2025
Chronotherapeutic intervention targeting emotion regulation brain circuitry, symptoms, and suicide risk in adolescents and young adults with bipolar disorder: a pilot randomised trial
Kim J, Sankar A, Marks R, Carrubba E, Lecza B, Quatrano S, Spencer L, Constable R, Pittman B, Lebowitz E, Silverman W, Swartz H, Blumberg H. Chronotherapeutic intervention targeting emotion regulation brain circuitry, symptoms, and suicide risk in adolescents and young adults with bipolar disorder: a pilot randomised trial. BMJ Mental Health 2025, 28: e301338. PMID: 39971594, PMCID: PMC11840897, DOI: 10.1136/bmjment-2024-301338.Peer-Reviewed Original ResearchConceptsBipolar disorderEmotion regulationSuicide riskBrain circuitryChronotherapeutic interventionsEmotional face stimuliLeft amygdala responseRisk of bipolar disorderTargeting emotion regulationReduce suicide riskHigher suicide riskYoung adultsFunctional MRI dataPost-treatment improvementAmygdala responsePotential intervention targetsEmotion dysregulationMania symptomsMood episodesFace stimuliCircuitry dysfunctionRegulation therapyDaily rhythmsWeekly sessionsSelf-monitoring
2022
Best Practice for Improving Sleep in the ICU. Part I: Non-pharmacologic
Korwin A, Knauert M. Best Practice for Improving Sleep in the ICU. Part I: Non-pharmacologic. 2022, 231-248. DOI: 10.1007/978-3-031-06447-0_14.ChaptersIntensive care unitICU patientsNormal sleepCritical care treatmentNon-pharmacologic therapiesNon-pharmacologic interventionsMost ICU patientsAbnormal circadian rhythmPoor quality sleepCircadian functionAcute illnessCritical illnessPatient characteristicsIll adultsCare unitChronotherapeutic interventionsCare treatmentSleep preferenceCurrent evidencePatient careCircadian disruptionSleepPatientsFuture interventionsPractice change
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