2025
Governance Considerations for Point-of-Care Ultrasound: a HIMSS-SIIM Enterprise Imaging Community Whitepaper in Collaboration with AIUM
Ma I, Francavilla M, Nomura J, Kielski A, Fernandez F, Piro K, Liu R, Valenzuela J, Toland M, Koehler J, Cohen G, Eid M, Choi W, Nolan J, Ferre R, McBee M, Kummer T, Lanspa M, Brown J, DeStigter K, Desyatnikova S, Bottemiller A. Governance Considerations for Point-of-Care Ultrasound: a HIMSS-SIIM Enterprise Imaging Community Whitepaper in Collaboration with AIUM. Journal Of Imaging Informatics In Medicine 2025, 1-15. DOI: 10.1007/s10278-024-01365-7.Peer-Reviewed Original ResearchEnterprise imagePoint-of-care ultrasoundWorkflow solutionTechnology governanceWorkflow needsInformation governancePatient care outcomesPoint-of-careUnique workflowCare outcomesClinical governancePoint-of-care ultrasound imagingHealthcare settingsHealthcare systemOperational efficiencyImagesImplementationInformationHealthcareEducational requirementsGovernance committeeClinical informationInstitutional policiesWorkflowGovernance Considerations for Point-of-Care Ultrasound: a HIMSS-SIIM Enterprise Imaging Community Whitepaper in Collaboration with AIUM.
Ma I, Francavilla M, Nomura J, Kielski A, Fernandez F, Piro K, Liu R, Valenzuela J, Toland M, Koehler J, Cohen G, Eid M, Choi W, Nolan J, Ferre R, McBee M, Kummer T, Lanspa M, Brown J, DeStigter K, Desyatnikova S, Bottemiller A. Governance Considerations for Point-of-Care Ultrasound: a HIMSS-SIIM Enterprise Imaging Community Whitepaper in Collaboration with AIUM. Journal Of Imaging Informatics In Medicine 2025 PMID: 39753828, DOI: 10.1007/s10278-024-01365-7.Peer-Reviewed Original ResearchEnterprise imagePoint-of-care ultrasoundWorkflow solutionTechnology governanceWorkflow needsInformation governancePatient care outcomesPoint-of-careUnique workflowCare outcomesClinical governancePoint-of-care ultrasound imagingHealthcare settingsHealthcare systemOperational efficiencyImagesImplementationInformationHealthcareEducational requirementsGovernance committeeClinical informationInstitutional policiesWorkflow
2024
Lost in the Ds: Unexplained Loss of Rh(D) Antigen Expression By Serological Testing In Two Patients
Carmichael G, Lee E, Tormey C, Yurtsever N, Shah B, Bizzario L. Lost in the Ds: Unexplained Loss of Rh(D) Antigen Expression By Serological Testing In Two Patients. American Journal Of Clinical Pathology 2024, 162: s148-s148. DOI: 10.1093/ajcp/aqae129.329.Peer-Reviewed Original ResearchPeripheral blood smearRed blood cellsPolymerase chain reactionD+ red blood cellsPost stem cell transplantationD antigenMetastatic breast cancerSerological testsRed blood cell genotypingBlood cellsBlood smearsAnti-D formationRhD blood typeMyelodysplastic syndromeCell transplantationSmear resultsBreast cancerGenotypic findingsStandard polymerase chain reactionRBC genotypingRhD antigenMedical recordsCase 2Clinical informationElectronic medical recordsChanges in cerebrospinal fluid proteins across the spectrum of untreated and treated chronic HIV-1 infection
Hu Z, Cinque P, Dravid A, Hagberg L, Yilmaz A, Zetterberg H, Fuchs D, Gostner J, Blennow K, Spudich S, Kincer L, Zhou S, Joseph S, Swanstrom R, Price R, Gisslén M. Changes in cerebrospinal fluid proteins across the spectrum of untreated and treated chronic HIV-1 infection. PLOS Pathogens 2024, 20: e1012470. PMID: 39316609, PMCID: PMC11469498, DOI: 10.1371/journal.ppat.1012470.Peer-Reviewed Original ResearchConceptsHIV-1 infectionHIV-associated dementiaCerebrospinal fluidCerebrospinal fluid proteinCerebrospinal fluid HIV-1 RNAImpact of HIV-1 infectionTreating chronic HIV-1 infectionChronic HIV-1 infectionHIV-1 RNAHIV-1 progressionTreat chronic infectionsInflammatory cell lineagesNeurofilament light chain proteinCSF escapeChronic infectionHIV-1Light chain proteinProtein changesClinical centersCNS injuryCSF proteinClinical informationCell lineagesInfectionCerebrospinal fluid proteomeRetinal integrity in human babesiosis: a pilot study
Dionne E, Adelman R, Cekic O, Golden M, Moffarah A, Krause P, Farhadian S. Retinal integrity in human babesiosis: a pilot study. BMC Ophthalmology 2024, 24: 310. PMID: 39048971, PMCID: PMC11267664, DOI: 10.1186/s12886-024-03568-6.Peer-Reviewed Original ResearchConceptsEvidence of retinopathyNo study patientRetina of patientsCohort of patientsAbnormal vessel formationComplication of babesiosisRetinal tearsRetinal inflammationRetinal eye examResultsTen patientsRetinal integrityRetinal examinationRetinal bleedingIndirect ophthalmoscopeRetinal abnormalitiesStudy patientsChart reviewCase reportEye examPilot studyPatientsAnimal studiesSmall studyClinical informationHuman babesiosisIncreased Patient Engagement with Utilization of Online Cryomanagement Platform
Lynch C, Pandolfi E, Walimbe P, Ng C, Gonsalez S, Desai V. Increased Patient Engagement with Utilization of Online Cryomanagement Platform. Reproductive BioMedicine Online 2024, 48: 104062. DOI: 10.1016/j.rbmo.2024.104062.Peer-Reviewed Original Research
2023
DEMENTIA STAGING, NEUROPSYCHIATRIC SYMPTOMS, AND DIVORCE OR SEPARATION IN LATE LIFE: A CASE CONTROL STUDY
Monin J, McAvay G, Zang E, Vander Wyck B, Carrión C, Allore H. DEMENTIA STAGING, NEUROPSYCHIATRIC SYMPTOMS, AND DIVORCE OR SEPARATION IN LATE LIFE: A CASE CONTROL STUDY. Innovation In Aging 2023, 7: 94-95. PMCID: PMC10735856, DOI: 10.1093/geroni/igad104.0307.Peer-Reviewed Original ResearchAlzheimer's Disease Research CenterCase-control studyNational Alzheimer's Coordinating CenterDisease Research CenterNPI symptomsDivorce/separationCoordinating CenterAgitation/aggressionDepression/dysphoriaAdjusted odds ratioDementia stagingConditional logistic regressionStages of dementiaCase/control statusInitial visitNeuropsychiatric symptomsOdds ratioNPI scoresMarried casesStandardized clinical informationClinical informationGreater oddsBehavioral symptomsControl studyControl status1494. Impact of Polypharmacy on Gait Speed and Falls in Older People Living with HIV.
Kosana P, Wu K, Tassiopoulos K, Letendre S, Ma Q, Erlandson K, Farhadian S. 1494. Impact of Polypharmacy on Gait Speed and Falls in Older People Living with HIV. Open Forum Infectious Diseases 2023, 10: ofad500.1329. PMCID: PMC10677239, DOI: 10.1093/ofid/ofad500.1329.Peer-Reviewed Original ResearchSlow gait speedGait speedPrescription medicationsLogistic regression modelsStudy participantsMedical comorbiditiesRecurrent fallsOlder PWHIncreased oddsClinical informationOlder peopleAntiretroviral drug useImpact of polypharmacyManagement of polypharmacyHigher CD4 countsNumber of comorbiditiesPlasma viral loadPercent of participantsCross-sectional analysisSelf-reported raceGeriatric outcomesLow CD4Medication burdenCD4 countCD8 ratioDetection of Intracerebral Hemorrhage Using Low-Field, Portable Magnetic Resonance Imaging in Patients With Stroke
Mazurek M, Parasuram N, Peng T, Beekman R, Yadlapalli V, Sorby-Adams A, Lalwani D, Zabinska J, Gilmore E, Petersen N, Falcone G, Sujijantarat N, Matouk C, Payabvash S, Sze G, Schiff S, Iglesias J, Rosen M, de Havenon A, Kimberly W, Sheth K. Detection of Intracerebral Hemorrhage Using Low-Field, Portable Magnetic Resonance Imaging in Patients With Stroke. Stroke 2023, 54: 2832-2841. PMID: 37795593, PMCID: PMC11103256, DOI: 10.1161/strokeaha.123.043146.Peer-Reviewed Original ResearchExamining sociodemographic correlates of opioid use, misuse, and use disorders in the All of Us Research Program.
Yeh H, Peltz-Rauchman C, Johnson C, Pawloski P, Chesla D, Waring S, Stevens A, Epstein M, Joseph C, Miller-Matero L, Gui H, Tang A, Boerwinkle E, Cicek M, Clark C, Cohn E, Gebo K, Loperena R, Mayo K, Mockrin S, Ohno-Machado L, Schully S, Ramirez A, Qian J, Ahmedani B. Examining sociodemographic correlates of opioid use, misuse, and use disorders in the All of Us Research Program. PLOS ONE 2023, 18: e0290416. PMID: 37594966, PMCID: PMC10437856, DOI: 10.1371/journal.pone.0290416.Peer-Reviewed Original ResearchConceptsOpioid use disorderOpioid usePrescription opioidsElectronic health recordsReduced oddsDiagnosis of OUDSociodemographic characteristicsPrevalence of OUDNonmedical useLifetime opioid useEHR dataNon-Hispanic white participantsImportant clinical informationNon-medical useLifetime prevalenceStreet opioidsHigher oddsOpioidsClinical informationUse disordersUs Research ProgramSociodemographic correlatesLogistic regressionPrevalenceHealth recordsAssociations between dementia staging, neuropsychiatric behavioral symptoms, and divorce or separation in late life: A case control study
Monin J, McAvay G, Zang E, Vander Wyk B, Carrión C, Allore H. Associations between dementia staging, neuropsychiatric behavioral symptoms, and divorce or separation in late life: A case control study. PLOS ONE 2023, 18: e0289311. PMID: 37585365, PMCID: PMC10431668, DOI: 10.1371/journal.pone.0289311.Peer-Reviewed Original ResearchConceptsAdjusted odds ratioAlzheimer's Disease Research CenterAgitation/aggressionDepression/dysphoriaCase-control studyElation/euphoriaNational Alzheimer's Coordinating CenterDisease Research CenterBehavioral symptomsDivorce/separationOlder adultsCoordinating CenterDementia stagingConditional logistic regressionStages of dementiaCase/control statusInitial visitOdds ratioIndividual symptomsNPI scoresStandardized clinical informationClinical informationMarried casesGreater oddsControl studyPaper 29: Untreated Type 4 Ramp Injuries at Index Anterior Cruciate Ligament Reconstruction Surgery Result in Higher Rates of Revision ACL-R within the First 2 Years
Green J, Moran J, Medvecky M, Katz L, Gardner E, Joo P, Wang A, Allen C, Jimenez A, Santos E, McLaughlin W. Paper 29: Untreated Type 4 Ramp Injuries at Index Anterior Cruciate Ligament Reconstruction Surgery Result in Higher Rates of Revision ACL-R within the First 2 Years. Orthopaedic Journal Of Sports Medicine 2023, 11: 2325967123s00055. PMCID: PMC10392483, DOI: 10.1177/2325967123s00055.Peer-Reviewed Original ResearchRamp lesionsRevision ACLACL reconstructionACL tearsRAMP groupRevision surgeryRisk factorsLevel I academic centerInitial ACL reconstructionMeniscal ramp lesionsRetrospective chart reviewSignificant biomechanical changesHigh rateStudent's t-testConcomitant ACLAssociated injuriesChart reviewPatient ageSurgery resultsPreoperative MRIClinical dataClinical informationLesions intraAcademic centersPatientsApproach to the liver biopsy diagnosis of adult cholangiopathies
Nalbantoglu I, Misdraji J. Approach to the liver biopsy diagnosis of adult cholangiopathies. Diagnostic Histopathology 2023, 29: 23-35. DOI: 10.1016/j.mpdhp.2022.10.004.Commentaries, Editorials and LettersPrimary biliary cholangitisChronic biliary disordersBiliary cholangitisBiliary disordersPrimary sclerosing cholangitisLiver biopsy diagnosisAutoimmune hepatitisSclerosing cholangitisAdult patientsInflammatory variantClinical featuresHistologic featuresHistologic findingsBiopsy diagnosisDifferential diagnosisCholangitisCorrect diagnosisCholangiopathyClinical informationCareful assessmentDiagnosisDisordersWide spectrumVast majorityHepatitis
2022
Recommended practices and ethical considerations for natural language processing‐assisted observational research: A scoping review
Fu S, Wang L, Moon S, Zong N, He H, Pejaver V, Relevo R, Walden A, Haendel M, Chute C, Liu H. Recommended practices and ethical considerations for natural language processing‐assisted observational research: A scoping review. Clinical And Translational Science 2022, 16: 398-411. PMID: 36478394, PMCID: PMC10014687, DOI: 10.1111/cts.13463.Peer-Reviewed Original ResearchConceptsWorld Health OrganizationElectronic health recordsNatural language processingObservational clinical studyReporting guidelinesObservational researchStandardized reporting guidelinesClinical studiesObservational studyClinical informationNLP methodologyClinical researchHealth OrganizationHealth recordsBiallelic PRMT7 pathogenic variants are associated with a recognizable syndromic neurodevelopmental disorder with short stature, obesity, and craniofacial and digital abnormalities
Cali E, Suri M, Scala M, Ferla M, Alavi S, Faqeih E, Bijlsma E, Wigby K, Baralle D, Mehrjardi M, Schwab J, Platzer K, Steindl K, Hashem M, Jones M, Niyazov D, Jacober J, Littlejohn R, Weis D, Zadeh N, Rodan L, Goldenberg A, Lecoquierre F, Dutra-Clarke M, Horvath G, Young D, Orenstein N, Bawazeer S, Silfhout A, Herenger Y, Dehghani M, Seyedhassani S, Bahreini A, Nasab M, Ercan-Sencicek A, Firoozfar Z, Movahedinia M, Efthymiou S, Striano P, Karimiani E, Salpietro V, Taylor J, Redman M, Stegmann A, Laner A, Abdel-Salam G, Li M, Bengala M, Müller A, Digilio M, Rauch A, Gunel M, Titheradge H, Schweitzer D, Kraus A, Valenzuela I, McLean S, Phornphutkul C, Salih M, Begtrup A, Schnur R, Torti E, Haack T, Prada C, Alkuraya F, Houlden H, Maroofian R. Biallelic PRMT7 pathogenic variants are associated with a recognizable syndromic neurodevelopmental disorder with short stature, obesity, and craniofacial and digital abnormalities. Genetics In Medicine 2022, 25: 135-142. PMID: 36399134, PMCID: PMC10620944, DOI: 10.1016/j.gim.2022.09.016.Peer-Reviewed Original ResearchConceptsShort statureClinical characteristicsSyndromic neurodevelopmental disorderNeurodevelopmental disordersSevere developmental delay/intellectual disabilityPhenotypic spectrumDetailed clinical characteristicsDevelopmental delay/intellectual disabilityMain clinical characteristicsProminent supraorbital ridgesThin upper lipBroad nasal tipProtein arginine methyltransferase 7Endocrine abnormalitiesEye abnormalitiesClinical informationIntellectual developmental disabilitiesPathogenic variantsShort noseVariable findingsNatural historyBifrontal narrowingNasal tipUpper lipLower lipNIMG-04. LONGITUDINAL TRACKING OF PERITUMORAL EDEMA VOLUME USING PACS-INTEGRATED TOOLS PROVIDES CRITICAL INFORMATION IN TREATMENT ASSESSMENT OF NSCLC BRAIN METASTASES AFTER RADIOSURGERY
Kaur M, Petersen G, von Reppert M, Jekel L, de Santo I, Varghese S, Chiang V, Aboian M. NIMG-04. LONGITUDINAL TRACKING OF PERITUMORAL EDEMA VOLUME USING PACS-INTEGRATED TOOLS PROVIDES CRITICAL INFORMATION IN TREATMENT ASSESSMENT OF NSCLC BRAIN METASTASES AFTER RADIOSURGERY. Neuro-Oncology 2022, 24: vii162-vii162. PMCID: PMC9661156, DOI: 10.1093/neuonc/noac209.624.Peer-Reviewed Original ResearchNSCLC brain metastasesPeritumoral edema volumeBrain metastasesEdema volumeLongest diameterGamma KnifeClinical practiceCE lesionsCommon intracranial malignancyStandard of careFLAIR hyperintense regionVolumetric measurementsIntracranial malignanciesEdema/Lung cancerTreatment responsePeritumoral volumesClinical informationPeritumoral edemaLongitudinal assessmentTreatment assessmentNeuroradiology practiceHyperintense regionsMetastasisLesionsMachine learning to predict abnormal myocardial perfusion from pre-test features
Miller RJH, Hauser MT, Sharir T, Einstein AJ, Fish MB, Ruddy TD, Kaufmann PA, Sinusas AJ, Miller EJ, Bateman TM, Dorbala S, Di Carli M, Huang C, Liang JX, Han D, Dey D, Berman DS, Slomka PJ. Machine learning to predict abnormal myocardial perfusion from pre-test features. Journal Of Nuclear Cardiology 2022, 29: 2393-2403. PMID: 35672567, PMCID: PMC9588501, DOI: 10.1007/s12350-022-03012-6.Peer-Reviewed Original ResearchConceptsAbnormal myocardial perfusionAbnormal perfusionMyocardial perfusionDiamond-Forrester modelCAD consortiumConsecutive patientsInternational registryPre-test informationSPECT-MPIClinical informationPhysician's decisionPatientsPerfusionTesting populationExpert visual interpretationRegistryPopulationMethodsWePhysiciansCytomorphologic features of SMARCA4‐deficient non–small cell lung carcinoma and correlation with immunohistochemical and molecular features
Sun T, Gilani SM, Podany P, Harigopal M, Zhong M, Wang H. Cytomorphologic features of SMARCA4‐deficient non–small cell lung carcinoma and correlation with immunohistochemical and molecular features. Cancer Cytopathology 2022, 130: 620-629. PMID: 35468657, DOI: 10.1002/cncy.22581.Peer-Reviewed Original ResearchConceptsNon-small cell lung carcinomaCell lung carcinomaCytomorphologic featuresLung carcinomaExtensive antibody panelHigh-grade featuresCommon cytologic featuresDifferent anatomic sitesVariable expressionMajority of casesSquamoid featuresCo-mutated genesUndifferentiated carcinomaImmunohistochemical profileGlandular featuresPapillary architectureAnatomic sitesCytologic featuresAggressive carcinomasClinical informationAntibody panelEpithelial markersScant cytoplasmCarcinomaNuclear enlargementAn Assessment of the Therapeutic Landscape for the Treatment of Heart Disease in the RASopathies
Yi JS, Perla S, Bennett AM. An Assessment of the Therapeutic Landscape for the Treatment of Heart Disease in the RASopathies. Cardiovascular Drugs And Therapy 2022, 37: 1193-1204. PMID: 35156148, PMCID: PMC11726350, DOI: 10.1007/s10557-022-07324-0.Peer-Reviewed Original ResearchConceptsRAS-MAPK pathwayRAS/mitogen-activated protein kinase (MAPK) pathwayMitogen-activated protein kinase pathwayPost-developmental processesProtein kinase pathwayHypertrophic cardiomyopathyKinase pathwayRASopathy patientsDevelopmental diseasesNoonan syndromeTreatment of HCMRASopathiesCardiofaciocutaneous syndromePathwayNeurofibromatosis type 1Cardiovascular defectsValvular abnormalitiesCardiovascular manifestationsHeart diseaseClinical informationCostello syndromeCongenital heartMultiple lentiginesTherapeutic landscapeAntineoplastic drugs
2021
The 2021 WHO Classification of Tumors of the Thymus and Mediastinum: What Is New in Thymic Epithelial, Germ Cell, and Mesenchymal Tumors?
Marx A, Chan JKC, Chalabreysse L, Dacic S, Detterbeck F, French CA, Hornick JL, Inagaki H, Jain D, Lazar AJ, Marino M, Marom EM, Moreira AL, Nicholson AG, Noguchi M, Nonaka D, Papotti MG, Porubsky S, Sholl LM, Tateyama H, Thomas de Montpréville V, Travis WD, Rajan A, Roden AC, Ströbel P. The 2021 WHO Classification of Tumors of the Thymus and Mediastinum: What Is New in Thymic Epithelial, Germ Cell, and Mesenchymal Tumors? Journal Of Thoracic Oncology 2021, 17: 200-213. PMID: 34695605, DOI: 10.1016/j.jtho.2021.10.010.Peer-Reviewed Original ResearchConceptsThymic epithelial tumorsGerm cell tumorsCell tumorsMesenchymal neoplasmsWHO classificationEpithelial tumorsMediastinal germ cell tumorsLow tumor mutational burdenTumor mutational burdenNew tumor entityClear cell carcinomaPositron emission tomographyClassification of tumorsThymic EpithelialThymic carcinomaFifth editionB3 thymomaTargetable mutationsCell carcinomaMesenchymal tumorsMetaplastic thymomaImmunohistochemical characterizationClinical informationMutational burdenDiagnostic advances
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