2025
Psychometric evaluation of the Chinese version of Templer’s death anxiety scale using item response theory
Chen F, Deng Y, Li S, Zhang Q, Knobf M, Ye Z. Psychometric evaluation of the Chinese version of Templer’s death anxiety scale using item response theory. Measurement And Evaluations In Cancer Care 2025, 3: 100012. DOI: 10.1016/j.ymecc.2024.100012.Peer-Reviewed Original ResearchMokken scale analysisTempler's Death Anxiety ScaleEvaluate death anxietyDifferential Item FunctioningDeath Anxiety ScaleDeath anxietyFear of deathItem response theoryChinese versionCancer patientsChinese cancer patientsAnxiety ScaleAcceptance of deathItem response theory analysisDifferential item functioning analysisGender differencesPsychometric evaluationItem FunctioningModerate difficultyAnxietyLocal independenceResponse theoryItemsIncreasing recognitionFearIn the time of COVID-19: challenges, successes and lessons learned from studies in cancer patients
Mack P, Crawford J, Chang A, Yin A, Klein S, Shea P, Hirsch F, Zidar D, Simon V, Gleason C, McBride R, Cordon-Cardo C, VanOudenhove J, Halene S, Lee F, Mantis N, Kushi L, Weiskopf D, Merchant A, Reckamp K, Skarbinski J, Figueiredo J. In the time of COVID-19: challenges, successes and lessons learned from studies in cancer patients. Journal Of The National Cancer Institute 2025, djaf073. PMID: 40127178, DOI: 10.1093/jnci/djaf073.Peer-Reviewed Original ResearchChanging public health landscapePublic health landscapeEnrollment of participantsSARS-CoV-2National Cancer InstituteRisk of SARS-CoV-2 infectionU.S. National Cancer InstituteNational Institute of AllergyOverall healthHealth landscapeSelf-reportCohort studyStudy designBiospecimen collectionInstitute of AllergySARS-CoV-2 infectionCancer InstituteStandard serological testsData elementsStudy immune responsesHematologic malignanciesClinicopathological dataNational InstituteCancer patientsCOVID-19The Role of the Interventional Radiologist in Stopping Bleeding in Cancer Patients
Fish A, Madoff D. The Role of the Interventional Radiologist in Stopping Bleeding in Cancer Patients. Current Oncology Reports 2025, 1-7. PMID: 40120057, DOI: 10.1007/s11912-025-01663-5.Peer-Reviewed Original ResearchUterine artery embolizationBronchial artery embolizationArtery embolizationBronchial arterial chemoembolizationMalignancy-related bleedingLife-threatening complicationsImproved long-term controlMultidisciplinary approachLong-term controlTumor bleedingArterial chemoembolizationSuperselective embolizationIschemic complicationsEmbolization techniquesInterventional radiologistsControl hemorrhageLung cancerHemostatic solutionsCancer patientsEmbolizationEndovascular interventionStop bleedingImprove outcomesBleedingHemorrhagePrecision projections of the delay of resistance mutations in non-small cell lung cancer via suppression of APOBEC
Nousias O, Mandell J, Anderson K, Townsend J. Precision projections of the delay of resistance mutations in non-small cell lung cancer via suppression of APOBEC. Lung Cancer 2025, 202: 108487. PMID: 40090261, DOI: 10.1016/j.lungcan.2025.108487.Peer-Reviewed Original ResearchNon-small cell lung cancer patientsNon-small cell lung cancerCell lung cancer patientsCell lung cancerLung cancer patientsEvolution of drug resistanceLung cancerDrug resistanceCancer patientsTyrosine kinase inhibitor therapyKinase inhibitor therapyTyrosine kinase inhibitorsPersonalized therapeutic strategiesTKI therapyInhibitor therapyTherapeutic failureResistance mutationsTherapeutic efficacyKinase inhibitorsAPOBEC mutationsTherapeutic strategiesTreatment efficacyCancer progressionImprove outcomesCancerIntegrating epidemiology and genomics data to estimate the prevalence of acquired cysteine drug targets in the U.S. cancer patient population
Arun A, Liarakos D, Mendiratta G, Kim J, Goshua G, Olson P, Stites E. Integrating epidemiology and genomics data to estimate the prevalence of acquired cysteine drug targets in the U.S. cancer patient population. The Pharmacogenomics Journal 2025, 25: 5. PMID: 40044654, DOI: 10.1038/s41397-025-00364-3.Peer-Reviewed Original ResearchConceptsGenomic dataEstimates of mutation ratesSomatic missense mutationsGenomic informationPopulation-level estimatesCancer patient populationMissense mutationsNon-epidemiologicallyCancer patientsMutation ratePathogenic mutationsCysteine residuesCancer epidemiologyMutation-specificMutation abundanceDrug targetsMutationsIntegrates epidemiologyAbundancePatient populationEpidemiologyGenomePopulationTargeted therapyResiduesUnderstanding oncologic emergencies and related emergency department visits and hospitalizations: a systematic review
Yilmaz S, Aryal K, King J, Bischof J, Hong A, Wood N, Gould Rothberg B, Hudson M, Heinert S, Wattana M, Coyne C, Reyes-Gibby C, Todd K, Lyman G, Klotz A, Abar B, Grudzen C, Bastani A, Baugh C, Henning D, Bernstein S, Rico J, Ryan R, Yeung S, Qdaisat A, Padela A, Madsen T, Liu R, Adler D. Understanding oncologic emergencies and related emergency department visits and hospitalizations: a systematic review. BMC Emergency Medicine 2025, 25: 40. PMID: 40045233, PMCID: PMC11883922, DOI: 10.1186/s12873-025-01183-2.Peer-Reviewed Original ResearchConceptsEmergency departmentEmergency visitsPredictors of ED usePeer-reviewed original research studiesSystematic reviewOncologic emergencyCancer incidence ratesCare delivery pathwaysGeriatric oncology researchManagement of oncologic emergenciesEmergency department visitsResultsThe search strategyTreatment side effectsOriginal research studiesCancer patientsVulnerable patient populationAcute careSingle-site studyWeb of ScienceCare venuesED useDepartment visitsHealth systemED visitsED presentations127 Analytical Validation and Prospective Study of a High-Sensitivity HER2 (HS-HER2) Quantitative Immunofluorescence Assay for Enhanced Stratification of HER2-Low Breast Cancer Patients
Chan N, Gaule P, Benanto J, Robbins C, Scott L, Hill S, Morrison R, Liebler D, Fulton R, Rimm D. 127 Analytical Validation and Prospective Study of a High-Sensitivity HER2 (HS-HER2) Quantitative Immunofluorescence Assay for Enhanced Stratification of HER2-Low Breast Cancer Patients. Laboratory Investigation 2025, 105: 102351. DOI: 10.1016/j.labinv.2024.102351.Peer-Reviewed Original ResearchThe Central Vein Sign as a Radiologic Tool to Predict the Diagnosis of Radiation Necrosis in Intracranial Metastatic Cancer Patients
Antonios J, Adenu-Mensah N, Theriault B, Millares-Chavez M, Huttner A, Aboian M, Chiang V. The Central Vein Sign as a Radiologic Tool to Predict the Diagnosis of Radiation Necrosis in Intracranial Metastatic Cancer Patients. Clinical And Translational Neuroscience 2025, 9: 10. DOI: 10.3390/ctn9010010.Peer-Reviewed Original ResearchCentral vein signRadiation necrosisTumor progressionDiagnosis of radiation necrosisDifferentiate RNCerebral radiation necrosisIntracranial metastatic diseaseCancer therapy responseMetastatic cancer patientsNon-invasive markerMetastatic diseaseSurgical biopsyTherapy responsePredictive markerPatient cohortPrimary treatmentRadiological toolsCancer patientsRadiological imagingTreatment decisionsPerivascular spacesPatientsTreatmentNecrosisMarkersSafety and feasibility of concomitant scalp cooling and limb cryocompression to prevent paclitaxel-induced alopecia and neuropathy
Bandla A, Wong R, Santhanakrishnan P, Magarajah G, Yee Y, Ng W, Ow S, Chan G, Choo J, Lim S, Wong A, Vijayan J, Paxman R, Lee Y, Hui F, Hairom Z, Ang E, Loprinzi C, Thakor N, Lee S, Kumarakulasinghe N, Lim J, Sundar R. Safety and feasibility of concomitant scalp cooling and limb cryocompression to prevent paclitaxel-induced alopecia and neuropathy. Supportive Care In Cancer 2025, 33: 180. PMID: 39937296, PMCID: PMC11821790, DOI: 10.1007/s00520-024-08982-6.Peer-Reviewed Original ResearchConceptsChemotherapy-induced alopeciaChemotherapy-induced peripheral neuropathyScalp coolingHealthy volunteersCancer patientsPrevention of chemotherapy-induced alopeciaCIPN preventionPrevent chemotherapy-induced peripheral neuropathyEORTC QualityWeekly paclitaxel chemotherapyQoL scoresStandard-of-careBody temperature changesCryocompressionCore body temperature changesWeekly paclitaxelCTCAE v4.0Paclitaxel chemotherapyPhysician gradingLimbPatient toleranceAdverse eventsPeripheral neuropathyChemotherapyCryotherapyAssociation between psychological flexibility and self-perceived burden in patients with cervical cancer: A computer-simulated network analysis
Chen F, Xiong Y, Li S, Deng Y, Zhang Q, Xiao Z, Knobf M, Ye Z. Association between psychological flexibility and self-perceived burden in patients with cervical cancer: A computer-simulated network analysis. European Journal Of Oncology Nursing 2025, 74: 102822. PMID: 39893708, DOI: 10.1016/j.ejon.2025.102822.Peer-Reviewed Original ResearchN-acetylcysteine (NAC) supplementation improves dyspnea and may normalize von Willebrand plasma levels in gynecologic patients with Post-Acute-COVID-Sequela (PASC)/Long COVID
Bellone S, Siegel E, Santin A. N-acetylcysteine (NAC) supplementation improves dyspnea and may normalize von Willebrand plasma levels in gynecologic patients with Post-Acute-COVID-Sequela (PASC)/Long COVID. Gynecologic Oncology Reports 2025, 57: 101682. PMID: 39944180, PMCID: PMC11814706, DOI: 10.1016/j.gore.2025.101682.Peer-Reviewed Original ResearchVon Willebrand factorN-acetylcysteinePost-acute sequelae of COVID-19Gynecologic patientsVWF levelsLevels of clotting factorsVon Willebrand factor levelsOral N-acetylcysteineProspective randomized studyShortness of breathGynecologic oncology clinicChronically elevated levelsLong COVIDCOVID-19 patientsN-acetylcysteine supplementationSequelae of COVID-19Microvascular inflammationSubjective improvementThrombotic complicationsRandomized studyRed blood cellsControl patientsPrecursor of glutathionePlasma levelsCancer patientsSocial support, fear of cancer recurrence and sleep quality in breast cancer: A moderated network analysis
Jiang Y, Wu X, Li H, Xiong Y, Knobf M, Ye Z. Social support, fear of cancer recurrence and sleep quality in breast cancer: A moderated network analysis. European Journal Of Oncology Nursing 2025, 74: 102799. PMID: 39842318, DOI: 10.1016/j.ejon.2025.102799.Peer-Reviewed Original ResearchFear of cancer recurrenceSocial supportSleep qualityPittsburgh Sleep Quality Index scalePerceived Social Support ScaleLevels of social supportEffect of social supportModerating effect of social supportHigh social supportSocial Support ScaleGeneralized anxietyBreast cancerCancer recurrenceCancer patientsSleep efficiencySupport ScaleMental healthBreast cancer patientsIndex scaleSleep problemsBuffering factorsJohnson-NeymanAnxietyFearSupport
2024
Artificial Intelligence–Driven Patient Selection for Preoperative Portal Vein Embolization for Patients with Colorectal Cancer Liver Metastases
Kuhn T, Engelhardt W, Kahl V, Alkukhun A, Gross M, Iseke S, Onofrey J, Covey A, Camacho J, Kawaguchi Y, Hasegawa K, Odisio B, Vauthey J, Antoch G, Chapiro J, Madoff D. Artificial Intelligence–Driven Patient Selection for Preoperative Portal Vein Embolization for Patients with Colorectal Cancer Liver Metastases. Journal Of Vascular And Interventional Radiology 2024, 36: 477-488. PMID: 39638087, DOI: 10.1016/j.jvir.2024.11.025.Peer-Reviewed Original ResearchTotal liver volumeMetastatic colorectal cancer patientsPreoperative portal vein embolizationColorectal cancer liver metastasesPortal vein embolizationCancer liver metastasesMulticenter retrospective studyColorectal cancer patientsStudent's t-testBoard-certified radiologistsVein embolizationConsecutive patientsLiver metastasesLiver volumePatient selectionRetrospective studyCancer patientsRadiomic featuresInclusion criteriaPatientsSemi-automatic segmentationLab valuesT-testSDAUCPelvic Floor Physical Therapy Prehabilitation (PrePFPT) for the prevention of low anterior resection syndrome
Coppersmith N, Schultz K, Esposito A, Reinhart K, Ray E, Leeds I, Pantel H, Reddy V, Longo W, Mongiu A. Pelvic Floor Physical Therapy Prehabilitation (PrePFPT) for the prevention of low anterior resection syndrome. Surgical Oncology Insight 2024, 1: 100097. DOI: 10.1016/j.soi.2024.100097.Peer-Reviewed Original ResearchLow anterior resection syndromeAnterior resection syndromePelvic floor physical therapyQuality of life outcomesSymptoms of low anterior resection syndromeImprove patient qualityPhysical therapyRectal cancerPrehabilitationDevelopment of low anterior resection syndromeStudy designTreatment of low anterior resection syndromeTreatment of rectal cancerIncidence of low anterior resection syndromeLife outcomesEvaluated pre-Patients' qualityRectal cancer patientsCancer patientsDevelopment of symptomsNeoadjuvant chemoradiotherapyDefecatory dysfunctionImproved recoveryInternational trialsSyndromePractice Patterns and Trends in the Surgical Management of Mismatch Repair Deficient Colon Cancer
Gupta P, Zhan P, Leeds I, Mongiu A, Reddy V, Pantel H. Practice Patterns and Trends in the Surgical Management of Mismatch Repair Deficient Colon Cancer. Journal Of Surgical Research 2024, 304: 371-382. PMID: 39615154, DOI: 10.1016/j.jss.2024.10.041.Peer-Reviewed Original ResearchLynch syndromePractice patternsCancers associated with Lynch syndromeColorectal cancerColon cancerNonmetastatic colorectal cancerDiagnosed CRC patientsMismatch repairDetect mismatch repairSurgical managementMMR-DMMR testingCRC patientsSurgical practice patternsAssociated with decreased ratesBlack raceRate of extended resectionDNA mismatch repairMismatch repair-proficient tumorsNational Cancer DatabaseNonmetastatic CRC patientsColon cancer patientsGermline mutationsCancer patientsTreatment decisionsMouse Models Enable the Functional Investigation of Tertiary Lymphoid Structures in Cancer
Jeevanandam A, Yin Z, Connolly K, Joshi N. Mouse Models Enable the Functional Investigation of Tertiary Lymphoid Structures in Cancer. Methods In Molecular Biology 2024, 2864: 57-76. PMID: 39527217, DOI: 10.1007/978-1-0716-4184-2_4.Peer-Reviewed Original ResearchConceptsTertiary lymphoid structuresTertiary lymphoid structure formationSecondary lymphoid organsLymphoid structuresMurine modelFeatures of tertiary lymphoid structuresFunction of tertiary lymphoid structuresMouse modelPersistent inflammatory stimulationAssociated with positive clinical outcomesTissue-specific regulatory mechanismsPositive clinical outcomesPrognostic significanceClinical outcomesGut environmentNonlymphoid tissuesLymphoid aggregatesLymphoid organsMouse lungCancer patientsGenetic sequencesInflammatory stimulationRegulatory mechanismsTherapeutic modulationClinical effortsDrug-Induced Thrombocytopenia: A Critical Condition in Hospitalized Cancer Patients
Abouelkheer Y, Ranat R, Phuong L, Boxer D, Ahasic A. Drug-Induced Thrombocytopenia: A Critical Condition in Hospitalized Cancer Patients. Blood 2024, 144: 5544-5544. DOI: 10.1182/blood-2024-211937.Peer-Reviewed Original ResearchDrug-induced thrombocytopeniaHigh risk of bleedingPlatelet factor 4Risk of bleedingPlatelet countPostoperative dayIntravenous immunoglobulinSurgical cancer patientsCancer patientsSevere thrombocytopeniaCase of severe thrombocytopeniaRecovery of platelet countsHigh riskEtiology of thrombocytopeniaBone marrow suppressionClear-cell carcinomaHeparin-induced thrombocytopeniaDisseminated intravascular coagulopathyImmune-mediated conditionsPostoperative day 3Postoperative day 7Consumption of plateletsPlanned surgical resectionPlatelet factor 4 antigenAdministration of dexamethasoneMulti-day vs single-day dexamethasone for the prophylaxis of chemotherapy-induced nausea and vomiting: systematic review and meta-analysis
Chow R, Celio L, Im J, Caini S, Eng L, Prsic E, Scotté F, Aapro M. Multi-day vs single-day dexamethasone for the prophylaxis of chemotherapy-induced nausea and vomiting: systematic review and meta-analysis. Supportive Care In Cancer 2024, 32: 736. PMID: 39432169, DOI: 10.1007/s00520-024-08934-0.Peer-Reviewed Original ResearchConceptsDexamethasone-sparing regimenChemotherapy-induced nausea and vomitingModerately emetogenic chemotherapyHighly emetogenic chemotherapyRandomized controlled trialsComplete responseMeta-analysisEmetogenic chemotherapyNo vomitingRescue medicationProphylaxis of chemotherapy-induced nausea and vomitingSystematic reviewSchedule of dexamethasoneNausea and vomitingChemotherapy-induced nauseaResultsTen trialsAntiemetic regimenCumulative meta-analysisEffect estimatesSafety profileComprehensive systematic reviewMethodsOvid MEDLINERegimensAdult cancer patientsCancer patientsModeling epithelial-mesenchymal transition in patient-derived breast cancer organoids
Bar-Hai N, Ben-Yishay R, Arbili-Yarhi S, Herman N, Avidan-Noy V, Menes T, Mansour A, Awwad F, Balint-Lahat N, Goldinger G, Hout-Siloni G, Adileh M, Berger R, Ishay-Ronen D. Modeling epithelial-mesenchymal transition in patient-derived breast cancer organoids. Frontiers In Oncology 2024, 14: 1470379. PMID: 39469640, PMCID: PMC11513879, DOI: 10.3389/fonc.2024.1470379.Peer-Reviewed Original ResearchEpithelial-mesenchymal transitionPatient-derived breast cancer modelsCancer patientsCell plasticityTGF-bBreast cancer organoidsCancer cell plasticityBreast cancer modelBreast cancer patientsEMT-like featuresE-cadherin downregulationEMT-like processCancer modelsOrganoid linesCancer organoidsEpithelial plasticityInvasive phenotypeCellular plasticityE-cadherinOrganoidsPatientsCancerDedifferentiation processMorphological changesCytoskeletal reorganizationPredicting Radiation-Induced Acute Toxicity in Breast Cancer Patients: A Radiogenomic Approach
Wei S, Zhang Y, Sowmiyanarayanan S, Yehia Z, Jan I, Yue N, Haffty B, Nie K. Predicting Radiation-Induced Acute Toxicity in Breast Cancer Patients: A Radiogenomic Approach. International Journal Of Radiation Oncology • Biology • Physics 2024, 120: e341. DOI: 10.1016/j.ijrobp.2024.07.752.Peer-Reviewed Original ResearchBreast cancer patientsRadiation dermatitisSide effectsCancer patientsBreast cancer patients treated with radiationRadiogenomic approachCancer patients treated with radiationRadiation-induced acute toxicityPatients treated with radiationRadiomic featuresSingle nucleotide polymorphismsAcute radiation dermatitisBreast-conserving surgeryRadiation side effectsPeripheral blood samplesTotal radiation dosePersonalized treatment strategiesGenetic statusRadiation therapyMammographic patternsRadiomic texture featuresTherapy side effectsClinical parametersRetrospective studyClinical features
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