2024
Novel Mechanical Aspiration Thrombectomy in Patients With Acute Pulmonary Embolism: Results From the Prospective APEX-AV Trial
Ranade M, Foster M, Brady P, Sokol S, Butty S, Klein A, Maholic R, Safar A, Patel T, Zlotnick D, Gans D, Pollak J, Ferrera D, Stegman B, Basra S, Moriarty J, Keeling B, Investigators A. Novel Mechanical Aspiration Thrombectomy in Patients With Acute Pulmonary Embolism: Results From the Prospective APEX-AV Trial. Journal Of The Society For Cardiovascular Angiography & Interventions 2024, 4: 102463. PMID: 40061412, PMCID: PMC11887559, DOI: 10.1016/j.jscai.2024.102463.Peer-Reviewed Original ResearchAcute intermediate-risk PEMechanical aspiration thrombectomyIntermediate-risk PEPulmonary embolismAspiration thrombectomyRV/LV ratioClot burdenAdverse eventsMm HgLow rate of adverse eventsMean pulmonary artery pressureEnd pointsRate of adverse eventsAcute pulmonary embolismPulmonary artery pressureSafety end pointDevice-related deathsTreat pulmonary embolismSingle-arm studyEffectiveness end pointAccess site bleedingStatistically significant reductionCardiac injuryClinical deteriorationArterial pressureEarly Warning Scores With and Without Artificial Intelligence
Edelson D, Churpek M, Carey K, Lin Z, Huang C, Siner J, Johnson J, Krumholz H, Rhodes D. Early Warning Scores With and Without Artificial Intelligence. JAMA Network Open 2024, 7: e2438986. PMID: 39405061, PMCID: PMC11544488, DOI: 10.1001/jamanetworkopen.2024.38986.Peer-Reviewed Original ResearchConceptsEarly Warning ScoreWarning ScoreCohort studyYale New Haven Health SystemClinical deterioration eventsHigh-risk thresholdHealth systemRetrospective cohort studyPatient encountersDeteriorating patientsOverall PPVMain OutcomesInpatient encountersEDI scoresHospital encountersDeterioration eventsClinical deteriorationIntensive care unitEarly warning toolCare unitDecision support toolArtificial intelligenceScoresReceiver operating characteristic curveNEWS2
2022
NEIM-02 DEVELOPMENT OF A DEEP LEARNING MODEL FOR DISCRIMINATING TRUE PROGRESSION FROM PSEUDOPROGRESSION IN GLIOBLASTOMA PATIENTS
Moassefi M, Faghani S, Conte G, Rouzrokh P, Kowalchuk R, Trifiletti D, Erickson B. NEIM-02 DEVELOPMENT OF A DEEP LEARNING MODEL FOR DISCRIMINATING TRUE PROGRESSION FROM PSEUDOPROGRESSION IN GLIOBLASTOMA PATIENTS. Neuro-Oncology Advances 2022, 4: i17-i18. PMCID: PMC9354212, DOI: 10.1093/noajnl/vdac078.069.Peer-Reviewed Original ResearchMagnetic resonance imagingGlioblastoma patientsMedian overall survival rangesTreatment planningOriginal radiation fieldOverall survival rangesStandard treatment regimenConventional magnetic resonance imagingT2-weighted imagesPatient treatment plansDiagnosing PSPAdjuvant temozolomideConcurrent chemoradiotherapySurgical resectionEnhancing lesionsAggressive tumorsMultimodal treatmentTreatment regimenAggressive managementRecurrence locationTrue progressionClinical historyClinical deteriorationMedical historyClinical challengeGasdermin D-dependent platelet pyroptosis exacerbates NET formation and inflammation in severe sepsis
Su M, Chen C, Li S, Li M, Zeng Z, Zhang Y, Xia L, Li X, Zheng D, Lin Q, Fan X, Wen Y, Liu Y, Chen F, Luo W, Bu Y, Qin J, Guo M, Qiu M, Sun L, Liu R, Wang P, Hwa J, Tang WH. Gasdermin D-dependent platelet pyroptosis exacerbates NET formation and inflammation in severe sepsis. Nature Cardiovascular Research 2022, 1: 732-747. PMID: 35967457, PMCID: PMC9362711, DOI: 10.1038/s44161-022-00108-7.Peer-Reviewed Original ResearchToll-like receptor 4S100A8/A9Gasdermin DSevere sepsisNeutrophil extracellular trap formationPathology of sepsisRapid clinical deteriorationInflammatory cytokine releaseKey inflammatory cellsExtracellular trap formationGSDMD-deficient miceClinical deteriorationCecal ligationInflammatory cellsInflammatory cytokinesCytokine releaseReceptor 4SepsisExcessive releasePharmacological inhibitionGenetic ablationNET formationPyroptosisSignificant upregulationInflammation
2020
Education needed to improve antimicrobial use during end-of-life care of older adults with advanced cancer: A cross-sectional survey
Datta R, Topal J, McManus D, Sanft T, Dembry LM, Morrison LJ, Quagliarello V, Juthani-Mehta M. Education needed to improve antimicrobial use during end-of-life care of older adults with advanced cancer: A cross-sectional survey. Palliative Medicine 2020, 35: 236-241. PMID: 32928066, DOI: 10.1177/0269216320956811.Peer-Reviewed Original ResearchConceptsEscalation of careAdvance care planningLife careAdvanced cancerCross-sectional surveyIntravenous antimicrobialsOlder adultsAntimicrobial useCare planningSingle-center cross-sectional surveyEducational interventionAdvance care plansRole of antimicrobialsClinical deteriorationPercent of respondentsAdverse eventsOral antimicrobialsMedicine subspecialistsCare plansInpatient medicineCareCancerPatientsAdultsSubspecialistsSerum mitochondrial DNA predicts the risk of acute exacerbation and progression of idiopathic pulmonary fibrosis
Sakamoto K, Furukawa T, Yamano Y, Kataoka K, Teramachi R, Walia A, Suzuki A, Inoue M, Nakahara Y, Ryu C, Hashimoto N, Kondoh Y. Serum mitochondrial DNA predicts the risk of acute exacerbation and progression of idiopathic pulmonary fibrosis. European Respiratory Journal 2020, 57: 2001346. PMID: 32855220, PMCID: PMC8177039, DOI: 10.1183/13993003.01346-2020.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisAcute exacerbationPulmonary fibrosisDisease progressionFatal interstitial lung diseaseInterstitial lung diseaseSerum mitochondrial DNAAccepted biomarkersClinical deteriorationMedian survivalDeadly complicationDisease courseLethal complicationLung functionLung diseaseUnknown etiologyExacerbationUnmet needProgressionComplicationsRapid deteriorationPatientsFibrosisDevastating diseaseDiseaseNonepileptic Electroencephalographic Correlates of Episodic Increases in Intracranial Pressure
Sheikh ZB, Maciel CB, Dhakar MB, Hirsch LJ, Gilmore EJ. Nonepileptic Electroencephalographic Correlates of Episodic Increases in Intracranial Pressure. Journal Of Clinical Neurophysiology 2020, 39: 149-158. PMID: 32701765, DOI: 10.1097/wnp.0000000000000750.Peer-Reviewed Original ResearchBiliary Disease: Calculous and Acalculous Cholecystitis
Davis K, Ruangvoravat L. Biliary Disease: Calculous and Acalculous Cholecystitis. DeckerMed Critical Care Of The Surgical Patient 2020 DOI: 10.2310/7ccsp.8325.ChaptersBiliary diseaseAcalculous cholecystitisElective cholecystectomyClinical deteriorationHemodynamic compromiseSecondary insultsSymptomatic cholelithiasisIll patientsSignificant morbidityExcellent outcomesPrimary etiologyCholecystitisCholelithiasisPatientsGallbladderDiseaseVast majorityCholangitisCholecystectomyMorbidityIntensivistsInflammationEtiologyInfectionMortalityBiliary Disease: Calculous and Acalculous Cholecystitis
Davis K, Ruangvoravat L. Biliary Disease: Calculous and Acalculous Cholecystitis. DeckerMed Gastroenterology Hepatology And Endoscopy 2020 DOI: 10.2310/gastro.8325.ChaptersBiliary diseaseAcalculous cholecystitisElective cholecystectomyClinical deteriorationHemodynamic compromiseSecondary insultsSymptomatic cholelithiasisIll patientsSignificant morbidityExcellent outcomesPrimary etiologyCholecystitisCholelithiasisPatientsGallbladderDiseaseVast majorityCholangitisCholecystectomyMorbidityIntensivistsInflammationEtiologyInfectionMortalityDelayed blood transfusion is associated with mortality following radical cystectomy
Tan W, Wang Y, Trinh Q, Preston M, Kelly J, Hrouda D, Kibel A, Krasnow R, Liu J, Chung B, Chang S, Mossanen M. Delayed blood transfusion is associated with mortality following radical cystectomy. Scandinavian Journal Of Urology 2020, 54: 290-296. PMID: 32538224, DOI: 10.1080/21681805.2020.1777195.Peer-Reviewed Original ResearchConceptsDelayed blood transfusionEarly blood transfusionBlood transfusionRadical cystectomyBladder cancer treated with radical cystectomyPatients treated with radical cystectomyAssociated with 90-day mortalityIncreased 90-day mortalityTime of blood transfusionPrimary end pointRetrospective cohort studyMultivariate logistic regressionAssociated with mortalityDelayed transfusionMedian ageClinical deteriorationCystectomyHigher CCIOlder patientsTransfusionCohort studyEnd pointsPatient mortalityPatientsIndex admissionWarfarin-associated intracranial haemorrhage in pregnant woman with double mechanical valve replacement: a case presentation
Oguz M, Ayaz A, Adin M. Warfarin-associated intracranial haemorrhage in pregnant woman with double mechanical valve replacement: a case presentation. BMC Cardiovascular Disorders 2020, 20: 286. PMID: 32527293, PMCID: PMC7291738, DOI: 10.1186/s12872-020-01547-5.Peer-Reviewed Case Reports and Technical NotesConceptsPregnant womenDouble mechanical valve replacementProsthetic valve diseaseMechanical valve replacementIntensive care unitSignificant mass effectClouding of consciousnessMultidisciplinary management planGravida twoMajor bleedingClinical deteriorationWarfarin anticoagulationRare complicationValve replacementWarfarin treatmentMajor hemorrhageCare unitHealthy newbornsValve diseaseIntracranial hemorrhageSubdural haematomaEye dropsMitral valveThrombogenic riskEmergency clinicCovarying patterns of white matter lesions and cortical atrophy predict progression in early MS
Muthuraman M, Fleischer V, Kroth J, Ciolac D, Radetz A, Koirala N, Gonzalez-Escamilla G, Wiendl H, Meuth S, Zipp F, Groppa S. Covarying patterns of white matter lesions and cortical atrophy predict progression in early MS. Neurology Neuroimmunology & Neuroinflammation 2020, 7: e681. PMID: 32024782, PMCID: PMC7051213, DOI: 10.1212/nxi.0000000000000681.Peer-Reviewed Original ResearchConceptsCortical atrophyDisability progressionLesion distributionWM lesionsEarly relapsing-remitting MSShort-term disability progressionWhite matter lesion distributionDisability Status Scale scoreRapid clinical deteriorationRelapsing-remitting MSStatus Scale scoreWhite matter lesionsIndividual patient outcomesLeft-lateralized patternClinical worseningClinical deteriorationClinical disabilityFunctional disabilityStudy cohortMatter lesionsEarly MSPatient outcomesHigh riskIndependent cohortSecond cohort
2018
Using System Inflammatory Response Syndrome as an Easy-to-Implement, Sustainable, and Automated Tool for All-Cause Deterioration Among Medical Inpatients
Fogerty RL, Sussman LS, Kenyon K, Li F, Sukumar N, Kliger AS, Acker K, Sankey C. Using System Inflammatory Response Syndrome as an Easy-to-Implement, Sustainable, and Automated Tool for All-Cause Deterioration Among Medical Inpatients. Journal Of Patient Safety 2018, Publish Ahead of Print: &na;. PMID: 29369071, DOI: 10.1097/pts.0000000000000463.Peer-Reviewed Original ResearchConceptsDefinition of sepsisClinical deteriorationMedical inpatientsAdult inpatientsSystemic inflammatory response syndrome criteriaElectronic health record toolsInflammatory response syndromeAcademic medical centerSyndrome criteriaResponse syndromeClinical benefitMedical CenterHigh riskMinimal additional resourcesInpatientsSIRSSepsisPatientsIntervention toolSpectrum disorderDeteriorationAdmissionSyndrome
2017
Rothman Index variability predicts clinical deterioration and rapid response activation
Wengerter BC, Pei KY, Asuzu D, Davis KA. Rothman Index variability predicts clinical deterioration and rapid response activation. The American Journal Of Surgery 2017, 215: 37-41. PMID: 28818297, DOI: 10.1016/j.amjsurg.2017.07.031.Peer-Reviewed Original ResearchConceptsSurgical patientsRothman IndexRRT activationRapid response team activationRapid response activationInpatient acuityHospital mortalityClinical deteriorationPrimary outcomeSecondary outcomesTeam activationPatientsRI variabilityControl casesResponse activationActivationOutcomesAcuityGlobal measuresMortalityRRT
2016
“Frontiers in Fontan failure: A summary of conference proceedings”
Hebson C, Book W, Elder RW, Ford R, Jokhadar M, Kanter K, Kogon B, Kovacs AH, Levit RD, Lloyd M, Maher K, Reshamwala P, Rodriguez F, Romero R, Tejada T, Valente A, Veldtman G, McConnell M. “Frontiers in Fontan failure: A summary of conference proceedings”. Congenital Heart Disease 2016, 12: 6-16. PMID: 27597140, DOI: 10.1111/chd.12407.Peer-Reviewed Original Research“Deterioration to Door Time”: An Exploratory Analysis of Delays in Escalation of Care for Hospitalized Patients
Sankey CB, McAvay G, Siner JM, Barsky CL, Chaudhry SI. “Deterioration to Door Time”: An Exploratory Analysis of Delays in Escalation of Care for Hospitalized Patients. Journal Of General Internal Medicine 2016, 31: 895-900. PMID: 26969311, PMCID: PMC4945556, DOI: 10.1007/s11606-016-3654-x.Peer-Reviewed Original ResearchConceptsMedical intensive care unitEscalation of careIntensive care unitClinical deteriorationCare escalationHospitalized patientsCare unitDoor timeInpatient medicineRetrospective cohort studySeverity of illnessRisk of deathAcademic medical centerHospital mortalityICU transferCohort studyInpatient floorInpatient settingMedical CenterGeneral floorPatientsCareMortalityCurrent eraPrevious studiesTreatment of Edema Associated With Intracerebral Hemorrhage
Leasure A, Kimberly WT, Sansing LH, Kahle KT, Kronenberg G, Kunte H, Simard JM, Sheth KN. Treatment of Edema Associated With Intracerebral Hemorrhage. Current Treatment Options In Neurology 2016, 18: 9. PMID: 26874842, DOI: 10.1007/s11940-015-0392-z.Peer-Reviewed Original ResearchPerihematomal edemaIntracerebral hemorrhageHypertonic salineFirst-line medical therapyTreatment of ICHWorse clinical outcomesLarge clinical trialsSubsequent continuous infusionTreatment of edemaEdema refractoryClinical deteriorationBrain herniationCommon complicationDecompressive craniectomyMedical therapyClinical outcomesContinuous infusionEdema formationClinical trialsBolus formClinical researchHemorrhageNext major advanceEdemaPilot studyEsophageal adenocarcinoma and squamous cell carcinoma in children and adolescents: Report of 3 cases and comprehensive literature review
Theilen T, Chou A, Klimstra D, LaQuaglia M. Esophageal adenocarcinoma and squamous cell carcinoma in children and adolescents: Report of 3 cases and comprehensive literature review. Journal Of Pediatric Surgery Case Reports 2016, 5: 23-29. PMID: 27057484, PMCID: PMC4819333, DOI: 10.1016/j.epsc.2015.12.008.Peer-Reviewed Original ResearchSquamous cell carcinomaCell carcinomaEsophageal adenocarcinomaPatients treated with surgeryCases of esophageal adenocarcinomaMalignant esophageal tumorsHistory of dysphagiaCases of SCCYears of ageCases of ACMetastatic diseaseEsophageal tumorsAC tumorsPresenting symptomsSCC tumorsGastroesophageal junctionMale predominanceMalignant diseasePatient demographicsYounger patientsDistal esophagusClinical deteriorationAdenocarcinomaDisease characteristicsTumor
2015
MORTALITY REDUCTION ASSOCIATED WITH PROACTIVE USE OF EMR-BASED ACUITY SCORE BY AN RN TEAM AT AN URBAN HOSPITAL
Rothman M, Rimar J, Coonan S, Allegretto S, Balcezak T. MORTALITY REDUCTION ASSOCIATED WITH PROACTIVE USE OF EMR-BASED ACUITY SCORE BY AN RN TEAM AT AN URBAN HOSPITAL. BMJ Quality & Safety 2015, 24: 734. DOI: 10.1136/bmjqs-2015-ihiabstracts.21.Peer-Reviewed Original ResearchIntervention periodRothman IndexPatient's conditionAdult medical-surgical patientsHigh-risk patientsMedical-surgical patientsRisk-adjusted mortalityRisk of mortalityQuality of careElectronic medical recordsHigh-quality careClinical deteriorationRisk patientsNursing assessmentPatient populationMedical recordsMortality reductionPercent of dischargesUrban hospitalMortality rateAcuity scoresPatientsEarly identificationPatient volumeQuality care
2014
Post-operative Abdominal Wall Cellulitis
Davarpanah A, Lischuk A, Bokhari S, Kaplan L. Post-operative Abdominal Wall Cellulitis. 2014, 259-265. DOI: 10.1007/978-0-85729-781-5_26.Peer-Reviewed Original Research
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