2025
Reduced removal of waste products from energy metabolism takes center stage in human brain aging
Mangia S, DiNuzzo M, Ponticorvo S, Dienel G, Behar K, Benveniste H, Hyder F, Giove F, Herculano-Houzel S, Petroff O, Eberly L, Filip P, Michaeli S, Rothman D. Reduced removal of waste products from energy metabolism takes center stage in human brain aging. Scientific Reports 2025, 15: 8127. PMID: 40057554, PMCID: PMC11890754, DOI: 10.1038/s41598-025-90342-3.Peer-Reviewed Original ResearchMicroglia modulate the cerebrovascular reactivity through ectonucleotidase CD39
Fu Z, Ganesana M, Hwang P, Tan X, Kinkaid M, Sun Y, Bian E, Weybright A, Chen H, Sol-Church K, Eyo U, Pridans C, Quintana F, Robson S, Kumar P, Venton B, Schaefer A, Kuan C. Microglia modulate the cerebrovascular reactivity through ectonucleotidase CD39. Nature Communications 2025, 16: 956. PMID: 39843911, PMCID: PMC11754601, DOI: 10.1038/s41467-025-56093-5.Peer-Reviewed Original ResearchConceptsCerebral blood flowEctonucleotidases CD39Whisker stimulationResponse to whisker stimulationCerebrovascular reactivityDeletion of CD39Blood flowInjection of adenosine triphosphateModulation of cerebral blood flowRegulation of cerebral blood flowExtracellular adenosine triphosphateInjection of adenosineBorder-associated macrophagesMicroglia repopulationExtracellular adenosineAdenosine triphosphateFemale miceBlood flow anomaliesP2RY12 receptorCo-transmitterMouse modelPharmacological inhibitionCD39MicrogliaMice
2024
Relative Cerebral Blood Flow as an Indirect Imaging Surrogate in Patients With Anterior Circulation Large Vessel Occlusion and Association of Baseline Characteristics With Poor Collateral Status.
Salim H, Hamam O, Parilday G, Moustafa R, Ghandour S, Rutgers M, Sharara M, Cho A, Mazumdar I, Radmard M, Shin C, Montes D, Malhotra A, Romero J, Yedavalli V. Relative Cerebral Blood Flow as an Indirect Imaging Surrogate in Patients With Anterior Circulation Large Vessel Occlusion and Association of Baseline Characteristics With Poor Collateral Status. Journal Of The American Heart Association 2024, 13: e034581. PMID: 39158542, DOI: 10.1161/jaha.124.034581.Peer-Reviewed Original ResearchConceptsAnterior circulation large vessel occlusionAcute ischemic strokeLarge vessel occlusionCollateral statusAdmission laboratory valuesChronic kidney diseaseBaseline characteristicsCerebral blood flowVessel occlusionPoor CSConsecutive patientsMale sexLaboratory valuesComputed tomography perfusion dataPretreatment computed tomography perfusionKidney diseasePredictors of favorable outcomeAssociation of baseline characteristicsRetrospective multicenter studyBlood flowPoor collateral statusIndications of CSCerebral perfusion parametersPatient baseline characteristicsRelative cerebral blood flowHemodynamics regulate spatiotemporal artery muscularization in the developing circle of Willis
Cheng S, Xia I, Wanner R, Abello J, Stratman A, Nicoli S. Hemodynamics regulate spatiotemporal artery muscularization in the developing circle of Willis. ELife 2024, 13 DOI: 10.7554/elife.94094.3.Peer-Reviewed Original ResearchVascular smooth muscle cellsVascular smooth muscle cell differentiationWall shear stressVSMC differentiationEndothelial cellsAnalysis of blood flowBlood flowShear stressBrain arteriesPulsatile flowCerebrovascular diseaseDedifferentiated vascular smooth muscle cellsRegulate cerebral blood flowSmooth muscle cellsRed blood cell velocityDedifferentiation of vascular smooth muscle cellsCerebral blood flowBlood cell velocityArterial muscularizationVenous plexusCell progenitorsMuscle cellsBlood flow activationArteryFlowHemodynamics regulate spatiotemporal artery muscularization in the developing circle of Willis
Cheng S, Xia I, Wanner R, Abello J, Stratman A, Nicoli S. Hemodynamics regulate spatiotemporal artery muscularization in the developing circle of Willis. ELife 2024, 13: rp94094. PMID: 38985140, PMCID: PMC11236418, DOI: 10.7554/elife.94094.Peer-Reviewed Original ResearchConceptsVascular smooth muscle cellsWall shear stressVascular smooth muscle cell differentiationVSMC differentiationEndothelial cellsAnalysis of blood flowBlood flowShear stressBrain arteriesPulsatile flowCerebrovascular diseaseDedifferentiated vascular smooth muscle cellsRegulate cerebral blood flowSmooth muscle cellsRed blood cell velocityDedifferentiation of vascular smooth muscle cellsCerebral blood flowBlood cell velocityArterial muscularizationVenous plexusCell progenitorsMuscle cellsBlood flow activationArteryFlowImpact of jugular vein ligation on cerebrospinal fluid clearance from G-lymphatic system in mice
Ruze A, Mouton L, Singhabahu R, Gottschalk J, Spajer M, Thomas J, Lenck S, Santin M. Impact of jugular vein ligation on cerebrospinal fluid clearance from G-lymphatic system in mice. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2024 DOI: 10.58530/2024/1185.Peer-Reviewed Original ResearchJugular vein ligationVein ligationBilateral jugular vein ligationVenous outflow abnormalitiesCerebrospinal fluid clearanceCerebral blood flowFluid clearanceOutflow abnormalitiesLymphatic perfusionPost-surgeryLymphatic flowFluid homeostasisBrain volumetryBlood flowMiceCerebrovascular changesNeurological disordersLigationProgressive alterationBrainBaselineSystem's roleHypertensionAbnormalitiesCNSEarly-treatment cerebral blood flow change as a predictive biomarker of antidepressant treatment response: evidence from the EMBARC clinical trial.
Dang Y, Lu B, Vanderwal T, Castellanos F, Yan C. Early-treatment cerebral blood flow change as a predictive biomarker of antidepressant treatment response: evidence from the EMBARC clinical trial. Psychological Medicine 2024, 54: 3053-3062. PMID: 38720516, DOI: 10.1017/s0033291724001156.Peer-Reviewed Original ResearchMajor depressive disorderBrain regionsTreatment of Major Depressive DisorderHamilton Depression Rating Scale scoresBiomarkers of antidepressant treatment responseCerebral blood flowBiosignatures of Antidepressant ResponseDepression Rating Scale scoresSerotonin reuptake inhibitor treatmentAntidepressant treatment responseResponse to antidepressantsTreatment responseRating Scale scoresBiomarkers of treatment responseAssociated with increased cerebral perfusionEstablishing ModeratorsAntidepressant responseAntidepressant effectsDepressive disorderTemporal cortexNeural biomarkersPostcentral regionsCerebral blood flow changesWhole-brainDisabling illness0488 Exploring Study Recruitment Trends in the Acute Post-Stroke Setting
Schwarz J, Masroor K, Radulescu R, Tsang S, Sheth K, Redeker N, Yaggi H, Geer J. 0488 Exploring Study Recruitment Trends in the Acute Post-Stroke Setting. Sleep 2024, 47: a210-a210. DOI: 10.1093/sleep/zsae067.0488.Peer-Reviewed Original ResearchContinuous positive airway pressureObstructive sleep apneaPositive airway pressureAcute ischemic strokeAirway pressureUpper airway closureSleep-disordered breathingYale-New Haven HospitalCerebral blood flowOSA screeningOSA treatmentSleep apneaImpact cerebral blood flowAcademic medical centerSympathetic activityClinical trialsPatient populationHemodynamic changesRisk factorsPatientsFunctional recoveryExclusion criteriaAirway closureCardiovascular diseaseBlood flowCerebral Blood Flow Changes and Neuroticism in Late-Life Depression
Anderson T, Steffens D, Wang L, Pearlson G. Cerebral Blood Flow Changes and Neuroticism in Late-Life Depression. American Journal Of Geriatric Psychiatry 2024, 32: s49-s50. DOI: 10.1016/j.jagp.2024.01.121.Peer-Reviewed Original ResearchMontgomery Asberg Depression Rating ScaleLate-life depressionAsberg Depression Rating ScaleLeft putamenFrontal poleLow neuroticismGroup differencesDecreased CBFLLD subjectsDepression severityDepression groupLLD groupCerebral blood flowNever-depressed control subjectsNever-depressed healthy controlsNEO Personality InventoryNever-depressed groupDepression Rating ScaleNeuroticism personality traitFrontal lobe structuresGroup effectBrain morphological changesT1-weighted MPRAGE imagesHealthy controlsSignificant group effectMacro- and microvascular contributions to cerebral structural alterations in patients with asymptomatic carotid artery stenosis
Schmitzer L, Kaczmarz S, Göttler J, Hoffmann G, Kallmayer M, Eckstein H, Hedderich D, Kufer J, Zimmer C, Preibisch C, Hyder F, Sollmann N. Macro- and microvascular contributions to cerebral structural alterations in patients with asymptomatic carotid artery stenosis. Cerebrovascular And Brain Metabolism Reviews 2024, 44: 1629-1642. PMID: 38506325, PMCID: PMC11418673, DOI: 10.1177/0271678x241238935.Peer-Reviewed Original ResearchInternal carotid artery stenosisInternal carotid artery stenosis patientsCerebral blood flowCarotid artery stenosisPeak width of skeletonized mean diffusivitySmall vessel diseaseContralateral alterationsArtery stenosisAsymptomatic internal carotid artery stenosisWhite matterAsymptomatic carotid artery stenosisCapillary transit time heterogeneityCerebral structural alterationsCortical thicknessMagnetic resonance imagingHemodynamic alterationsRisk factorsPatientsDTI metricsResonance imagingDorsal cingulate cortexBlood flowIschemic strokeMean diffusivityStenosisDysregulated cerebral blood flow, rather than gray matter Volume, exhibits stronger correlations with blood inflammatory and lipid markers in depression
Kang L, Wang W, Nie Z, Gong Q, Yao L, Xiang D, Zhang N, Tu N, Feng H, Zong X, Bai H, Wang G, Wang F, Bu L, Liu Z. Dysregulated cerebral blood flow, rather than gray matter Volume, exhibits stronger correlations with blood inflammatory and lipid markers in depression. NeuroImage Clinical 2024, 41: 103581. PMID: 38430800, PMCID: PMC10944186, DOI: 10.1016/j.nicl.2024.103581.Peer-Reviewed Original ResearchConceptsGray matter volumeCerebral blood flowMatter volumeArterial spin labelingRight middle temporal gyrusPredictors of MDDMiddle temporal gyrusImmune markersBrain functional changesProportion of MDDExploratory correlation analysisTumor necrosis factor-alphaBlood flowMDD patientsDepressive disorderAngular gyrusTemporal gyrusNecrosis factor-alphaMDDBrain regionsCerebral blood flow changesBlood lipid levelsInferior temporalCase-control comparisonCD4 countNeurovascular effects of cocaine: relevance to addiction
Clare K, Park K, Pan Y, Lejuez C, Volkow N, Du C. Neurovascular effects of cocaine: relevance to addiction. Frontiers In Pharmacology 2024, 15: 1357422. PMID: 38455961, PMCID: PMC10917943, DOI: 10.3389/fphar.2024.1357422.Peer-Reviewed Original ResearchBrain functionAssociated with adverse medical consequencesCerebral blood flowRelevant to addictionHealthy non-drugBrain imaging studiesCerebral blood flow deficitsCocaine addictionAddictive drugsCocaine misuseCocaine useTargeted pharmacological interventionsCocaineNon-drugAdverse medical consequencesNeuronal activityDebilitating neurological complicationsPharmacological interventionsAddictionCBF changesBrainImaging studiesMedical consequencesNeurological complicationsCerebrovascular accidentFirst-in-Human Study of 18F-SynVesT-2: An SV2A PET Imaging Probe with Fast Brain Kinetics and High Specific Binding
Drake L, Wu Y, Naganawa M, Asch R, Zheng C, Najafzadeh S, Pracitto R, Lindemann M, Li S, Ropchan J, Labaree D, Emery P, Dias M, Henry S, Nabulsi N, Matuskey D, Hillmer A, Gallezot J, Carson R, Cai Z, Huang Y. First-in-Human Study of 18F-SynVesT-2: An SV2A PET Imaging Probe with Fast Brain Kinetics and High Specific Binding. Journal Of Nuclear Medicine 2024, 65: jnumed.123.266470. PMID: 38360052, PMCID: PMC10924160, DOI: 10.2967/jnumed.123.266470.Peer-Reviewed Original ResearchFirst-in-human studyPlasma free fractionTime-activity curvesCentrum semiovaleNonhuman primate's resultsFirst-in-humanFree fractionNondisplaceable binding potentialRegional time-activity curvesLow nonspecific uptakeRegional distribution volumesHigh-resolution research tomograph scannerTest-retest reproducibilityCerebral blood flowSynaptic vesicle glycoprotein 2AHealthy volunteersArterial input functionNonspecific uptakePET imaging probeDistribution volumeSynapse densityIndividual MR imagesHighest specific bindingMR imagingPET imaging
2023
Pericytes are protective in experimental pneumococcal meningitis through regulating leukocyte infiltration and blood–brain barrier function
Teske N, Dyckhoff-Shen S, Beckenbauer P, Bewersdorf J, Engelen-Lee J, Hammerschmidt S, Kälin R, Pfister H, Brouwer M, Klein M, Glass R, van de Beek D, Koedel U. Pericytes are protective in experimental pneumococcal meningitis through regulating leukocyte infiltration and blood–brain barrier function. Journal Of Neuroinflammation 2023, 20: 267. PMID: 37978545, PMCID: PMC10655320, DOI: 10.1186/s12974-023-02938-z.Peer-Reviewed Original ResearchConceptsModel of pneumococcal meningitisPneumococcal meningitisLeukocyte infiltrationAnimal model of pneumococcal meningitisPrevented blood-brain barrierToll-like receptor inhibitorsDegree of leukocyte infiltrationSerotypes of Streptococcus pneumoniaeUnfavorable disease courseBlood-brain barrier disruptionHuman pericytesExperimental pneumococcal meningitisBlood-brain barrier integrityRegulating leukocyte infiltrationBlood-brain barrier functionRegulation of cerebral blood flowAdult mouse modelInfection in vivoUpregulation of chemokine expressionIncreased cerebral edemaMaintenance of blood-brain barrier integrityBlood-brain barrierCerebral blood flowMouse meningitis modelIn vitro studiesAssociation between intraprocedural drops in blood pressure and infarct growth rate patterns after acute large-vessel occlusions
Galecio-Castillo M, Quispe-Orozco D, Farooqui M, Dajles A, Vivanco-Suarez J, Rodriguez-Calienes A, Prasad A, Begunova L, Petersen N, Ortega-Gutierrez S. Association between intraprocedural drops in blood pressure and infarct growth rate patterns after acute large-vessel occlusions. Journal Of NeuroInterventional Surgery 2023, 16: 1275-1281. PMID: 37923382, PMCID: PMC11271969, DOI: 10.1136/jnis-2023-020899.Peer-Reviewed Original ResearchRelative cerebral blood flowInfarct growth ratesFinal infarct volumeHypoperfusion intensity ratioAlberta Stroke Program Early CT ScoreMedian arterial pressureDiffusion-weighted imaging (DWI) magnetic resonance imagingCerebral infarction 2Modified Rankin scoreLarge vessel occlusionEndovascular therapyInfarct volumeStroke onsetBlood pressureAcute large vessel occlusionHealth Stroke Scale scoreStroke Scale scoreAcute ischemic strokeCohort observational studySubgroup of patientsCerebral blood flowBlood pressure dropLVO-AISRankin scoreInfarct growthNeurovascular coupling is optimized to compensate for the increase in proton production from nonoxidative glycolysis and glycogenolysis during brain activation and maintain homeostasis of pH, pCO2, and pO2
DiNuzzo M, Dienel G, Behar K, Petroff O, Benveniste H, Hyder F, Giove F, Michaeli S, Mangia S, Herculano‐Houzel S, Rothman D. Neurovascular coupling is optimized to compensate for the increase in proton production from nonoxidative glycolysis and glycogenolysis during brain activation and maintain homeostasis of pH, pCO2, and pO2. Journal Of Neurochemistry 2023, 168: 632-662. PMID: 37150946, PMCID: PMC10628336, DOI: 10.1111/jnc.15839.Peer-Reviewed Original ResearchHigher cerebral blood flowCerebral blood flowOxygen extraction fractionNeurovascular couplingBlood flowLower oxygen extraction fractionNonoxidative glycolysisCerebral metabolic rateBrain pHCapillary densityNeurovascular diseasesNonoxidative metabolismTissue oxygenationHuman cortexBrain functionExtraction fractionBrain activationMitochondrial ATP productionPET measurementsCMROOxygen consumptionHomeostasisGlycogenolysisFMRI contrastActivationBlunted neural reward response to alcohol and greater alcohol motivation in binge drinkers in a randomized clinical experiment
Blaine S, Fogelman N, Lacadie C, Constable T, Sinha R. Blunted neural reward response to alcohol and greater alcohol motivation in binge drinkers in a randomized clinical experiment. Alcohol Clinical And Experimental Research 2023, 47: 1067-1078. PMID: 37070596, PMCID: PMC10289130, DOI: 10.1111/acer.15082.Peer-Reviewed Original ResearchAlcohol taste testFunctional magnetic resonance imagingAlcohol motivationSupplementary motor areaOrbitofrontal cortexInferior frontal gyrus regionsPerfusion functional magnetic resonance imagingEnhanced neural responseNeural reward responsesMedial orbitofrontal cortexPlacebo sessionAlcohol use disorderBrain reward regionsPlacebo-controlled effectsNeural processesOFC responsesReward responsesNeural responsesPlacebo beerSocial drinkersCerebral blood flowReward regionsBD relativeVentral striatumAlcohol effectsEmbracing Heterogeneity in The Multicenter Stroke Preclinical Assessment Network (SPAN) Trial
Morais A, Locascio J, Sansing L, Lamb J, Nagarkatti K, Imai T, van Leyen K, Aronowski J, Koenig J, Bosetti F, Lyden P, Ayata C, Bosetti F, Koenig J, Lyden P, Lamb J, Nagarkatti K, Hess D, Kamat P, Khan M, Dhandapani K, Arbab A, Siddiqui S, Smith C, Nisar M, Leira E, Chauhan A, Dhanesha N, Patel R, Kumskova M, Thedens D, Wang K, Ayata C, Morais A, Imai T, Qin T, Jin X, Erdogan T, Yu L, Mandeville J, Kimberly W, Whittier J, Lo E, Arai K, Van Leyen K, Sansing L, Hyder F, Mihailovic J, Sanganahalli B, Diaz-Perez S, Velazquez S, Beatty H, Johnson C, Herman A, Boisserand L, Immakavar E, Koehler R, Dawson T, Dawson V, Shi Y, Avery B, Lannon S, Bibic A, Akhter K, Karuppagounder S, Aronowski J, McCullough L, Obertas L, Goh A, Huang S, Chauhan A. Embracing Heterogeneity in The Multicenter Stroke Preclinical Assessment Network (SPAN) Trial. Stroke 2023, 54: 620-631. PMID: 36601951, PMCID: PMC9870939, DOI: 10.1161/strokeaha.122.040638.Peer-Reviewed Original ResearchConceptsTotal anesthesia durationAnesthesia durationIndependent predictorsMultivariable analysisClinical trialsTransient focal cerebral ischemiaFocal cerebral ischemiaCerebral blood flowLaser Doppler flowCentralized randomizationModified intentionTreat populationExperimental strokeCerebral ischemiaDoppler flowRodent modelsMCAOBlood flowNetwork trialFlow dropPreclinical trialsMouse cohortsStudy designTrialsTrial onset
2022
Cerebral Blood Flow of the Frontal Lobe in Untreated Children with Trigonocephaly versus Healthy Controls: An Arterial Spin Labeling Study
Long A, Persing J, Alperovich M. Cerebral Blood Flow of the Frontal Lobe in Untreated Children with Trigonocephaly versus Healthy Controls: An Arterial Spin Labeling Study. Plastic & Reconstructive Surgery 2022, 151: 526e-527e. PMID: 36730155, DOI: 10.1097/prs.0000000000009946.Peer-Reviewed Original ResearchStress-level glucocorticoids increase fasting hunger and decrease cerebral blood flow in regions regulating eating
Bini J, Parikh L, Lacadie C, Hwang JJ, Shah S, Rosenberg SB, Seo D, Lam K, Hamza M, De Aguiar RB, Constable T, Sherwin RS, Sinha R, Jastreboff AM. Stress-level glucocorticoids increase fasting hunger and decrease cerebral blood flow in regions regulating eating. NeuroImage Clinical 2022, 36: 103202. PMID: 36126514, PMCID: PMC9486604, DOI: 10.1016/j.nicl.2022.103202.Peer-Reviewed Original ResearchConceptsCerebral blood flowRegional cerebral blood flowBlood flowMetabolic hormonesRandomized double-blind cross-over designDouble-blind cross-over designStress level glucocorticoidsPrimary sensory cortexPerfusion magnetic resonanceCross-over designMedial temporal gyrusWhole-brain voxelMedial brainstemSaline daysOvernight infusionCBF responseHunger ratingsPlasma insulinGlucocorticoid effectsHedonic signalsObesity riskLimbic regionsFood intakeNeural regulationDistinct brain networks
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply