2025
Clinical Utility Findings of a Transcriptomic Psoriasis Biologic Test Demonstrate Altered Physician Prescribing Behavior and Improved Patient Outcomes
Strober B, Bukhalo M, Armstrong A, Pariser D, Kircik L, Johnson B, Montgomery P, Dickerson T. Clinical Utility Findings of a Transcriptomic Psoriasis Biologic Test Demonstrate Altered Physician Prescribing Behavior and Improved Patient Outcomes. Dermatology And Therapy 2025, 15: 1787-1796. PMID: 40349264, PMCID: PMC12126387, DOI: 10.1007/s13555-025-01441-y.Peer-Reviewed Original ResearchImprove patient outcomesPatient outcomesPrescribing behaviorStatistical analysis of concordanceTreatment-as-usual armPhysician prescribing behaviorWeek 4Clinical utilityBiologic drug classesDermal biomarker patchPhysician behaviorAnalysis of patientsManagement of patientsManagement of psoriasisUtilization findingsFisher's exact testHealthcare systemMedication changesInclusion of mindfulnessPhysiciansPsoriasis AreaPatient responseProspective studyLesional skinClinical endpointsLow Stability and Specificity of Polygenic Risk Scores for Major Psychiatric Disorders Limit their Clinical Utility
Mollon J, Schultz L, Knowles E, Jacquemont S, Glahn D, Almasy L. Low Stability and Specificity of Polygenic Risk Scores for Major Psychiatric Disorders Limit their Clinical Utility. Biological Psychiatry 2025 PMID: 40113122, DOI: 10.1016/j.biopsych.2025.03.006.Peer-Reviewed Original ResearchAlcohol use disorderPolygenic risk scoresSchizophrenia polygenic risk scoresPercentage of individualsHigh riskDepressive disorderLack of clinical utilityUse disorderValidity of polygenic risk scoresSchizophreniaClinical utilityMDDRisk scoreEffect sizeSNP effect sizesWhite British individualsDisordersHigh-risk individualsUK BiobankType 2 diabetesBritish individualsPRS-CSIndividualsT2DPsychiatryStandard to Handheld: A New Wave in Thoracic Ultrasound and Patient Care—A Direct Comparison of Portable Handheld Against Standard in Thoracic Ultrasound
Halim D, Kelly A, Hayes J, Bennett K, Tzouvelekis A, Ampazis D, Sampsonas F. Standard to Handheld: A New Wave in Thoracic Ultrasound and Patient Care—A Direct Comparison of Portable Handheld Against Standard in Thoracic Ultrasound. Medicina 2025, 61: 313. PMID: 40005430, PMCID: PMC11857366, DOI: 10.3390/medicina61020313.Peer-Reviewed Original ResearchConceptsLevels of experienceNon-inferiorityPortable ultrasound deviceOverall image qualityLung pathologyUltrasound deviceInterquartile rangeRespiratory departmentThoracic ultrasoundAnatomical visualizationHandheld ultrasound devicePatient careImprove healthcareOperator's level of experienceNo significant differenceLikert scaleTrainee levelStatistically significant variablesDiagnostic accuracyClinical decisionsOverall perceptionOnline questionnaireClinical utilityMedian rateClinical settingSerial Lactate in Clinical Medicine - A Narrative Review.
Falter F, Tisherman S, Perrino A, Kumar A, Bush S, Nordström L, Pathan N, Liu R, Mebazaa A. Serial Lactate in Clinical Medicine - A Narrative Review. Journal Of Intensive Care Medicine 2025, 8850666241303460. PMID: 39925111, DOI: 10.1177/08850666241303460.Peer-Reviewed Original ResearchResponse to therapyWarning ScoreAcute clinical areasHospital IT systemsElectronic patient recordsPoint of careNursing workforceClinical medicineDeteriorating patientsClinical areasSerial lactateMultidisciplinary groupHospital areasPrognostic guidePatient recordsLactate clearanceTreatment decisionsClinical utilityIntensive careEmergency roomPatient statusLactate levelsDisciplines of clinical medicineTherapyOperating roomNew diagnosis in psychiatry: beyond heuristics
McGorry P, Hickie I, Kotov R, Schmaal L, Wood S, Allan S, Altınbaş K, Boyce N, Bringmann L, Caspi A, Cuthbert B, Gawęda Ł, Groen R, Guloksuz S, Hartmann J, Krueger R, Mei C, Nieman D, Öngür D, Raballo A, Scheffer M, Schreuder M, Shah J, Wigman J, Yuen H, Nelson B. New diagnosis in psychiatry: beyond heuristics. Psychological Medicine 2025, 55: e26. PMID: 39911018, PMCID: PMC12017357, DOI: 10.1017/s003329172400223x.Peer-Reviewed Original ResearchConceptsHierarchical Taxonomy of PsychopathologyMechanisms of mental disordersTaxonomy of PsychopathologyResearch Domain CriteriaTransdiagnostic modelTransdiagnostic researchMental disordersHierarchical taxonomyCategorical approachMental healthRDoCHiTOPPsychiatryNosologyResearch utilizationClinical utilityParadigmPsychopathologyHeuristic modelDSMDisordersIllnessResearchNew diagnosesClinicDevelopment of a Clinical and Ultrasonic Parameter-Based Nomogram Model to Predict Restenosis after Superficial Femoral Artery Stenting
Wang Y, Gao M, Zhao X, Han P, Zhang L, Dardik A. Development of a Clinical and Ultrasonic Parameter-Based Nomogram Model to Predict Restenosis after Superficial Femoral Artery Stenting. Annals Of Vascular Surgery 2025, 113: 175-185. PMID: 39855385, DOI: 10.1016/j.avsg.2024.12.068.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAlloysDecision Support TechniquesEndovascular ProceduresFemaleFemoral ArteryHumansMaleMiddle AgedNomogramsPeripheral Arterial DiseasePredictive Value of TestsRecurrenceReproducibility of ResultsRetrospective StudiesRisk AssessmentRisk FactorsSelf Expandable Metallic StentsStentsTime FactorsTreatment OutcomeConceptsIn-stent restenosisSuperficial femoral arteryDecision curve analysisSuperficial femoral artery stentingLogistic regression analysisPeripheral arterial diseaseReceiver operating characteristicNomogram modelClinical utilityCurve analysisMultivariate logistic regression analysisSelf-expanding bare nitinol stentsTreated with stentingReceiver operating characteristic curveRisk of in-stent restenosisNomogram's clinical utilityBare nitinol stentsPrediction of in-stent restenosisExcellent discriminatory powerRegression analysisFemoral artery stentingArtery flow rateRetrospective studyTraining cohortSFA stenting
2024
Pre-natal and post-natal screening and testing in neonatal abstinence syndrome
Ostfeld-Johns S. Pre-natal and post-natal screening and testing in neonatal abstinence syndrome. Seminars In Perinatology 2024, 49: 152009. PMID: 39603974, DOI: 10.1016/j.semperi.2024.152009.Peer-Reviewed Original ResearchSubstance useSubstance use disorder diagnosisEvidence of clinical utilityDecrease stigmaDelivery hospitalizationsBirthing personsHealthcare providersIncreased stigmaCompassionate communicationPrenatal visitHealthcare systemNeonatal abstinence syndromePromote engagementPotential withdrawal symptomsPost-natal screeningRisk of withdrawalToxicology testingDisorder diagnosisAbstinence syndromeHealthcareStigmaWithdrawal symptomsFamily environmentClinical utilityNewbornsIs Clot Composition Associated With Cause of Stroke? A Systematic Review and Meta‐Analysis
Sujijantarat N, Templeton K, Antonios J, Renedo D, Koo A, Haynes J, Fathima B, Amllay A, Nowicki K, Huttner A, Giles J, Navaratnam D, Sansing L, Hebert R, King J, Matouk C. Is Clot Composition Associated With Cause of Stroke? A Systematic Review and Meta‐Analysis. Stroke Vascular And Interventional Neurology 2024, 4 DOI: 10.1161/svin.124.001426.Peer-Reviewed Original ResearchCause of strokeRed blood cellsWhite blood cellsBlood cellsMechanical thrombectomyCardioembolic groupHistological compositionMeta-analysisLow red blood cellQuantity of red blood cellsRandom-effects meta-analysisAcute ischemic strokeEffects meta-analysisEnglish-language articlesMean percentage differenceAdult patientsMEDLINE databaseCochrane LibraryClinical utilityIschemic strokeLanguage articlesPatientsPercentage differenceArteryCellular compositionThe Clinical Utility of Pulmonary Function Tests in the Diagnosis and Characterization of Central Airway Obstruction: A Narrative Review
Ampazis D, Vlachakos V, Anagnostopoulos N, Tzouvelekis A, Sampsonas F. The Clinical Utility of Pulmonary Function Tests in the Diagnosis and Characterization of Central Airway Obstruction: A Narrative Review. Journal Of Clinical Medicine 2024, 13: 6299. PMID: 39518438, PMCID: PMC11546877, DOI: 10.3390/jcm13216299.Peer-Reviewed Original ResearchClinical utility of upfront liquid biopsy in non-small cell lung cancer in the community setting.
Doro L, Ozcan G, Vredenburgh J, Collier E. Clinical utility of upfront liquid biopsy in non-small cell lung cancer in the community setting. Journal Of Clinical Oncology 2024, 20: 316-316. DOI: 10.1200/op.2024.20.10_suppl.316.Peer-Reviewed Original ResearchNon-small cell lung cancerNon-small cell lung cancer patientsCell lung cancerLiquid biopsyAdvanced non-small cell lung cancerLung cancerDiagnosis of advanced non-small cell lung cancerDiagnosed NSCLCNext generation sequencingMolecular profilingClinical utilityLiquid biopsy resultsComprehensive molecular profilingTarget genetic abnormalitiesKRAS G12C mutationProportion of patientsProgression of eGFRPartial responsePlasma genotypingBiopsy resultsBRCA carriersTreatment failureOncoKB databaseSystemic treatmentActionable mutationsStrength of evidence underlying the CMS-FDA parallel review of comprehensive genomic profiling tests in the cancer setting
Stackland S, Schnabel D, Dinan M, Presley C, Gross C. Strength of evidence underlying the CMS-FDA parallel review of comprehensive genomic profiling tests in the cancer setting. Journal Of The National Cancer Institute 2024, 117: 144-151. PMID: 39288939, PMCID: PMC11717411, DOI: 10.1093/jnci/djae196.Peer-Reviewed Original ResearchComprehensive genomic profilingComprehensive genomic profiling testCenter for Medical Technology PolicyClinical careClinical outcomesDiagnostic testsAssessed clinical outcomesOutcomes of patientsStrength of evidenceCourse of clinical careEfficacy of diagnostic testsNovel diagnostic testsPeer-reviewed literatureGenomic profiling testsFoundationOne CDxGenomic testingSolid tumorsStudy designGenomic alterationsGenomic profilingF1CDxCancer settingClinical utilityCancer typesCompare groupsFactor VIII Levels and ISTH Disseminated Intravascular Coagulation Scores Do Not Distinguish Disseminated Intravascular Coagulation from the Coagulopathy of Liver Disease
Allen C, Heskel M, Butt A, Tormey C, Pine A, Lee A, Gautam S. Factor VIII Levels and ISTH Disseminated Intravascular Coagulation Scores Do Not Distinguish Disseminated Intravascular Coagulation from the Coagulopathy of Liver Disease. Acta Haematologica 2024, 148: 220-225. PMID: 39004080, PMCID: PMC12106121, DOI: 10.1159/000540239.Peer-Reviewed Original ResearchISTH DIC scoreFactor VIII levelsArea under the curveDIC scoreLiver diseaseFactor VIIIRetrospective chart review of patientsChart review of patientsCoagulopathy of liver diseaseReview of patientsRetrospective chart reviewCalculate area under the curveReceiver operating characteristic curveMultiple logistic regressionISTH scoreLaboratory parametersClinical challengeClinical utilityPatientsCharacteristic curveLab variablesLogistic regressionLiverDiseaseDiagnostic toolPrediction models for risk assessment of surgical site infection after spinal surgery: A systematic review
Lauinger A, Blake S, Fullenkamp A, Polites G, Grauer J, Arnold P. Prediction models for risk assessment of surgical site infection after spinal surgery: A systematic review. North American Spine Society Journal (NASSJ) 2024, 19: 100518. PMID: 39253699, PMCID: PMC11382011, DOI: 10.1016/j.xnsj.2024.100518.Peer-Reviewed Original ResearchSurgical site infectionPreoperative risk modelSpinal surgerySite infectionAdverse eventsAssessment of surgical site infectionACS NSQIP surgical risk calculatorPostoperative surgical site infectionNSQIP surgical risk calculatorRate of adverse eventsSpine surgery patientsRisk of adverse eventsStratify patient riskSurgical risk calculatorField of spine surgeryClinical prediction toolSpine surgeryRisk modelSurgery patientsSurgeryAddressing factorsPatient riskClinical utilitySystematic reviewUnique susceptibilityHypermethylated TAGMe as a universal-cancer-only methylation marker and its application in diagnosis and recurrence monitoring of urothelial carcinoma
Yang Z, Chen Q, Dong S, Xu P, Zheng W, Mao Z, Qian C, Zheng X, Dai L, Wang C, Shi H, Li J, Yuan J, Yu W, Xu C. Hypermethylated TAGMe as a universal-cancer-only methylation marker and its application in diagnosis and recurrence monitoring of urothelial carcinoma. Journal Of Translational Medicine 2024, 22: 608. PMID: 38956589, PMCID: PMC11218302, DOI: 10.1186/s12967-024-05420-3.Peer-Reviewed Original ResearchConceptsRecurrence monitoringMethodsThe methylation levelsIndicator of recurrenceBackgroundUrothelial carcinomaClinical recurrenceUrothelial carcinomaBenign diseaseUrological malignanciesPostoperative surveillanceUC diagnosisUC patientsTraining cohortUrothelial markersValidation cohortRecurrenceClinical scenariosUrinary systemClinical utilityCarcinomaMethylation markersPatientsUrine samplesTissue samplesUrineDiagnosisApplications of MRI in Schizophrenia: Current Progress in Establishing Clinical Utility
Sun H, Liu N, Qiu C, Tao B, Yang C, Tang B, Li H, Zhan K, Cai C, Zhang W, Lui S. Applications of MRI in Schizophrenia: Current Progress in Establishing Clinical Utility. Journal Of Magnetic Resonance Imaging 2024, 61: 616-633. PMID: 38946400, DOI: 10.1002/jmri.29470.Peer-Reviewed Original ResearchMagnetic resonance imagingTreatment outcome of schizophreniaOutcome of schizophreniaSevere mental illnessSchizophrenia patientsSchizophreniaIllness onsetPredicting symptomsBrain abnormalitiesClinical utilityMental illnessTreatment outcomesDecades of researchFindings of magnetic resonance imagingScreening high-risk individualsLife of affected individualsHigh-risk individualsPromote clinical translationResonance imagingIncreased mortality rateResponse processApplication of magnetic resonance imagingSymptomsPrognostic toolResearch findingsAssessment of Days Alive Out of Hospital as a Possible End Point in Trials of Stroke Prevention for Atrial Fibrillation: A ROCKET AF Analysis
Harrington J, Hellkamp A, Mahaffey K, Breithardt G, Halperin J, Hankey G, Becker R, Nessel C, Berkowitz S, Fox K, Singer D, Goodman S, Patel M, Piccini J. Assessment of Days Alive Out of Hospital as a Possible End Point in Trials of Stroke Prevention for Atrial Fibrillation: A ROCKET AF Analysis. Journal Of The American Heart Association 2024, 13: e028951. PMID: 38780169, PMCID: PMC11255646, DOI: 10.1161/jaha.122.028951.Peer-Reviewed Original ResearchAtrial fibrillationROCKET AFClinical trialsEnd pointsLow overall event ratesInternational double-blindClinical trials of interventionsRandomized clinical trialsAssessment of dayOverall event rateDouble-blindAnticoagulation trialsTreatment armsIncreased riskWarfarinTrials of interventionsClinical utilityTreatment groupsEvent ratesPatientsDAOHPoisson regressionComorbiditiesFibrillationTrialsPalm‐Sized Lab‐In‐A‐Magnetofluidic Tube Platform for Rapid and Sensitive Virus Detection
Li Z, Zhang S, Zhang J, Avery L, Banach D, Zhao H, Liu C. Palm‐Sized Lab‐In‐A‐Magnetofluidic Tube Platform for Rapid and Sensitive Virus Detection. Advanced Science 2024, 11: 2310066. PMID: 38634211, PMCID: PMC11187901, DOI: 10.1002/advs.202310066.Peer-Reviewed Original ResearchDetect SARS-CoV-2Molecular diagnostics of infectious diseasesMolecular diagnosticsMolecular detection of virusesSARS-CoV-2Point-of-care molecular diagnosticsDiagnostics of infectious diseasesNucleic acid extractionMolecular detection methodsViral lysisNucleic acid sample preparationSensitive molecular diagnosticsAccurate molecular diagnosticsCRISPR detectionEarly treatmentSensitive virus detectionDetection of virusesClinical utilityNucleic acid amplificationHIV virusEarly treatment of diseaseIsothermal amplificationMagnetic beadsMicrocentrifuge tubesClinical samplesIntrinsic RNA Targeting Triggers Indiscriminate DNase Activity of CRISPR‐Cas12a
Zhang J, Li Z, Guo C, Guan X, Avery L, Banach D, Liu C. Intrinsic RNA Targeting Triggers Indiscriminate DNase Activity of CRISPR‐Cas12a. Angewandte Chemie International Edition 2024, 63: e202403123. PMID: 38516796, PMCID: PMC11073899, DOI: 10.1002/anie.202403123.Peer-Reviewed Original ResearchProtospacer adjacent motifTrans-cleavage activityUniversal assayCRISPR-Cas12a systemSingle-stranded DNAClinical samplesRNA substratesAdjacent motifRNA targetsRNA sensingDNA targetsNucleic acid detectionCas12a assayTranscription stepDNARNAMolecular diagnosticsHPV-16 DNADNA activityNucleic acid testingAcid detectionAssayHIV RNAClinical utilityProtospacerIntrinsic RNA Targeting Triggers Indiscriminate DNase Activity of CRISPR‐Cas12a
Zhang J, Li Z, Guo C, Guan X, Avery L, Banach D, Liu C. Intrinsic RNA Targeting Triggers Indiscriminate DNase Activity of CRISPR‐Cas12a. Angewandte Chemie 2024, 136 DOI: 10.1002/ange.202403123.Peer-Reviewed Original ResearchProtospacer adjacent motifTrans-cleavage activityUniversal assayCRISPR-Cas12a systemSingle-stranded DNAClinical samplesRNA substratesAdjacent motifRNA targetsRNA sensingDNA targetsNucleic acid detectionCas12a assayTranscription stepDNARNAMolecular diagnosticsHPV-16 DNADNA activityNucleic acid testingAcid detectionAssayHIV RNAClinical utilityProtospacerIn‐person validation of the Ichthyosis Scoring System
Echeandia‐Francis C, Sun Q, Asch S, Bayart C, Benjamin L, Cipriano S, Craiglow B, Dyer J, Levy M, Lilly E, Newell B, Liang J, Gan G, Deng Y, Paller A, Choate K. In‐person validation of the Ichthyosis Scoring System. Pediatric Dermatology 2024, 41: 247-252. PMID: 38234066, DOI: 10.1111/pde.15508.Peer-Reviewed Original ResearchInterrater intraclass correlation coefficientsIntrarater reliabilityIn-personIntraclass correlation coefficientIn-person evaluationContent validityInterrater reliabilityHeterogeneous group of skin disordersGroup of skin disordersIntraraterMedical professionalsInterrater agreementErythema evaluationIchthyosis subtypesPhotographic evaluationErythema scoreInterraterErythemaQuantify severitySkin disordersClinical utilityIchthyosisScoring systemHeterogeneous groupCorrelation coefficient
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