2025
Plain language summary of publication to understand the ROSALIA study: a new biosimilar denosumab for bone health
Eastell R, Jeka S, Lustberg M, Edgerton C, Żuchowski P, Vogg B. Plain language summary of publication to understand the ROSALIA study: a new biosimilar denosumab for bone health. Therapeutic Advances In Musculoskeletal Disease 2025, 17: 1759720x251335147. PMID: 40322084, PMCID: PMC12046156, DOI: 10.1177/1759720x251335147.Peer-Reviewed Original ResearchPostmenopausal osteoporosisBone densityAnti-drug antibodiesRisk of fractureIncreased bone densityNon-clinical studiesResults of switchingDenosumabAdverse eventsBone healthClinical studiesImmune systemMineral ResearchOsteoporosisTreatment groupsJournal of BoneChange treatmentPatient advocacy groupsBoneTreatmentPatientsAntibodiesWomenPersonalizing core decompression grafting technique for osteonecrosis of the femoral head: calculating the volume of bone resected and adjunct volume required to fill the defect
Bergemann R, Massey A, Tommasini S, Wiznia D. Personalizing core decompression grafting technique for osteonecrosis of the femoral head: calculating the volume of bone resected and adjunct volume required to fill the defect. Journal Of Orthopaedic Surgery And Research 2025, 20: 229. PMID: 40033401, PMCID: PMC11874654, DOI: 10.1186/s13018-025-05606-5.Peer-Reviewed Original ResearchConceptsAdjunctive therapyVolume of boneCore decompressionBone marrow aspirate concentrateRisk of complicationsFemoral headSynthetic bone substituteAmount of boneBone substituteAspirate concentrateExpandable reamerBone regenerationBone graftPrevent collapseDebilitating diseaseReamer systemBoneAdjunctGrafting techniqueDecompression
2024
Both enantiomers of β-aminoisobutyric acid BAIBA regulate Fgf23 via MRGPRD receptor by activating distinct signaling pathways in osteocytes
Sakamoto E, Kitase Y, Fitt A, Zhu Z, Awad K, Brotto M, White K, Welc S, Bergwitz C, Bonewald L. Both enantiomers of β-aminoisobutyric acid BAIBA regulate Fgf23 via MRGPRD receptor by activating distinct signaling pathways in osteocytes. Cell Reports 2024, 43: 114397. PMID: 38935499, PMCID: PMC11350516, DOI: 10.1016/j.celrep.2024.114397.Peer-Reviewed Original ResearchActivate distinct signaling pathwaysSignaling pathwayFibroblast growth factor 23Urinary phosphate excretionReceptor type DInduce FGF23Urine phosphateElevated FGF23Phosphate excretionFGF23L-BAIBAExercise-induced increasePhosphate homeostasisSclerostinPhosphate metabolismReceptorsD-enantiomerBonePathwayIntermittent Methionine Restriction Reduces Marrow Fat Accumulation and Preserves More Bone Mass than Continuous Methionine Restriction
Plummer J, Horowitz M, Johnson J. Intermittent Methionine Restriction Reduces Marrow Fat Accumulation and Preserves More Bone Mass than Continuous Methionine Restriction. Aging Biology 2024, 2: 20230019. PMID: 38550776, PMCID: PMC10977905, DOI: 10.59368/agingbio.20230019.Peer-Reviewed Original ResearchMetabolic health benefitsBone massMethionine restrictionContinuous MRStatic histomorphometric analysisAccumulation of marrow fatMarrow fat accumulationLean body massMethionine-restricted dietLong-term adherenceCortical boneFemale miceMale miceDietary interventionHistomorphometric analysisDeleterious effectsContinuous interventionMarrow fatMiceAge-related pathologiesIntermittent formMammalian healthspanBoneConsistent with such findingsStrength of bone
2023
Case Study #8: Alpha-Therapy with Radium-223 Dichloride for Metastatic Castration-Resistant Prostate Cancer
Pasquini L, Morris M. Case Study #8: Alpha-Therapy with Radium-223 Dichloride for Metastatic Castration-Resistant Prostate Cancer. 2023, 387-405. DOI: 10.1007/978-3-031-39005-0_19.Peer-Reviewed Original ResearchMetastatic castration-resistant prostate cancerCastration-resistant prostate cancerProstate cancerRadium-223Radiopharmaceutical therapyTreatment of metastatic castration-resistant prostate cancerMinimal bone marrow toxicityRadium-223 dichlorideVisceral metastatic diseaseBone marrow toxicityNearby cancer cellsBone painMarrow toxicityMetastatic diseaseOverall survivalCombination therapyMetastatic spreadBone involvementAlpha therapyClinical developmentTreatment strategiesPalliative effectCancer cellsCancerBoneUpdate of pediatric bone tumors—other mesenchymal tumors of bone, hematopoietic neoplasms of bone, and WHO classification of undifferentiated small round cell sarcomas of bone
Wang A, Maloney E, Al-Dasuqi K, Irshaid L, Ahmed A, Haims A, Porrino J. Update of pediatric bone tumors—other mesenchymal tumors of bone, hematopoietic neoplasms of bone, and WHO classification of undifferentiated small round cell sarcomas of bone. Skeletal Radiology 2023, 52: 1443-1463. PMID: 36656343, DOI: 10.1007/s00256-023-04286-8.Peer-Reviewed Original ResearchConceptsUndifferentiated small round cell sarcomaSmall round cell sarcomasBone tumorsRound cell sarcomasPediatric populationCell sarcomaMesenchymal tumorsHematopoietic neoplasmsWorld Health Organization classificationGiant cell-rich tumorsPediatric bone tumorsOsteogenic tumorsOrganization classificationVascular tumorsNotochordal tumorsTumorsGenetic sequencing techniquesChondrogenic tumorsCertain lesionsSoft tissueBoneSarcomaNeoplasmsSeparate manuscriptDetailed update
2022
Update of pediatric bone tumors—notochordal tumors, chondrogenic tumors, and vascular tumors of the bone
Lee H, Wang A, Cheng R, Moran J, Al-Dasuqi K, Irshaid L, Maloney E, Porrino J. Update of pediatric bone tumors—notochordal tumors, chondrogenic tumors, and vascular tumors of the bone. Skeletal Radiology 2022, 52: 1101-1117. PMID: 36369290, DOI: 10.1007/s00256-022-04235-x.Peer-Reviewed Original ResearchEffect of Posterior Osteophytes on Total Knee Arthroplasty Coronal Soft Tissue Balance: Do They Matter?
Gustke K, Cherian J, Simon P, Morrison T. Effect of Posterior Osteophytes on Total Knee Arthroplasty Coronal Soft Tissue Balance: Do They Matter? The Journal Of Arthroplasty 2022, 37: s226-s230. PMID: 35216852, DOI: 10.1016/j.arth.2022.01.034.Peer-Reviewed Original ResearchConceptsPosterior osteophytesTotal knee arthroplastyBone resectionRemoval of posterior osteophytesPreoperative computed tomography scansLateral osteophytesOsteophyte sizeComputed tomography scanOsteophyte removalCoronal balanceTomography scanResectionRobotic arm-assisted total knee arthroplastyOsteophytesKnee arthroplastySoft tissue balanceBoneGap balancingExtension balanceTissue balanceChapter 10 Hormonal regulation of calcium balance
Holt E, Lupsa B, Lee G, Bassyouni H, Peery H. Chapter 10 Hormonal regulation of calcium balance. 2022, 303-333. DOI: 10.1016/b978-0-12-815844-9.00010-5.Chapters
2020
Osteocyte RANKL is required for cortical bone loss with age and is induced by senescence
Kim HN, Xiong J, MacLeod RS, Iyer S, Fujiwara Y, Cawley KM, Han L, He Y, Thostenson JD, Ferreira E, Jilka RL, Zhou D, Almeida M, O'Brien CA. Osteocyte RANKL is required for cortical bone loss with age and is induced by senescence. JCI Insight 2020, 5: e138815. PMID: 32870816, PMCID: PMC7566701, DOI: 10.1172/jci.insight.138815.Peer-Reviewed Original ResearchConceptsCortical bone lossBone lossControl miceAged miceCortical boneAge-associated bone lossOsteoclastogenic cytokine RANKLOsteocyte-derived RANKLTrabecular boneMonths of ageSenescent cellsConditional knockout miceHuman cell culture modelsRANKL levelsCytokine RANKLRANKL productionKnockout miceTranscription factor GATA4Cell culture modelSenolytic compoundsRANKLMiceAgeBoneCellular senescenceIntracellular Staphylococcus aureus in bone and joint infections: A mechanism of disease recurrence, inflammation, and bone and cartilage destruction
Alder KD, Lee I, Munger AM, Kwon HK, Morris MT, Cahill SV, Back J, Yu KE, Lee FY. Intracellular Staphylococcus aureus in bone and joint infections: A mechanism of disease recurrence, inflammation, and bone and cartilage destruction. Bone 2020, 141: 115568. PMID: 32745687, DOI: 10.1016/j.bone.2020.115568.Peer-Reviewed Original ResearchConceptsArticular cartilage lossJoint infectionCartilage lossStaphylococcus aureusIntracellular Staphylococcus aureusPotential combination therapyFurther studiesPotential treatment solutionAntibiotic therapyDisease recurrenceProinflammatory stateCartilage destructionMorbidity rateCombination therapyDismal outcomeMassive boneConsequence of boneHigh mortalityMedical interventionsInfectionIntracellular infectionMusculoskeletal systemDevastating afflictionFundamental cellular componentsBone
2019
Melorheostosis
Fick CN, Fratzl-Zelman N, Roschger P, Klaushofer K, Jha S, Marini JC, Bhattacharyya T. Melorheostosis. The American Journal Of Surgical Pathology 2019, 43: 1554-1559. PMID: 31386640, PMCID: PMC7832124, DOI: 10.1097/pas.0000000000001310.Peer-Reviewed Original ResearchConceptsClinical presentationBone biopsyCortical bone depositionProminent cement linesPatient's clinical presentationCommon histologic findingsRadiologic patternsPathologic findingsRadiographic findingsHistologic patternHistologic findingsDifferential diagnosisBone diseaseDripping candle waxDense cortical boneMelorheostosisPatientsMultiple patientsClinical pathologistsBone depositionCortical boneBiopsyDiagnosisDistinct patternsBone
2018
Vibrational spectroscopic analysis of hydroxyapatite in HYP mice and individuals with X-linked hypophosphatemia
Amenta E, King HE, Petermann H, Uskoković V, Tommasini SM, Macica CM. Vibrational spectroscopic analysis of hydroxyapatite in HYP mice and individuals with X-linked hypophosphatemia. Therapeutic Advances In Chronic Disease 2018, 9: 268-281. PMID: 30719271, PMCID: PMC6348532, DOI: 10.1177/2040622318804753.Peer-Reviewed Original ResearchUnaffected controlsPhosphate-wasting disordersWild-type micePersistent osteomalaciaDegenerative arthritisPeriodontal diseasePrimary teethPermanent teethFemoral cortical boneAdult disordersNeutral endopeptidaseHyp miceBone remodelingBiochemical milieuXLHCommon formCortical boneUse of dentinHypophosphatemiaSignificant differencesTeethInactivating mutationBoneUnaffected individualsMiceRickets: The Skeletal Disorders of Impaired Calcium or Phosphate Availability
Imel E, Carpenter T. Rickets: The Skeletal Disorders of Impaired Calcium or Phosphate Availability. 2018, 497-524. DOI: 10.1007/978-3-319-73782-9_23.Peer-Reviewed Original Research
2017
Is It “Fractured” or “Broken”? A Patient Survey Study to Assess Injury Comprehension after Orthopedic Trauma
Ghorbanhoseini M, Riedel MD, Gonzalez T, Hafezi P, Kwon JY. Is It “Fractured” or “Broken”? A Patient Survey Study to Assess Injury Comprehension after Orthopedic Trauma. Archives Of Bone And Joint Surgery 2017, 5: 235-242. PMID: 28913381, PMCID: PMC5592365, DOI: 10.22038/abjs.2017.19541.1507.Peer-Reviewed Original ResearchPrevious fractureOrthopaedic traumaPatient quality measuresOrthopedic outpatient clinicPatient survey studyUnderstanding of terminologyAcademic teaching hospitalSevere characteristicsOutpatient clinicOptimal carePatient levelTeaching hospitalInclusion criteriaPatient understandingPatient injuryOrthopaedic surgeonsPatient comprehensionOrthopedic historyPatientsRespondersInjuryMajority of peopleBoneTraumaFamily membersAdipocyte Accumulation in the Bone Marrow during Obesity and Aging Impairs Stem Cell-Based Hematopoietic and Bone Regeneration
Ambrosi T, Scialdone A, Graja A, Gohlke S, Jank A, Bocian C, Woelk L, Fan H, Logan D, Schürmann A, Saraiva L, Schulz T. Adipocyte Accumulation in the Bone Marrow during Obesity and Aging Impairs Stem Cell-Based Hematopoietic and Bone Regeneration. Cell Stem Cell 2017, 20: 771-784.e6. PMID: 28330582, PMCID: PMC5459794, DOI: 10.1016/j.stem.2017.02.009.Peer-Reviewed Original ResearchConceptsStem cell-basedHematopoietic regenerationAdipocyte accumulationStem cell-like characteristicsCell-like characteristicsBone resident cellsDipeptidyl peptidase-4Bone marrow cavityCompetitive repopulationLethal irradiationHematopoietic nicheBone marrowCell-basedPeptidase-4Osteogenic lineageAged animalsBone healingDiabetes therapyAdipocyte lineageBoneMarrow cavityAge-dependentMolecular identityObesityAdipogenic lineages
2016
Fibula Osteocutaneous Flap for Mandibular Reconstruction
Ariyan S. Fibula Osteocutaneous Flap for Mandibular Reconstruction. 2016, 369-372. DOI: 10.1007/978-3-319-40631-2_88.Peer-Reviewed Original ResearchPrevious radiation therapyHead neck cancerMicrovascular free flapsFibula osteocutaneous flapHead-neck areaSurgical treatmentBilateral resectionNeck cancerIntraoral bacteriaRadiation therapyOsteocutaneous flapFree flapNeck areaResectionIntraoral reconstructionDurable techniquePoor hygieneMandibular reconstructionSoft tissueMandibleTissue/Contralateral angleFlapBoneTherapyCase of a Missed Giant Cell Tumor of Bone: An Opportunity to Observe its Natural History Disease.
Russo GS, Rubio DR, Yacob A, Lindskog DM, Alomari AK, Friedlaender GE. Case of a Missed Giant Cell Tumor of Bone: An Opportunity to Observe its Natural History Disease. Connecticut Medicine 2016, 80: 399-403. PMID: 29782126.Peer-Reviewed Case Reports and Technical NotesConceptsGiant cell tumorAnterior cruciate ligamentCell tumorsIncidental findingRoutine preoperative imagingPre-operative MRIInitial MRIPreoperative imagingSecond MRIMetaphyseal lesionsCruciate ligamentEnlarged massBenign neoplasmsRetrospective evaluationNatural historyTumorsYoung womenHistory diseaseMRIBoneLesionsPainPatientsNeoplasmsHistologyAnabolic actions of Notch on mature bone
Liu P, Ping Y, Ma M, Zhang D, Liu C, Zaidi S, Gao S, Ji Y, Lou F, Yu F, Lu P, Stachnik A, Bai M, Wei C, Zhang L, Wang K, Chen R, New M, Rowe D, Yuen T, Sun L, Zaidi M. Anabolic actions of Notch on mature bone. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: e2152-e2161. PMID: 27036007, PMCID: PMC4839423, DOI: 10.1073/pnas.1603399113.Peer-Reviewed Original ResearchConceptsOvariectomy-induced bone lossEGFP reporter miceStimulation of NotchBone lossAnabolic actionAnabolic responseReporter miceMature micePresenilin 1Bone healingLigand Jagged1Bone formationTime pointsMiceAdult boneGenetic disruptionMature boneBone matrixConditional activationNotch expressionTerminal osteoblast differentiationNotch activationOsteoblast differentiationBoneOsteocytes
2015
Fetal liver hematopoietic stem cell niches associate with portal vessels
Khan J, Mendelson A, Kunisaki Y, Birbrair A, Kou Y, Arnal-Estapé A, Pinho S, Ciero P, Nakahara F, Ma'ayan A, Bergman A, Merad M, Frenette P. Fetal liver hematopoietic stem cell niches associate with portal vessels. Science 2015, 351: 176-180. PMID: 26634440, PMCID: PMC4706788, DOI: 10.1126/science.aad0084.Peer-Reviewed Original Research
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