2025
Unraveling the Neural Landscape of Mental Disorders using Double Functional Independent Primitives (dFIPs)
Soleimani N, Iraji A, Pearlson G, Preda A, Calhoun V. Unraveling the Neural Landscape of Mental Disorders using Double Functional Independent Primitives (dFIPs). Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2025 PMID: 40222638, DOI: 10.1016/j.bpsc.2025.03.015.Peer-Reviewed Original ResearchAutism spectrum disorderFunctional network connectivityBipolar disorderPsychiatric conditionsMental disordersMental illnessResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingConnectivity patternsBrain network alterationsFunctional connectivity patternsNeurobiological underpinningsDepressive disorderEmotion regulationNeural signaturesPsychiatric diagnosisConnectivity alterationsBrain regionsSpectrum disorderCognitive functionNeural landscapeCerebellar connectivitySocial behaviorNetwork alterationsSchizophreniaRetinal thickness: A window into cognitive impairment in bipolar disorder
Chart-Pascual J, Cano-Escalera G, Graña M, Zorrilla I, Lopez-Peña P, Requena C, Ceballos A, Landaluce I, Urcola H, Alvarez-Mon M, Blumberg H, Radua J, Gonzalez-Pinto A. Retinal thickness: A window into cognitive impairment in bipolar disorder. Spanish Journal Of Psychiatry And Mental Health 2025 PMID: 40081818, DOI: 10.1016/j.sjpmh.2025.01.001.Peer-Reviewed Original ResearchRetinal nerve fiber layerMacular ganglion cell layerGanglion cell layerOptical coherence tomographyInner plexiform layerBipolar disorderCoherence tomographyPeripapillary retinal nerve fiber layerNerve fiber layerMeasure retinal thicknessCognitive impairmentMarker of BDAssociated with CIPeripapillary RNFLRetinal thicknessRetinal thinningRetinal changesFiber layerHealthy controlsAssociated with worse cognitive performanceQuality of lifePlexiform layerBiological markersFunctional deficitsThickness alterationsRelation Between Brain Morphological Features and Psychiatric Hospitalization Risk in Major Depressive and Bipolar Disorders
Miskowiak K, Macoveanu J, Ozenne B, Beaman E, Dam V, Fisher P, Knudsen G, Kessing L, Jørgensen M, Frokjaer V, Sankar A. Relation Between Brain Morphological Features and Psychiatric Hospitalization Risk in Major Depressive and Bipolar Disorders. Acta Psychiatrica Scandinavica 2025 PMID: 39980329, DOI: 10.1111/acps.13790.Peer-Reviewed Original ResearchBipolar disorderPsychiatric hospitalHippocampal asymmetryMood disordersMatter volumeCognitive functionRisk of relapseStructural magnetic resonance imaging scansHippocampal gray matter volumeWhole-brain white matter volumeRight hippocampus volumeBrain morphological featuresGray matter volumeBrain structural measuresMarker of cognitive functionExploratory analysisWhite matter volumePrefrontal volumesDepressive disorderMajor depressionPsychiatric rehospitalizationBrain reserveHippocampus volumeMagnetic resonance imaging scansRisk of hospitalizationChronotherapeutic intervention targeting emotion regulation brain circuitry, symptoms, and suicide risk in adolescents and young adults with bipolar disorder: a pilot randomised trial
Kim J, Sankar A, Marks R, Carrubba E, Lecza B, Quatrano S, Spencer L, Constable R, Pittman B, Lebowitz E, Silverman W, Swartz H, Blumberg H. Chronotherapeutic intervention targeting emotion regulation brain circuitry, symptoms, and suicide risk in adolescents and young adults with bipolar disorder: a pilot randomised trial. BMJ Mental Health 2025, 28: e301338. PMID: 39971594, PMCID: PMC11840897, DOI: 10.1136/bmjment-2024-301338.Peer-Reviewed Original ResearchConceptsBipolar disorderEmotion regulationSuicide riskBrain circuitryChronotherapeutic interventionsEmotional face stimuliLeft amygdala responseRisk of bipolar disorderTargeting emotion regulationReduce suicide riskHigher suicide riskYoung adultsFunctional MRI dataPost-treatment improvementAmygdala responsePotential intervention targetsEmotion dysregulationMania symptomsMood episodesFace stimuliCircuitry dysfunctionRegulation therapyDaily rhythmsWeekly sessionsSelf-monitoringLUMATEPERONE IN THE TREATMENT OF PATIENTS WITH MAJOR DEPRESSIVE DISORDER AND BIPOLAR DISORDER WITH ANXIOUS DISTRESS AND MIXED FEATURES
Bhagwagar *, Kozauer S, Earley W, Huo J, Sachs G, Durgam S. LUMATEPERONE IN THE TREATMENT OF PATIENTS WITH MAJOR DEPRESSIVE DISORDER AND BIPOLAR DISORDER WITH ANXIOUS DISTRESS AND MIXED FEATURES. The International Journal Of Neuropsychopharmacology 2025, 28: i316-i316. PMCID: PMC11814723, DOI: 10.1093/ijnp/pyae059.563.Peer-Reviewed Original ResearchClinical Global Impression Scale-SeverityMajor depressive disorderMADRS total scoreClinical Global Impression Scale-Severity scoresAnxious distressBipolar depressionBipolar II disorderDSM-5Bipolar disorderTotal scoreII disorderBipolar IDepressive disorderDepressive episodeAssociated with major depressive disorderDepression Rating ScaleDSM-5 criteriaBipolar disorder diagnosisPost-hoc analysis of studyIncreased suicide riskPoor treatment responseSingle-item scoresEpisode specifierTreat schizophreniaDisorder diagnosisPREDICTING DEPRESSED AND ELEVATED MOOD SYMPTOMATOLOGY IN BIPOLAR DISORDER USING BRAIN FUNCTIONAL CONNECTOMES
Sankar *, Shen X, Colic L, Goldman D, Villa L, Kim J, Pittman B, Scheinost D, Constable R, Blumberg H. PREDICTING DEPRESSED AND ELEVATED MOOD SYMPTOMATOLOGY IN BIPOLAR DISORDER USING BRAIN FUNCTIONAL CONNECTOMES. The International Journal Of Neuropsychopharmacology 2025, 28: i15-i15. PMCID: PMC11814904, DOI: 10.1093/ijnp/pyae059.027.Peer-Reviewed Original ResearchConnectome-based predictive modelingBipolar disorderMood symptomatologyMood symptomsFunctional connectomeYoung Mania Rating ScaleFunctional magnetic resonance imaging dataPredictors of functional impairmentEmotion processing taskMania Rating ScaleMood symptom severityMood symptom scoresBrain functional connectomeMagnetic resonance imaging dataBrain function disturbancesHamilton DepressionPredicting depressionSymptom severityRating ScaleFunctional impairmentDisordersMoodSymptomatologyProcessing tasksDepressionLate life mood disorders and suicidality
Khasnavis S, Asghar-Ali A. Late life mood disorders and suicidality. 2025, 235-246. DOI: 10.1093/med/9780198874799.003.0017.Peer-Reviewed Original ResearchMood disordersPresentation of mood disordersOlder adultsStudy of mental healthDepressive illnessBipolar disorderTreatment allianceMental healthHealth of older adultsTreatment formulationDisordersMoodCulturally responsive approachSuicideIntersection of cultureAdultsYoung individualsOlder patientsAge groupsIllnessHealthTreatmentAllianceIndividualsRole of Psychologists in Enhancing Care Quality for Individuals With Serious Mental Illnesses: Introduction to a Special Section
Hunt M, Hegeman B, Resnick S. Role of Psychologists in Enhancing Care Quality for Individuals With Serious Mental Illnesses: Introduction to a Special Section. Psychological Services 2025, 22: 1-3. PMID: 39869689, DOI: 10.1037/ser0000930.Peer-Reviewed Original ResearchConceptsMental illnessProvision of evidence-based practiceMental health recoveryEnhance care qualityMental health symptomsHigh-quality careSerious mental illnessEvidence-based practiceSchizoaffective disorderBipolar disorderSignificant social stigmaCare qualityHealth recoveryCare gapsEnhance careHealth symptomsSpecialty careTreatment providersPsychologistsSocial stigmaCareTraining supportSMIDisordersSpecial sectionNeural signatures of risk-taking adaptions across health, bipolar disorder, and lithium treatment
Scholl J, Panchal P, Nelissen N, Atkinson L, Kolling N, Saunders K, Geddes J, Rushworth M, Nobre A, Harrison P, Harmer C. Neural signatures of risk-taking adaptions across health, bipolar disorder, and lithium treatment. Molecular Psychiatry 2025, 1-11. PMID: 39880901, DOI: 10.1038/s41380-025-02900-w.Peer-Reviewed Original ResearchBipolar disorderDecision-making taskReward-guided decision-making taskFunctional magnetic resonance imagingWeeks of lithiumSymptoms of maniaDorsolateral prefrontal cortexMood Disorder QuestionnaireRisk-takingReward outcomesReward processingPrefrontal cortexMood ratingsNeural signaturesNeural mechanismsRisk-related behaviorsLithium treatmentMoodDiagnosed BDBD studiesFunction of riskDisordersOutcome historyMagnetic resonance imagingMDQGenomics yields biological and phenotypic insights into bipolar disorder
Lee B, Kim J, Lee Y, Kang J, Cheon M, Kim D, Aslan M, Harvey P, Huang G. Genomics yields biological and phenotypic insights into bipolar disorder. Nature 2025, 639: 968-975. PMID: 39843750, DOI: 10.1038/s41586-024-08468-9.Peer-Reviewed Original ResearchFine-mappingGenetic architectureGenome-wide significant lociMulti-ancestry meta-analysisGenetic architecture of bipolar disorderRare variant signalsSignificant lociGenetic determinantsBipolar disorderVariant signalsLatino ancestryCell typesEast Asian cohortsPhenotypic insightsPathophysiology of bipolar disorderGenesMedium spiny neuronsBipolar disorder subtypesPatient ascertainmentAetiology of bipolar disorderGABAergic interneuronsSpiny neuronsAsian cohortGenomeGlobal burdenOn being and having: a qualitative study of self-perceptions in bipolar disorder
Ponticiello M, Chang A, Chang R, Mirza S, Martin A. On being and having: a qualitative study of self-perceptions in bipolar disorder. Frontiers In Psychiatry 2025, 15: 1509979. PMID: 39906682, PMCID: PMC11790665, DOI: 10.3389/fpsyt.2024.1509979.Peer-Reviewed Original ResearchBipolar disorderStudy of self-perceptionInterpretative phenomenological analysis approachParticipants' illness experiencesSevere mental illnessPhenomenological analysis approachSemi-structured interviewsSense of selfPatient experienceIllness experiencePatient perspectiveMental illnessExternal locusThematic analysisStable BDBipolar experiencesQualitative studyProcess of namingSelf-perceptionIndividual needsMeaningful lifeIllnessLack of researchInner realityQualitative researchPhenome-wide association studies between SERINC2 and neuropsychiatric disorders
Liu P, Luo X, Cao L, Zhang Y, Ji J, Wang X, Wang K, Pan X, Yang R, Tan Z, Tan Y, Li C, Guo X, Wang Z, Luo X. Phenome-wide association studies between SERINC2 and neuropsychiatric disorders. Frontiers In Psychiatry 2025, 15: 1420395. PMID: 39902246, PMCID: PMC11788846, DOI: 10.3389/fpsyt.2024.1420395.Peer-Reviewed Original ResearchGray matter volumeBipolar disorderNeuropsychiatric disordersDisease-risk alleleSubcortical gray matter volumesSubstance use disordersMRNA expressionCortical surface areaAssociated with alcoholCocaine dependenceMarijuana dependencePolysubstance dependenceMatter volumeNicotine dependenceBrain regionsSchizophreniaSubcortical structuresSNP-disease associationsPhenome-wide association studyAutismOCDFDR correctionDisordersRegulatory effectsAssociation studiesEvaluating the Exposome Score for Schizophrenia in a Transdiagnostic Psychosis Cohort: Associations With Psychosis Risk, Symptom Severity, and Personality Traits
Kromenacker B, Yassin W, Keshavan M, Parker D, Thakkar V, Pearlson G, Keedy S, McDowell J, Gershon E, Ivleva E, Hill S, Clementz B, Tamminga C. Evaluating the Exposome Score for Schizophrenia in a Transdiagnostic Psychosis Cohort: Associations With Psychosis Risk, Symptom Severity, and Personality Traits. Schizophrenia Bulletin 2025, sbae219. PMID: 39777534, DOI: 10.1093/schbul/sbae219.Peer-Reviewed Original ResearchES-SCZSymptom severityExposome scoreModel of personalityPersonality factor scoresBipolar-Schizophrenia NetworkExpression of psychosisMood symptom severityMore severe symptomsFamily socioeconomic statusPatterns of associationDecreased conscientiousnessIncreased neuroticismPsychosis cohortPsychosis samplePsychosis groupPsychotic diagnosesInvestigate causal pathwaysPsychosis riskBipolar disorderPersonality traitsCausal pathwaysWithin-group associationsPsychosisFactor scoresMolecular and Cellular Mechanisms of Bipolar Disorder
McClung C, Blumberg H. Molecular and Cellular Mechanisms of Bipolar Disorder. 2025, 301-316. DOI: 10.1093/med/9780197640654.003.0024.Peer-Reviewed Original ResearchBipolar disorderMechanisms of bipolar disorderMood-stabilizing medicationsBrain circuit abnormalitiesBipolar disorder pathophysiologyCircadian rhythm disruptionCircuit abnormalitiesDisorder pathophysiologyHuman studiesSleep-wakeContribution of environmental influencesGenetic findingsCellular basisEnvironmental influencesRhythm disruptionCellular mechanismsApplication of Stem Cells to Understanding Psychiatric Disorders
Birtele M, Quadrato G, Brennand K. Application of Stem Cells to Understanding Psychiatric Disorders. 2025, 53-64. DOI: 10.1093/med/9780197640654.003.0005.Peer-Reviewed Original ResearchPsychiatric disordersHuman induced pluripotent stem cellsAnimal models of autism spectrum disorderModel of autism spectrum disorderNeuroimaging studies of patientsModel psychiatric disordersAutism spectrum disorderStem cellsBipolar disorderDerivation of human induced pluripotent stem cellsNeuroimaging studiesApplication of stem cellsNeural processesSpectrum disorderStudy of patientsMental illnessPluripotent stem cellsDisordersComplex genetic risk factorsGenetic risk factorsTherapeutic approachesAnimal modelsNeural pathologyRisk factorsDisease predisposition
2024
Cognitive–Emotional Impairments in Euthymic Bipolar Disorder—New Insights Into Emotion Regulation and Cognitive Control Deficits
Seelig E, Joormann J, Wolkenstein L. Cognitive–Emotional Impairments in Euthymic Bipolar Disorder—New Insights Into Emotion Regulation and Cognitive Control Deficits. Emotion 2024 DOI: 10.1037/emo0001479.Peer-Reviewed Original ResearchBipolar disorderCognitive controlER strategiesCC deficitsStrategy useResponse to negative affectSelf-reported habitual useHabitual useDown-regulate positive emotionsHealthy controlsDeficient cognitive controlCognitive control deficitsER strategy useMaladaptive ER strategiesSpontaneous strategy useNo group differencesEuthymic patientsMood inductionER deficitsEmotion regulationNegative affectImpaired CCPositive affectControl deficitsCompetence deficitsCognitive Remediation in Patients With Bipolar Disorder: A Randomized Trial by Sequential tDCS and Navigated rTMS Targeting the Primary Visual Cortex
Zhou H, Wang M, Xu T, Zhang X, Zhao X, Tang L, Zhao P, Wang D, Lai J, Wang F, Zhang S, Hu S. Cognitive Remediation in Patients With Bipolar Disorder: A Randomized Trial by Sequential tDCS and Navigated rTMS Targeting the Primary Visual Cortex. CNS Neuroscience & Therapeutics 2024, 30: e70179. PMID: 39703101, PMCID: PMC11659637, DOI: 10.1111/cns.70179.Peer-Reviewed Original ResearchConceptsRepetitive transcranial magnetic stimulationNeuronavigated repetitive transcranial magnetic stimulationTranscranial direct current stimulationBipolar disorderNavigated repetitive transcranial magnetic stimulationNon-invasive brain stimulationDepressive symptomsBD patientsRating ScaleYoung Mania Rating ScaleHamilton Depression Rating ScaleCognitive impairmentTHINC-integrated toolMania Rating ScaleDepression Rating ScaleTranscranial direct current stimulation treatmentImprove cognitive impairmentVisual cortexTHINC-itCognitive remediationDepressive episodeTranscranial magnetic stimulationNeurocognitive effectsNeurocognitive functionDirect current stimulationPolygenic Risk Scores and Twin Concordance for Schizophrenia and Bipolar Disorder
Song J, Pasman J, Johansson V, Kuja-Halkola R, Harder A, Karlsson R, Lu Y, Kowalec K, Pedersen N, Cannon T, Hultman C, Sullivan P. Polygenic Risk Scores and Twin Concordance for Schizophrenia and Bipolar Disorder. JAMA Psychiatry 2024, 81: 1246-1252. PMID: 39196586, PMCID: PMC11359115, DOI: 10.1001/jamapsychiatry.2024.2406.Peer-Reviewed Original ResearchPolygenic risk scoresGenome-wide association studiesSwedish Twin RegistryBipolar disorderCase-control studyTwin concordanceTwin heritabilityLevels of polygenic risk scoreTwin RegistrySwedish national register dataCompare polygenic risk scoresRisk scoreNational register dataHeritable psychiatric disorderAffected co-twinsPairs of twinsPsychosis phenotypeIllness vulnerabilityClinical interviewPsychiatric disordersGenetic liabilityMain OutcomesStructural equation modelingPsychosisSchizophreniaThe involvement of the cerebellar vermis across the psychotic-affective spectrum in enriched samples of recent-onset schizophrenia, bipolar disorder, and major depressive disorder
Xiao Y, Kandala S, Huang J, Liu J, McGonigle T, Barch D, Tang Y, Fan G, Wang F, Womer F. The involvement of the cerebellar vermis across the psychotic-affective spectrum in enriched samples of recent-onset schizophrenia, bipolar disorder, and major depressive disorder. Journal Of Psychiatric Research 2024, 181: 14-22. PMID: 39577028, DOI: 10.1016/j.jpsychires.2024.11.023.Peer-Reviewed Original ResearchBipolar disorderFunctional connectivityVermis volumeDepressive disorderCognitive measuresSpectrum of schizophreniaRecent-onset schizophreniaCerebellar vermisBrain functional connectivityPsychotic psychopathologyTotal vermisMDDSchizophreniaSubcortical regionsVisual learningFrontotemporal regionsPosterior vermisExploratory analysisDisordersCanonical correlationVermisFunctional alterationsNo significant associationSubregionsSignificant diagnosesBipolar disorder among individuals with atopic dermatitis: a case–control study in the All of Us Research Program
Wride A, Chen G, Fan R, Leasure A, Jones S, Levey D, Damsky W, Cohen J. Bipolar disorder among individuals with atopic dermatitis: a case–control study in the All of Us Research Program. Clinical And Experimental Dermatology 2024, 50: 760-763. PMID: 39425681, DOI: 10.1093/ced/llae451.Peer-Reviewed Original Research
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