2025
[18F]MK-6240 Radioligand Delivery Indices as Surrogates of Cerebral Perfusion: Bias and Correlation Against [15O]Water.
Fu J, Juttukonda M, Garimella A, Salvatore A, Lois C, Ranasinghe A, Efthimiou N, Sari H, Aye W, Guehl N, El Fakhri G, Johnson K, Dickerson B, Izquierdo-Garcia D, Catana C, Price J. [18F]MK-6240 Radioligand Delivery Indices as Surrogates of Cerebral Perfusion: Bias and Correlation Against [15O]Water. Journal Of Nuclear Medicine 2025, 66: 410-417. PMID: 39947916, PMCID: PMC11876731, DOI: 10.2967/jnumed.124.268701.Peer-Reviewed Original Research
2023
Multivariate analysis of perfusion and oxygenation patterns in asymptomatic unilateral carotid artery stenosis
Kufer J, Göttler J, Hoffmann G, Schmitzer L, Zimmer C, Hyder F, Preibisch C, Kaczmarz S. Multivariate analysis of perfusion and oxygenation patterns in asymptomatic unilateral carotid artery stenosis. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2023 DOI: 10.58530/2023/0878.Peer-Reviewed Original ResearchInternal carotid artery stenosisCarotid artery stenosisArtery stenosisInternal carotid artery stenosis patientsAsymptomatic internal carotid artery stenosisUnilateral carotid artery stenosisSystemic blood pressureAnalysis of perfusionIncreased stroke riskCerebral hemodynamic changesDegree of stenosisPhysiologic MRICerebral perfusionComplex pathophysiologyMultivariate analysisHemodynamic changesBlood pressureCarotid arteryTreatment decisionsStenosisDisease-specific patternsStroke riskMeasurement of Cerebral Perfusion Indices from the Early Phase of [18F]MK6240 Dynamic Tau PET Imaging
Guehl N, Dhaynaut M, Hanseeuw B, Moon S, Lois C, Thibault E, Fu J, Price J, Johnson K, El Fakhri G, Normandin M. Measurement of Cerebral Perfusion Indices from the Early Phase of [18F]MK6240 Dynamic Tau PET Imaging. Journal Of Nuclear Medicine 2023, 64: 968-975. PMID: 36997330, PMCID: PMC10241011, DOI: 10.2967/jnumed.122.265072.Peer-Reviewed Original ResearchConceptsTime-activity curvesCerebral perfusionMetabolite-corrected arterial input functionBrain time-activity curvesEarly phaseRegional time-activity curvesIndices of cerebral perfusionDynamic [<sup>18</sup>FBlood-brain barrierPlasma to brain tissueStatistically significant differenceArterial blood samplesForty-nine subjectsCNArterial input functionPathophysiological mechanismsPerfusion indicatorsPET imagingBlood samplesSignificant differenceSurrogate indexNoninvasive estimationAnatomical informationCompound BForty-nineIn vivo imaging of cerebral glucose metabolism informs on subacute to chronic post-stroke tissue status – A pilot study combining PET and deuterium metabolic imaging
Meerwaldt A, Straathof M, Oosterveld W, van Heijningen C, van Leent M, Toner Y, Munitz J, Teunissen A, Daemen C, van der Toorn A, van Vliet G, van Tilborg G, De Feyter H, de Graaf R, Hol E, Mulder W, Dijkhuizen R. In vivo imaging of cerebral glucose metabolism informs on subacute to chronic post-stroke tissue status – A pilot study combining PET and deuterium metabolic imaging. Cerebrovascular And Brain Metabolism Reviews 2023, 43: 778-790. PMID: 36606595, PMCID: PMC10108187, DOI: 10.1177/0271678x221148970.Peer-Reviewed Original ResearchConceptsTransient middle cerebral artery occlusionPositron emission tomographyGlucose metabolismPost-ischemic brain tissueMiddle cerebral artery occlusionFDG positron emission tomographyFluorodeoxyglucose positron emission tomographyMetabolic imagingSignificant glial activationAcute ischemic strokeCerebral artery occlusionCerebral energy metabolismDeuterium metabolic imagingActive glucose metabolismGlial activationRecanalization therapyArtery occlusionIschemic strokeStroke severityCerebral perfusionC57BL/6 micePoor outcomeElevated lactate productionPathophysiological changesBaseline values
2021
Review of studies on dynamic cerebral autoregulation in the acute phase of stroke and the relationship with clinical outcome
Nogueira R, Aries M, Minhas J, Petersen N, Xiong L, Kainerstorfer J, Castro P. Review of studies on dynamic cerebral autoregulation in the acute phase of stroke and the relationship with clinical outcome. Cerebrovascular And Brain Metabolism Reviews 2021, 42: 430-453. PMID: 34515547, PMCID: PMC8985432, DOI: 10.1177/0271678x211045222.Peer-Reviewed Original ResearchConceptsDynamic cerebral autoregulationAcute phaseClinical outcomesCerebral autoregulationAcute ischemic strokeCerebral hemodynamic parametersPotential therapeutic targetCerebrovascular disease statesAcute strokeIschemic strokeStroke onsetCerebral perfusionCerebral circulationIntracerebral hemorrhageHigh morbidityHemodynamic parametersIndividual patientsPerfusion interventionsNew therapiesTherapeutic targetHemodynamic aspectsPatientsAdditional treatmentDisease statesRelevant studiesBleeding risk in patients with cardiac disease from ischaemic stroke reperfusion therapy: an update
Chen BJ, Daneshvari NO, Johansen MC. Bleeding risk in patients with cardiac disease from ischaemic stroke reperfusion therapy: an update. BMJ Neurology Open 2021, 3: e000156. PMID: 34485911, PMCID: PMC8372809, DOI: 10.1136/bmjno-2021-000156.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsSymptomatic intracranial hemorrhageAcute ischemic strokeReperfusion therapyEndovascular therapyHeart failureAtrial fibrillationIntravenous rtPACardiac diseaseRisk factorsRate of sICHRisk of sICHPre-existing cardiac conditionsIntravenous tissue plasminogen activatorStroke reperfusion therapyIndependent risk factorTissue plasminogen activatorVentricular assist deviceEligible patientsCardiac indicationsIschemic strokeCerebral perfusionIntracranial hemorrhagePoor outcomePost strokePoststroke outcomes
2019
Repair of type A aortic intramural hematoma with ascending and hemiarch reconstruction using circulatory arrest and retrograde cerebral perfusion
Assi R, Siki M, Desai N, Bavaria J. Repair of type A aortic intramural hematoma with ascending and hemiarch reconstruction using circulatory arrest and retrograde cerebral perfusion. ASVIDE 2019, 6: 280-280. DOI: 10.21037/asvide.2019.280.Peer-Reviewed Original ResearchRepair of type A aortic intramural hematoma with ascending and hemiarch reconstruction using circulatory arrest and retrograde cerebral perfusion.
Assi R, Siki MA, Desai ND, Bavaria JE. Repair of type A aortic intramural hematoma with ascending and hemiarch reconstruction using circulatory arrest and retrograde cerebral perfusion. Annals Of Cardiothoracic Surgery 2019, 8: 567-569. PMID: 31667156, PMCID: PMC6785493, DOI: 10.21037/acs.2019.08.06.Peer-Reviewed Original ResearchCerebral protection strategies in aortic arch surgery: A network meta-analysis
Hameed I, Rahouma M, Khan FM, Wingo M, Demetres M, Tam DY, Lau C, Iannacone EM, Di Franco A, Palaniappan A, Anderson H, Fremes SE, Girardi LN, Gaudino M. Cerebral protection strategies in aortic arch surgery: A network meta-analysis. Journal Of Thoracic And Cardiovascular Surgery 2019, 159: 18-31. PMID: 30902473, DOI: 10.1016/j.jtcvs.2019.02.045.Peer-Reviewed Original ResearchDeep hypothermic circulatory arrestAntegrade cerebral perfusionRetrograde cerebral perfusionHypothermic circulatory arrestAortic arch surgeryCerebral perfusionCirculatory arrestArch surgeryPostoperative strokeSecondary outcomesPrimary outcomeBilateral antegrade cerebral perfusionGeneric inverse variance methodCerebral protection strategiesCirculatory arrest durationTransient neurologic deficitsOperative mortality rateBetter postoperative outcomesInverse variance methodSystematic literature searchCerebral protectionOperative mortalityRespiratory complicationsNeurologic deficitsPostoperative outcomes
2018
Neuroprotective Strategies in Repair and Replacement of the Aortic Arch
Manetta F, Mullan CW, Catalano MA. Neuroprotective Strategies in Repair and Replacement of the Aortic Arch. International Journal Of Angiology 2018, 27: 098-109. PMID: 29896042, PMCID: PMC5995688, DOI: 10.1055/s-0038-1649512.Peer-Reviewed Original Research
2017
Reduced Cerebrovascular Reactivity and Increased Resting Cerebral Perfusion in Rats Exposed to a Cafeteria Diet
Gomez-Smith M, Janik R, Adams C, Lake EM, Thomason LAM, Jeffers MS, Stefanovic B, Corbett D. Reduced Cerebrovascular Reactivity and Increased Resting Cerebral Perfusion in Rats Exposed to a Cafeteria Diet. Neuroscience 2017, 371: 166-177. PMID: 29229555, DOI: 10.1016/j.neuroscience.2017.11.054.Peer-Reviewed Original ResearchConceptsRat endothelial cell antigen-1Cerebrovascular reactivityCafeteria dietMagnetic resonance imagingCerebral perfusionStandard chowAnimals fed standard chowEndothelial cell antigen-1Arterial spin labeling magnetic resonance imagingContinuous arterial spin labeling (CASL) magnetic resonance imagingEndothelin-1 injectionReduced Cerebrovascular ReactivityUltra-processed dietFed standard chowSprague-Dawley ratsShort-term consumptionCell antigen-1CAF ratsCerebrovascular functionIschemic lesionsCerebral microvasculatureDiet ratsSensorimotor cortexBrain perfusionDawley ratsOutcomes of Elective Aortic Hemiarch Reconstruction for Aneurysmal Disease in the Elderly
Kilic A, Arnaoutakis GJ, Bavaria JE, Sultan I, Desai ND, Vallabhajosyula P, Williams ML, Milewski RK, Szeto WY. Outcomes of Elective Aortic Hemiarch Reconstruction for Aneurysmal Disease in the Elderly. The Annals Of Thoracic Surgery 2017, 104: 1522-1530. PMID: 28648536, DOI: 10.1016/j.athoracsur.2017.03.067.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAged, 80 and overAorta, ThoracicAortic Aneurysm, ThoracicBlood Vessel Prosthesis ImplantationCirculatory Arrest, Deep Hypothermia InducedCohort StudiesElective Surgical ProceduresFemaleGeriatric AssessmentHospital MortalityHumansMaleMiddle AgedPlastic Surgery ProceduresPostoperative CarePostoperative ComplicationsPrognosisPropensity ScoreRegistriesRetrospective StudiesRisk AssessmentSex FactorsSurvival AnalysisTreatment OutcomeConceptsModerate hypothermic circulatory arrestAntegrade cerebral perfusionHypothermic circulatory arrestHemiarch reconstructionElderly patientsAneurysmal diseaseOperative mortalityCerebral perfusionCirculatory arrestConcomitant aortic valve replacementRisk-adjusted operative mortalityCoronary artery bypassOperative mortality rateAortic valve replacementGreater comorbidity burdenLow operative mortalityOverall stroke rateSafe strategyIntensive care unitComorbidity burdenArtery bypassHospital stayRoot replacementValve replacementCare unitThe role of resuscitative endovascular balloon occlusion of the aorta (REBOA) as an adjunct to ACLS in non-traumatic cardiac arrest
Daley J, Morrison JJ, Sather J, Hile L. The role of resuscitative endovascular balloon occlusion of the aorta (REBOA) as an adjunct to ACLS in non-traumatic cardiac arrest. The American Journal Of Emergency Medicine 2017, 35: 731-736. PMID: 28117180, DOI: 10.1016/j.ajem.2017.01.010.Peer-Reviewed Original ResearchConceptsNon-traumatic cardiac arrestResuscitative endovascular balloon occlusionEndovascular balloon occlusionBalloon occlusionCardiac arrestCase seriesIntra-aortic balloon pumpMajor public health problemAortic balloon occlusionCoronary perfusion pressureSmall case seriesNumerous animal studiesPublic health problemHigh mortality rateCardiogenic shockAortic occlusionBalloon pumpCerebral perfusionIll patientsPerfusion pressureCirculatory supportHemorrhagic shockCardiac outputHuman evidenceMortality rate
2016
Volume of Plasma Expansion and Functional Outcomes in Stroke
Miller JB, Lewandowski C, Wira CR, Taylor A, Burmeister C, Welch R. Volume of Plasma Expansion and Functional Outcomes in Stroke. Neurocritical Care 2016, 26: 191-195. PMID: 27629275, DOI: 10.1007/s12028-016-0316-0.Peer-Reviewed Original ResearchConceptsNeurological recoveryNIHSS scoreIschemic strokeFunctional outcomeFavorable outcomeMultivariable-adjusted logistic regression modelsModified Rankin Scale scoreLarge-vessel ischemic strokeHigher NIHSS scoreIsotonic saline treatmentMedian National InstitutesWorse neurological recoveryHealth Stroke ScaleAcute ischemic strokeMultivariable-adjusted modelsRankin Scale scoreIntravenous volume infusionConclusionsThe present studyLogistic regression modelsStroke ScaleStudy patientsAcute strokeCerebral perfusionClinical outcomesMean ageThe Impact of Deep Versus Moderate Hypothermia on Postoperative Kidney Function After Elective Aortic Hemiarch Repair
Arnaoutakis GJ, Vallabhajosyula P, Bavaria JE, Sultan I, Siki M, Naidu S, Milewski RK, Williams ML, Hargrove WC, Desai ND, Szeto WY. The Impact of Deep Versus Moderate Hypothermia on Postoperative Kidney Function After Elective Aortic Hemiarch Repair. The Annals Of Thoracic Surgery 2016, 102: 1313-1321. PMID: 27318775, DOI: 10.1016/j.athoracsur.2016.04.007.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAgedAorta, ThoracicAortic Aneurysm, ThoracicCause of DeathCerebrovascular CirculationCirculatory Arrest, Deep Hypothermia InducedCohort StudiesDatabases, FactualElective Surgical ProceduresFemaleFollow-Up StudiesGlomerular Filtration RateHospital MortalityHumansHypothermia, InducedLogistic ModelsMaleMiddle AgedMultivariate AnalysisPerfusionPostoperative ComplicationsRetrospective StudiesSurvival AnalysisTreatment OutcomeConceptsAntegrade cerebral perfusionRetrograde cerebral perfusionAcute kidney injuryModerate hypothermic circulatory arrestDeep hypothermic circulatory arrestHypothermic circulatory arrestGlomerular filtration rateHemiarch repairCerebral perfusionCirculatory arrestEjection fractionAneurysmal diseaseLower baseline glomerular filtration rateOccurrence of AKIAortic cross-clamp timeBaseline glomerular filtration rateHigher acute kidney injuryLonger cardiopulmonary bypass timeLow preoperative ejection fractionPostoperative acute kidney injuryAortic hemiarch replacementBaseline renal dysfunctionCerebral perfusion strategyCerebral protection strategiesDistal organ protection
2015
[Retracted] How to Perfuse: Concepts of Cerebral Protection during Arch Replacement
Habertheuer A, Wiedemann D, Kocher A, Laufer G, Vallabhajosyula P. [Retracted] How to Perfuse: Concepts of Cerebral Protection during Arch Replacement. BioMed Research International 2015, 2015: 981813. PMID: 26713319, PMCID: PMC4680049, DOI: 10.1155/2015/981813.Peer-Reviewed Original ResearchConceptsAntegrade cerebral perfusionCerebral protectionCerebral perfusionPerfusion strategyBilateral antegrade cerebral perfusionAvailable surgical strategiesCardiac surgery communityCerebral perfusion strategyComplex aortic pathologiesSingle-center dataDegree of hypothermiaComplete circulatory arrestArch replacementArch surgeryAortic pathologyArch reconstructionCirculatory arrestCirculatory managementEuropean multicenterHypothermic arrestIschemic insultThoracic aneurysmSurgical interventionSurgical strategySurgical approachDirect innominate artery cannulation: An alternate technique for antegrade cerebral perfusion during aortic hemiarch reconstruction
Jassar AS, Vallabhajosyula P, Bavaria JE, Gutsche J, Desai ND, Williams ML, Milewski RK, Hargrove WC, Szeto WY. Direct innominate artery cannulation: An alternate technique for antegrade cerebral perfusion during aortic hemiarch reconstruction. Journal Of Thoracic And Cardiovascular Surgery 2015, 151: 1073-1078. PMID: 26725716, DOI: 10.1016/j.jtcvs.2015.11.027.Peer-Reviewed Original ResearchMeSH KeywordsAgedAorta, ThoracicAortic Aneurysm, ThoracicBlood Vessel Prosthesis ImplantationBrachiocephalic TrunkCatheterization, PeripheralCerebrovascular CirculationFemaleHeart Arrest, InducedHospital MortalityHumansHypothermia, InducedMaleMiddle AgedPerfusionPostoperative ComplicationsRegional Blood FlowReoperationTime FactorsTreatment OutcomeConceptsAntegrade cerebral perfusionModerate hypothermic circulatory arrestHypothermic circulatory arrestHemiarch reconstructionInnominate arteryCerebral perfusionCirculatory arrestReversible ischemic neurologic deficitExcellent cerebral protectionInnominate artery cannulationIschemic neurologic deficitAortic valve replacementRenal failure rateProximal aortic aneurysmIncidence of injuryACP timeAscending aorticCrossclamp timeArtery cannulationCerebral protectionCentral cannulationNeurologic deficitsPatient ageRoot replacementValve replacementModerate Versus Deep Hypothermic Circulatory Arrest for Elective Aortic Transverse Hemiarch Reconstruction
Vallabhajosyula P, Jassar AS, Menon RS, Komlo C, Gutsche J, Desai ND, Hargrove WC, Bavaria JE, Szeto WY. Moderate Versus Deep Hypothermic Circulatory Arrest for Elective Aortic Transverse Hemiarch Reconstruction. The Annals Of Thoracic Surgery 2015, 99: 1511-1517. PMID: 25825200, DOI: 10.1016/j.athoracsur.2014.12.067.Peer-Reviewed Original ResearchConceptsModerate hypothermic circulatory arrestDeep hypothermic circulatory arrestHypothermic circulatory arrestDirect innominate artery cannulationAntegrade cerebral perfusionInnominate artery cannulationCerebral perfusionCirculatory arrestHemiarch reconstructionTransfusion requirementsArtery cannulationMHCA groupCerebral perfusion strategyCerebral protection strategiesConcomitant root replacementRetrograde cerebral perfusionAortic valve replacementFresh frozen plasmaAortic aneurysm diseaseHemodialysis rateAortic reconstructionNeurologic complicationsGroup patientsPostoperative outcomesRoot replacement
2014
Time and Diffusion Lesion Size in Major Anterior Circulation Ischemic Strokes
Hakimelahi R, Vachha B, Copen W, Papini G, He J, Higazi M, Lev M, Schaefer P, Yoo A, Schwamm L, González R. Time and Diffusion Lesion Size in Major Anterior Circulation Ischemic Strokes. Stroke 2014, 45: 2936-2941. PMID: 25190444, DOI: 10.1161/strokeaha.114.005644.Peer-Reviewed Original ResearchConceptsAnterior circulation ischemic strokeMiddle cerebral artery occlusionDiffusion-weighted imagingCerebral artery occlusionStroke onsetIschemic strokeInfarct sizeDWI lesionsInfarct volumeArtery occlusionIntravenous tissue-type plasminogen activatorProximal middle cerebral arteryDistal internal carotid arteryAcute infarct volumeDWI lesion volumeMajority of patientsMiddle cerebral arteryInternal carotid arteryAcute infarct sizeSame inclusion criteriaTraditional time windowTissue-type plasminogen activatorCerebral perfusionConsecutive patientsInfarct growthCannulation of the right atrium via left thoracotomy
Saxena P, Vallabhajosyula P, Pochettino A. Cannulation of the right atrium via left thoracotomy. European Journal Of Cardio-Thoracic Surgery 2014, 46: 129-131. PMID: 24394553, DOI: 10.1093/ejcts/ezt566.Peer-Reviewed Original Research
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