2025
Cardiac Magnetic Resonance Imaging in Immune Checkpoint Inhibitor–Related Myocarditis
Hammer M, Tysarowski M, Fuss C, Bader A. Cardiac Magnetic Resonance Imaging in Immune Checkpoint Inhibitor–Related Myocarditis. Echocardiography 2025, 42: e70131. PMID: 40067334, DOI: 10.1111/echo.70131.Peer-Reviewed Original ResearchConceptsImmune-related adverse eventsImmune checkpoint inhibitorsCardiac magnetic resonance imagingMagnetic resonance imagingAssociated with immune-related adverse eventsCardiac immune-related adverse eventsMechanisms of immune checkpoint inhibitorsICI-associated myocarditisICI-related myocarditisResonance imagingPersonalized cancer immunotherapySevere cardiovascular complicationsImmune tolerance pathwayCheckpoint inhibitorsCancer immunotherapyCardiac complicationsCombination therapyTumor cytotoxicityClinical presentationCardiovascular complicationsAdverse eventsTherapeutic efficacyOncological treatmentTherapeutic strategiesMyocarditis
2024
Acute Cardiac Events in Hospitalized Older Adults With Respiratory Syncytial Virus Infection
Woodruff R, Melgar M, Pham H, Sperling L, Loustalot F, Kirley P, Austin E, Yousey-Hindes K, Openo K, Ryan P, Brown C, Lynfield R, Davis S, Barney G, Tesini B, Sutton M, Talbot H, Zahid H, Kim L, Havers F, Rowlands J, Spina N, Engesser K, Salazar-Sanchez Y, George A, Staten H, Bleecker M, Leegwater L, Tellez Nunez V, Falkowski A, Felsen C, Licherdell E, St George K, Pacheco F, Desiato J, Labozzo N, Zmek E, Alden N, Strayhorn N, Fawcett E, Surell C, Como-Sabetti K, Mumm E, Bilski K, Markus T, Ndi D, Billings K. Acute Cardiac Events in Hospitalized Older Adults With Respiratory Syncytial Virus Infection. JAMA Internal Medicine 2024, 184: 602-611. PMID: 38619857, PMCID: PMC11019447, DOI: 10.1001/jamainternmed.2024.0212.Peer-Reviewed Original ResearchRespiratory syncytial virus infectionRespiratory syncytial virusRespiratory syncytial virus seasonAcute cardiac eventsCardiac eventsWeighted estimated prevalenceIn-hospital deathAdjusted risk ratiosIntensive care unitClassification of DiseasesCross-sectional studyHospitalized adultsCardiac complicationsRSV infectionRSV diseaseLaboratory-confirmed RSV infectionOlder adultsCases of RSV infectionReceipt of invasive mechanical ventilationCardiovascular diseaseIntensive care unit admissionSevere outcomesEstimated prevalenceAcute heart failurePotential cardiac complications
2023
The Utilization of Protamine during Peripheral Vascular Interventions in the VQI
Ali S, Shebl F, Aboian E, Strosberg D, Fischer U, Cardella J, Guzman R, Ochoa Chaar C. The Utilization of Protamine during Peripheral Vascular Interventions in the VQI. Annals Of Vascular Surgery 2023, 101: 72-79. PMID: 38110083, DOI: 10.1016/j.avsg.2023.10.019.Peer-Reviewed Original ResearchPeripheral vascular interventionsAdjusted rate ratiosProtamine useCardiac complicationsPropensity matchingVascular interventionsChronic obstructive pulmonary diseasePropensity scoreCharacteristics of patientsPeripheral arterial diseaseCongestive heart failureObstructive pulmonary diseaseMultivariable Poisson regressionUse of protamineSignificant differencesMedical comorbiditiesP2Y12 inhibitorsPerioperative bleedingPerioperative medicationsPerioperative outcomesDistal embolizationPatient comorbiditiesCarotid surgeryHeart failurePulmonary diseaseThe Role of Vascular Biomarkers in Outcomes of Patients with Kidney Disease
Shi A, Mansour S. The Role of Vascular Biomarkers in Outcomes of Patients with Kidney Disease. Nephron 2023, 147: 778-781. PMID: 37611550, PMCID: PMC10841333, DOI: 10.1159/000533415.Peer-Reviewed Original ResearchConceptsAcute kidney injuryAngpt-2 levelsCardiovascular diseaseVascular biomarkersPoor outcomeChronic kidney disease patientsPoor long-term outcomesGrowth factorKidney transplant recipientsOutcomes of patientsKidney disease progressionKidney disease patientsLong-term outcomesPlacental growth factorVascular endothelial growth factorEndothelial growth factorAKI patientsAKI survivorsCardiac complicationsKidney injuryTransplant recipientsCardiac surgeryHeart failureHospitalized patientsEndothelial damageCarbon dioxide angiography during peripheral vascular interventions is associated with decreased cardiac and renal complications in patients with chronic kidney disease
Lee S, Ali S, Cardella J, Turner J, Guzman R, Dardik A, Ochoa Chaar C. Carbon dioxide angiography during peripheral vascular interventions is associated with decreased cardiac and renal complications in patients with chronic kidney disease. Journal Of Vascular Surgery 2023, 78: 201-208. PMID: 36948278, DOI: 10.1016/j.jvs.2023.03.029.Peer-Reviewed Original ResearchConceptsAdvanced chronic kidney diseaseChronic kidney diseasePeripheral vascular interventionsContrast volume usagePC-AKICarbon dioxide angiographyCardiac complicationsPropensity matchingKidney diseaseVascular interventionsPost-contrast acute kidney injuryAcute kidney injuryOutcomes of patientsPeripheral arterial diseasePoor renal functionMultivariate logistic regressionLower contrast volumeVolume of contrastCardiac comorbiditiesKidney injuryMinor amputationRenal complicationsRenal functionEndovascular therapyArterial diseaseImage guided dilation of sinus ostium in revision sinus surgery
Han J, Palmer J, Adappa N, Nachlas N, Chandra R, Jacobs J, Manes R, McKenzie K. Image guided dilation of sinus ostium in revision sinus surgery. American Journal Of Otolaryngology 2023, 44: 103803. PMID: 36889144, DOI: 10.1016/j.amjoto.2023.103803.Peer-Reviewed Original ResearchConceptsRevision sinus surgeryAdverse eventsSinus ostiumSinus surgeryUS clinical sitesOperative adverse eventsBalloon sinus dilationSphenoid sinus ostiumCardiac complicationsMulticenter studyMaxillary sinusSinus dilationSafety outcomesSinusClinical sitesEndoscopic photosPerformance endpointOstiumSurgeryDilation systemSurgeon's abilitySubjectsDirect causeDilationOutcomes
2022
Cardiac Complications of Human Babesiosis
Spichler-Moffarah A, Ong E, O’Bryan J, Krause PJ. Cardiac Complications of Human Babesiosis. Clinical Infectious Diseases 2022, 76: e1385-e1391. PMID: 35983604, PMCID: PMC10169432, DOI: 10.1093/cid/ciac525.Peer-Reviewed Original ResearchConceptsYale-New Haven HospitalCardiac complicationsRisk factorsIntensive care unit stayCardiovascular disease risk factorsHuman babesiosisCommon cardiac complicationHigh-grade parasitemiaLife-threatening complicationsDisease risk factorsLonger median lengthQT interval prolongationHigh mortality rateUnit stayComplication groupTick-borne diseaseAdult patientsCardiac outcomesMost patientsThin blood smearsHeart failureInterval prolongationModerate illnessRecord reviewAtrial fibrillationEarly outcomes of growth friendly instrumentation in children with Williams syndrome
O’Neill N, Cook D, Verhofste B, Smith J, Emans J. Early outcomes of growth friendly instrumentation in children with Williams syndrome. Spine Deformity 2022, 10: 717-725. PMID: 35000131, DOI: 10.1007/s43390-021-00453-w.Peer-Reviewed Original ResearchConceptsEarly-onset scoliosisVertical expandable prosthetic titanium ribGrowth-friendly treatmentGrowth-friendly instrumentationSurgical treatmentCardiovascular complicationsCase seriesCurve magnitudeExpandable prosthetic titanium ribSevere early onset scoliosisPerioperative cardiac complicationsSpine deformity surgeryT1-S1 lengthT1-T12 lengthWilliams syndromeInitial surgical treatmentCoronal curve magnitudeMedian followCardiac complicationsIndex surgeryInitial surgeryMedian durationResultsSeven patientsMedian ageAssociated complicationsThe Enhanced Cardiac Outcome of Conjugated SGLT2 Inhibitors and GLP-1RA Therapy in Diabetic Patients
Fadah K, Alashi A, Deoker A. The Enhanced Cardiac Outcome of Conjugated SGLT2 Inhibitors and GLP-1RA Therapy in Diabetic Patients. Current Cardiology Reports 2022, 24: 17-22. PMID: 35000149, DOI: 10.1007/s11886-021-01619-8.Peer-Reviewed Original ResearchConceptsDiabetic populationDiabetic patientsSGLT2 inhibitorsGlucagon-like peptide-1 receptor agonistsSodium-glucose cotransporter 2 inhibitorsMajor adverse cardiovascular eventsReal-world cohort studyPeptide-1 receptor agonistsAdditional cardiovascular benefitsGLP-1RA therapyAdverse cardiovascular eventsCotransporter 2 inhibitorsMechanism of actionGLP-1RAsAntihyperglycemic therapyCardiac complicationsCardiac mortalityCardiovascular eventsCardiac outcomesCardiovascular benefitsCohort studyDrug therapyReceptor agonistCardioprotective processesReviewCardiovascular diseaseCardiac surgeons’ perspectives and practices regarding people who use drugs: A scoping review
Muncan B, Kim EK, Amabile A, Weimer MB, Tiako M, Vallabhajosyula P, Kalogeropoulos AP, Geirsson A. Cardiac surgeons’ perspectives and practices regarding people who use drugs: A scoping review. Journal Of Cardiac Surgery 2022, 37: 630-639. PMID: 34989450, DOI: 10.1111/jocs.16201.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCardiac surgeonsInfective endocarditisAddiction medicine specialistsInfectious disease specialistsMultidisciplinary care teamEvidence-based guidelinesJoanna Briggs Institute guidelinesPoor health outcomesPreferred Reporting ItemsComprehensive literature searchWillingness of surgeonsCardiac complicationsCardiovascular complicationsSurgical treatmentSurgical managementDisease specialistsAim of studyCare teamInstitute guidelinesMedicine specialistsEquitable careIndependent authorsPsychosocial factorsReporting ItemsHealth outcomes
2020
The impact of hospital size on national trends and outcomes in isolated open proximal aortic surgery
Hirji S, Shah R, Aranki S, McGurk S, Singh S, Mallidi H, Pelletier M, Shekar P, Kaneko T. The impact of hospital size on national trends and outcomes in isolated open proximal aortic surgery. Journal Of Thoracic And Cardiovascular Surgery 2020, 163: 1269-1278.e9. PMID: 32713639, DOI: 10.1016/j.jtcvs.2020.03.180.Peer-Reviewed Original ResearchMeSH KeywordsAdultAortic AneurysmAortic DiseasesAortic DissectionAortic RuptureBenchmarkingBlood Vessel Prosthesis ImplantationDatabases, FactualFemaleHealth Facility SizeHospital Bed CapacityHospital CostsHospital MortalityHospitalizationHumansLength of StayMaleMiddle AgedPostoperative ComplicationsThoracic Surgical ProceduresUnited StatesConceptsProximal aortic surgeryAortic surgeryImpact of hospital sizeHospital sizeIn-hospital cardiac complicationsLarge hospitalsProximal aortic operationsRe-do proceduresHospital costsPatients aged >Propensity-score matching analysisOverall in-hospital mortalityIn-hospital mortalityIn-hospital outcomesShorter length of stayLower hospital costsPropensity-score matchingIn-hospital mortality trendsBenchmark hospital performanceLength of stayNational Inpatient SampleConcomitant valvularAortic operationsOperative mortalityCardiac complicationsCardiac Complications in Neurocritical Care Patients
Kim J, Izzy S. Cardiac Complications in Neurocritical Care Patients. Current Clinical Neurology 2020, 49-56. DOI: 10.1007/978-3-030-36548-6_4.Peer-Reviewed Original ResearchNeurologic injuryAcute neurologic injuryNeurocritical care patientsSpecific neurologic diseasesCardiac complicationsNeurologic recoveryHemodynamic instabilityCare patientsCardiovascular changesMyocardial ischemiaCardiovascular functionNeurologic diseaseCardiovascular systemInjuryPatientsHypertensionNeurointensivistsComplicationsIschemiaArrhythmiasCardiologistsDisease
2019
Clinical Impact of Atrial Fibrillation on Short-Term Outcomes and In-Hospital Mortality in Patients with Takotsubo Syndrome: A Propensity-Matched National Study
Yassin A, Subahi A, Adegbala O, Abubakar H, Dawdy J, Mishra T, Akintoye E, Shereef H, Ghandour M, Alhusain R, Shokr M, Oviedo C, Afonso L. Clinical Impact of Atrial Fibrillation on Short-Term Outcomes and In-Hospital Mortality in Patients with Takotsubo Syndrome: A Propensity-Matched National Study. Cardiovascular Revascularization Medicine 2019, 21: 522-526. PMID: 31439442, DOI: 10.1016/j.carrev.2019.07.022.Peer-Reviewed Original ResearchConceptsCost of hospitalizationAtrial fibrillationHospital mortalityHospital complicationsVentricular arrhythmiasNational Inpatient Sample databasePropensity score-matched analysisMajor cardiac complicationsTakotsubo syndrome patientsIn-Hospital MortalityNon-routine dischargeAtrial fibrillation groupAtrial fibrillation patientsShort-term outcomesNational Inpatient SampleLength of stayPotential confounding factorsCardiac complicationsHospital stayFibrillation groupFibrillation patientsSecondary outcomesTakotsubo syndromePrimary outcomeCardiac arrestCardiac Complications Related to Spine Surgery: Timing, Risk Factors, and Clinical Effect.
Bovonratwet P, Bohl DD, Malpani R, Haynes MS, Rubio DR, Ondeck NT, Shultz BN, Mahal AR, Grauer JN. Cardiac Complications Related to Spine Surgery: Timing, Risk Factors, and Clinical Effect. Journal Of The American Academy Of Orthopaedic Surgeons 2019, 27: 256-263. PMID: 30897607, DOI: 10.5435/jaaos-d-17-00650.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overDatabases, FactualFemaleHeart ArrestHumansIncidenceIntraoperative ComplicationsLength of StayMaleMiddle AgedMonitoring, PhysiologicMultivariate AnalysisMyocardial InfarctionOrthopedic ProceduresPatient ReadmissionPerioperative PeriodPostoperative ComplicationsRisk FactorsSpineTime FactorsYoung AdultConceptsCardiac complicationsSpine surgeryRisk factorsPostoperative periodNational Surgical Quality Improvement Program databaseSurgeons National Surgical Quality Improvement ProgramNational Surgical Quality Improvement ProgramQuality Improvement Program databaseSurgical Quality Improvement ProgramPerioperative cardiac complicationsHigh-risk patientsImprovement Program databaseInsulin-dependent diabetesLarge cohort studyQuality Improvement ProgramPreoperative anemiaPostoperative lengthCohort studyPerioperative periodPrimary outcomeClinical effectsCardiac arrestMyocardial infarctionProgram databaseAmerican CollegeMyocarditis with checkpoint inhibitor immunotherapy: case report of late gadolinium enhancement on cardiac magnetic resonance with pathology correlate
Gallegos C, Rottmann D, Nguyen VQ, Baldassarre LA. Myocarditis with checkpoint inhibitor immunotherapy: case report of late gadolinium enhancement on cardiac magnetic resonance with pathology correlate. European Heart Journal - Case Reports 2019, 3: yty149. PMID: 31020225, PMCID: PMC6439394, DOI: 10.1093/ehjcr/yty149.Peer-Reviewed Case Reports and Technical NotesLate gadolinium enhancementCardiovascular magnetic resonanceCardiac complicationsGadolinium enhancementAnti-programmed cell death protein 1 monoclonal antibodyCell death protein 1 monoclonal antibodyLeft ventricular ejection fractionNon-ischemic patternAcute heart failureCheckpoint inhibitor therapyRefractory cardiogenic shockCarotid artery dissectionCheckpoint inhibitor immunotherapyVentricular ejection fractionArea of myocardiumCardiac magnetic resonanceDirect histological correlationAreas of LGEArtery dissectionCardiogenic shockCheckpoint inhibitorsImmunosuppressive therapyVentricular dysfunctionEjection fractionHeart failure
2018
National trends in Fontan operation and in-hospital outcomes in the USA
Akintoye E, Miranda W, Veldtman G, Connolly H, Egbe A. National trends in Fontan operation and in-hospital outcomes in the USA. Heart 2018, 105: 708-714. PMID: 30377261, DOI: 10.1136/heartjnl-2018-313680.Peer-Reviewed Original ResearchConceptsFontan operationHospital mortalityPostoperative complicationsClinical Modification procedure codesHypoplastic left heart syndromePostoperative cardiac complicationsCongenital heart disease diagnosisNationwide Inpatient SampleAcute care facilitiesLength of stayNumber of patientsDiseases-Ninth RevisionVolume of proceduresSignificant declineNumber of proceduresCardiac complicationsRespiratory complicationsHospital dischargeHospital outcomesPatient demographicsMedian ageHeart syndromeHospitalisation costsPatient populationSignificant changesFinancial Implications and Impact of Pre-existing Atrial Fibrillation on In-Hospital Outcomes in Patients Who Underwent Transcatheter Aortic Valve Implantation (from the National Inpatient Database)
Abubakar H, Yassin A, Akintoye E, Bakhit K, Pahuja M, Shokr M, Lieberman R, Afonso L. Financial Implications and Impact of Pre-existing Atrial Fibrillation on In-Hospital Outcomes in Patients Who Underwent Transcatheter Aortic Valve Implantation (from the National Inpatient Database). The American Journal Of Cardiology 2018, 121: 1587-1592. PMID: 29622287, DOI: 10.1016/j.amjcard.2018.02.052.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAortic Valve StenosisArrhythmias, CardiacAtrial FibrillationCardiac Pacing, ArtificialCardiac TamponadeComorbidityDatabases, FactualFemaleHeart ArrestHeart FailureHospital CostsHospital MortalityHumansLength of StayLinear ModelsLogistic ModelsMaleMyocardial InfarctionPacemaker, ArtificialPericardial EffusionPostoperative ComplicationsPostoperative HemorrhageStrokeTranscatheter Aortic Valve ReplacementUnited StatesConceptsTranscatheter aortic valve implantationPre-existing atrial fibrillationLength of stayPeriprocedural cardiac complicationsAortic valve implantationAtrial fibrillationCost of hospitalizationCardiac complicationsHospital mortalityEnd pointValve implantationLonger hospital LOSUnderwent Transcatheter Aortic Valve ImplantationPre-existing AFHospital LOSIncidence of AFLonger LOSNationwide Inpatient Sample databaseIn-Hospital OutcomesPrimary end pointSecondary end pointsClinical end pointsHospital-level characteristicsMixed-effects logistic modelTAVI patientsComparison of Internal Medicine and General Surgery Residents' Assessments of Risk of Postsurgical Complications in Surgically Complex Patients
Healy JM, Davis KA, Pei KY. Comparison of Internal Medicine and General Surgery Residents' Assessments of Risk of Postsurgical Complications in Surgically Complex Patients. JAMA Surgery 2018, 153: 203-207. PMID: 29049425, PMCID: PMC5885933, DOI: 10.1001/jamasurg.2017.3936.Peer-Reviewed Original ResearchConceptsInternal medicine residentsComplex patientsGeneral surgery residentsPostsurgical complicationsMedicine residentsGeneral surgeryInternal medicineSurgery residentsSurgical site infectionSmall bowel resectionInguinal hernia repairInternal medicine serviceRisk-adjusted outcomesRisk-adjusted modelsDuodenal ulcer repairGeneral surgery practiceComplex clinical scenariosGeneral surgery traineesRisk of interventionCardiac complicationsComplex patient scenariosPostoperative complicationsSurgical complicationsSite infectionSurgical riskSurgeons overestimate postoperative complications and death when compared with the National Surgical Quality Improvement Project risk calculator
Pei KY, Healy J, Davis KA. Surgeons overestimate postoperative complications and death when compared with the National Surgical Quality Improvement Project risk calculator. Journal Of Surgical Research 2018, 225: 95-100. PMID: 29605041, DOI: 10.1016/j.jss.2018.01.008.Peer-Reviewed Original ResearchConceptsComplex surgical patientsGeneral surgery residentsSurgical patientsRisk calculatorNational Surgical Quality Improvement ProjectSurgical Quality Improvement ProjectSurgery residentsSurgical site infectionOverall response rateSurgical Risk CalculatorPrediction of morbidityQuality improvement projectRisk-adjusted modelsCardiac complicationsPostoperative complicationsPostoperative morbiditySite infectionSurgical riskComplex patientsAmerican CollegeClinical scenariosMorbidityResponse rateComplicationsPatients
2017
Comparison of In-Hospital Outcomes of Transcatheter Aortic Valve Implantation Versus Surgical Aortic Valve Replacement in Obese (Body Mass Index ≥ 30 Kg/M2) Patients
Ando T, Akintoye E, Trehan N, Telila T, Briasoulis A, Takagi H, Grines C, Afonso L. Comparison of In-Hospital Outcomes of Transcatheter Aortic Valve Implantation Versus Surgical Aortic Valve Replacement in Obese (Body Mass Index ≥ 30 Kg/M2) Patients. The American Journal Of Cardiology 2017, 120: 1858-1862. PMID: 28860018, DOI: 10.1016/j.amjcard.2017.07.098.Peer-Reviewed Original ResearchMeSH KeywordsAgedAortic ValveAortic Valve StenosisBody Mass IndexComorbidityFemaleFollow-Up StudiesHospital MortalityHumansIncidenceInpatientsMaleObesityPostoperative ComplicationsPrevalencePrognosisPropensity ScoreRisk AssessmentRisk FactorsSurvival RateTime FactorsTranscatheter Aortic Valve ReplacementUnited StatesConceptsTranscatheter aortic valve implantationSurgical aortic valve replacementAortic valve replacementTAVI patientsNonroutine dischargeObese patientsValve replacementTranscatheter Aortic Valve Implantation Versus Surgical Aortic Valve ReplacementNationwide Inpatient Sample databaseHigher co-morbidity burdenCertain perioperative complicationsAcute kidney injuryIn-Hospital OutcomesShorter hospital stayAortic valve implantationCo-morbidity burdenMedian hospital costsAcute myocardial infarctionLength of stayCharlson scoreDeyo's modificationHospital mortalityCardiac complicationsHospital stayKidney injury
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