2025
Efficacy and Safety of IV Thrombolysis for Acute Ischemic Stroke Patients With Moyamoya Disease
Chen H, Colasurdo M, Khunte M, Malhotra A, Gandhi D. Efficacy and Safety of IV Thrombolysis for Acute Ischemic Stroke Patients With Moyamoya Disease. Neurology 2025, 104: e210243. PMID: 39772663, DOI: 10.1212/wnl.0000000000210243.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeTreated with IV thrombolysisIn-hospital mortalityMoyamoya disease patientsIV thrombolysisMoyamoya diseasePropensity score matchingIntracranial hemorrhageRisk factors of acute ischemic strokeSelf-careIschemic stroke patientsAcute ischemic stroke patientsStroke patientsTreating acute ischemic strokeNationwide Readmissions DatabaseRisk factorsRate of routine dischargeRoutine dischargeEfficacy outcomesAssociated with different ratesProspective studyBypass surgeryRetrospective analysisEstablished treatmentReadmissions Database
2024
Coronary artery calcium measurement on attenuation correction computed tomography using artificial intelligence: correlation with coronary flow capacity and prognosis
Cho S, Lee J, Cho K, Park K, Kim J, Moon J, Kim K, Kim J, Song H. Coronary artery calcium measurement on attenuation correction computed tomography using artificial intelligence: correlation with coronary flow capacity and prognosis. European Journal Of Nuclear Medicine And Molecular Imaging 2024, 52: 1050-1059. PMID: 39404786, PMCID: PMC11754321, DOI: 10.1007/s00259-024-06948-8.Peer-Reviewed Original ResearchConceptsCoronary flow capacityCoronary artery calciumMyocardial blood flowLeft ventricular ejection fraction < 40%Significant ischaemiaStress myocardial blood flowEjection fraction < 40%Coronary artery calcium measurementAcute coronary syndromeNonfatal myocardial infarctionCoronary stent insertionPrognostic significancePrognostic valueStent insertionArtery calciumPrognostic associationBypass surgeryCalcium measurementsHeart failureCardiovascular eventsCoronary syndromeAngina pectorisMultivariate analysisRisk factorsPatientsEndoscopic Reduction of an Acute Gastric Volvulus
Pungwe P, Ukwade D, Patel A, Ajayi T, Ketwaroo G. Endoscopic Reduction of an Acute Gastric Volvulus. Cureus 2024, 16: e58198. PMID: 38741858, PMCID: PMC11090073, DOI: 10.7759/cureus.58198.Peer-Reviewed Original ResearchAcute gastric volvulusGastric volvulusComputerized tomographyParaesophageal herniaRoux-en-Y gastric bypass surgeryCases of gastric volvulusGastric bypass surgeryRoux-en-YNasogastric tube placementEndoscopic reductionTube placementBypass surgeryEndoscopic detorsionLaparoscopic gastropexyDistal stomachEsophagogastroduodenoscopyVolvulusHerniaInsulin Requirement and Infrainguinal Bypass Outcomes in Patients with Peripheral Arterial Disease
Alameddine D, Satam K, Slade M, Wang H, Mena-Hurtado C, Turner J, Inzucchi S, Ochoa Chaar C. Insulin Requirement and Infrainguinal Bypass Outcomes in Patients with Peripheral Arterial Disease. Annals Of Vascular Surgery 2024, 102: 25-34. PMID: 38307234, DOI: 10.1016/j.avsg.2023.11.044.Peer-Reviewed Original ResearchInsulin-requiring diabetes mellitusPeripheral arterial diseaseDiabetes mellitusInfrainguinal bypassInsulin requirementsArtery diseaseRisk of MALEBypass surgeryImpact of insulin useRates of primary patencyVascular Quality Initiative databaseOutcomes of patientsPeripheral arterial bypass surgeryInfrainguinal bypass surgeryStratification of patientsCrude rateElevated hemoglobin A1cArtery bypass surgeryAssociation of DMChronic limb-threatening ischemiaIncreased risk of MALEVascular Quality InitiativeLower extremity revascularizationAdverse limb eventsLimb-threatening ischemia
2023
Comparing results of bypass surgery and percutaneous coronary intervention for left main disease by surgical revascularization pump strategy
Jarrett C, Pelletier M, Abu-Omar Y, Baeza C, Elgudin Y, Markowitz A, Zhou Z, Redfors B, Dressler O, Kappetein A, Serruys P, Stone G, Sabik J. Comparing results of bypass surgery and percutaneous coronary intervention for left main disease by surgical revascularization pump strategy. JTCVS Open 2023, 16: 372-388. PMCID: PMC11884416, DOI: 10.1016/j.xjon.2023.03.018.Peer-Reviewed Original ResearchOn-pump coronary artery bypass graftingCoronary artery bypass graftingOff-pump coronary artery bypass graftingArtery bypass graftingComposite end pointIschemia-driven revascularizationPercutaneous coronary interventionBypass graftingCoronary interventionEnd pointsBypass surgeryOn-pump coronary artery bypass grafting groupOutcomes of off-pump coronary artery bypass graftingComposite study end-pointComposite outcome of deathMyocardial infarctionCoronary artery bypass surgeryCoronary artery bypass grafting groupResults of bypass surgeryStudy end pointOutcome of deathArtery bypass surgeryKaplan-Meier estimatesOff-pump strategyRate of deathPerioperative complications following open or endovascular revascularization for chronic limb-threatening ischemia in the BEST-CLI Trial
Siracuse J, Farber A, Menard M, Conte M, Kaufman J, Jaff M, Kiang S, Ochoa Chaar C, Osborne N, Singh N, Tan T, Guzman R, Strong M, Hamza T, Doros G, Rosenfield K. Perioperative complications following open or endovascular revascularization for chronic limb-threatening ischemia in the BEST-CLI Trial. Journal Of Vascular Surgery 2023, 78: 1012-1020.e2. PMID: 37318428, DOI: 10.1016/j.jvs.2023.05.040.Peer-Reviewed Original ResearchConceptsChronic limb-threatening ischemiaSingle-segment great saphenous veinLimb-threatening ischemiaRisk-adjusted analysisCohort 2Cohort 1BEST-CLICardiovascular eventsEndovascular revascularizationPerioperative complicationsRevascularization strategyLower extremity bypass surgeryMajor adverse cardiovascular eventsBest Surgical TherapyBEST-CLI trialPeri-procedure complicationsAdverse cardiovascular eventsPeri-procedural complicationsThirty-day mortalityAcute renal failureGreat saphenous veinEndovascular revascularization strategiesBest EndovascularPerioperative morbidityBypass surgeryGastric cancer after Bariatric Bypass Surgery. Do they relate? (A Systematic Review)
Doukas S, Doukas P, Vageli D, Broder A. Gastric cancer after Bariatric Bypass Surgery. Do they relate? (A Systematic Review). Obesity Surgery 2023, 33: 1876-1888. PMID: 37041375, DOI: 10.1007/s11695-023-06567-6.Peer-Reviewed Original ResearchConceptsBariatric bypass surgeryBypass surgeryGastric cancerGastric cancer risk assessmentGastric bypass surgeryH. pylori infectionGastric cancer surveillanceCancer-promoting factorGastric cancer casesCancer risk assessmentBile refluxMorbid obesityTobacco smokingPylori infectionCancer surveillanceRisk factorsCancer casesFamily historyEffective treatmentSurgeryAdvanced stageSystematic reviewCancerFurther investigationObesity
2022
Identifying quality of life outcome patterns to inform treatment choices in ischemic cardiomyopathy
Mori M, Mark DB, Khera R, Lin H, Jones P, Huang C, Lu Y, Geirsson A, Velazquez EJ, Spertus JA, Krumholz HM. Identifying quality of life outcome patterns to inform treatment choices in ischemic cardiomyopathy. American Heart Journal 2022, 254: 12-22. PMID: 35932911, DOI: 10.1016/j.ahj.2022.07.007.Peer-Reviewed Original ResearchConceptsCoronary artery bypass surgeryGuideline-directed medical therapyTreatment choiceBetter outcomesIschemic cardiomyopathyQOL outcomesQoL dataKansas City Cardiomyopathy Questionnaire overall summary scoreQOL trajectoriesOutcome patternsIschemic Heart Failure (STICH) trialHeart Failure TrialMain baseline predictorsArtery bypass surgeryOverall summary scoreDifferent treatment choicesLogistic regression modelsBypass surgeryMedical therapySurgical treatmentFailure TrialLife scoresQOL scoresPatient's probabilityBaseline predictorsEndoscopic vs Open Vein Harvest in Drug-Eluting Stents or Bypass Surgery for Left Main Disease Trial
Jarrett C, Pelletier M, Abu-Omar Y, Baeza C, Elgudin Y, Markowitz A, Vega P, Dressler O, Kappetein A, Serruys P, Stone G, Sabik J. Endoscopic vs Open Vein Harvest in Drug-Eluting Stents or Bypass Surgery for Left Main Disease Trial. The Annals Of Thoracic Surgery 2022, 115: 72-78. PMID: 35283098, DOI: 10.1016/j.athoracsur.2021.12.079.Peer-Reviewed Original ResearchConceptsEndoscopic vein harvesting groupCoronary artery bypass graftingOpen vein harvestingEndoscopic vein harvestingIschemia-driven revascularizationOpen vein harvested patientsBlood product transfusionComposite of deathGraft stenosisProduct transfusionVein harvestingEndoscopic vein harvest patientsOpen vein harvesting groupMyocardial infarctionOutcomes of coronary artery bypass graftingPrimary end pointArtery bypass graftingIn-hospital bleedingKaplan-Meier estimatesTime-to-first-event analysisDrug-eluting stentsBypass surgeryBypass graftingVenous graftsEnd pointsSex disparities in in-hospital outcomes of left ventricular aneurysm complicating acute myocardial infarction: A United States nationwide analysis
Pajjuru V, Thandra A, Walters R, Papudesi B, Aboeata A, Vallabhajosyula S, Altin S, Sutton N, Alla V, Goldsweig A. Sex disparities in in-hospital outcomes of left ventricular aneurysm complicating acute myocardial infarction: A United States nationwide analysis. American Heart Journal Plus Cardiology Research And Practice 2022, 13: 100104. PMID: 38560084, PMCID: PMC10978193, DOI: 10.1016/j.ahjo.2022.100104.Peer-Reviewed Original ResearchAcute myocardial infarctionNational Inpatient SampleHospital mortalityLV aneurysmHospital outcomesMyocardial infarctionLeft ventricularHigh incidenceSex disparitiesLarge population-based cohort studyPopulation-based cohort studyGuideline-directed therapyInter-hospital transferPercutaneous coronary interventionLength of stayBackground Previous studiesBaseline characteristicsBypass surgeryCohort studyCoronary atherectomyCoronary interventionAneurysm surgeryVentricular aneurysmInpatient SampleNationwide analysis
2021
Transfusion Practices in Pediatric Cardiac Surgery Requiring Cardiopulmonary Bypass: A Secondary Analysis of a Clinical Database
Hanson SJ, Karam O, Birch R, Goel R, Patel RM, Sola-Visner M, Sachais BS, Hauser RG, Luban NLC, Gottschall J, Josephson CD, Hendrickson JE, Karafin MS, Nellis ME, Lung A. Transfusion Practices in Pediatric Cardiac Surgery Requiring Cardiopulmonary Bypass: A Secondary Analysis of a Clinical Database. Pediatric Critical Care Medicine 2021, 22: 978-987. PMID: 34261944, PMCID: PMC8570986, DOI: 10.1097/pcc.0000000000002805.Peer-Reviewed Original ResearchConceptsCongenital heart diseaseBiventricular surgeryCardiopulmonary bypass surgeryHeart diseaseMedian internationalBypass surgeryMembrane oxygenationPlatelet countBlood componentsVentricular surgeryHemoglobin valuesBlood Institute Recipient EpidemiologyDonor Evaluation Study-IIIHigher median platelet countNormal international normalized ratioIntraoperative platelet transfusionLimited physiologic reserveMultiple blood productsPretransfusion platelet countU.S. hospitalsMedian platelet countBlood component transfusionBlood component usageExtracorporeal membrane oxygenationInternational normalized ratioAngiographic Patency of Coronary Artery Bypass Conduits: A Network Meta‐Analysis of Randomized Trials
Gaudino M, Hameed I, Robinson NB, Ruan Y, Rahouma M, Naik A, Weidenmann V, Demetres M, Tam D, Hare DL, Girardi LN, Biondi‐Zoccai G, Fremes S. Angiographic Patency of Coronary Artery Bypass Conduits: A Network Meta‐Analysis of Randomized Trials. Journal Of The American Heart Association 2021, 10: e019206. PMID: 33686866, PMCID: PMC8174193, DOI: 10.1161/jaha.120.019206.Peer-Reviewed Original ResearchConceptsCoronary artery bypass conduitsTouch saphenous veinAngiographic patency ratesRadial arterySaphenous veinPatency ratesGraft occlusionRandomized trialsBypass conduitRight internal thoracic arteryTouch saphenous vein graftsCoronary bypass surgerySaphenous vein graftsGraft occlusion rateInternal thoracic arteryBest conduitNetwork Meta-AnalysisSystematic literature searchGastroepiploic arteryBypass surgeryPrimary outcomeThoracic arteryAngiographic patencyVein graftsOcclusion rateIn coronary artery disease, PCI increases all-cause and cause-specific mortality compared with CABG.
Nanna MG, Newby LK. In coronary artery disease, PCI increases all-cause and cause-specific mortality compared with CABG. Annals Of Internal Medicine 2021, 174: jc27. PMID: 33646845, DOI: 10.7326/acpj202103160-027.Peer-Reviewed Original Research
2020
Overall and Cause-Specific Mortality in Randomized Clinical Trials Comparing Percutaneous Interventions With Coronary Bypass Surgery
Gaudino M, Hameed I, Farkouh ME, Rahouma M, Naik A, Robinson NB, Ruan Y, Demetres M, Biondi-Zoccai G, Angiolillo DJ, Bagiella E, Charlson ME, Benedetto U, Ruel M, Taggart DP, Girardi LN, Bhatt DL, Fremes SE. Overall and Cause-Specific Mortality in Randomized Clinical Trials Comparing Percutaneous Interventions With Coronary Bypass Surgery. JAMA Internal Medicine 2020, 180: 1638-1646. PMID: 33044497, PMCID: PMC7551235, DOI: 10.1001/jamainternmed.2020.4748.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionRandomized clinical trialsCause-specific mortalityCoronary artery diseaseBare metal stentsNoncardiac mortalityCause mortalityCoronary interventionArtery diseaseClinical trialsTrials of PCIEnd pointLeft main diseaseCoronary artery bypassStudy end pointCoronary bypass surgeryData extractionTreatment of patientsCochrane Library databasesPreferred Reporting ItemsRandom-effects modelArtery bypassCardiac mortalityRevascularization TrialBypass surgeryLong-Term Results of the RAPCO Trials
Buxton B, Hayward P, Raman J, Moten S, Rosalion A, Gordon I, Seevanayagam S, Matalanis G, Benedetto U, Gaudino M, Hare D, Gaer J, Negri J, Komeda M, Bellomo R, Doolan L, McNicol L, Brennan J, Chan R, Clark D, Dick R, Dortimer A, Ecclestone D, Farouque O, Fernando D, Horrigan M, Jackson A, Oliver L, Mehta N, Nadurata V, Nadarajah N, Proimos G, Rowe M, Sia B, Webb C, Anaveker N, Barlis P, Calafiore P, Chan B, Cotroneo J, Johns J, Jones E, Kertes P, O’Donnell D, Sylviris S, Tonkin A, Fabini R, Kearney L, Lim R, Molan M, Smith G, Wellman C, Eng J, Hameed I, Shaw M, Gerbo S. Long-Term Results of the RAPCO Trials. Circulation 2020, 142: 1330-1338. PMID: 33017209, DOI: 10.1161/circulationaha.119.045427.Peer-Reviewed Original ResearchConceptsRight internal thoracic arteryFree right internal thoracic arteryRadial arteryPatient survival estimatesSaphenous veinYears of ageInternal thoracic artery graftsSurvival estimatesFree RITA graftThoracic artery graftsCoprimary end pointsCoronary bypass surgeryInternal thoracic arteryLong-term mortalityLong-term patencyCoronary targetsRA armRITA graftArtery graftBypass surgeryGraft failureRA groupPrimary outcomeThoracic arterySV graftsSex‐related differences in outcomes after coronary artery bypass surgery—A patient‐level pooled analysis of randomized controlled trials: rationale and study protocol
Gaudino M, Alexander JH, Egorova N, Kurlansky P, Lamy A, Bakaeen F, Hameed I, Di Franco A, Demetres M, Robinson NB, Chikwe J, Lawton JS, Devereaux PJ, Taggart DP, Flather M, Reents W, Boening A, Diegeler A, Girardi LN, Fremes SE, Benedetto U. Sex‐related differences in outcomes after coronary artery bypass surgery—A patient‐level pooled analysis of randomized controlled trials: rationale and study protocol. Journal Of Cardiac Surgery 2020, 35: 2754-2758. PMID: 32720394, DOI: 10.1111/jocs.14903.Peer-Reviewed Original ResearchConceptsSex-related differencesPooled analysisSystematic reviewPatient-level pooled analysisCoronary artery bypass surgeryMultiple arterial graftsArtery bypass surgeryCoronary artery bypassLong-term followSex-related outcomesTreatment effectsPreferred Reporting ItemsSystematic literature searchPeer-reviewed scientific journalsImpact of sexDifferential treatment effectsCABG studiesArtery bypassCause mortalityPrimary endpointBypass surgeryArterial graftsMyocardial infarctionStudy protocolProspective RegisterCritical Illness Related Corticosteroid Insufficiency (CIRCI)
Khosla A, Ahasic A. Critical Illness Related Corticosteroid Insufficiency (CIRCI). 2020, 423-428. DOI: 10.1007/978-3-030-26710-0_55.Peer-Reviewed Original ResearchCritical illness related corticosteroid insufficiencyHypothalamic pituitary adrenal axisCorticosteroid insufficiencyCritical illness-related corticosteroid insufficiencyACTH stimulation testingRelative adrenal insufficiencyCardiopulmonary bypass surgeryIntensive care unitPituitary-adrenal axisRefractory hypotensionAdrenal insufficiencyBypass surgeryCritical illnessSystemic inflammationIll patientsSeptic shockCare unitGlucocorticoid activityStimulation testingAdrenal axisCardiac arrestConventional therapyPatient's illnessSuch illnessesCortisol measurements
2019
Intraoperative graft flow profiles in coronary artery bypass surgery: A meta‐analysis
Silva M, Rong LQ, Naik A, Rahouma M, Hameed I, Robinson B, Ruan Y, Jiang Y, Abed AW, Girardi LN, Gaudino M. Intraoperative graft flow profiles in coronary artery bypass surgery: A meta‐analysis. Journal Of Cardiac Surgery 2019, 35: 279-285. PMID: 31730721, DOI: 10.1111/jocs.14359.Peer-Reviewed Original ResearchConceptsMean graft flowPulsatility indexVenous graftsIMA graftsVenous conduitsGraft flowArterial graftsPedicled internal mammary artery graftsInternal mammary artery graftCoronary artery bypass surgeryMammary artery graftsPump CABG proceduresArtery bypass surgerySystematic literature searchIMA conduitsOPCABG surgeryArtery graftPrimary endpointSecondary endpointsBypass surgeryCABG proceduresIntraoperative flowONCABGOPCABGGraftCopper Deficiency and Cytopenia: A Systematic Review
Kharel P, Gnanapandithan K, Pandey R, Jha S, Grimshaw A, Giri S. Copper Deficiency and Cytopenia: A Systematic Review. Blood 2019, 134: 5025. DOI: 10.1182/blood-2019-132265.Peer-Reviewed Original ResearchTotal parenteral nutritionWhite blood cellsSystematic reviewParenteral nutritionHematological manifestationsPlatelet countCase reportTotal parenteral nutrition useCopper deficiencyParenteral nutrition useGastric bypass surgeryEvaluation of patientsLow platelet countSmall retrospective studiesTime of presentationGm/dlFull-text reviewFull textJejunal feedsBariatric surgeryBypass surgerySurgery patientsClinical courseMedian ageCase seriesThe RADial artery International ALliance (RADIAL) extended follow-up study: rationale and study protocol
Gaudino M, Benedetto U, Fremes S, Ballman K, Biondi-Zoccai G, Sedrakyan A, Nasso G, Raman J, Buxton B, Hayward PA, Moat N, Collins P, Webb C, Peric M, Petrovic I, Yoo KJ, Hameed I, Di Franco A, Moscarelli M, Speziale G, Girardi LN, Hare DL, Taggart DP, Investigators R. The RADial artery International ALliance (RADIAL) extended follow-up study: rationale and study protocol. European Journal Of Cardio-Thoracic Surgery 2019, 56: 1025-1030. PMID: 31535147, DOI: 10.1093/ejcts/ezz247.Peer-Reviewed Original ResearchConceptsPatency ratesSaphenous veinGood mid-term patency ratesMid-term patency ratesCoronary artery bypass surgeryRadial artery graftArtery bypass surgeryEvent-free survivalSaphenous vein graftsLong-term outcomesImproved patency ratesRA armArtery graftPostoperative yearRepeat revascularizationBypass surgeryCardiac eventsVein graftsClinical correlatesStudy protocolObservational studyRole of RasGraftTrialsSurvival
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