2025
Evolution of EEG Findings in Patients with Acute Brain Injury
Narrett J, Byrnes M, Gilmore E, Hirsch L, Punia V, Sivaraju A. Evolution of EEG Findings in Patients with Acute Brain Injury. Neurocritical Care 2025, 1-8. PMID: 40038178, DOI: 10.1007/s12028-025-02227-y.Peer-Reviewed Original ResearchAcute brain injuryLateralized rhythmic delta activityLateralized periodic dischargesRhythmic delta activityEEG findingsContinuous electroencephalographyPeriodic dischargesDelta activityEEG patternsRetrospective chart review of patientsChart review of patientsSporadic epileptiform dischargesFollow-up EEGReview of patientsBrain injuryGeneralized periodic dischargesRetrospective chart reviewAcute symptomatic seizuresAntiseizure medication treatmentEvolution of EEG patternsConclusionsIn patientsElectrographic seizuresNeurological outcomeBackgroundIncreasing useElectroclinical seizuresOuter radial glia promotes white matter regeneration after neonatal brain injury
Jinnou H, Rosko L, Yamashita S, Henmi S, Prasad J, Lam V, Agaronyan A, Tu T, Imamura Y, Kuboyama K, Sawamoto K, Hashimoto-Torii K, Ishibashi N, Gallo V. Outer radial glia promotes white matter regeneration after neonatal brain injury. Cell Reports Medicine 2025, 6: 101986. PMID: 40023165, DOI: 10.1016/j.xcrm.2025.101986.Peer-Reviewed Original ResearchConceptsOuter radial gliaActivating transcription factor 5Oligodendrocyte precursor cellsTreating white matter injuryNeonatal brain injuryWhite matter injuryPeriventricular white matterWhite matter regenerationImprove functional recoveryPopulation of neural stem cellsNeural stem cellsBrain injuryOuter subventricular zoneSubventricular zoneProliferative capacityPostnatal developmentVentricular zoneFunctional recoveryPrecursor cellsStem cellsWhite matterRadial gliaTherapeutic targetNeonatal pigletsInjuryRole of non-human primate models in accelerating research and developing countermeasures against Zika virus infection
Li A, Coffey L, Mohr E, Raper J, Chahroudi A, Ausderau K, Aliota M, Friedrich T, Mitzey A, Koenig M, Golos T, Jaeger H, Roberts V, Lo J, Smith J, Hirsch A, Streblow D, Newman C, O’Connor D, Lackritz E, Van Rompay K, Waldorf K, Workgroup Z, Waldorf K, Barrett A, Beasley D, Bennie J, Bourne N, Brault A, Cehovin A, Coelho C, Diamond M, Emperador D, Faria N, Fay P, Golding J, Harris E, Hasanin N, Jaenisch T, Ko A, Lackritz E, Leighton T, Leo Y, Mehr A, Memish Z, Méndez-Rico J, Moore K, Mura M, Ng L, Osterholm M, Ostrowsky J, Peeling R, Rabe I, Salje H, Staples J, Thomas S, Ulrich A, Vanhomwegen J, Wongsawat J. Role of non-human primate models in accelerating research and developing countermeasures against Zika virus infection. The Lancet Microbe 2025, 101030. PMID: 40024258, DOI: 10.1016/j.lanmic.2024.101030.Peer-Reviewed Original ResearchNon-human primate modelZika virus infectionZika virus researchPrimate modelVirus infectionCases of congenital microcephalyFetal brain injuryLaboratory-confirmed casesGestational ageZika virus strainsBrain injuryPerinatal complicationsZika virus epidemicTesting medical countermeasuresCongenital microcephalyGlobal health concernVirus researchDevelopmental abnormalitiesZika virusVirus strainsMedical countermeasuresCongenital brain injuryInfectionZikaVirus epidemicExploring Calcium Channels as Potential Therapeutic Targets in Blast Traumatic Brain Injury
Wachtler N, O’Brien R, Ehrlich B, McGuone D. Exploring Calcium Channels as Potential Therapeutic Targets in Blast Traumatic Brain Injury. Pharmaceuticals 2025, 18: 223. PMID: 40006037, PMCID: PMC11859800, DOI: 10.3390/ph18020223.Peer-Reviewed Original ResearchCalcium signalingCalcium channelsTherapeutic strategiesCalcium homeostasisFunction of calcium channelsDysregulated calcium signalingModulation of injuryTraumatic brain injuryBrain injuryLoss of calcium homeostasisBlast-related traumatic brain injuryDevelopment of neuroprotective interventionsIntracellular calcium dynamicsPlasma membrane stabilityExtracellular calciumBlast traumatic brain injuryPreclinical modelsTherapeutic outcomesNeuroprotective interventionsMembrane abnormalitiesPharmacological inhibitorsNeuronal somataExclusion criteriaCalcium dynamicsSecondary injuryReconstructing Covert Consciousness
Fischer D, Edlow B, Freeman H, Alaiev D, Wu Q, Ware J, Detre J, Aguirre G. Reconstructing Covert Consciousness. Neurology 2025, 104: e210208. PMID: 39883908, PMCID: PMC11781786, DOI: 10.1212/wnl.0000000000210208.Peer-Reviewed Original ResearchConceptsCovert consciousnessNeural decodingConscious assessmentCognitive motor dissociationFunctional neuroanatomyDisorders of consciousnessBrain activitySemantic decodingLevel of consciousnessConscious experienceMotor dissociationExperience—isBrain injuryDecodingPatient behaviorBrainEnhanced granularityImperfect assumptionsGoogle Scholar databasesUnresponsive patientsFMRIConsciousnessPatientsQualitative Analysis of Symptoms from the Central Thalamic Deep Brain Stimulation Trial for Traumatic Brain Injury
Gerber L, Shulman K, Wright M, Schiff N, Fins J. Qualitative Analysis of Symptoms from the Central Thalamic Deep Brain Stimulation Trial for Traumatic Brain Injury. Neurorehabilitation 2025 DOI: 10.1177/10538135241296732.Peer-Reviewed Original ResearchStudy of deep brain stimulationTraumatic brain injuryDeep brain stimulation trialsDeep brain stimulationBrain injuryRandomized feasibility studySecondary qualitative analysisFamily membersSelf-regulationChronic traumatic brain injurySemi-structured interviewsBrain stimulationFamily perspectiveStimulation trialsTrial participantsExecutive controlResults SubjectsSymptom assessmentOutcome measuresQualitative analysisCognitive symptomsAnalysis of symptomsNarrative dataQualitative dataPost-injuryAdherence to Recommendations and Yield of Critical Care EEG Monitoring: A Prospective Multicentric Study.
Bellante F, Santos S, Gérard L, Jacquet L, Piagnerelli M, Taccone F, Thooft A, Wittebole X, Legros B, Gaspard N. Adherence to Recommendations and Yield of Critical Care EEG Monitoring: A Prospective Multicentric Study. Journal Of Clinical Neurophysiology 2025 PMID: 39810297, DOI: 10.1097/wnp.0000000000001143.Peer-Reviewed Original ResearchGroup of patientsAcute brain injuryClinical seizuresElectrographic seizuresStatus epilepticusClinical factorsEEG monitoringSociety recommendationsMulticenter prospective observational studySeizure riskAmerican Clinical Neurophysiology SocietyMental statusCritically ill adult patientsRefractory status epilepticusConvulsive status epilepticusProspective multicentre studyDetection of electrographic seizuresIll adult patientsLow-risk groupIntensive care unitTime of dischargeBrain injuryPrimary admission diagnosisPatient selectionAdult patients
2024
A Hybrid Transformer-Convolutional Neural Network for Segmentation of Intracerebral Hemorrhage and Perihematomal Edema on Non-Contrast Head Computed Tomography (CT) with Uncertainty Quantification to Improve Confidence
Tran A, Desser D, Zeevi T, Abou Karam G, Dierksen F, Dell'Orco A, Kniep H, Hanning U, Fiehler J, Zietz J, Sanelli P, Malhotra A, Duncan J, Aneja S, Falcone G, Qureshi A, Sheth K, Nawabi J, Payabvash S. A Hybrid Transformer-Convolutional Neural Network for Segmentation of Intracerebral Hemorrhage and Perihematomal Edema on Non-Contrast Head Computed Tomography (CT) with Uncertainty Quantification to Improve Confidence. Bioengineering 2024, 11: 1274. PMID: 39768092, PMCID: PMC11672977, DOI: 10.3390/bioengineering11121274.Peer-Reviewed Original ResearchNon-contrast head computed tomographyPerihematomal edemaHead computed tomographyIntracerebral hemorrhageComputed tomographyVolume similarityUniversity Medical Center Hamburg-EppendorfSecondary brain injuryYale cohortInfratentorial locationMulticentre trialCT scanTreatment planningNon-contrastHamburg-EppendorfImaging markersHemorrhagic strokeHemorrhageEdemaCohortBrain injuryDice coefficientUnnecessary Scans Lead to Unnecessary Re-scans: Evaluating Clinical Management of Low and Intermediate Risk Pediatric Traumatic Brain Injuries
Rivero R, Curran I, Hellmann Z, Carroll M, Hornick M, Solomon D, DiLuna M, Morrell P, Christison-Lagay E. Unnecessary Scans Lead to Unnecessary Re-scans: Evaluating Clinical Management of Low and Intermediate Risk Pediatric Traumatic Brain Injuries. Journal Of Pediatric Surgery 2024, 60: 162097. PMID: 39693726, DOI: 10.1016/j.jpedsurg.2024.162097.Peer-Reviewed Original ResearchPediatric Emergency Care Applied Research NetworkPECARN guidelinesPediatric Emergency Care Applied Research Network criteriaClinically important traumatic brain injuryComputed tomographyRisk patientsCross-sectional imagingIntermediate risk group patientsHead traumaIntracranial injuryIntermediate risk patientsRisk group patientsLow-risk injuriesLow-risk patientsRetrospective cohort studyClinically significant progressionEvaluate clinical managementIncreased hospital costsMild head traumaPenetrating head traumaLength of stayTraumatic brain injuryNon-accidental traumaBrain injuryRetrospective reviewGenetic vulnerability and adverse mental health outcomes following mild traumatic brain injury: a meta-analysis of CENTER-TBI and TRACK-TBI cohorts
Kals M, Wilson L, Levey D, Parodi L, Steyerberg E, Richardson S, He F, Sun X, Jain S, Palotie A, Ripatti S, Rosand J, Manley G, Maas A, Stein M, Menon D, Consortium T, Ackerlund C, Adams H, Amrein K, Andelic N, Andreassen L, Anke A, Antoni A, Audibert G, Azouvi P, Azzolini M, Bartels R, Barzó P, Beauvais R, Beer R, Bellander B, Belli A, Benali H, Berardino M, Beretta L, Blaabjerg M, Bragge P, Brazinova A, Brinck V, Brooker J, Brorsson C, Buki A, Bullinger M, Cabeleira M, Caccioppola A, Calappi E, Calvi M, Cameron P, Lozano G, Carbonara M, Castaño-León A, Cavallo S, Chevallard G, Chieregato A, Citerio G, Clusmann H, Coburn M, Coles J, Cooper J, Correia M, Čović A, Curry N, Czeiter E, Czosnyka M, Dahyot-Fizelier C, Dark P, Dawes H, De Keyser V, Degos V, Della Corte F, Boogert H, Depreitere B, Đilvesi Đ, Dixit A, Donoghue E, Dreier J, Dulière G, Ercole A, Esser P, Ezer E, Fabricius M, Feigin V, Foks K, Frisvold S, Furmanov A, Gagliardo P, Galanaud D, Gantner D, Gao G, George P, Ghuysen A, Giga L, Glocker B, Golubović J, Gomez P, Gratz J, Gravesteijn B, Grossi F, Gruen R, Gupta D, Haagsma J, Haitsma I, Helbok R, Helseth E, Horton L, Huijben J, Hutchinson P, Jacobs B, Jankowski S, Jarrett M, Jiang J, Johnson F, Jones K, Karan M, Kolias A, Kompanje E, Kondziella D, Koskinen L, Kovács N, Kowark A, Lagares A, Lanyon L, Laureys S, Lecky F, Ledoux D, Lefering R, Legrand V, Lejeune A, Levi L, Lightfoot R, Lingsma H, Maegele M, Majdan M, Manara A, Maréchal H, Martino C, Mattern J, McFadyen C, McMahon C, Melegh B, Menovsky T, Mikolic A, Misset B, Muraleedharan V, Murray L, Negru A, Nelson D, Newcombe V, Nieboer D, Nyirádi J, Oresic M, Ortolano F, Otesile O, Parizel P, Payen J, Perera N, Perlbarg V, Persona P, Peul W, Piippo-Karjalainen A, Pirinen M, Pisica D, Ples H, Polinder S, Pomposo I, Posti J, Puybasset L, Rădoi A, Ragauskas A, Raj R, Rambadagalla M, Rehorčíková V, Helmrich I, Rhodes J, Richter S, Rocka S, Roe C, Roise O, Rosenfeld J, Rosenlund C, Rosenthal G, Rossaint R, Rossi S, Rueckert D, Rusnák M, Sahuquillo J, Sakowitz O, Sanchez-Porras R, Sandor J, Schäfer N, Schmidt S, Schoechl H, Schoonman G, Schou R, Schwendenwein E, Sewalt C, Singh R, Skandsen T, Smielewski P, Sorinola A, Stamatakis E, Stanworth S, Stevens R, Stewart W, Stocchetti N, Sundström N, Takala R, Tamás V, Tamosuitis T, Taylor M, Ao B, Tenovuo O, Theadom A, Thibaut A, Thomas M, Tibboel D, Timmers M, Tolias C, Trapani T, Tudora C, Unterberg A, Vajkoczy P, Valeinis E, Vallance S, Vámos Z, van der Jagt M, van der Naalt J, Van der Steen G, van Dijck J, van Erp I, van Essen T, Van Hecke W, van Heugten C, Van Praag D, van Veen E, van Wijk R, Vyvere T, Vargiolu A, Vega E, Velt K, Verheyden J, Vespa P, Vik A, Vilcinis R, Volovici V, von Steinbüchel N, Voormolen D, Vulekovic P, Whitehouse D, Wiegers E, Williams G, Wolf S, Yang Z, Ylén P, Younsi A, Zeiler F, Ziverte A, Zoerle T, Adeoye O, Badjatia N, Barber J, Bergin M, Boase K, Bodien Y, Chesnut R, Corrigan J, Crawford K, Diaz-Arrastia R, Dikmen S, Duhaime A, Ellenbogen R, Feeser V, Ferguson A, Foreman B, Gaudette E, Giacino J, Gonzalez L, Gopinath S, Grandhi R, Gullapalli R, Hemphill C, Hotz G, Huie R, Jha R, Keene D, Kitagawa R, Korley F, Kramer J, Kreitzer N, Levin H, Lindsell C, Machamer J, Madden C, Martin A, McAllister T, McCrea M, Merchant R, Mukherjee P, Nelson L, Ngwenya L, Noel F, Nolan A, Okonkwo D, Palacios E, Perl D, Puccio A, Rabinowitz M, Robertson C, Rodgers R, Rosenthal E, Sander A, Sandsmark D, Schneider A, Schnyer D, Seabury S, Sherer M, Sugar G, Temkin N, Toga A, Torres-Espin A, Valadka A, Vassar M, Wang K, Wang V, Yue J, Yuh E, Zafonte R. Genetic vulnerability and adverse mental health outcomes following mild traumatic brain injury: a meta-analysis of CENTER-TBI and TRACK-TBI cohorts. EClinicalMedicine 2024, 78: 102956. PMID: 39720422, PMCID: PMC11667043, DOI: 10.1016/j.eclinm.2024.102956.Peer-Reviewed Original ResearchPost-traumatic stress disorderMild traumatic brain injuryPolygenic risk scoresPTSD-PRSMDD-PRSTraumatic brain injuryTRACK-TBIProportion of outcome variancePost-traumatic Stress Disorder Checklist-5Odds of post-traumatic stress disorderAdverse mental health outcomesAssociations of polygenic risk scoresBrain injuryPatient Health Questionnaire-9Mental health outcomesOdds ratioMonths post-injuryRisk of depressionDisorder-specificDepressive disorderStress disorderChecklist-5Genetic vulnerabilityOutcome varianceCohort of African AmericansChallenges with Formulating Accurate Prognosis for Patients with Severe Acute Brain Injury
Carhuapoma L, Hwang D. Challenges with Formulating Accurate Prognosis for Patients with Severe Acute Brain Injury. Neurocritical Care 2024, 1-8. PMID: 39627563, DOI: 10.1007/s12028-024-02170-4.Peer-Reviewed Original ResearchSevere acute brain injuryAcute brain injuryBrain injurySelf-fulfilling prophecyClinical grading scaleCritically ill patientsEarly withdrawalPrognostic outcomesGrading scaleIll patientsPatientsAccurate prognosisHigher mortalityPredicting outcomeLack of complete dataWithdrawal of life-sustaining treatmentComplete dataOutcomesPrognosticationInjuryLife-sustaining treatmentTraumatic Brain Injury in U.S. Veterans: Prevalence and Associations with Physical, Mental, and Cognitive Health
Karr J, Rippey C, Hubert T, Stein M, Adams T, Pietrzak R. Traumatic Brain Injury in U.S. Veterans: Prevalence and Associations with Physical, Mental, and Cognitive Health. Archives Of Physical Medicine And Rehabilitation 2024 PMID: 39613218, DOI: 10.1016/j.apmr.2024.11.010.Peer-Reviewed Original ResearchPosttraumatic stress disorderAlcohol use disorderDrug use disordersTraumatic brain injuryActivities of daily livingInstrumental activities of daily livingU.S. veteransAnxiety disordersSuicidal ideationUse disorderHealth conditionsPrevalence of traumatic brain injuryU.S. military veteransBrain injuryActivities of daily living disabilitySelf-reported health professional diagnosisOdds of mild cognitive impairmentU.S. veteran populationMental health conditionsMild cognitive impairmentPhysical health conditionsDepressive disorderStress disorderAssociated with higher oddsSuicide attemptsThe association between female sex and depression following traumatic brain injury: A systematic review and meta-analysis
Sandhu M, Schonwald A, Boyko M, Jafar T, Freedman I, Woeste J, Kurup A, Funaro M, Zlotnik A, Gruenbaum S, Elsamadicy A, Reynolds R, Gruenbaum B. The association between female sex and depression following traumatic brain injury: A systematic review and meta-analysis. Neuroscience & Biobehavioral Reviews 2024, 168: 105952. PMID: 39603437, DOI: 10.1016/j.neubiorev.2024.105952.Peer-Reviewed Original ResearchPost-TBI depressionTraumatic brain injurySpectrum of TBI severityBrain injuryDiagnosis of depressionNeurobehavioral symptomsTBI severitySystematic reviewDepressionMeta-analysisStatistically significant differenceMedian ageFemale patientsPooled analysisFemale sexRisk factorsSevere casesParticipantsPotential associationSignificant differenceSexSeverityRiskInjurySubjectsFever Prevention in Patients With Acute Vascular Brain Injury
Greer D, Helbok R, Badjatia N, Ko S, Guanci M, Sheth K, Diringer M, Mehta Y, Cava L, Hinduja A, Lele A, Sarwal A, Kulik T, Keller E, Smith G, Dennesen P, Dimitriadis K, Schonenberger S, Gunther A, Meisel A, Wolf S, Kollmar R, Barlinn K, Jeon S, Han M, Hong J, Lee R, Falcone G, Dashti S, Busl K, Ermak D, Berkeley J, Amory C, Swor R, DeGeorgia M, Green-LaRoche D, Thompson B, Hatton K, Sung G, Mehta C, Zurasky J, Da Silva I, James M, Aysenne A, Cervantes A, Devlin T, Chang I, Morris N, Venkatasubramanian C, Mushlschlegel S, Zachariah J, Chaudry F, Claassen J, Dangayach N, Choi H, Sadaka F, Miller C. Fever Prevention in Patients With Acute Vascular Brain Injury. JAMA 2024, 332: 1525-1534. PMID: 39320879, PMCID: PMC11425189, DOI: 10.1001/jama.2024.14745.Peer-Reviewed Original ResearchVascular brain injuryStandard care groupCare groupMajor adverse eventsPrimary outcomeStandard care patientsBlinded outcome assessmentIntensive care unit dischargeFunctional outcomesAdverse eventsBrain injuryFever preventionFever burdenPrincipal secondary end pointBetween-group differencesOpen-label randomized clinical trialPrevention groupFunctional recoveryPrincipal secondary outcomeCare patientsAssociated with worse outcomesMain OutcomesImpact functional outcomesSecondary end pointsTemperature management deviceChronic headaches after traumatic brain injury: Diagnostic complexity associated with increased cost
McGeary D, Swan A, Kennedy E, Dismuke-Greer C, McGeary C, Sico J, Amuan M, Manhapra A, Bouldin E, Watson P, Kenney K, Myers M, Werner J, Mitchell J, Carlson K, Delgado R, Esmaeili A, Pugh M. Chronic headaches after traumatic brain injury: Diagnostic complexity associated with increased cost. Neurorehabilitation 2024, 55: 303-317. PMID: 39422976, DOI: 10.3233/nre-230277.Peer-Reviewed Original ResearchTraumatic brain injuryChronic headacheTraumatic brain injury diagnosisPost-9/11-era veteransPost-traumatic headacheAssociated with higher costsCare burdenBrain injuryHealthcare costsHeadache diagnosisEra veteransClinical characteristicsHeadache disordersHigher expendituresCareVeteransIndividual headachesHigh costHeadacheIntensive treatmentRefractory headacheOutcomesDiagnosisInjuryConfoundingClinical Implementation of fMRI and EEG to Detect Cognitive Motor Dissociation
Bodien Y, Fecchio M, Freeman H, Sanders W, Meydan A, Lawrence P, Kirsch J, Fischer D, Cohen J, Rubin E, He J, Schaefer P, Hochberg L, Rapalino O, Cash S, Young M, Edlow B. Clinical Implementation of fMRI and EEG to Detect Cognitive Motor Dissociation. Neurology Clinical Practice 2024, 15: e200390. PMID: 39473967, PMCID: PMC11515113, DOI: 10.1212/cpj.0000000000200390.Peer-Reviewed Original ResearchCognitive motor dissociationTask-based functional MRIMotor dissociationLanguage functionEvidence-based guidelinesBehavioral evidenceFunctional MRIEEG assessmentClinical careBrain injuryEvidence baseClinical assessmentPatient selectionClinical implementationPatientsReports lessonsEEGFMRIUnited StatesEffective strategyAssessmentEthical implicationsCareBrainReorganization of integration and segregation networks in brain-based visual impairment
Diez I, Troyas C, Bauer C, Sepulcre J, Merabet L. Reorganization of integration and segregation networks in brain-based visual impairment. NeuroImage Clinical 2024, 44: 103688. PMID: 39432973, PMCID: PMC11535411, DOI: 10.1016/j.nicl.2024.103688.Peer-Reviewed Original ResearchIntraparietal sulcusReduced gray matter volumeResting state functional connectivityCerebral visual impairmentGray matter volumeFunctional network architectureMultimodal integration areasMode networkMatter volumeNeurotypical developmentFunctional connectivityVisual processingEnvironmental experiencesCerebral connectivityPrimary visual cortexHuman brainConnectome analysisBrain injuryNetwork organizationVisual cortexImpairmentInvestigate differencesCompared to controlsFunctional changesParticipantsDelayed Withdrawal of Life-Sustaining Treatment in Disorders of Consciousness: Practical and Theoretical Considerations
Williams A, Bass G, Hampton S, Klinedinst R, Giacino J, Fischer D. Delayed Withdrawal of Life-Sustaining Treatment in Disorders of Consciousness: Practical and Theoretical Considerations. Neurocritical Care 2024, 1-10. PMID: 39407075, DOI: 10.1007/s12028-024-02143-7.Peer-Reviewed Original ResearchWithdrawal of life-sustaining treatmentPatient's recovery trajectorySurrogate decision makersSurrogates of patientsPost-acute-care facilityAcute care cliniciansLife-sustaining treatmentDisorders of consciousnessQuality of lifeNeurological recoveryCare cliniciansPsychosocial factorsSevere acute brain injuryAcute time periodAcceptable quality of lifeHospital dischargeRecovery trajectoriesCliniciansPost-injuryBrain injuryNeurological prognosisDecision-makingPatientsPreestablished goalsInjuryTibolone treatment after traumatic brain injury exerts a sex-specific and Y chromosome-dependent regulation of methylation and demethylation enzymes and estrogen receptors in the cerebral cortex
Pinto-Benito D, Bautista-Abad A, Lagunas N, Ontiveros N, Ganchala D, Garcia-Segura L, Arevalo M, Grassi D. Tibolone treatment after traumatic brain injury exerts a sex-specific and Y chromosome-dependent regulation of methylation and demethylation enzymes and estrogen receptors in the cerebral cortex. Biochimica Et Biophysica Acta (BBA) - Molecular Basis Of Disease 2024, 1871: 167532. PMID: 39366643, DOI: 10.1016/j.bbadis.2024.167532.Peer-Reviewed Original ResearchRepetitive Mild Closed-Head Injury Induced Synapse Loss and Increased Local BOLD-fMRI Signal Homogeneity
Markicevic M, Mandino F, Toyonaga T, Cai Z, Fesharaki-Zadeh A, Shen X, Strittmatter S, Lake E. Repetitive Mild Closed-Head Injury Induced Synapse Loss and Increased Local BOLD-fMRI Signal Homogeneity. Journal Of Neurotrauma 2024, 41: 2528-2544. PMID: 39096127, PMCID: PMC11698675, DOI: 10.1089/neu.2024.0095.Peer-Reviewed Original ResearchChronic variable stressRegional homogeneityFunctional brain abnormalitiesSynapse densityMild closed-head injuryClosed-head injuryTraumatic brain injuryTreat traumatic brain injuryNeurobiological alterationsMild head injuryVariable stressBrain abnormalitiesPositron emission tomographyMultimodal studiesSynaptic densityMagnetic resonance imagingBrain imagingBrain injuryInduce synapse lossFMRIInjured miceMouse modelEmission tomographyResonance imagingCompensatory mechanisms
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