2025
Effects of Long-Term Cocaine Self-Administration on Kappa Opioid Receptors in Socially Housed Cynomolgus Monkeys as Assessed with PET Imaging and Neuronally Derived Exosomes
Johnson B, Allen M, Nader S, Sai K, Kumar A, Su Y, Singh S, Li S, Huang Y, Deep G, Nader M. Effects of Long-Term Cocaine Self-Administration on Kappa Opioid Receptors in Socially Housed Cynomolgus Monkeys as Assessed with PET Imaging and Neuronally Derived Exosomes. Biological Psychiatry 2025 PMID: 40054763, DOI: 10.1016/j.biopsych.2025.02.900.Peer-Reviewed Original ResearchLong-term cocaine self-administrationKappa-opioid receptorsCocaine self-administrationSelf-administrationKappa opioid receptor availabilityPeripheral measuresSocially housed monkeysOpioid receptorsCocaine intakeCocaine SAIntravenous cocaineCocaine misuseBrain regionsCocainePET imagingCynomolgus monkeysSocial rankPET studiesPharmacological interventionsMonkeysPET scansBrainBlood samplesDominant femalesSocialPlasma microRNAs to Select Optimal Patients for Antibody Production from Anti-Addiction Vaccines
Kosten T, Koirala A, Nielsen D, Domingo C, Thomas Y, Gunaratne P, Coarfa C. Plasma microRNAs to Select Optimal Patients for Antibody Production from Anti-Addiction Vaccines. Vaccines 2025, 13: 181. PMID: 40006728, PMCID: PMC11860428, DOI: 10.3390/vaccines13020181.Peer-Reviewed Original ResearchDE-miRsAnti-drug antibodiesPlasma microRNAsAnti-addiction vaccinesAnti-cocaine vaccinePotential response biomarkersMiR-150Vaccine trial participantsIllicit amphetamineNon-respondersResponse biomarkersMiRsAntibody respondersAnti-addictiveAntibody levelsAntibody productionStudy predictorsVaccineTrial participantsMicroRNAsCocaineAntibodiesLow ABFalse discovery ratePatientsPredicting antiretroviral medication adherence among substance-using people with HIV: test and extension of the information-motivation-behavioral skills model
Krishnan A, Ranjit Y, Zhou X, Altice F. Predicting antiretroviral medication adherence among substance-using people with HIV: test and extension of the information-motivation-behavioral skills model. Journal Of Behavioral Medicine 2025, 1-11. PMID: 39924604, DOI: 10.1007/s10865-025-00557-y.Peer-Reviewed Original ResearchCocaine use disorderSubstance use disordersBehavioral skillsInformation-motivation-behavioral (IMB) skills modelSkills modelInformation-motivation-behavioral skills modelAntiretroviral medication adherenceUse disorderAntiretroviral therapyART adherenceMedication adherenceDaily adherenceImprove ART adherenceMotivational barriersDisordersAntiretroviral therapy adherenceMotivational factorsPractical barriersReduce HIV transmissionEnhance ART adherenceSuboptimal adherenceVirological failureHIV transmissionCocaineAdherenceStructural Brain Changes Associated With Cognitive Behavioral Therapy in Cocaine Use Disorder Treatment
McCurdy L, DeVito E, Loya J, Nich C, Kiluk B, Potenza M. Structural Brain Changes Associated With Cognitive Behavioral Therapy in Cocaine Use Disorder Treatment. Drug And Alcohol Dependence 2025, 267: 112224. DOI: 10.1016/j.drugalcdep.2024.112224.Peer-Reviewed Original Research
2024
Characterizing and responding to stimulant overdoses: Findings from a mixed methods study of people who use cocaine and other stimulants in New England
Hughto J, Kelly P, Vento S, Pletta D, Noh M, Silcox J, Rich J, Green T. Characterizing and responding to stimulant overdoses: Findings from a mixed methods study of people who use cocaine and other stimulants in New England. Drug And Alcohol Dependence 2024, 266: 112501. PMID: 39608288, PMCID: PMC11685032, DOI: 10.1016/j.drugalcdep.2024.112501.Peer-Reviewed Original ResearchStimulant overdoseHelp-seekingIllicit stimulant useCrack cocaine useCocaine involvementSevere symptomsSymptom severityCocaine useAdjusted multivariable logistic regression modelsMultivariate logistic regression modelStimulant useModerate-to-severe symptomsSubstance useStudy of peopleCrack cocaineOverdose experiencesCocaineLogistic regression modelsHigher educational attainmentOverdose historySymptomsParticipantsStimulation typeOverdosePersonsStability and Reliability of Repeated Plasma Pregnenolone Levels After Oral Pregnenolone Dosing in Individuals with Cocaine Use Disorder: Pilot Findings
Gao H, Magin Z, Fogelman N, Sinha R, Angarita G, Milivojevic V. Stability and Reliability of Repeated Plasma Pregnenolone Levels After Oral Pregnenolone Dosing in Individuals with Cocaine Use Disorder: Pilot Findings. Life 2024, 14: 1483. PMID: 39598281, PMCID: PMC11595496, DOI: 10.3390/life14111483.Peer-Reviewed Original ResearchCocaine use disorderSubstance use disordersUse disorderPregnenolone levelsTreatment of cocaine use disorderReduce alcohol cravingTreatment-seeking individualsAssociated across timeAdministration of pregnenoloneEight-week trialSignificant main effectAlcohol cravingPregnenolone administrationNegative health risksDouble-blind clinical trialMain effectPilot findingsLevels of pregnenoloneChronic dosingStudy medication doseMedication dosesDisordersCocainePilot studyStress biologyA shared spatial topography links the functional connectome correlates of cocaine use disorder and dopamine D2/3 receptor densities
Ricard J, Labache L, Segal A, Dhamala E, Cocuzza C, Jones G, Yip S, Chopra S, Holmes A. A shared spatial topography links the functional connectome correlates of cocaine use disorder and dopamine D2/3 receptor densities. Communications Biology 2024, 7: 1178. PMID: 39300138, PMCID: PMC11413242, DOI: 10.1038/s42003-024-06836-9.Peer-Reviewed Original ResearchConceptsCocaine use disorderPatterns of functional connectivityUse disorderFunctional connectivityReceptor densityLarge-scale functional brain networksMaintenance of substance useDopamine D2/3 receptorsDopamine receptor densityCortico-striatal circuitsProfile of functional connectivitySubstance use disordersFunctional brain networksNeurotransmitter receptor densityD2/3 receptorsDopamine systemTransporter bindingSubcortical systemsBrain networksSubstance useCocaineSpatial topographyDisordersDopamineBiological mechanismsAssociation patterns of antisocial personality disorder across substance use disorders
Low A, Stiltner B, Nunez Y, Adhikari K, Deak J, Pietrzak R, Kranzler H, Gelernter J, Polimanti R. Association patterns of antisocial personality disorder across substance use disorders. Translational Psychiatry 2024, 14: 346. PMID: 39198385, PMCID: PMC11358160, DOI: 10.1038/s41398-024-03054-z.Peer-Reviewed Original ResearchConceptsAntisocial personality disorderSubstance use disordersPersonality disorderUse disorderAssociation of antisocial personality disorderPresence of antisocial personality disorderPrevalence of antisocial personality disorderHazardous useDSM-5 SUD diagnosesSubstance use disorder severityDiagnostic criteriaInteraction effects with sexTobacco use disorderDSM-5Association of alcoholSUD diagnosisDisordersCocaineRacial/ethnic backgroundsIndividualsCocUDSeverityCannabisAssociation patternsAssociationMeasurement invariance of the Perceived Stress Scale across race, sex, and time, and differential impacts on cocaine use treatment outcomes
Schick M, Kiluk B, Nich C, LaPaglia D, Haeny A. Measurement invariance of the Perceived Stress Scale across race, sex, and time, and differential impacts on cocaine use treatment outcomes. Journal Of Substance Use And Addiction Treatment 2024, 166: 209493. PMID: 39151798, PMCID: PMC11392621, DOI: 10.1016/j.josat.2024.209493.Peer-Reviewed Original ResearchCocaine use disorderPerceived Stress ScaleTreatment retentionMeasurement invarianceTreatment outcomesSubstance use treatment outcomesStress ScalePredicting treatment retentionSelf-efficacyCoping self-efficacyTwo-factor modelInfluence treatment outcomeCocaine abuse/dependenceDSM-IVUse disorderCocaine useBetween-group differencesMetric invarianceScalar invarianceTwo-factorCocainePharmacological treatmentFactor analysisDifferential impactAbuse/dependenceCase report: Tremor in the placebo condition of a blinded clinical trial of intermittent theta-burst stimulation for cocaine use disorder
Steele V, Rotenberg A, Philip N, Hallett M, Stein E, Salmeron B. Case report: Tremor in the placebo condition of a blinded clinical trial of intermittent theta-burst stimulation for cocaine use disorder. Frontiers In Psychiatry 2024, 15: 1391771. PMID: 39045554, PMCID: PMC11263940, DOI: 10.3389/fpsyt.2024.1391771.Peer-Reviewed Original ResearchCocaine use disorderIntermittent theta burst stimulationTheta burst stimulationPlacebo responseUse disorderClinically relevant effectsBlind clinical trialClinical responseNew-onsetPlacebo conditionClinical trialsSham iTBSFunctional disordersPersistent tremorBurst stimulationCocaineDisordersShamStimulationTrialsWeak E-fieldsRelevant effectsTremorExamining cocaine use reductions and long-term outcomes in two clinical trials of continuing care for cocaine dependence
Votaw V, Tuchman F, Roos C, Hebden H, McKay J, Kiluk B, Witkiewitz K. Examining cocaine use reductions and long-term outcomes in two clinical trials of continuing care for cocaine dependence. Journal Of Substance Use And Addiction Treatment 2024, 163: 209394. PMID: 38735481, PMCID: PMC11180556, DOI: 10.1016/j.josat.2024.209394.Peer-Reviewed Original ResearchCocaine use disorderCocaine useAssociated with less cocaine useTelephone-based continuing careLevel of cocaine useFollow-upDrug use consequencesAssociated with lower levelsClinical trialsBaseline to 12-month follow-upCocaine dependenceTreatment entryProblem severityUse disorderTimeline FollowbackCocaineInitial treatment phaseAbstinenceLow-frequency useLong-term functional outcomeEffect sizeTreatment phaseLong-term outcomesRandomized clinical trialsNegative consequencesUnderstanding the patient and supporter journey in cocaine use disorder
Leclair D, Waye K, Gomez-Mancilla B, Kiluk B, Karanam A, Banerjee P, Muthusamy V, Maahs S. Understanding the patient and supporter journey in cocaine use disorder. Frontiers In Psychiatry 2024, 15: 1230626. PMID: 38659460, PMCID: PMC11040082, DOI: 10.3389/fpsyt.2024.1230626.Peer-Reviewed Original ResearchIntrinsic connectivity demonstrates a shared role of the posterior cingulate for cue reactivity in both gambling and cocaine use disorders
Vaccaro A, Lacadie C, Potenza M. Intrinsic connectivity demonstrates a shared role of the posterior cingulate for cue reactivity in both gambling and cocaine use disorders. Addictive Behaviors 2024, 155: 108027. PMID: 38581751, PMCID: PMC11273263, DOI: 10.1016/j.addbeh.2024.108027.Peer-Reviewed Original ResearchConceptsCocaine use disorderPosterior cingulate cortexCue reactivityBehavioral addictionsUse disorderGambling disorderPosterior cingulatePosterior cingulate cortex connectivityHealthy comparison subjectsIntrinsic connectivity distributionIntervention developmentCocaine cuesFMRI taskAddictive disordersCingulate cortexComparison subjectsNeurobiological foundationsSad videosDecreased connectivityFunctional connectivityCocainePost hoc analysisAddictionRelevant to maintenanceGamblingSubstance use and spine density: a systematic review and meta-analysis of preclinical studies
Oliva H, Prudente T, Nunes E, Cosgrove K, Radhakrishnan R, Potenza M, Angarita G. Substance use and spine density: a systematic review and meta-analysis of preclinical studies. Molecular Psychiatry 2024, 29: 2873-2885. PMID: 38561468, PMCID: PMC11894807, DOI: 10.1038/s41380-024-02519-3.Peer-Reviewed Original ResearchSpine densityPrefrontal cortexSubstance useDrug self-administrationHippocampal spine densityEffects of cocaineSubstance use disordersConvergence of findingsSpine density changesSubstances of abuseMeta-analysis of preclinical studiesNucleus accumbensBehavioral sensitizationSelf-administrationBrain mechanismsPreclinical studiesBrain regionsMorphine effectsSynaptic density changesMeta-analysisAmphetamineSynaptic densityCocaineModerate-to-highCortexPatient perspectives on current and potential therapies and clinical trial approaches for cocaine use disorder
Maahs S, Leclair D, Gomez-Mancilla B, Kiluk B, Muthusamy V, Banerjee P, Dasgupta S, Waye K. Patient perspectives on current and potential therapies and clinical trial approaches for cocaine use disorder. Frontiers In Psychiatry 2024, 15: 1230699. PMID: 38487570, PMCID: PMC10937549, DOI: 10.3389/fpsyt.2024.1230699.Peer-Reviewed Original ResearchCocaine use disorderLong-term abstinenceSubstance use disordersBarriers to therapyWithdrawal symptomsUse disorderCraving controlClinical trialsCocaineClinical trial approachesDesign of clinical trialsCravingScreening questionnaireDisordersClinical trial outcomesTrial outcomesPerspectives of individualsRemissionParticipantsDrug seekersPotential therapiesTherapyIndividualsRecruited participantsAbstinenceNeurovascular effects of cocaine: relevance to addiction
Clare K, Park K, Pan Y, Lejuez C, Volkow N, Du C. Neurovascular effects of cocaine: relevance to addiction. Frontiers In Pharmacology 2024, 15: 1357422. PMID: 38455961, PMCID: PMC10917943, DOI: 10.3389/fphar.2024.1357422.Peer-Reviewed Original ResearchBrain functionAssociated with adverse medical consequencesCerebral blood flowRelevant to addictionHealthy non-drugBrain imaging studiesCerebral blood flow deficitsCocaine addictionAddictive drugsCocaine misuseCocaine useTargeted pharmacological interventionsCocaineNon-drugAdverse medical consequencesNeuronal activityDebilitating neurological complicationsPharmacological interventionsAddictionCBF changesBrainImaging studiesMedical consequencesNeurological complicationsCerebrovascular accident
2023
Correction: Voltage-gated potassium channels control extended access cocaine seeking: a role for nucleus accumbens astrocytes
Xia M, Anderson T, Prantzalos E, Hawkinson T, Clarke H, Keohane S, Sun R, Turner J, Ortinski P. Correction: Voltage-gated potassium channels control extended access cocaine seeking: a role for nucleus accumbens astrocytes. Neuropsychopharmacology 2023, 49: 1060-1060. PMID: 38040958, PMCID: PMC11039452, DOI: 10.1038/s41386-023-01767-1.Peer-Reviewed Original ResearchCocaineAstrocytesVoltage-gated potassium channels control extended access cocaine seeking: a role for nucleus accumbens astrocytes
Xia M, Anderson T, Prantzalos E, Hawkinson T, Clarke H, Keohane S, Sun R, Turner J, Ortinski P. Voltage-gated potassium channels control extended access cocaine seeking: a role for nucleus accumbens astrocytes. Neuropsychopharmacology 2023, 49: 551-560. PMID: 37660129, PMCID: PMC10789875, DOI: 10.1038/s41386-023-01718-w.Peer-Reviewed Original ResearchConceptsNucleus accumbens shellNAc astrocytesCocaine self-administration trainingCocaine-associated behaviorsReward-related learningSelf-administration trainingImpact of dopamineCocaine-seekingAccumbens shellDopaminergic signalingBehavioral effectsDopamine levelsCocaineInhibition of Kv7 channelsIntracellular Ca2+ transientsDopamineAstrocytic Ca2+ signalingExogenous dopamineBehavioral implicationsCa2+ transientsDrug useCa2+ imagingVoltage-gated channel activityPotassium channel functionCa2+ signalingIntegrative data analysis of clinical trials network studies to examine the impact of psychosocial treatments for black people who use cocaine: Study protocol
Haeny A, McCuistian C, Burlew A, Ruglass L, Espinosa A, Jordan A, Roundtree C, Lopez J, Morgan-López A. Integrative data analysis of clinical trials network studies to examine the impact of psychosocial treatments for black people who use cocaine: Study protocol. Contemporary Clinical Trials 2023, 133: 107329. PMID: 37652354, PMCID: PMC10635737, DOI: 10.1016/j.cct.2023.107329.Peer-Reviewed Original ResearchConceptsStudy protocolPsychosocial treatmentsPsychostimulant useTreatment effectivenessRandomized clinical trialsCocaine use severityClinical trialsInclusion criteriaOutcome measuresStudy-level moderatorsGeneral populationUse disordersTreatment approachesScale scoreTreatment interventionsComparative effectivenessSynthetic opioidsCocaine useIntegrative data analysisNIDA CTNDeath rateBehavioral interventionsUse severityCTN studiesCocainePhencyclidine Positivity on Urine Drug Screening in Patients Treated for Alcohol Withdrawal on a Dual-diagnosis Medically Assisted Withdrawal Unit
Wang P, Dore S, Weleff J, Butler R, Barnett B. Phencyclidine Positivity on Urine Drug Screening in Patients Treated for Alcohol Withdrawal on a Dual-diagnosis Medically Assisted Withdrawal Unit. Journal Of Addiction Medicine 2023, 17: 695-701. PMID: 37934534, DOI: 10.1097/adm.0000000000001217.Peer-Reviewed Original ResearchConceptsAlcohol withdrawalLength of stayPCP-positiveDual diagnosisMultivariate logistic regressionAlcohol use disorderRisk of readmissionToxicological screeningLogistic regressionRetrospective study of patientsSurvival analysisUrine drug screensUrine toxicology screenWithdrawing unitUse disorderAdmission toxicology screeningStudy of patientsCocaine positivityStatistically significant associationPhencyclidineMultivariate linear regression modelPCPRetrospective studyUnivariate testsCocaine
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