2024
Novel Mechanical Aspiration Thrombectomy in Patients With Acute Pulmonary Embolism: Results From the Prospective APEX-AV Trial
Ranade M, Foster M, Brady P, Sokol S, Butty S, Klein A, Maholic R, Safar A, Patel T, Zlotnick D, Gans D, Pollak J, Ferrera D, Stegman B, Basra S, Moriarty J, Keeling B, Investigators A. Novel Mechanical Aspiration Thrombectomy in Patients With Acute Pulmonary Embolism: Results From the Prospective APEX-AV Trial. Journal Of The Society For Cardiovascular Angiography & Interventions 2024, 4: 102463. PMID: 40061412, PMCID: PMC11887559, DOI: 10.1016/j.jscai.2024.102463.Peer-Reviewed Original ResearchAcute intermediate-risk PEMechanical aspiration thrombectomyIntermediate-risk PEPulmonary embolismAspiration thrombectomyRV/LV ratioClot burdenAdverse eventsMm HgLow rate of adverse eventsMean pulmonary artery pressureEnd pointsRate of adverse eventsAcute pulmonary embolismPulmonary artery pressureSafety end pointDevice-related deathsTreat pulmonary embolismSingle-arm studyEffectiveness end pointAccess site bleedingStatistically significant reductionCardiac injuryClinical deteriorationArterial pressureNovel strategies for targeting neutrophil against myocardial infarction
Jiang K, Hwa J, Xiang Y. Novel strategies for targeting neutrophil against myocardial infarction. Pharmacological Research 2024, 205: 107256. PMID: 38866263, DOI: 10.1016/j.phrs.2024.107256.Peer-Reviewed Original Research
2023
Acute Pain Management Protocol for Ophthalmic Procedures
Dhodapkar R, Jin A, Liu J. Acute Pain Management Protocol for Ophthalmic Procedures. 2023, 291-311. DOI: 10.1007/978-3-031-21291-8_18.ChaptersMotor nerve blockNerve blockOphthalmic proceduresPost-procedural painPain management protocolPostoperative painMaxillary divisionRetrobulbar injectionCardiac injuryTrigeminal nerveFacial nerveExtraocular musclesLocal anestheticsTenon's blockOculoplastic proceduresTrigeminovagal reflexGold standardPainAnesthesiaNerveManagement protocolExtra careOculocardiacBradycardiaAkinesia
2022
Effects of Melatonin on Cardiac Injury and Inflammatory Biomarkers in Patients Undergoing Coronary Artery Bypass Graft Surgery: a Meta-analysis
Farshidianfar M, Ardekani A, Tabrizi R, Lankarani K, Taherifard E, Abdollahi A, Azizi A, Akbari M. Effects of Melatonin on Cardiac Injury and Inflammatory Biomarkers in Patients Undergoing Coronary Artery Bypass Graft Surgery: a Meta-analysis. Cardiology And Therapy 2022, 12: 11-20. PMID: 36352301, PMCID: PMC9986370, DOI: 10.1007/s40119-022-00287-1.Peer-Reviewed Original ResearchCardiac injuryInflammatory biomarkersEffects of melatoninCABG candidatesCoronary artery bypass graft surgeryArtery bypass graft surgeryPost-coronary artery bypass graftingMelatonin supplementationReduce cardiac injuryBypass graft surgeryArtery bypass graftingCardiac troponin IRandom-effects modelRandomized controlled trialsCABG patientsGraft surgeryCABG surgeryBypass graftingClinical significanceTroponin IWeb of ScienceCochrane LibraryControlled trialsEgger's testCABGThe cardiomyocyte disrupts pyrimidine biosynthesis in non-myocytes to regulate heart repair
Li S, Yokota T, Wang P, Hoeve J, Ma F, Le TM, Abt ER, Zhou Y, Wu R, Nanthavongdouangsy M, Rodriguez A, Wang Y, Lin YJ, Muranaka H, Sharpley M, Braddock DT, MacRae VE, Banerjee U, Chiou PY, Seldin M, Huang D, Teitell M, Gertsman I, Jung M, Bensinger SJ, Damoiseaux R, Faull K, Pellegrini M, Lusis A, Graeber TG, Radu CG, Deb A. The cardiomyocyte disrupts pyrimidine biosynthesis in non-myocytes to regulate heart repair. Journal Of Clinical Investigation 2022, 132: e149711. PMID: 34813507, PMCID: PMC8759793, DOI: 10.1172/jci149711.Peer-Reviewed Original ResearchConceptsCardiac injuryHeart repairENPP1 inhibitorsPyrimidine biosynthesisHeart injuryIschemic cardiac injuryAdministration of uridineEctonucleotide pyrophosphatase/phosphodiesterase 1Augmenting tissue repairP53-mediated cell deathSmall molecule screeningCardiac muscle cellsPyrophosphatase/phosphodiesterase 1Systemic administrationNonmyocyte cellsMurine modelHeart functionCardiac repairGenotoxic stressInjuryIntercellular regulationMuscle cellsPopulation of cellsExtracellular ATPMolecule screening
2021
MAP Kinase Phosphatase-5 Deficiency Protects Against Pressure Overload-Induced Cardiac Fibrosis
Zhong C, Min K, Zhao Z, Zhang C, Gao E, Huang Y, Zhang X, Baldini M, Roy R, Yang X, Koch WJ, Bennett AM, Yu J. MAP Kinase Phosphatase-5 Deficiency Protects Against Pressure Overload-Induced Cardiac Fibrosis. Frontiers In Immunology 2021, 12: 790511. PMID: 34992607, PMCID: PMC8724134, DOI: 10.3389/fimmu.2021.790511.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood PressureCardiomegalyCells, CulturedDisease Models, AnimalDual-Specificity PhosphatasesEchocardiographyFibrosisHeartHeart FailureHumansInterleukin-4MacrophagesMaleMAP Kinase Signaling SystemMatrix Metalloproteinase 9MiceMice, KnockoutMyocardiumPhosphorylationPrimary Cell CultureVentricular RemodelingConceptsMitogen-activated protein kinase phosphatase 5Transverse aortic constrictionCardiac fibrosisMMP-9 expressionPressure overloadCardiac hypertrophyPressure overload-induced cardiac fibrosisOverload-induced cardiac fibrosisTAC-induced cardiac hypertrophyExcessive extracellular matrix depositionPro-fibrotic macrophagesCardiac pressure overloadP38 MAPKMatrix metalloproteinase-9Regulation of MMPsProtein kinase phosphatase 5JNK/ERKIL-4 stimulationExtracellular matrix depositionCardiac injuryAortic constrictionMyocardial fibrosisHeart diseaseFibrotic remodelingMetalloproteinase-9Understanding the role of left and right ventricular strain assessment in patients hospitalized with COVID-19
Park J, Kim Y, Pereira J, Hennessey KC, Faridi KF, McNamara RL, Velazquez EJ, Hur DJ, Sugeng L, Agarwal V. Understanding the role of left and right ventricular strain assessment in patients hospitalized with COVID-19. American Heart Journal Plus Cardiology Research And Practice 2021, 6: 100018. PMID: 34095889, PMCID: PMC8168299, DOI: 10.1016/j.ahjo.2021.100018.Peer-Reviewed Original ResearchLV global longitudinal strainGlobal longitudinal strainFree wall strainLV ejection fractionAbnormal LV global longitudinal strainRV free wall strainCardiac injuryWorse outcomesHigh riskCOVID-19Normal LV ejection fractionLV-GLS valuesSubclinical cardiac injuryRetrospective chart reviewCoronavirus disease 2019Abnormal rightGLS cutoffHospital mortalityChart reviewTransthoracic echocardiographyEjection fractionPrimary outcomeVentricular functionClinical variablesAbnormal LVPRO-THROMBOTIC SIGNATURE FROM NEUTROPHIL ACTIVATION AND DECREASED ADAMTS13 TO VWF RATIO IS A KEY DRIVER OF CARDIAC INJURY IN HOSPITALIZED PATIENTS WITH COVID-19
Wang S, Pine A, Mankbadi M, Chang C, Madeeva D, Zhang H, Dajani A, Crandall I, Sugeng L, Lee A, Chun H. PRO-THROMBOTIC SIGNATURE FROM NEUTROPHIL ACTIVATION AND DECREASED ADAMTS13 TO VWF RATIO IS A KEY DRIVER OF CARDIAC INJURY IN HOSPITALIZED PATIENTS WITH COVID-19. Journal Of The American College Of Cardiology 2021, 77: 3193. PMID: 34167644, PMCID: PMC8091195, DOI: 10.1016/s0735-1097(21)04548-4.Peer-Reviewed Original ResearchTargeting OCT3 attenuates doxorubicin-induced cardiac injury
Huang KM, Thomas M, Magdy T, Eisenmann ED, Uddin ME, DiGiacomo DF, Pan A, Keiser M, Otter M, Xia SH, Li Y, Jin Y, Fu Q, Gibson AA, Bonilla IM, Carnes CA, Corps KN, Coppola V, Smith SA, Addison D, Nies AT, Bundschuh R, Chen T, Lustberg MB, Wang J, Oswald S, Campbell MJ, Yan PS, Baker SD, Hu S, Burridge PW, Sparreboom A. Targeting OCT3 attenuates doxorubicin-induced cardiac injury. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2020168118. PMID: 33495337, PMCID: PMC7865186, DOI: 10.1073/pnas.2020168118.Peer-Reviewed Original ResearchConceptsOrganic cation transporter 3Cardiac injuryCardiovascular functionSide effectsTranslational relevanceCalcium-binding proteins S100A8Irreversible cardiac injuryCurrent preventative strategiesPotential translational relevanceCardiac damagePlasma levelsCardiac accumulationBreast cancerAntitumor effectsPharmacological targetingPreventative strategiesModest protectionProteins S100A8Critical transporterTransporter 3Pharmacological inhibitorsOverexpression modelIntervention strategiesDoxorubicinCardiotoxicity
2020
Malignant Arrhythmias in Patients With COVID-19
Turagam M, Musikantow D, Goldman M, Bassily-Marcus A, Chu E, Shivamurthy P, Lampert J, Kawamura I, Bokhari M, Whang W, Bier B, Malick W, Hashemi H, Miller M, Choudry S, Pumill C, Ruiz-Maya T, Hadley M, Giustino G, Koruth J, Langan N, Sofi A, Dukkipati S, Halperin J, Fuster V, Kohli-Seth R, Reddy V. Malignant Arrhythmias in Patients With COVID-19. Circulation Arrhythmia And Electrophysiology 2020, 13: e008920-e008920. PMID: 33026892, PMCID: PMC7668347, DOI: 10.1161/circep.120.008920.Peer-Reviewed Original ResearchConceptsMalignant cardiac arrhythmiasAtrioventricular blockAssociated with several metabolic derangementsCardiac arrhythmiasPeak troponin I levelPrimary composite end pointVentricular arrhythmia historySevere metabolic derangementTroponin I levelsComposite end pointSevere metabolic imbalanceCoronary artery diseaseMount Sinai HospitalArrhythmia historyDefinitive dispositionVentricular tachycardia/fibrillationCardiac injuryMalignant arrhythmiasVentricular tachyarrhythmiasMetabolic derangementsCardiac arrestCardiovascular deathConsecutive inpatientsArtery diseaseI levelsA current review of COVID-19 for the cardiovascular specialist
Lang J, Wang X, Moura F, Siddiqi H, Morrow D, Bohula E. A current review of COVID-19 for the cardiovascular specialist. American Heart Journal 2020, 226: 29-44. PMID: 32497913, PMCID: PMC7252118, DOI: 10.1016/j.ahj.2020.04.025.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine MonophosphateAlanineAntimalarialsAntiviral AgentsBetacoronavirusBiomarkersCardiovascular DiseasesChloroquineCoronavirus InfectionsCOVID-19HumansHydroxychloroquineHypoxiaPandemicsPlasmaPneumonia, ViralReceptor, Angiotensin, Type 2Risk FactorsSARS-CoV-2Takotsubo CardiomyopathyVirus InternalizationConceptsAcute cardiac injuryCardiac injuryAdverse outcomesLevels of cardiac troponinAssociated with adverse outcomesHyperinflammatory cytokine stormType 2 myocardial infarctionPre-existing cardiovascular diseaseLevel of suspicionComplications of COVID-19Stress-related cardiomyopathyIncreased blood levelsCardiovascular risk factorsNonischemic myocardial injurySevere COVID-19Cardiovascular complications of COVID-19Nonischemic causesTakotsubo syndromeNatriuretic peptideD-dimerHigher mortality riskCardiovascular complicationsDiffuse thrombosisInflammatory milieuMyocardial dysfunction
2019
Doxorubicin-Induced Cardiotoxicity in Collaborative Cross (CC) Mice Recapitulates Individual Cardiotoxicity in Humans
Zeiss CJ, Gatti DM, Toro-Salazar O, Davis C, Lutz CM, Spinale F, Stearns T, Furtado MB, Churchill GA. Doxorubicin-Induced Cardiotoxicity in Collaborative Cross (CC) Mice Recapitulates Individual Cardiotoxicity in Humans. G3: Genes, Genomes, Genetics 2019, 9: 2637-2646. PMID: 31263061, PMCID: PMC6686936, DOI: 10.1534/g3.119.400232.Peer-Reviewed Original ResearchConceptsCardiac diseaseCardiac pathologyCardiac troponin I levelsUltimate severityChronic cardiac injuryTroponin I levelsPotential predictive biomarkersDoxorubicin-Induced CardiotoxicityComplete blood countPanel of biomarkersCurrent mouse modelsEffect of treatmentCardiac troponin IProgressive cardiotoxicityLight chain 3Acute periodAcute phaseCardiac injuryRenal toxicityBlood countPredictive biomarkersChronic timepointsCollaborative Cross miceSame doseI levelsMolecular Imaging Targets in Heart Failure and Left Ventricular Remodeling
Boutagy N, Feher A, Sikanderkhel S, Sinusas A. Molecular Imaging Targets in Heart Failure and Left Ventricular Remodeling. 2019, 405-435. DOI: 10.1002/9781118754467.ch13.ChaptersHeart failureManagement of HFMultimodality cardiovascular imagingMolecular imaging targetsMagnetic resonance imagingPositron emission tomographySingle photon emissionExtracellular matrix depositionCardiac injuryVentricle remodelingVentricular remodelingStandard clinical toolResonance imagingEmission tomographyClinical toolCompensatory mechanismsCardiac perfusionCardiovascular imagingNuclear imaging modalitiesImaging modalitiesImaging targetsPhoton emissionMatrix depositionNoninvasive measurementMolecular imaging
2016
Amelioration of ER stress by 4-phenylbutyric acid reduces chronic hypoxia induced cardiac damage and improves hypoxic tolerance through upregulation of HIF-1α
Jain K, Suryakumar G, Ganju L, Singh SB. Amelioration of ER stress by 4-phenylbutyric acid reduces chronic hypoxia induced cardiac damage and improves hypoxic tolerance through upregulation of HIF-1α. Vascular Pharmacology 2016, 83: 36-46. PMID: 27058435, DOI: 10.1016/j.vph.2016.03.004.Peer-Reviewed Original ResearchMeSH KeywordsAltitudeAnimalsApoptosisApoptosis Regulatory ProteinsChronic DiseaseCytoprotectionDisease Models, AnimalEndoplasmic Reticulum StressHypertrophy, Right VentricularHypoxiaHypoxia-Inducible Factor 1, alpha SubunitMaleMolecular ChaperonesMyocardiumOxidative StressPhenylbutyratesProtein CarbonylationProteolysisRats, Sprague-DawleySignal TransductionTime FactorsUnfolded Protein ResponseUp-RegulationConceptsChronic hypoxiaHIF-1αCardiac damageUnfolded protein responseER stressHypoxic toleranceRight ventricular enlargementExposure of ratsHypoxia-inducible factor-1ER stress modulationEndoplasmic reticulum stressInducible factor-1Ventricular enlargementCardiac injuryCardioprotective actionCardiovascular diseaseCardiac hypertrophyMarked upregulationActivation of UPRUnderlying causeUPR markersHypoxiaReticulum stressConcomitant suppressionFactor 1Cost‐effectiveness of the Cardiac Component of the Focused Assessment of Sonography in Trauma Examination in Blunt Trauma
Hall MK, Omer T, Moore CL, Taylor RA. Cost‐effectiveness of the Cardiac Component of the Focused Assessment of Sonography in Trauma Examination in Blunt Trauma. Academic Emergency Medicine 2016, 23: 415-423. PMID: 26857839, DOI: 10.1111/acem.12936.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedBlood PressureCost-Benefit AnalysisDecision Support TechniquesFemaleHeart InjuriesHumansHypotensionLife ExpectancyMedicareMiddle AgedModels, EconometricPoint-of-Care SystemsQuality-Adjusted Life YearsReproducibility of ResultsUltrasonographyUnited StatesWounds, NonpenetratingConceptsNormotensive blunt trauma patientsIncremental cost-effectiveness ratioBlunt trauma patientsTrauma patientsBlunt traumaNormotensive patientsHypotensive patientsFocused assessmentBlunt cardiac injuryIncidental pericardial effusionCardiac componentCost-effectiveness ratioDecision analytic modelProbability of deathPericardial effusionPrompt treatmentClinical probabilityCardiac injurySurgical interventionTrauma (FAST) examFAST examLow prevalencePatientsTrauma (FAST) examinationPay thresholds
2015
Identification of a Receptor for Extracellular Renalase
Wang L, Velazquez H, Chang J, Safirstein R, Desir GV. Identification of a Receptor for Extracellular Renalase. PLOS ONE 2015, 10: e0122932. PMID: 25906147, PMCID: PMC4407985, DOI: 10.1371/journal.pone.0122932.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryCell LineCytoprotectionDown-RegulationEpidermal Growth FactorEssential HypertensionHumansHypertensionMitogen-Activated Protein KinasesMonoamine OxidasePlasma Membrane Calcium-Transporting ATPasesPolymorphism, Single NucleotideProtein Interaction Domains and MotifsSignal TransductionConceptsAcute kidney injuryIntrinsic enzymatic activityMAPK signalingExtracellular renalaseHuman proximal tubular cell line HK-2Enzymatic activitySingle nucleotide gene polymorphismsAcute ischemic kidneyWild-type miceProtein-protein interactionsPlasma membrane ATPaseKidney injuryIschemic kidneyEssential hypertensionIschemic injuryCardiac injuryPMCA4b expressionRecombinant renalaseEpidermal growth factorType miceCardiac hypertrophyHK-2Control studyGene polymorphismsCell signalingPerioperative heart-type fatty acid binding protein is associated with acute kidney injury after cardiac surgery
Schaub JA, Garg AX, Coca SG, Testani JM, Shlipak MG, Eikelboom J, Kavsak P, McArthur E, Shortt C, Whitlock R, Parikh CR. Perioperative heart-type fatty acid binding protein is associated with acute kidney injury after cardiac surgery. Kidney International 2015, 88: 576-583. PMID: 25830762, PMCID: PMC4556547, DOI: 10.1038/ki.2015.104.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAgedAged, 80 and overBiomarkersCardiac Surgical ProceduresChi-Square DistributionFatty Acid Binding Protein 3Fatty Acid-Binding ProteinsFemaleHumansLogistic ModelsMaleMiddle AgedMultivariate AnalysisNorth AmericaOdds RatioPerioperative PeriodProportional Hazards ModelsProspective StudiesRisk AssessmentRisk FactorsSeverity of Illness IndexUp-RegulationConceptsAcute kidney injurySevere acute kidney injuryCardiac surgeryKidney injuryKidney injury molecule-1Neutrophil gelatinase-associated lipocalinHeart-type fatty acid binding proteinAKI risk factorsInjury molecule-1Long-term mortalityBrain natriuretic peptideGelatinase-associated lipocalinH-FABP levelsMulti-center cohortTRIBE-AKI cohortFatty acid binding proteinLiver fatty acidHeart fatty acidCommon complicationSecondary outcomesSerum creatininePrimary outcomeInterleukin-18Risk stratificationCardiac injury
2014
Anthracycline-related cardiotoxicity in childhood cancer survivors
Lipshultz SE, Karnik R, Sambatakos P, Franco VI, Ross SW, Miller TL. Anthracycline-related cardiotoxicity in childhood cancer survivors. Current Opinion In Cardiology 2014, 29: 103-112. PMID: 24284979, DOI: 10.1097/hco.0000000000000034.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAnthracycline-related cardiotoxicityCardiovascular complicationsAnthracycline treatmentRisk factorsCardioprotective agentGrowth hormone replacement therapyPrevention of cardiotoxicityHormone replacement therapySerious cardiovascular complicationsChildhood cancer survivorsLong-term outcomesUse of biomarkersDosage of anthracyclinesCardiac transplantationCardiac dysfunctionCancer survivorsCardiac injuryClinical manifestationsReplacement therapyEarly recognitionChildhood cancerCardiotoxic effectsΒ-blockersEnzyme inhibitorsCardiotoxicity
2011
Management of Pediatric Cardiac Trauma in the ED
Kamdar G, Santucci K, Emerson B. Management of Pediatric Cardiac Trauma in the ED. Clinical Pediatric Emergency Medicine 2011, 12: 323-332. DOI: 10.1016/j.cpem.2011.09.001.Peer-Reviewed Original ResearchCardiac traumaStructural cardiac damageBlunt chest traumaAggressive resuscitationAortic injuryCardiac tamponadeCardiac contusionChest traumaCardiac enzymesMultisystem injuriesCommotio cordisCardiac damageCardiac injuryClinical syndromeClassic signsHigh indexTraumaInjuryCardiac cycleDiagnosisChildrenContusionTamponadeEchocardiographyComplications
2010
Role of Novel Biomarkers in Chronic Kidney Disease: Renalase
Desir G. Role of Novel Biomarkers in Chronic Kidney Disease: Renalase. 2010, 309-316. DOI: 10.1007/978-88-470-1463-3_24.Peer-Reviewed Original ResearchChronic kidney diseaseBlood pressureKidney diseaseCardiac functionRenalase knockout mouseAcute kidney injurySevere cardiovascular complicationsCardiovascular complicationsKidney injuryEssential hypertensionCardiac injuryMyocardial injuryEarly biomarkersRenalase geneNovel biomarkersKnockout miceTherapeutic utilityRenalaseInjuryProtein expressionSingle nucleotide polymorphismsPreliminary dataDiseaseModest increaseBiomarkers
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