2025
Reduced removal of waste products from energy metabolism takes center stage in human brain aging
Mangia S, DiNuzzo M, Ponticorvo S, Dienel G, Behar K, Benveniste H, Hyder F, Giove F, Herculano-Houzel S, Petroff O, Eberly L, Filip P, Michaeli S, Rothman D. Reduced removal of waste products from energy metabolism takes center stage in human brain aging. Scientific Reports 2025, 15: 8127. PMID: 40057554, PMCID: PMC11890754, DOI: 10.1038/s41598-025-90342-3.Peer-Reviewed Original ResearchA telescopic independent component analysis on functional magnetic resonance imaging dataset
Mirzaeian S, Faghiri A, Calhoun V, Iraji A. A telescopic independent component analysis on functional magnetic resonance imaging dataset. Network Neuroscience 2025, 9: 61-76. PMCID: PMC11949590, DOI: 10.1162/netn_a_00421.Peer-Reviewed Original ResearchRight frontoparietal networkVisual networkIndependent component analysisBrain functionExtraction of informationFunctional magnetic resonance imaging datasetsImage datasetsFrontoparietal networkMagnetic resonance imaging datasetFMRI dataGroup differencesLeverage informationSmall networksDMNNetworkComponent analysisIncomplete viewAbstract Brain functionFunctional sourceIdentifying Genetic Variants for Brain Connectivity Using Ball Covariance Ranking and Aggregation
Dai W, Zhang H. Identifying Genetic Variants for Brain Connectivity Using Ball Covariance Ranking and Aggregation. Journal Of The American Statistical Association 2025, ahead-of-print: 1-19. DOI: 10.1080/01621459.2025.2450837.Peer-Reviewed Original ResearchSingle nucleotide polymorphismsDetect single nucleotide polymorphismsGene-based analysisControlling false discovery rateControlling false discoveriesSNP setsFunctional connectivityFalse discovery rateGenetic architectureNovel genesGenetic basisNucleotide polymorphismsGenetic variantsUK Biobank dataPsychiatric disordersDiscovery rateBrain functionFalse discoveriesBiobank dataCorrelations of neural activityBrain regionsBiological etiologyBrain connectivityEQTLNeural activityBrain connectivity correlates of the impact of a digital intervention for individuals with subjective cognitive decline on depression and IL-18
Catalogna M, Somerville Y, Saporta N, Nathansohn-Levi B, Shelly S, Edry L, Zagoory-Sharon O, Feldman R, Amedi A. Brain connectivity correlates of the impact of a digital intervention for individuals with subjective cognitive decline on depression and IL-18. Scientific Reports 2025, 15: 6863. PMID: 40011544, PMCID: PMC11865443, DOI: 10.1038/s41598-025-91457-3.Peer-Reviewed Original ResearchConceptsBrain connectivityCognitive declineResting-state functional connectivityEffect sizeCognitive behavioral therapyLate-life depressionSelf-reported depressionMedium effect sizeDigital interventionsInterventions targeting mental healthMood regulationBehavioral therapyDepressive symptomsDecreased connectivityPost-intervention changesFunctional connectivityTwo-week interventionCognitive functionSpatial cognitionDepression scoresBrain healthBehavioral outcomesBrain functionPsychological techniquesPsychological healthProtective role of parenthood on age-related brain function in mid- to late-life
Orchard E, Chopra S, Ooi L, Chen P, An L, Jamadar S, Yeo B, Rutherford H, Holmes A. Protective role of parenthood on age-related brain function in mid- to late-life. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2411245122. PMID: 39999172, PMCID: PMC11892684, DOI: 10.1073/pnas.2411245122.Peer-Reviewed Original ResearchConceptsBrain functionFunctional connectivityPatterns of brain functionAssociated with higher connectivityConsistent with animal modelsBrain structuresCaregiving environmentAssociated with patternsAge-related alterationsBrain healthAging trajectoriesLate-lifeSpatial topographyAdult brainImpact of caregivingBrainPreliminary findingsHuman parentingImpact of ageCaregiving experienceChildrenCaregiversHigher connectivityEffect of parenthoodOne-bodyTHE ANTERIOR CINGULATE CORTEX LINKS SEROTONIN TRANSPORTER GENETICS AND EMOTION PROCESSING
Kloebl *, Murgaš M, Reed M, Silberbauer L, Hartmann A, Godbersen G, Hahn A, Gryglewski G, Rujescu D, Lanzenberger R. THE ANTERIOR CINGULATE CORTEX LINKS SEROTONIN TRANSPORTER GENETICS AND EMOTION PROCESSING. The International Journal Of Neuropsychopharmacology 2025, 28: i18-i19. PMCID: PMC11814669, DOI: 10.1093/ijnp/pyae059.032.Peer-Reviewed Original ResearchAnterior cingulate cortex activationAnterior cingulate cortexEmotional processingSerotonin reuptake inhibitorsSerotonin transporterSerotonin transporter expressionBrain functionHappy facesNeutral facesCingulate cortexReuptake inhibitorsBrain activitySerotonin transporter binding potentialMeasures of emotional processingSingle nucleotide polymorphism rs25531Anterior cingulate cortex connectivityImpact of 5-HTTLPRAssess attributional styleSituational Attributions QuestionnaireAcute tryptophan depletionFacial emotion processingIncreased amygdala activationSerotonin transporter bindingSerotonin transporter polymorphismEffect of citalopramSelf-reports map the landscape of task states derived from brain imaging
Mckeown B, Goodall-Halliwell I, Wallace R, Chitiz L, Mulholland B, Karapanagiotidis T, Hardikar S, Strawson W, Turnbull A, Vanderwal T, Ho N, Wang H, Xu T, Milham M, Wang X, Zhang M, Gonzalez Alam T, Vos de Wael R, Bernhardt B, Margulies D, Wammes J, Jefferies E, Leech R, Smallwood J. Self-reports map the landscape of task states derived from brain imaging. Communications Psychology 2025, 3: 8. PMID: 39843761, PMCID: PMC11754446, DOI: 10.1038/s44271-025-00184-y.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingBrain activityFunctional magnetic resonance imaging studyBrain functionPsychological statePatterns of brain activitySelf-reportTask statesDescription of brain functionIndicator of cognitionSelf-reported descriptionsBrain systemsTask performanceObject representationsIntrospective descriptionsIntrospective reportsBrain imagingMagnetic resonance imagingBrainDescription of experimentsSelf-reports of experienceTaskResonance imagingCognitionLearningGenetic Etiology Link to Brain Function Underlying ADHD Symptoms and its Interaction with Sleep Disturbance: An ABCD Study
Feng A, Zhi D, Fu Z, Yu S, Luo N, Calhoun V, Sui J. Genetic Etiology Link to Brain Function Underlying ADHD Symptoms and its Interaction with Sleep Disturbance: An ABCD Study. Neuroscience Bulletin 2025, 1-13. PMID: 39827443, DOI: 10.1007/s12264-025-01349-9.Peer-Reviewed Original ResearchAttention deficit hyperactivity disorderPolygenic risk scoresSleep disturbanceAttention deficit hyperactivity disorder symptomsBrain functionAdolescent Brain Cognitive Development StudySevere attentional deficitsAssociated with polygenic risk scoresAttention deficit hyperactivity disorder casesCentral executive networkCognitive Development StudyDeficit hyperactivity disorderFunctional networksSensory-motor networkADHD symptomsExecutive networkAttention deficitMode networkHyperactivity disorderABCD studyBehavior problemsMaintaining sleepNeurodevelopmental disordersSensory-motorExperience sleep disturbances
2024
Gut-brain axis and neuroplasticity in health and disease: a systematic review
Di Napoli A, Pasquini L, Visconti E, Vaccaro M, Rossi-Espagnet M, Napolitano A. Gut-brain axis and neuroplasticity in health and disease: a systematic review. La Radiologia Medica 2024, 130: 327-358. PMID: 39718685, DOI: 10.1007/s11547-024-01938-0.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imaging studyDiffusion tensor imagingHealthy subjectsArterial spin labelingGut-brain axisBrain connectivityStructural magnetic resonance imagingMagnetic resonance imaging studiesInflammatory bowel syndromeAssociated with connectivityMagnetic resonance imagingGut microbiotaBowel syndromeImaging studiesTranscranial magnetic stimulationTemporal cortexNon-human subjectsResonance imagingCurrent evidenceStructural MRISomatosensory cortexPatientsPsychiatric diseasesBrain functionTensor imagingTranscranial optogenetic brain modulator for precise bimodal neuromodulation in multiple brain regions
Shin H, Nam M, Lee S, Yang S, Yang E, Jung J, Kim H, Woo J, Cho Y, Yoon Y, Cho I. Transcranial optogenetic brain modulator for precise bimodal neuromodulation in multiple brain regions. Nature Communications 2024, 15: 10423. PMID: 39613730, PMCID: PMC11607408, DOI: 10.1038/s41467-024-54759-0.Peer-Reviewed Original ResearchConceptsBrain regionsBrain modulesModulation of brain functionTranscranial brain stimulationMultiple brain regionsUpconversion particlesSymptoms of Parkinson's diseaseOptical crosstalkStudy of neural circuitsFood competition testBrain dysfunctionExternal light sourceLight sourcesBrain functionStudy of complex behaviorsSpatial resolutionNeural circuitsBrain disordersDevelopment of treatmentsOptogenetic techniquesBrain stimulationNeural populationsBrainParkinson's diseaseNeuromodulationInter-Modality Source Coupling: A Fully-Automated Whole-Brain Data-Driven Structure-Function Fingerprint Shows Replicable Links to Reading in a Large-Scale (N8K) Analysis
Kotoski A, Liu J, Morris R, Calhoun V. Inter-Modality Source Coupling: A Fully-Automated Whole-Brain Data-Driven Structure-Function Fingerprint Shows Replicable Links to Reading in a Large-Scale (N8K) Analysis. IEEE Transactions On Biomedical Engineering 2024, 71: 3383-3389. PMID: 38968021, PMCID: PMC11700228, DOI: 10.1109/tbme.2024.3423703.Peer-Reviewed Original ResearchReading abilityBrain structuresSchool-aged childrenResting-stateStructural magnetic resonance imagingInferior frontal areasFunctional brain changesInferior parietal lobuleHigher reading abilityFunctional connectivity patternsLow reading abilityLingual gyrusNeural basisParietal lobuleReading developmentBrain changesCognitive processesReplication linksRs-fMRICortical regionsReading scoresBrain functionCognitive growthFrontal areasConnectivity patternsFunctional Connectivity Biomarkers in Schizophrenia
Howell A, Anticevic A. Functional Connectivity Biomarkers in Schizophrenia. Advances In Neurobiology 2024, 40: 237-283. PMID: 39562448, DOI: 10.1007/978-3-031-69491-2_10.Peer-Reviewed Original ResearchConceptsFunctional connectivityResponse to antipsychotic medicationDebilitating neuropsychiatric disorderAbnormal brain functionFood and Drug AdministrationFunctional connectivity biomarkersAntipsychotic medicationNeural alterationsNeural changesPsychiatric conditionsNeuropsychiatric disordersNeural mechanismsBrain regionsSchizophreniaFC biomarkersNational Institutes of HealthConnectivity biomarkersBrain functionMagnetic resonance imaging (MRI)-based studyUS Food and Drug AdministrationFC metricsTreatment responseFDA-approved biomarkersPublic health problemPatient subgroupsAstrocytic GLUT1 reduction paradoxically improves central and peripheral glucose homeostasis
Ardanaz C, de la Cruz A, Minhas P, Hernández-Martín N, Pozo M, Valdecantos M, Valverde Á, Villa-Valverde P, Elizalde-Horcada M, Puerta E, Ramírez M, Ortega J, Urbiola A, Ederra C, Ariz M, Ortiz-de-Solórzano C, Fernández-Irigoyen J, Santamaría E, Karsenty G, Brüning J, Solas M. Astrocytic GLUT1 reduction paradoxically improves central and peripheral glucose homeostasis. Science Advances 2024, 10: eadp1115. PMID: 39423276, PMCID: PMC11488540, DOI: 10.1126/sciadv.adp1115.Peer-Reviewed Original ResearchConceptsPeripheral glucose homeostasisBrain glucose metabolismGlucose metabolismAstrocytic glucose transporterGlucose homeostasisPeripheral glucose metabolismSystemic glucose metabolismATP releasePurinergic signalingBlood-borne glucoseBrain metabolismAstrocytesBrain energeticsInsulin signalingCognitive functionGlucose transportBrain functionMiceBrainGLUT1MetabolismHomeostasisObesityThe human claustrum tracks slow waves during sleep
Lamsam L, Gu B, Liang M, Sun G, Khan K, Sheth K, Hirsch L, Pittenger C, Kaye A, Krystal J, Damisah E. The human claustrum tracks slow waves during sleep. Nature Communications 2024, 15: 8964. PMID: 39419999, PMCID: PMC11487173, DOI: 10.1038/s41467-024-53477-x.Peer-Reviewed Original ResearchExploring Spatio-temporal Interpretable Dynamic Brain Function with Transformer for Brain Disorder Diagnosis
Li L, Zhang L, Cao P, Yang J, Wang F, Zaiane O. Exploring Spatio-temporal Interpretable Dynamic Brain Function with Transformer for Brain Disorder Diagnosis. Lecture Notes In Computer Science 2024, 15002: 195-205. DOI: 10.1007/978-3-031-72069-7_19.Peer-Reviewed Original ResearchBrain functional modulesState-of-the-art performanceMajor depressive disorderTransformer-based frameworkSelf-attention mechanismState-of-the-artEnd-to-endSpatio-temporal representationBrain disorder diagnosisBipolar disorderBrain disordersDiagnosis of major depressive disorderPatterns of brain activityClustering strategyDynamic brain functionAssociated with brain disordersDepressive disorderExperimental resultsDisorder diagnosisBrain activitySpatio-temporal characteristicsBrain functionFunctional modulesDisordersSpatio-temporal patternsCommon and unique brain aging patterns between females and males quantified by large‐scale deep learning
Du Y, Yuan Z, Sui J, Calhoun V. Common and unique brain aging patterns between females and males quantified by large‐scale deep learning. Human Brain Mapping 2024, 45: e70005. PMID: 39225381, PMCID: PMC11369911, DOI: 10.1002/hbm.70005.Peer-Reviewed Original ResearchConceptsBrain functional changesFunctional connectivityCognitive controlBrain agingBrain functionPatterns of brain agingResting-state brain functional connectivityBrain functional interactionsBrain functional connectivityHuman brain functionBrain aging patternsGender commonalitiesAge-related changesDeep learningHealthy participantsNormal agingNegative connectionFunctional changesBrainPositive connectionDeep learning modelsFunctional domainsAge effectsFunctional interactionsCross-validation schemeProbiotic Lactobacilli Ameliorate Antibiotic-Induced Cognitive and Behavioral Impairments in Mice
Yarullina D, Novoselova V, Alexandrova A, Arslanova A, Yakovleva O, Shaidullov I, Nikolaev Y, El-Registan G, Kudrin V, Sitdikova G. Probiotic Lactobacilli Ameliorate Antibiotic-Induced Cognitive and Behavioral Impairments in Mice. Microbiology Research 2024, 15: 1471-1485. DOI: 10.3390/microbiolres15030099.Peer-Reviewed Original ResearchObject recognition testOpen field testMetabolite 5-hydroxyindoleacetic acidNovel object recognition testAnxiety-related behaviorT-maze testGut microbiotaInfluence brain functionMicrobiota-gut-brain axisMicrobiota-gut-brainAntibiotic-inducedRegulating anxietyT-mazeRecognition testExploratory activityCognitive abilitiesBehavioral disordersBehavioral testsAntibiotic-treated miceFerrous oxidation-xylenol orange (FOX) assayBrain functionProbiotic lactobacilli strainsMRS brothLactobacilli strainsAdministration of probioticsInhibition of GSK3α,β rescues cognitive phenotypes in a preclinical mouse model of CTNNB1 syndrome
Alexander J, Vazquez-Ramirez L, Lin C, Antonoudiou P, Maguire J, Wagner F, Jacob M. Inhibition of GSK3α,β rescues cognitive phenotypes in a preclinical mouse model of CTNNB1 syndrome. EMBO Molecular Medicine 2024, 16: 2109-2131. PMID: 39103699, PMCID: PMC11393422, DOI: 10.1038/s44321-024-00110-5.Peer-Reviewed Original ResearchHeterozygous loss-of-function variantsLoss-of-function variantsWnt signal transductionWnt target gene expressionSynaptic adhesion complexesTarget gene expressionB-cateninCognitive phenotypesHeterozygous mouse linePreclinical mouse modelsWild-type littermatesBrain functionAdhesion complexesSignal transductionEfficacious treatmentNeuronal functional propertiesRegulation of changesGene expressionMotor deficitsHeterozygous miceN-cadherinNa/K-ATPaseBrainMotor disabilityMouse modelManifold learning uncovers nonlinear interactions between the adolescent brain and environment that predict emotional and behavioral problems
Busch E, Conley M, Baskin-Sommers A. Manifold learning uncovers nonlinear interactions between the adolescent brain and environment that predict emotional and behavioral problems. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2024 PMID: 39009136, PMCID: PMC11729530, DOI: 10.1016/j.bpsc.2024.07.001.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingParticipants' brain activityBehavior problemsAdolescent brainBrain activityModerate-to-large associationsLarge-scale cortical networksCognitive Development StudyMental health researchBrain-environment interactionsCognitive processesLongitudinal predictionSubcortical regionsAdolescent mental health researchInternalizing problemsDevelopmental theoryBrain functionCortical networksEnvironmental experiencesLatent structureAttention networkEnvironmental risk factorsModerating effectBrainMagnetic resonance imagingScepter: Weakly Supervised Framework for Spatiotemporal Dense Prediction of 4D Dynamic Brain Networks
Kazemivash B, Suresh P, Liu J, Ye D, Calhoun V. Scepter: Weakly Supervised Framework for Spatiotemporal Dense Prediction of 4D Dynamic Brain Networks. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2024, 00: 1-4. PMID: 40039527, DOI: 10.1109/embc53108.2024.10781876.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingDynamic brain networksDense predictionBrain networksDynamic patterns of neural activityPatterns of neural activityBrain dynamicsSpatiotemporal brain dynamicsConsistent with previous findingsWeakly supervised frameworkComputer visionWeak supervisionModel architectureNetwork issuesSupervised frameworkFMRI dataBrain parcellation methodBrain functionNeural activityNeuroscience researchComplexity of brain functionNeural interactionsDeep-stackingExperimental resultsNetwork
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