2025
Significance of birth in the maintenance of quiescent neural stem cells
Kawase K, Nakamura Y, Wolbeck L, Takemura S, Zaitsu K, Ando T, Jinnou H, Sawada M, Nakajima C, Rydbirk R, Gokenya S, Ito A, Fujiyama H, Saito A, Iguchi A, Kratimenos P, Ishibashi N, Gallo V, Iwata O, Saitoh S, Khodosevich K, Sawamoto K. Significance of birth in the maintenance of quiescent neural stem cells. Science Advances 2025, 11: eadn6377. PMID: 39841848, PMCID: PMC11753423, DOI: 10.1126/sciadv.adn6377.Peer-Reviewed Original ResearchConceptsNeural stem cellsQuiescent neural stem cellsStem cellsRadial gliaNeural stem cell poolAcquisition of quiescenceEmbryonic neural stem cellsPreterm birthPostnatal neural stem cellsCellular processesPostnatal neurogenesisGlutamine metabolismPostnatal brainLong-term maintenanceDevelopmental processesBirthNeurogenesisPretermCells
2024
Labor and delivery unit practices and racial and ethnic disparities in severe maternal and neonatal morbidity among nulliparous individuals with low-risk pregnancies
Leonard S, Xu X, Davies-Balch S, Main E, Bateman B, Rehkopf D, Lee H, Illuzzi J, Igbinosa I, Iwekaogwu I, Lyell D. Labor and delivery unit practices and racial and ethnic disparities in severe maternal and neonatal morbidity among nulliparous individuals with low-risk pregnancies. American Journal Of Epidemiology 2024, kwae459. PMID: 39691947, DOI: 10.1093/aje/kwae459.Peer-Reviewed Original ResearchLow-risk pregnanciesEthnic disparitiesUnit practicesAI/AN individualsNulliparous individualsNeonatal morbidityDisparity measuresAlaska NativesDelivery unitLatino individualsSevere neonatal morbidityWhite individualsLatent class analysisG-estimationSurvey responsesDisparitiesHospitalClass analysisMorbidityDeliveryIndividualsPracticeBirthPregnancyAI/ANBiodistribution of Polymeric Nanoparticles following in utero Delivery to a Nonhuman Primate
Eaton D, Lynn A, Surprenant J, Deschenes E, Guerra M, Rivero R, Yung N, O'Connor M, Glazer P, Bahtiyar M, Saltzman W, Stitelman D. Biodistribution of Polymeric Nanoparticles following in utero Delivery to a Nonhuman Primate. Biomedicine Hub 2024, 10: 543138. PMID: 39845408, PMCID: PMC11753793, DOI: 10.1159/000543138.Peer-Reviewed Original ResearchMonogenic diseasesNon-human primatesBiodistribution of polymeric nanoparticlesPreclinical mouse modelsStem cell populationFetal liverFetal malesSystemic deliveryFetal bonesAccumulation of NPIn-uteroMid-gestationNP accumulationBiodistribution studiesPolymeric NPsTherapeutic accessCell populationsMaternal tissuesZone of proliferationPolymeric nanoparticlesDiseaseBirthMiceDeliveryBiodistributionContinuous Glucose Monitoring among Infants Born Very Preterm: Evidence for Accuracy in Neonatal Intensive Care
Bonet J, Guiducci S, Res G, Brigadoi S, Sen S, Montaldo P, Priante E, Santoro N, Trevisanuto D, Baraldi E, Dalla Man C, Galderisi A. Continuous Glucose Monitoring among Infants Born Very Preterm: Evidence for Accuracy in Neonatal Intensive Care. The Journal Of Pediatrics 2024, 278: 114416. PMID: 39579867, DOI: 10.1016/j.jpeds.2024.114416.Peer-Reviewed Original ResearchBlood glucoseContinuous glucose monitoringSensor glucoseNeonatal intensive care unitInfants born pretermWeeks of gestationNeonatal intensive careIntensive care unitVery pretermGlucose monitoringCare unitIntensive carePoint-of-care blood glucoseInfantsPretermNeonatesPaired measurementsCGM accuracyHoursBirthweightGestationGlucoseBirthWeeksCT for Congenital Heart Disease
Fuss C. CT for Congenital Heart Disease. 2024, 277-293. DOI: 10.1007/978-981-97-6919-3_21.Peer-Reviewed Original ResearchCongenital heart diseaseHeart diseaseEvaluation of congenital heart diseaseManagement of congenital heart diseaseContrast doseAffected patientsBirth defectsStages of repairRadiation exposureAltered physiologySmall organ sizeCT roleDiseaseVariable stagesCongenitallyPatientsCTDoseSpatial image resolutionComplexity of defectsBirthTemporal complexity of the BOLD-signal in preterm versus term infants
Mella A, Vanderwal T, Miller S, Weber A. Temporal complexity of the BOLD-signal in preterm versus term infants. Cerebral Cortex 2024, 34: bhae426. PMID: 39582376, PMCID: PMC11586500, DOI: 10.1093/cercor/bhae426.Peer-Reviewed Original ResearchConceptsBirth ageWeeks gestational agePreterm brainGestational ageTerm infantsPreterm birthPretermCerebral developmentTerm equivalentNeonatesBOLD signalBirthScan ageInfantsAgeMixed effects modelsLinear mixed effects modelsEstimation of myelinResting state networksBrainHuman Connectome ProjectEffects modelDiffusion weighted imaging dataHIV, inflammation, and initiation of methamphetamine use in sexual and gender minorities assigned male at birth
Carrico A, Ryan D, Berona J, Dominguez B, Schrock J, McDade T, Newcomb M, D’Aquila R, Mustanski B. HIV, inflammation, and initiation of methamphetamine use in sexual and gender minorities assigned male at birth. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2407046121. PMID: 39348540, PMCID: PMC11474050, DOI: 10.1073/pnas.2407046121.Peer-Reviewed Original ResearchConceptsMethamphetamine useHIV diagnosisRate of incidenceRisk factorsHigh C-reactive proteinCox proportional-hazards modelC-reactive proteinPrevalence of methamphetamine useProportional-hazards modelSGM peopleIdentified risk factorsGender minoritiesInitiation of methamphetamine useHIV seroconversionInflammatory measuresPoisson regression analysisCohort studyHIVMethamphetaminePreventive interventionsBirthInflammationRegression analysisIncidenceDiagnosisPatient and community centered approaches to sepsis among birthing people
Richardson B, Cepin A, Grilo S, Moss R, Moller M, Brown S, Goffman D, Friedman A, Reddy U, Hall K. Patient and community centered approaches to sepsis among birthing people. Seminars In Perinatology 2024, 48: 151974. PMID: 39341761, PMCID: PMC11568907, DOI: 10.1016/j.semperi.2024.151974.Peer-Reviewed Original ResearchMaternal health equityHealth equityAcademic-community research partnershipsSevere maternal morbidityCo-designed interventionsBirthing peopleMaternal deathsUnderserved communitiesMaternal morbidityMoms studyResearch partnershipsSepsis-related morbidityCommunity centered approachRisk periodResearch principalsResearch processCentered approachCommunityMorbidityPeoplePostpartumInterventionEquityPartnershipBirthPredictors of Inflammation-Mediated Preterm Birth
Georges H, Norwitz E, Abrahams V. Predictors of Inflammation-Mediated Preterm Birth. Physiology 2024, 40: 26-36. PMID: 39106300, DOI: 10.1152/physiol.00022.2024.Peer-Reviewed Original ResearchA case study analysis of a successful birth center in northern Uganda
Telfer M, Zaslow R, Mbalinda S, Blatt R, Kim D, Kennedy H. A case study analysis of a successful birth center in northern Uganda. Birth 2024, 51: 783-794. PMID: 38923627, DOI: 10.1111/birt.12837.Peer-Reviewed Original ResearchBirth centersCommunity health workersHigh-resource countriesSmall group interviewsNeonatal mortality rateMidwifery careQuality MaternalBirthing peopleIntegrated careQuality careNorthern UgandaHealth workersMaternal deathsGroup interviewsCareNeonatal outcomesPerinatal morbidityQMNCDocument reviewField notesCommunity knowledgeNeonatal morbidityMortality rateBirthParticipant observationWho are the Parents? Risk and Resiliency Among Parents of Youth Receiving Intensive Home-Based Psychiatric Treatment
Conway C, Decker L, Adnopoz J, Woolston J. Who are the Parents? Risk and Resiliency Among Parents of Youth Receiving Intensive Home-Based Psychiatric Treatment. Journal Of Child & Adolescent Trauma 2024, 17: 1121-1131. PMID: 39686928, PMCID: PMC11646234, DOI: 10.1007/s40653-024-00643-4.Peer-Reviewed Original ResearchAdverse childhood eventsIntensive home-based treatmentNon-birthing parentsChildhood experiencesChildhood eventsHigher ACE scoresParents of childrenImpact parenting behaviorsExperiences of parentsParents of youthHome-based treatmentACE scoresEffective interventionsBirth parentsChildhood adversityChildhood experiences of parentingHigh-risk youthPractice recommendationsComplex clinical presentationParents' childhood experiencesScoresBirthChildhoodChildrenFuture policySmoking patterns by birth cohort in Argentina: an age-period-cohort population-based modeling study
Salgado M, Mok Y, Jeon J, Jaffri M, Tam J, Holford T, Sánchez-Romero L, Meza R, Mejia R. Smoking patterns by birth cohort in Argentina: an age-period-cohort population-based modeling study. The Lancet Regional Health - Americas 2024, 36: 100823. PMID: 39006127, PMCID: PMC11246057, DOI: 10.1016/j.lana.2024.100823.Peer-Reviewed Original ResearchCurrent smoking prevalenceSmoking prevalenceBirth cohortSmoking initiationCessation probabilitiesPopulation-based modelling studyTobacco control measuresRecent birth cohortsRate of quittingNationally representative surveySmoking ratesSmoking patternsYears of ageRepresentative surveySurveillance modelCancer interventionSmokingSmoking historyPrevalenceCohortGroup ageBirthInterventionCessationAgeHeat exposure induced risks of preterm birth mediated by maternal hypertension
Wang L, Di J, Wang Q, Zhang H, Zhao W, Shi X, Di Q, Ji J, Liang W, Huang C. Heat exposure induced risks of preterm birth mediated by maternal hypertension. Nature Medicine 2024, 30: 1974-1981. PMID: 38750350, DOI: 10.1038/s41591-024-03002-w.Peer-Reviewed Original ResearchRisk of maternal hypertensionRisk of preterm birthMaternal hypertensionPreterm birthClinical subtypes of preterm birthIncreased risk of preterm birthSubtypes of preterm birthIncidence of preterm birthBlood pressureMaternal blood pressureSingleton live birthsElevated blood pressureGestational weeksLarge-population studiesEarly pregnancyLive birthsClinical subtypesCohort studyIncreased riskHypertensionBirthMediation analysisEffects of heat exposureHeat exposureExposurePreterm and Early-Term Delivery After Heat Waves in 50 US Metropolitan Areas
Darrow L, Huang M, Warren J, Strickland M, Holmes H, Newman A, Chang H. Preterm and Early-Term Delivery After Heat Waves in 50 US Metropolitan Areas. JAMA Network Open 2024, 7: e2412055. PMID: 38787560, PMCID: PMC11127119, DOI: 10.1001/jamanetworkopen.2024.12055.Peer-Reviewed Original ResearchConceptsEarly-term birthPreterm birthCohort studyMetropolitan statistical areasAssociated with pregnancy outcomesEarly-term deliveryRate ratiosRates of pretermYears of ageNational Center for Health StatisticsGestational weeksCenter for Health StatisticsInduced deliveryPregnancy outcomesSingleton birthsPretermSocioeconomically disadvantaged subgroupsUS birthsEligible birthsPerinatal healthEthnic minority groupsBirth recordsConsecutive daysBirthHeat wavesThe Technical and Ethical Framework of Fetal Therapy: Past and Current Advances
Lynn A, Glazer P, Saltzman W, Stitelman D. The Technical and Ethical Framework of Fetal Therapy: Past and Current Advances. Current Stem Cell Reports 2024, 10: 30-36. DOI: 10.1007/s40778-024-00235-w.Peer-Reviewed Original ResearchFetal drug deliverySuccess of nanomedicineDrug deliveryPharmacological drug treatmentsMinimally invasive strategyFetal therapyFetal applicationsClinical studiesCongenital diseaseInvasive strategyDrug treatmentClinical translationClinical practiceTherapyMedical interventionsDeliveryFetalNanomedicineBirthDiseaseFindingsACliniciansSpeculum-free portable preterm imaging system
Boonya-Ananta T, Gonzalez M, Ajmal A, Du Le V, DeHoog E, Paidas M, Jayakumar A, Ramella-Roman J. Speculum-free portable preterm imaging system. Journal Of Biomedical Optics 2024, 29: 052918-052918. PMID: 38282917, PMCID: PMC10821769, DOI: 10.1117/1.jbo.29.5.052918.Peer-Reviewed Original ResearchConceptsNon-pregnant volunteersWeeks of gestationMortality rateNon-pregnant cervixCervical imagesPreterm birth riskStandard of careMaternal mortality rateUterine cervixPreterm birthPremature birthWomen's reproductive healthBirth riskCervixQuality of lifeDevelopmental impairmentReproductive healthBirthPatientsInfantsInfant mortality rateReducing infantInsertion sheathImaging probesPatient care
2023
Racial and Ethnic Disparities in Phthalate Exposure and Preterm Birth: A Pooled Study of Sixteen U.S. Cohorts
Welch B, Keil A, Buckley J, Engel S, James-Todd T, Zota A, Alshawabkeh A, Barrett E, Bloom M, Bush N, Cordero J, Dabelea D, Eskenazi B, Lanphear B, Padmanabhan V, Sathyanarayana S, Swan S, Aalborg J, Baird D, Binder A, Bradman A, Braun J, Calafat A, Cantonwine D, Christenbury K, Factor-Litvak P, Harley K, Hauser R, Herbstman J, Hertz-Picciotto I, Holland N, Jukic A, McElrath T, Meeker J, Messerlian C, Michels K, Newman R, Nguyen R, O’Brien K, Rauh V, Redmon B, Rich D, Rosen E, Schmidt R, Sparks A, Starling A, Wang C, Watkins D, Weinberg C, Weinberger B, Wenzel A, Wilcox A, Yolton K, Zhang Y, Ferguson K. Racial and Ethnic Disparities in Phthalate Exposure and Preterm Birth: A Pooled Study of Sixteen U.S. Cohorts. Environmental Health Perspectives 2023, 131: 127015. PMID: 38117586, PMCID: PMC10732302, DOI: 10.1289/ehp12831.Peer-Reviewed Original ResearchConceptsPhthalate metabolite concentrationsPreterm birthPhthalate exposurePhthalate metabolitesEthnic disparitiesU.S. cohortHypothetical interventionUrinary phthalate metabolite concentrationsMetabolite concentrationsWhite participantsUrinary phthalate metabolitesCovariate-adjusted differencesLatina participantsExposure-response modelPooled studiesOdds ratioPacific Islander participantsAsian/Pacific Islander participantsLogistic regressionMetabolite levelsBirthPregnancyPositive associationInterventionCohortAssociations between weekly gestational exposure of fine particulate matter, ozone, and nitrogen dioxide and preterm birth in a North Carolina Birth Cohort, 2003–2015
Krajewski A, Luben T, Warren J, Rappazzo K. Associations between weekly gestational exposure of fine particulate matter, ozone, and nitrogen dioxide and preterm birth in a North Carolina Birth Cohort, 2003–2015. Environmental Epidemiology 2023, 7: e278. PMID: 38912391, PMCID: PMC11189686, DOI: 10.1097/ee9.0000000000000278.Peer-Reviewed Original ResearchPreterm birthGestational exposureWeeks of pregnancyRisk of PTBInterquartile range increasePM 2.5 exposurePoisson regression modelsGestational weeksPotential confoundersFine particulate matterAssociation magnitudeRisk differenceNull associationBirth cohortExposure windowsResidential addressesMultipollutant modelsBirthWeeksPositive associationAssociationExposurePM 2.5Regression modelsCensus tracts“I had no choice”: A mixed‐methods study on access to care for vaginal breech birth
Schafer R, Dietrich M, Kennedy H, Mulvaney S, Phillippi J. “I had no choice”: A mixed‐methods study on access to care for vaginal breech birth. Birth 2023, 51: 413-423. PMID: 37968839, DOI: 10.1111/birt.12797.Peer-Reviewed Original ResearchVaginal breech birthBreech birthHospital systemTerm breech fetusHospital-based careUS hospital systemBreech fetusInterpretive description approachHospital birthsPerceptions of accessHospital settingCurrent recommendationsRespectful careReasonable optionPsychosocial surveysUS hospitalsDecisional satisfactionHome birthBirthMixed-methods studyCareMixed-method studyLack of accessOnly optionUterine Collagen Cross-Linking: Biology, Role in Disorders, and Therapeutic Implications
Kurt I, Kulhan M, AlAshqar A, Borahay M. Uterine Collagen Cross-Linking: Biology, Role in Disorders, and Therapeutic Implications. Reproductive Sciences 2023, 31: 645-660. PMID: 37907804, DOI: 10.1007/s43032-023-01386-7.Peer-Reviewed Original ResearchPreterm birthUterine fibroidsLysyl oxidaseWarrants further investigationUterine extracellular matrixCervical insufficiencyHealthy pregnancyUterine disordersUterine tissueAdvanced glycationTherapeutic implicationsTherapeutic targetPathogenic featuresSteroid hormonesNitric oxideBiomechanical strengthUterine collagenNormal biophysical propertiesFibroidsFurther investigationPentosidinePyridinolineDisordersBirthTissue integrity
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