2025
Unraveling the Neural Landscape of Mental Disorders using Double Functional Independent Primitives (dFIPs)
Soleimani N, Iraji A, Pearlson G, Preda A, Calhoun V. Unraveling the Neural Landscape of Mental Disorders using Double Functional Independent Primitives (dFIPs). Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2025 PMID: 40222638, DOI: 10.1016/j.bpsc.2025.03.015.Peer-Reviewed Original ResearchAutism spectrum disorderFunctional network connectivityBipolar disorderPsychiatric conditionsMental disordersMental illnessResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingConnectivity patternsBrain network alterationsFunctional connectivity patternsNeurobiological underpinningsDepressive disorderEmotion regulationNeural signaturesPsychiatric diagnosisConnectivity alterationsBrain regionsSpectrum disorderCognitive functionNeural landscapeCerebellar connectivitySocial behaviorNetwork alterationsSchizophreniaVoxel-Wise Map of Intracerebral Hemorrhage Locations Associated With Worse Outcomes
Karam G, Chen M, Zeevi D, Harms B, Berson E, Torres-Lopez V, Rivier C, Malhotra A, Qureshi A, Falcone G, Sheth K, Payabvash S. Voxel-Wise Map of Intracerebral Hemorrhage Locations Associated With Worse Outcomes. Stroke 2025, 56: 868-877. PMID: 40052269, DOI: 10.1161/strokeaha.124.048453.Peer-Reviewed Original ResearchConceptsImpact of intracerebral hemorrhageAssociated with worse outcomesClinical risk factorsVoxel-wise mapsMapping of brain regionsBaseline hematomaVoxel-wise analysisHematoma volumeICH locationBrain regionsValidation cohortWorse outcomesPresence of intraventricular hemorrhageRisk factorsBaseline hematoma volumeModified Rankin Scale scorePoor scan qualityMulticenter clinical trialRankin Scale scoreDeep white matterLow-risk categoryComprehensive stroke centerIntraventricular hemorrhageConsecutive patientsPatient ageBrain Signatures of Very Early Cognitive Decline in Asymptomatic Middle‐Aged Offspring of People With Alzheimer's Disease
Ramsingh N, Lin H, Ouyang Y, Ravona‐Springer R, Livny A, Soleimani L, Bendlin B, Matatov A, Niv T, Shamir T, Ganmore I, Heymann A, Sano M, Azuri J, Beeri M. Brain Signatures of Very Early Cognitive Decline in Asymptomatic Middle‐Aged Offspring of People With Alzheimer's Disease. International Journal Of Geriatric Psychiatry 2025, 40: e70060. PMID: 40050014, DOI: 10.1002/gps.70060.Peer-Reviewed Original ResearchConceptsSuperior longitudinal fasciculusCortical volumeCortical brain volumesWhite matterAlzheimer's Prevention studyEarly cognitive declineBrain signaturesBrain regionsCognitive changesWM microstructureMiddle-aged adultsBrain volumeLongitudinal fasciculusCognitive declinePreclinical cognitive changesOffspring of peopleBrain tractsPatient's offspringTarget individualsEarly interventionCorpus callosumParental historyBrainAlzheimer's diseaseLinear regression modelsEffects of Long-Term Cocaine Self-Administration on Kappa Opioid Receptors in Socially Housed Cynomolgus Monkeys as Assessed with PET Imaging and Neuronally Derived Exosomes
Johnson B, Allen M, Nader S, Sai K, Kumar A, Su Y, Singh S, Li S, Huang Y, Deep G, Nader M. Effects of Long-Term Cocaine Self-Administration on Kappa Opioid Receptors in Socially Housed Cynomolgus Monkeys as Assessed with PET Imaging and Neuronally Derived Exosomes. Biological Psychiatry 2025 PMID: 40054763, DOI: 10.1016/j.biopsych.2025.02.900.Peer-Reviewed Original ResearchLong-term cocaine self-administrationKappa-opioid receptorsCocaine self-administrationSelf-administrationKappa opioid receptor availabilityPeripheral measuresSocially housed monkeysOpioid receptorsCocaine intakeCocaine SAIntravenous cocaineCocaine misuseBrain regionsCocainePET imagingCynomolgus monkeysSocial rankPET studiesPharmacological interventionsMonkeysPET scansBrainBlood samplesDominant femalesSocialIdentifying Genetic Variants for Brain Connectivity Using Ball Covariance Ranking and Aggregation
Dai W, Zhang H. Identifying Genetic Variants for Brain Connectivity Using Ball Covariance Ranking and Aggregation. Journal Of The American Statistical Association 2025, ahead-of-print: 1-19. DOI: 10.1080/01621459.2025.2450837.Peer-Reviewed Original ResearchSingle nucleotide polymorphismsDetect single nucleotide polymorphismsGene-based analysisControlling false discovery rateControlling false discoveriesSNP setsFunctional connectivityFalse discovery rateGenetic architectureNovel genesGenetic basisNucleotide polymorphismsGenetic variantsUK Biobank dataPsychiatric disordersDiscovery rateBrain functionFalse discoveriesBiobank dataCorrelations of neural activityBrain regionsBiological etiologyBrain connectivityEQTLNeural activityDiminished reward circuit response underlies pain avoidance learning deficits in problem drinkers
Le T, Oba T, Li C. Diminished reward circuit response underlies pain avoidance learning deficits in problem drinkers. NeuroImage Clinical 2025, 45: 103762. PMID: 40009903, PMCID: PMC11908557, DOI: 10.1016/j.nicl.2025.103762.Peer-Reviewed Original ResearchConceptsPosterior cingulate cortexAvoidance learningReward circuitDrinking severityReward deficiencyLearning deficitsPain avoidanceProblem drinkersAlcohol useAvoidance learning deficitMedial orbitofrontal cortexReward circuit dysfunctionVentral tegmental areaPoor avoidance learningAssociated with problem drinkingOrbitofrontal cortexTegmental areaGo/NoGo taskCingulate cortexNeural correlatesBehavioral findingsCircuit dysfunctionAdult drinkersBrain regionsNeural processesBrain-wide pleiotropy investigation of alcohol drinking and tobacco smoking behaviors
Deiana G, He J, Cabrera-Mendoza B, Ciccocioppo R, Napolioni V, Polimanti R. Brain-wide pleiotropy investigation of alcohol drinking and tobacco smoking behaviors. Translational Psychiatry 2025, 15: 61. PMID: 39979292, PMCID: PMC11842717, DOI: 10.1038/s41398-025-03288-5.Peer-Reviewed Original ResearchConceptsImaging-derived phenotypesBrain imaging-derived phenotypesAlcohol drinkingBrain structuresProcessing of social cuesCorrelates of smoking behaviorRelationship of brain structureSequencing Consortium of AlcoholGlobal genetic correlationsSmoking behaviorSuperior longitudinal fasciculusAssociated with smoking initiationTobacco smokeTobacco smoking behaviorLatent causal variable approachesNicotine useBrain regionsPremotor cortexSocial cuesWhite matter hyperintensitiesLongitudinal fasciculusChemosensory processingCortical thicknessMendelian randomizationPleiotropic mechanismsClassification of psychedelics and psychoactive drugs based on brain-wide imaging of cellular c-Fos expression
Aboharb F, Davoudian P, Shao L, Liao C, Rzepka G, Wojtasiewicz C, Indajang J, Dibbs M, Rondeau J, Sherwood A, Kaye A, Kwan A. Classification of psychedelics and psychoactive drugs based on brain-wide imaging of cellular c-Fos expression. Nature Communications 2025, 16: 1590. PMID: 39939591, PMCID: PMC11822132, DOI: 10.1038/s41467-025-56850-6.Peer-Reviewed Original ResearchConceptsAcute fluoxetinePsychoactive drugsMarkers of neural plasticityImmediate early gene expressionC-fos expressionChronic fluoxetineNative brain tissueBehavioral effectsPsychedelic propertiesBrain regionsChance levelEarly gene expressionPsychoactive compoundsNeural plasticityFluoxetinePsilocybinMDMAMeasuring drug actionTested malesPsychedelicsPreclinical assaysDrug actionKetamineFemale miceDrug classificationFunctional connectivity changes in the prefrontal-thalamic-cerebellar circuit in adolescents with first-episode Schizophrenia
Song Y, Zhu H, Wu Z, Hu W, Zhang S, Zhou Y, Peng Y, Yang Y, Li W, Shi H, Yang G, Zhang Y, Lv L. Functional connectivity changes in the prefrontal-thalamic-cerebellar circuit in adolescents with first-episode Schizophrenia. European Child & Adolescent Psychiatry 2025, 1-10. PMID: 39928122, DOI: 10.1007/s00787-025-02656-2.Peer-Reviewed Original ResearchPrefrontal-thalamic-cerebellar circuitMedial prefrontal cortexMiddle temporal gyrusPosterior cerebellar lobeFunctional connectivityReduced FCTemporal gyrusResting-state functional magnetic resonance imaging scansFunctional magnetic resonance imaging scansLeft medial prefrontal cortexEarly stages of schizophreniaCerebellar lobeRight middle temporal gyrusHealthy controlsPositive symptom scoresFirst-episode schizophreniaVisuospatial Memory TestStages of schizophreniaFunctional connectivity changesRight posterior cerebellar lobePrefrontal cortexMemory testLeft precuneusFC abnormalitiesBrain regionsHIV, smoking, and the brain: a convergence of neurotoxicities
Orlinick B, Farhadian S. HIV, smoking, and the brain: a convergence of neurotoxicities. AIDS Research And Therapy 2025, 22: 13. PMID: 39915881, PMCID: PMC11804093, DOI: 10.1186/s12981-025-00714-y.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusCholinergic anti-inflammatory pathwayAnti-inflammatory pathwayNeurocognitive impairmentTobacco smokeEffect of human immunodeficiency virusEffects of tobacco smokingNeurotoxic effectsBrain volume changesClinically significant impactIncreased oxidative stressImmunodeficiency virusAlpha7 nicotinic acetylcholine receptorPWHBrain regionsMicroglial activationCognitive functionBrain healthIncreased neuroinflammationNeuronal apoptosisTherapeutic targetAcetylcholine receptorsGeneral populationNeurotoxicitySmokingPhenome-wide association studies between SERINC2 and neuropsychiatric disorders
Liu P, Luo X, Cao L, Zhang Y, Ji J, Wang X, Wang K, Pan X, Yang R, Tan Z, Tan Y, Li C, Guo X, Wang Z, Luo X. Phenome-wide association studies between SERINC2 and neuropsychiatric disorders. Frontiers In Psychiatry 2025, 15: 1420395. PMID: 39902246, PMCID: PMC11788846, DOI: 10.3389/fpsyt.2024.1420395.Peer-Reviewed Original ResearchGray matter volumeBipolar disorderNeuropsychiatric disordersDisease-risk alleleSubcortical gray matter volumesSubstance use disordersMRNA expressionCortical surface areaAssociated with alcoholCocaine dependenceMarijuana dependencePolysubstance dependenceMatter volumeNicotine dependenceBrain regionsSchizophreniaSubcortical structuresSNP-disease associationsPhenome-wide association studyAutismOCDFDR correctionDisordersRegulatory effectsAssociation studiesPattern integration and differentiation: Dual process model of episodic memory
Evensmoen H, Rimol L, Rise H, Hansen T, Nili H, Winkler A, Håberg A. Pattern integration and differentiation: Dual process model of episodic memory. Imaging Neuroscience 2025, 3: imag_a_00433. DOI: 10.1162/imag_a_00433.Peer-Reviewed Original ResearchEpisodic memoryBrain regionsAssociated with successful memoryModels of episodic memoryHuman episodic memoryDual-process modelActivity patternsSubsequent memoryAnterior hippocampusPosterior hippocampusSuccessful memoryEpisodic orderParticipation episodesObject presentationMemoryHippocampusTemporal compressionBrainEpisodesParticipantsPattern integrityFMRIItemsIdentification of risk variants and cross-disorder pleiotropy through multi-ancestry genome-wide analysis of alcohol use disorder
Icick R, Shadrin A, Holen B, Karadag N, Parker N, O’Connell K, Frei O, Bahrami S, Høegh M, Lagerberg T, Cheng W, Seibert T, Djurovic S, Dale A, Zhou H, Edenberg H, Gelernter J, Smeland O, Hindley G, Andreassen O. Identification of risk variants and cross-disorder pleiotropy through multi-ancestry genome-wide analysis of alcohol use disorder. Nature Mental Health 2025, 3: 253-265. DOI: 10.1038/s44220-024-00353-8.Peer-Reviewed Original ResearchAlcohol use disorderGenome-wide association studiesUse disorderAssociation studiesMulti-ancestry genome-wide association studyEtiology of alcohol use disordersIdentification of risk variantsAlcohol use disorder phenotypesGenome-wide significant lociAlcohol use disorder riskMapped to genesComplications of alcohol usePotential drug targetsAlcohol phenotypesCross-disorderPolygenic overlapPositive genetic correlationSignificant lociGenetic architectureGenetic liabilityGenetic lociBrain regionsRisk variantsGenetic studiesImmune-related genesComparing reliability-based measures of functional connectivity between movie and rest: An ROI-based approach
Shearer H, Eilbott J, Vila-Rodriguez F, Noble S, Xu T, Vanderwal T. Comparing reliability-based measures of functional connectivity between movie and rest: An ROI-based approach. Imaging Neuroscience 2025, 3: imag_a_00411. DOI: 10.1162/imag_a_00411.Peer-Reviewed Original ResearchResting-state FCBrain regionsAbstract Functional connectivityFunctional connectivityPrecision psychiatryMeasures of functional connectivityField of precision psychiatryPre-supplementary motor areaSensitive to individual differencesDorsolateral prefrontal cortexWhole-brain levelMovie-watchingPrefrontal cortexTemporoparietal junctionROI-based approachIndividual differencesResting-stateResearch to clinical useMotor areaIntra-class correlation coefficientFC dataAcquisition statePsychiatryClinical useBrain
2024
Single-Cell Analysis in Cerebrovascular Research: Primed for Breakthroughs and Clinical Impact
Albertson A, Winkler E, Yang A, Buckwalter M, Dingman A, Fan H, Herson P, McCullough L, Perez-Pinzon M, Sansing L, Sun D, Alkayed N. Single-Cell Analysis in Cerebrovascular Research: Primed for Breakthroughs and Clinical Impact. Stroke 2024, 56: 1082-1091. PMID: 39772596, DOI: 10.1161/strokeaha.124.049001.Peer-Reviewed Original ResearchSex differences in dorsal striatal volume and interest in quitting smoking
Huang S, MacLean R, Beltz A, McClernon F, Kozink R, Wilson S. Sex differences in dorsal striatal volume and interest in quitting smoking. Drug And Alcohol Dependence 2024, 267: 112543. PMID: 39764928, PMCID: PMC11771478, DOI: 10.1016/j.drugalcdep.2024.112543.Peer-Reviewed Original ResearchConceptsGray matter volumePutamen gray matter volumesVoxel-based morphometryStriatal grey matter volumeAverage gray matter volumeQuitting interestDorsal striatal volumesStructural magnetic resonance imagingQuit smokingMagnetic resonance imagingSubstance use behaviorsROI-based analysisSelf-reported interestDorsal striatumBrain mechanismsNeuroanatomical mechanismsMatter volumeStriatal volumeBrain regionsSensorimotor cuesVolumetric differencesSex differencesPutamenMultiple regression analysisSmoking behaviorThe role of personality traits and life stress in alcohol use disorder: Insights from NGF gene polymorphisms of Han Chinese population in Taiwan
Kuo S, Lin C, Yeh Y, Chen C, Huang Y, Chang T, Yang Y, Huang J, Yang B, Huang S. The role of personality traits and life stress in alcohol use disorder: Insights from NGF gene polymorphisms of Han Chinese population in Taiwan. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2024, 136: 111232. PMID: 39719220, DOI: 10.1016/j.pnpbp.2024.111232.Peer-Reviewed Original ResearchConceptsAlcohol use disorderLife Events QuestionnaireTridimensional Personality QuestionnaireHarm avoidancePersonality traitsLife stressUse disorderAssociated with alcohol use disorderAlcohol use disorder groupNegative Life Events QuestionnaireAlcohol use disorder patientsNerve growth factor geneChronic alcohol consumptionPersonality QuestionnaireNS scoresEvents QuestionnaireNeuropsychiatric conditionsBrain regionsNerve growth factor levelsSample of womenNerve growth factorPersonal characteristicsHan Chinese populationLEQ scoresAlcohol consumptionEpigenome-wide association studies identify novel DNA methylation sites associated with PTSD: a meta-analysis of 23 military and civilian cohorts
Katrinli S, Wani A, Maihofer A, Ratanatharathorn A, Daskalakis N, Montalvo-Ortiz J, Núñez-Ríos D, Zannas A, Zhao X, Aiello A, Ashley-Koch A, Avetyan D, Baker D, Beckham J, Boks M, Brick L, Bromet E, Champagne F, Chen C, Dalvie S, Dennis M, Fatumo S, Fortier C, Galea S, Garrett M, Geuze E, Grant G, Hauser M, Hayes J, Hemmings S, Huber B, Jajoo A, Jansen S, Kessler R, Kimbrel N, King A, Kleinman J, Koen N, Koenen K, Kuan P, Liberzon I, Linnstaedt S, Lori A, Luft B, Luykx J, Marx C, McLean S, Mehta D, Milberg W, Miller M, Mufford M, Musanabaganwa C, Mutabaruka J, Mutesa L, Nemeroff C, Nugent N, Orcutt H, Qin X, Rauch S, Ressler K, Risbrough V, Rutembesa E, Rutten B, Seedat S, Stein D, Stein M, Toikumo S, Ursano R, Uwineza A, Verfaellie M, Vermetten E, Vinkers C, Ware E, Wildman D, Wolf E, Young R, Zhao Y, van den Heuvel L, Uddin M, Nievergelt C, Smith A, Logue M. Epigenome-wide association studies identify novel DNA methylation sites associated with PTSD: a meta-analysis of 23 military and civilian cohorts. Genome Medicine 2024, 16: 147. PMID: 39696436, PMCID: PMC11658418, DOI: 10.1186/s13073-024-01417-1.Peer-Reviewed Original ResearchConceptsEpigenome-wide association studiesDNA methylationPsychiatric Genomics ConsortiumPost-traumatic stress disorderAssociation studiesMeta-analysis of epigenome-wide association studiesMethylation levelsGenome-wide expression dataEpigenetic gene regulationBrain regionsPGC-PTSDAnnotated genesBlood cell proportionsCpG lociGene regulationSusceptibility to post-traumatic stress disorderExpression dataAssociated with post-traumatic stress disorderIllumina HumanMethylation450Genomics ConsortiumOccurrence of post-traumatic stress disorderAssociated with biological differencesCpGMultiple brain regionsPostmortem brain samplesExploration of (R)-[11C]YH168 as a PET tracer for imaging monoacylglycerol lipase in the brain: from mice to non-human primates
He Y, Zheng M, Gu J, Reichert L, Trimborn J, Zhang H, Keller C, Crosby M, Collin L, Heer D, Pavlovic A, Topp A, Wittwer M, Grether U, Gobbi L, Schibli R, Huang Y, Mu L. Exploration of (R)-[11C]YH168 as a PET tracer for imaging monoacylglycerol lipase in the brain: from mice to non-human primates. European Journal Of Nuclear Medicine And Molecular Imaging 2024, 52: 1556-1565. PMID: 39673602, PMCID: PMC11839854, DOI: 10.1007/s00259-024-07013-0.Peer-Reviewed Original ResearchMonoacylglycerol lipaseNon-human primatesIn vitro autoradiographyBrain regionsMice to non-human primatesMAGL knockoutNon-displaceable binding potentialRhesus monkeysNon-human primate brainRegional non-displaceable binding potentialsRegional time-activity curvesMouse brainCingulate cortexFrontal cortexEndocannabinoid systemLevels of radioactive uptakeMouse brain slicesOccipital cortexBrains of miceOne-tissue compartment modelBinding potentialMAGL expressionPET scansKnockout micePrimate brainHierarchical gradients of multiple timescales in the mammalian forebrain
Song M, Shin E, Seo H, Soltani A, Steinmetz N, Lee D, Jung M, Paik S. Hierarchical gradients of multiple timescales in the mammalian forebrain. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2415695121. PMID: 39671181, PMCID: PMC11665873, DOI: 10.1073/pnas.2415695121.Peer-Reviewed Original ResearchConceptsTask-related activityHierarchical gradientIntrinsic timescalesFeatures of cortical circuitsCorrelations of neural activityCortex of monkeysTemporal correlation of neural activityBrain regionsAssociation areasNeural activitySpatial receptive fieldsBasal gangliaThalamic activityConnectivity patternsCortical circuitsHierarchical axisCortical projectionsMammalian brainTimescalesMammalian forebrainCortexBrainHierarchical organizationProperties of synapsesMultiple timescales
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