2025
Benzene exposure and risk of colorectal cancer by anatomical subsite in the Norwegian offshore petroleum workers cohort
Babigumira R, Veierød M, Larsen I, Berge L, Shala N, Marjerrison N, Samuelsen S, Bråtveit M, Kirkeleit J, Nordby K, Hosgood H, Demers P, Vermeulen R, Kromhout H, Engel L, Nilsen T, Silverman D, Friesen M, Rothman N, Lan Q, Grimsrud T, Stenehjem J. Benzene exposure and risk of colorectal cancer by anatomical subsite in the Norwegian offshore petroleum workers cohort. Environmental Research 2025, 276: 121407. PMID: 40118315, DOI: 10.1016/j.envres.2025.121407.Peer-Reviewed Original ResearchRisk of colorectal cancerOffshore petroleum workersJob-exposure matrixHazard ratioColorectal cancerAnatomic subsiteColorectal cancer riskConfidence intervalsColorectal cancer casesEstimate hazard ratiosCase-cohort analysisPetroleum workersWork historyExposure-response associationsPositive exposure-response associationsBody mass indexRight-sided colon cancerPublic health implicationsPhysical activityBenzene exposureMeat intakeAlcohol intakeQuartile 4Mass indexCase cohortSerum anti-mullerian hormone levels and age among Samoan women
O’Brien G, Lambert-Messerlian G, Hawley N, Fidow U, Naseri T, Reupena M, Kershaw E, Azar M, Pangburn M, McGarvey S. Serum anti-mullerian hormone levels and age among Samoan women. Reproductive Biology And Endocrinology 2025, 23: 45. PMID: 40108611, PMCID: PMC11921511, DOI: 10.1186/s12958-025-01379-y.Peer-Reviewed Original ResearchConceptsPCOS prevalencePolycystic ovary syndromeSerum anti-Mullerian hormoneAnti-Mullerian hormoneAnti-Mullerian hormone levelsSamoan womenAssociation of anti-Mullerian hormoneContraceptive useBody mass indexSerum anti-mullerian hormone levelsEthnic minority populationsHormonal contraceptive useAMH levelsAssociated with ageFree androgen indexMinority populationsSex hormone binding globulinReproductive healthAssociated with body mass indexSerum total testosteroneAndrogen indexPrevalence of obesityRelated declineTobacco useAdult womenHigh Risk of Persistence and Risk of Dysplasia after Ultrashort Barrett's Diagnosis.
Skef W, Haydel J, Rao A, Allencherril R, George R, Ketwaroo G, Thrift A, El-Serag H, Wenker T. High Risk of Persistence and Risk of Dysplasia after Ultrashort Barrett's Diagnosis. The American Journal Of Gastroenterology 2025 PMID: 40052679, DOI: 10.14309/ajg.0000000000003383.Peer-Reviewed Original ResearchFollow-up EGDRisk of dysplasiaBody mass indexBarrett's esophagusPersistent BEFollow-upCohort of United States veteransWhite raceLong segment BEUnited States veteransHispanic ethnicityPredictor of dysplasiaFollow-up endoscopyClinical risk factorsRetrospective cohort studyNon-Hispanic Black patientsNon-HispanicRisk of persistenceProportion of non-HispanicChi-square testConsecutive patientsStates veteransPathology databaseHighest risk of persistenceBE diagnosisA Randomized Phase 3 Study Evaluating the Efficacy and Safety of Alogliptin in Pediatric Participants with Type 2 Diabetes Mellitus
Peng X, Klingensmith G, Hsia D, Xie Y, Czerniak R, Tamborlane W, Shah A. A Randomized Phase 3 Study Evaluating the Efficacy and Safety of Alogliptin in Pediatric Participants with Type 2 Diabetes Mellitus. Diabetes Therapy 2025, 1-19. PMID: 40032809, DOI: 10.1007/s13300-025-01700-3.Peer-Reviewed Original ResearchType 2 diabetes mellitusAlogliptin treatmentEfficacy endpointPediatric patientsAntihyperglycemic therapyOral dipeptidyl peptidase-4 inhibitorHbA1c levelsRandomized phase 3 studyDipeptidyl peptidase-4 inhibitorsSafety of alogliptinPlacebo-controlled trialPhase 3 studyBaseline to weekPeptidase-4 inhibitorsBody mass indexImprove glycemic controlDouble-blindPlacebo groupSecondary endpointsBackground metforminSchedule APharmacological therapyMass indexGlycosylated hemoglobinInsulin therapyPharmacogenomics of the Etonogestrel Contraceptive Implant
Lazorwitz A, Aquilante C, Shortt J, Gignoux C, Teal S, Sheeder J. Pharmacogenomics of the Etonogestrel Contraceptive Implant. O&G Open 2025, 2: e066. DOI: 10.1097/og9.0000000000000066.Peer-Reviewed Original ResearchGenome-wide complex trait analysisComplex trait analysisSerum etonogestrel concentrationsBody mass indexGenetic lociEtonogestrel concentrationsDuration of implant useGenetic variantsTrait analysisGenome-wide significanceRare genetic variantsTOPMed imputation serverImplant usersExtraction of DNAImplant useImputation ServerMedian body mass indexPharmacogenomic variantsSteroid hormone metabolismContraceptive implant usersEtonogestrel contraceptive implantEtonogestrel implant usersAssociation analysisAllele frequenciesGenotyping resultsAssociation between induction start time and labor duration in nulliparous women undergoing elective induction of labor
Facco F, MacPherson C, Reddy U, Tita A, Silver R, El-Sayed Y, Wapner R, Rouse D, Saade G, Thorp J, Chauhan S, Costantine M, Chien E, Heyborne K, Srinivas S, Swamy G, Grobman W. Association between induction start time and labor duration in nulliparous women undergoing elective induction of labor. American Journal Of Perinatology 2025 PMID: 40015324, DOI: 10.1055/a-2547-4196.Peer-Reviewed Original ResearchInduction of laborCesarean delivery rateLabor durationShorter labor durationElective inductionBishop scoreNulliparous womenLow-risk nulliparous womenElective induction of laborModified Bishop scoreMean labour durationMulti-center randomized controlled trialDelivery rateBaseline maternal characteristicsBody mass indexFrequency of deliveryARRIVE trialInsurance statusCervical statusMaternal characteristicsSecondary analysisRupture of membranesSpontaneous laborWeeks 0 daysWomen MethodsThe Impact of Body Mass Index on Breast Reduction Outcomes: A Multi-Institutional Data Analysis of 45,000 Cases over 15 Years
Knoedler S, Matar D, Kosyk M, Perozzo F, Sofo G, Manente M, Vafa A, Boroumand S, Alfertshofer M, Orgill D, Kim B, Panayi A. The Impact of Body Mass Index on Breast Reduction Outcomes: A Multi-Institutional Data Analysis of 45,000 Cases over 15 Years. Aesthetic Plastic Surgery 2025, 1-15. PMID: 40000470, DOI: 10.1007/s00266-025-04743-w.Peer-Reviewed Original ResearchBody mass indexNational Surgical Quality Improvement ProgramAmerican College of SurgeonsSurgical complicationsMedical complicationsBreast reductionHealthy weightObese IMass indexImpact of body mass indexBody mass index subgroupsLevel of Evidence IIIThis journalSurgical Quality Improvement ProgramElevated body mass indexMultivariate logistic regression analysisCases of surgical complicationsEvidence-Based Medicine ratingsHealthy BMI rangeBreast reduction surgeryHigher BMI classesMulti-institutional databaseEvidence IIIThis journalFemale adult patientsLevel of evidenceQuality Improvement ProgramAntibiotics and Surgically Treated Acute Appendicitis, When, Where, and Why?
Hendrix A, Kammien A, Maung A, Battacharya B, Davis K, Schuster K. Antibiotics and Surgically Treated Acute Appendicitis, When, Where, and Why? Surgical Infections 2025 PMID: 39973176, DOI: 10.1089/sur.2024.264.Peer-Reviewed Original ResearchSurgical site infectionOrgan-space surgical site infectionBody mass indexElixhauser Comorbidity IndexEmergency appendectomyAcute appendicitisBi-variable logistic regression modelPredictive of surgical site infectionClean-contaminated abdominal surgeryIntra-abdominal infectious processIncidence of surgical site infectionOccurrence of surgical site infectionBroad-spectrum antibiotic treatmentOrgan-space infectionsPre-operative antibioticsHour of incisionBroad-spectrum antibioticsPredictive of infectionAdministration timePerforated appendicitisEmergency surgerySite infectionAbdominal surgerySurgical approachAntibiotic treatmentCorrecting for bias due to mismeasured exposure in mediation analysis with a survival outcome
Cheng C, Spiegelman D, Li F. Correcting for bias due to mismeasured exposure in mediation analysis with a survival outcome. Journal Of The Royal Statistical Society Series C (Applied Statistics) 2025, qlaf010. DOI: 10.1093/jrsssc/qlaf010.Peer-Reviewed Original ResearchExposure-mediator interactionProtective effect of physical activityHealth Professionals Follow-up StudyEffects of physical activityReduced body mass indexExposure measurement errorRisk of cardiovascular diseaseBody mass indexPhysical activityMismeasured exposureMass indexRare outcomesFollow-up studyCardiovascular diseaseMediation analysisCox regressionOutcomesBias formulaSurvival outcomesHealthGlycoproteoforms of Osteoarthritis-associated Lubricin in Plasma and Synovial Fluid
Afshari A, Chang V, Thomsson K, Höglund J, Browne E, Karadzhov G, Mahoney K, Lucas T, Rangel-Angarita V, Ryberg H, Gidwani K, Pettersson K, Rolfson O, Björkman L, Eisler T, Schmidt T, Jay G, Malaker S, Karlsson N. Glycoproteoforms of Osteoarthritis-associated Lubricin in Plasma and Synovial Fluid. Molecular & Cellular Proteomics 2025, 24: 100923. PMID: 39922311, PMCID: PMC11925169, DOI: 10.1016/j.mcpro.2025.100923.Peer-Reviewed Original ResearchA comprehensive spatio-cellular map of the human hypothalamus
Tadross J, Steuernagel L, Dowsett G, Kentistou K, Lundh S, Porniece M, Klemm P, Rainbow K, Hvid H, Kania K, Polex-Wolf J, Knudsen L, Pyke C, Perry J, Lam B, Brüning J, Yeo G. A comprehensive spatio-cellular map of the human hypothalamus. Nature 2025, 639: 708-716. PMID: 39910307, PMCID: PMC11922758, DOI: 10.1038/s41586-024-08504-8.Peer-Reviewed Original ResearchConceptsGenome-wide association study genesRare deleterious variantsHypothalamic cell typesCell typesSingle-nucleus sequencingBody mass indexTranscription mapDeleterious variantsNeuronal cell typesG protein-coupled receptorsStudy genesBiological functions1Spatial transcriptomicsTranscriptomic identityCellular componentsExpression levelsPro-opiomelanocortin neuronsHuman hypothalamusAssociated with body mass indexPopulation levelMetabolic disordersHypothalamic cellsExpressionNeuronal clustersTranscriptomeAssessing the Relationship Between Mandibular Contouring and Iatrogenic Jowling in Facial Feminization Surgery
Flores-Pérez P, Rancu A, Allam O, Vassallo M, Shen Y, Kauke-Navarro M, Parikh N, Alperovich M. Assessing the Relationship Between Mandibular Contouring and Iatrogenic Jowling in Facial Feminization Surgery. Journal Of Craniofacial Surgery 2025, 36: 761-763. PMID: 39899802, DOI: 10.1097/scs.0000000000011132.Peer-Reviewed Original ResearchPatient risk factorsFacial feminization surgeryRisk factorsFeminization surgeryPostoperative computed tomography imagesOptimal surgical strategySoft tissue outcomesSoft tissue changesFacial feminization proceduresBody mass indexPostoperative patient imagesChin volumeMandibular contourPostoperative photographsSurgical strategyMass indexBony measurementsSkeletal changesSurgeryTissue changesFeminization proceduresTomography imagesPatientsPatient imagesTissue outcomeRisk factors affecting polygenic score performance across diverse cohorts
Hui D, Dudek S, Kiryluk K, Walunas T, Kullo I, Wei W, Tiwari H, Peterson J, Chung W, Davis B, Khan A, Kottyan L, Limdi N, Feng Q, Puckelwartz M, Weng C, Smith J, Karlson E, Center R, BioBank P, Jarvik G, Ritchie M. Risk factors affecting polygenic score performance across diverse cohorts. ELife 2025, 12: rp88149. PMID: 39851248, PMCID: PMC11771958, DOI: 10.7554/elife.88149.Peer-Reviewed Original ResearchConceptsBody mass indexPolygenic scoresAssociated with body mass indexPolygenic score performancePhysical activityStandard deviation changeAlcohol consumptionMass indexDiverse cohortInteraction effectsRisk factorsBlood lipidsDeviation changeQuintileScore performanceCohortCovariatesBinary covariateAncestryModel R<sup>2</sup>Continuous covariatesDifferencesRisk factors affecting polygenic score performance across diverse cohorts
Hui D, Dudek S, Kiryluk K, Walunas T, Kullo I, Wei W, Tiwari H, Peterson J, Chung W, Davis B, Khan A, Kottyan L, Limdi N, Feng Q, Puckelwartz M, Weng C, Smith J, Karlson E, Jarvik G, Ritchie M. Risk factors affecting polygenic score performance across diverse cohorts. ELife 2025, 12 DOI: 10.7554/elife.88149.3.Peer-Reviewed Original ResearchBody mass indexPolygenic scoresAssociated with body mass indexPolygenic score performancePhysical activityStandard deviation changeBMI effectsBMI individualsAlcohol consumptionDiverse cohortMass indexInteraction effectsRisk factorsBlood lipidsDeviation changeQuintileScore performanceCohortCovariatesBinary covariateAncestryContinuous covariatesModel R 2DifferencesScoresQuantitative valve motion assessment in adolescents using point-of-care ultrasound: short communication
Riera A, Chen L, Wright D, Leviter J. Quantitative valve motion assessment in adolescents using point-of-care ultrasound: short communication. The Ultrasound Journal 2025, 17: 11. PMID: 39847270, PMCID: PMC11757829, DOI: 10.1186/s13089-025-00402-y.Peer-Reviewed Original ResearchTricuspid annular plane systolic excursionE-point septal separationPoint-of-care ultrasoundAnnular plane systolic excursionRight ventricular systolic functionPediatric emergency departmentAbnormal vital signsCross-sectional studyVentricular systolic functionBody mass indexUnpaired t-testM-mode measurementsEmergency departmentSystolic excursionAnthropometric dataSystolic functionCardiopulmonary complaintsNo significant correlationMass indexPsychiatric illnessMental statusPearson correlationExclusion criteriaSeptal separationMotion assessmentCorrelates of Impaired Sleep Duration Among Adults With Trauma Alone and With Posttraumatic Stress Disorder
Havlik J, Rhee T, Rosenheck R. Correlates of Impaired Sleep Duration Among Adults With Trauma Alone and With Posttraumatic Stress Disorder. Psychological Trauma Theory Research Practice And Policy 2025 PMID: 39836166, DOI: 10.1037/tra0001846.Peer-Reviewed Original ResearchImpaired sleep durationStress disorderSleep durationEffect sizePosttraumatic stress disorderClinically meaningful effect sizesNational Epidemiologic SurveyMeaningful effect sizesPsychiatric multimorbidityPTSDTrauma/PTSDImprove treatment outcomesMedical comorbiditySleep disturbanceImpaired sleepBehavioral variablesTreatment outcomesAllostatic loadNationally representative sampleAdjusted multivariable regressionEpidemiological surveyDisordersBody mass indexRepresentative sampleSleepSkeletal muscle adiposity, coronary microvascular dysfunction, and adverse cardiovascular outcomes
do A H Souza A, Troschel A, Marquardt J, Hadžić I, Foldyna B, Moura F, Hainer J, Divakaran S, Blankstein R, Dorbala S, Di Carli M, Aerts H, Lu M, Fintelmann F, Taqueti V. Skeletal muscle adiposity, coronary microvascular dysfunction, and adverse cardiovascular outcomes. European Heart Journal 2025, 46: 1112-1123. PMID: 39827905, DOI: 10.1093/eurheartj/ehae827.Peer-Reviewed Original ResearchCoronary microvascular dysfunctionBody mass indexCoronary flow reserveIntermuscular adipose tissueSubcutaneous adipose tissueHeart failureFat infiltrationMarker of coronary microvascular dysfunctionPreserved left ventricular ejection fractionCardiovascular outcomesAssociated with coronary microvascular dysfunctionHigher IMATIncreased IMATPresence of coronary microvascular dysfunctionSkeletal muscleFlow reserveIncreased risk of MACEMyocardial infarctionStress positron emission tomographyAssociated with increased MACERisk of heart failureLow coronary flow reserveThoracic vertebra levelVentricular ejection fractionIntermuscular adipose tissue areaUtilization of Low‐Dose Phentermine for Weight Loss Prior to Metabolic and Bariatric Surgery: A Prospective, Randomized, and Placebo‐Controlled Trial
Garcia L, Rivas H, Morton J. Utilization of Low‐Dose Phentermine for Weight Loss Prior to Metabolic and Bariatric Surgery: A Prospective, Randomized, and Placebo‐Controlled Trial. Obesity Science & Practice 2025, 11: e70043. PMID: 39830713, PMCID: PMC11739713, DOI: 10.1002/osp4.70043.Peer-Reviewed Original ResearchBody mass indexPreoperative weight lossLow-dose formulationsPlacebo groupWeight lossBariatric surgeryLaparoscopic Roux-en-Y gastric bypassPercentage total weight lossRoux-en-Y gastric bypassPlacebo-controlled trialPreoperative medication useTreatment groupsPost-operative complicationsFollow-up visitImprove weight lossMultivariate regression analysisAverage weight lossSleeve gastrectomyGastric bypassMass indexBariatric patientsTotal weight lossPhenterminePatientsOR timeEffect of glucagon-like peptide-1 receptor agonists on vascular risk factors among adults with type 2 diabetes and established atherosclerotic cardiovascular disease
King A, Tan X, Dhopeshwarkar N, Bohn R, Dea K, Leonard C, de Havenon A. Effect of glucagon-like peptide-1 receptor agonists on vascular risk factors among adults with type 2 diabetes and established atherosclerotic cardiovascular disease. American Journal Of Preventive Cardiology 2025, 21: 100922. PMID: 39896054, PMCID: PMC11786665, DOI: 10.1016/j.ajpc.2024.100922.Peer-Reviewed Original ResearchVascular risk factorsGLP-1 RAsRisk factorsType 2 diabetesAtherosclerotic cardiovascular diseaseUS electronic health records databaseElectronic health record databaseOW GLP-1 RAsRisk factor valuesHealth record databaseCardiovascular diseaseReal-world practiceBody mass indexOnce-weeklyEffects of glucagon-like peptide-1 receptor agonistsGlucagon-like peptide-1 receptor agonistsGLP-1Systolic blood pressureLow-density lipoprotein cholesterolPeptide-1 receptor agonistsEffects of once-weeklyMass indexRecord databaseSignificant mean reductionAssociated with significant reductionsAcid sphingomyelinase deficiency and Gaucher disease: Underdiagnosed and often treatable causes of hepatomegaly, splenomegaly, and low HDL cholesterol in lean individuals
Mistry P, Cassiman D, Jones S, Lachmann R, Lukina E, Prada C, Wasserstein M, Thurberg B, Foster M, Patel R, Underhill L, Peterschmitt M. Acid sphingomyelinase deficiency and Gaucher disease: Underdiagnosed and often treatable causes of hepatomegaly, splenomegaly, and low HDL cholesterol in lean individuals. Hepatology Communications 2025, 9: e0621. PMID: 39774103, PMCID: PMC11717527, DOI: 10.1097/hc9.0000000000000621.Peer-Reviewed Original ResearchConceptsGaucher disease type 1Acid sphingomyelinase deficiencyHDL cholesterolSphingomyelinase deficiencyDifferential diagnosis of patientsBiomarkers of disease activityLipoprotein phenotypeLower body mass indexMean HDL cholesterolLow HDL cholesterolLiver function testsDiagnosis of patientsBody mass indexModerate hepatosplenomegalySpleen volumeLipid abnormalitiesLow HDLDiagnostic delayIrreversible complicationsLiver volumeLyso-sphingomyelinMultisystemic manifestationsDisease activityLDL cholesterolDifferential diagnosis
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