Males: Secondary Analysis of a Randomized Trial
Sun H, Zinchuk A, Locascio J, Kushida C, Thomas R, Westover M. 0522 CPAP Improves Cognition in Brain-Healthy Males: Secondary Analysis of a Randomized Trial. Sleep 2023, 46: a230-a231. DOI: 10.1093/sleep/zsad077.0522.Peer-Reviewed Original ResearchObstructive sleep apneaApnea Positive Pressure Long-term Efficacy StudyPrimary analysisIndividual treatment effectsIntroduction Obstructive sleep apneaSecondary analysisLong-term Efficacy StudyBaseline cognitive scoresBrain age indexBaseline AHIBaseline polysomnogramMulticenter trialRandomized trialsSleep apneaAdherence ratesOSA treatmentTwo-armGroup 2Group 1Efficacy studiesCognitive impairmentCPAPBaseline cognitionMore depressionCognitive scores
2022
Social Support, social ties, and cognitive function of women with breast cancer: findings from the Women’s Health Initiative (WHI) Life and Longevity After Cancer (LILAC) Study
Yang Y, McLaughlin E, Naughton M, Lustberg M, Nolan T, Kroenke C, Weitlauf J, Saquib N, Shadyab A, Follis S, Pan K, Paskett E. Social Support, social ties, and cognitive function of women with breast cancer: findings from the Women’s Health Initiative (WHI) Life and Longevity After Cancer (LILAC) Study. Supportive Care In Cancer 2022, 31: 48. PMID: 36525119, PMCID: PMC9758078, DOI: 10.1007/s00520-022-07505-5.Peer-Reviewed Original ResearchConceptsWomen's Health Initiative (WHI) LifeBreast cancerMedian cognitive scoresCognitive functionCognitive scoresBreast cancer stage IMedical Outcomes Study Social Support SurveySocial supportCognitive functioningCancer stage IHigher social support scoresSocial Support SurveyMultivariable quantile regressionHigher cognitive functioningNon-Hispanic whitesSelf-reported cognitive functioningSocial support scoresMajority of participantsBaseline questionnaireCancer cohortHigh riskMethodsThe studyKruskal-Wallis testStage IHigh social support
2021
Impact of Type 1 Diabetes in the Developing Brain in Children: A Longitudinal Study.
Mauras N, Buckingham B, White NH, Tsalikian E, Weinzimer SA, Jo B, Cato A, Fox LA, Aye T, Arbelaez AM, Hershey T, Tansey M, Tamborlane W, Foland-Ross LC, Shen H, Englert K, Mazaika P, Marzelli M, Reiss AL. Impact of Type 1 Diabetes in the Developing Brain in Children: A Longitudinal Study. Diabetes Care 2021, 44: 983-992. PMID: 33568403, PMCID: PMC7985430, DOI: 10.2337/dc20-2125.Peer-Reviewed Original ResearchConceptsType 1 diabetesBrain volumeControl subjectsTotal brain volume differencesEarly-onset type 1 diabetesAge-matched control subjectsIntelligence quotientCognitive scoresWhite matter volumeBrain volume differencesContinuous glucose monitoringDiabetes groupFull-scale intelligence quotientDiabetes complicationsDiabetes controlTotal brainVerbal intelligence quotientDiabetesMatter volumeSensor glucoseCognitive testingGlucose monitoringMixed-effects modelsBrainGroup differences
2020
Genomics Links Inflammation With Neurocognitive Impairment in Children Living With Human Immunodeficiency Virus Type-1
Rawat P, Brummel S, Singh K, Kim J, Frazer K, Nichols S, Seage G, Williams P, Van Dyke R, Harismendy O, Trout R, Spector S. Genomics Links Inflammation With Neurocognitive Impairment in Children Living With Human Immunodeficiency Virus Type-1. The Journal Of Infectious Diseases 2020, 224: 870-880. PMID: 33373444, PMCID: PMC8408770, DOI: 10.1093/infdis/jiaa792.Peer-Reviewed Original ResearchMeSH Keywords14-3-3 ProteinsChildChild, PreschoolFemaleGenome-Wide Association StudyGenomicsHIV InfectionsHIV-1HumansInfantInfectious Disease Transmission, VerticalInflammasomesInflammationIntracellular Signaling Peptides and ProteinsMaleMembrane ProteinsMicrogliaNeurocognitive DisordersReceptors, CCRConceptsWhole-exome sequencingValidation cohortNeurocognitive impairmentOdds ratioRisk of NCIHuman immunodeficiency virus type 1Immunodeficiency virus type 1Single nucleotide variantsAdjusted odds ratioIL-1β releaseVirus type 1Microglial releaseIL-1βHuman microgliaDecreased oddsType 1Logistic regressionCognitive scoresCCRL2MicrogliaFurther studiesHIVInflammationCsACohort
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