2025
Dynamic Contrast-enhanced MRI Processing Comparison for Distinguishing True Progression From Pseudoprogression in High-grade Glioma.
Amer A, Ansari S, Krayyem A, Kundu S, Khose S, Pokhylevych H, Calle S, Patel C, Yang Z, Liu H, Johnson J. Dynamic Contrast-enhanced MRI Processing Comparison for Distinguishing True Progression From Pseudoprogression in High-grade Glioma. Journal Of Computer Assisted Tomography 2025 PMID: 39876523, DOI: 10.1097/rct.0000000000001716.Peer-Reviewed Original ResearchHigh-grade gliomasBlood-brain barrierDCE-MRIPeak contrast enhancementQuantify BBB permeabilityTreatment-related changesFollow-up subjectsKtrans mapsTrue progressionTumor progressionClinical dataConventional MRIPseudoprogressionBBB permeabilityCombined pathologyKtransContrast enhancementT1 enhancementStandard processing methodologyStatistically significant resultsClinical data setsPathologyPatientsGliomaSSS technique
2022
Extra-Virgin Olive Oil Enhances the Blood–Brain Barrier Function in Mild Cognitive Impairment: A Randomized Controlled Trial
Kaddoumi A, Denney T, Deshpande G, Robinson J, Beyers R, Redden D, Praticò D, Kyriakides T, Lu B, Kirby A, Beck D, Merner N. Extra-Virgin Olive Oil Enhances the Blood–Brain Barrier Function in Mild Cognitive Impairment: A Randomized Controlled Trial. Nutrients 2022, 14: 5102. PMID: 36501136, PMCID: PMC9736478, DOI: 10.3390/nu14235102.Peer-Reviewed Original ResearchConceptsClinical Dementia RatingMild cognitive impairmentBBB permeabilityAlzheimer's diseaseProtective effectP-tau/t-tau ratioCognitive impairmentBlood-brain barrier breakdownBlood-brain barrier functionBrain connectivityBehavioral scoresAbnormal BBB permeabilityAD mouse modelClearance of AβT-tau ratioEarly Alzheimer's diseaseFunctional brain activationSecondary outcomesBrain atrophyControlled TrialsPrimary outcomePreclinical findingsBrain amyloidBlood biomarkersBarrier breakdown
2014
African Trypanosome-Induced Blood–Brain Barrier Dysfunction under Shear Stress May Not Require ERK Activation
Sumpio BJ, Chitragari G, Moriguchi T, Shalaby S, Pappas-Brown V, Khan AM, Sekaran SD, Sumpio BE, Grab DJ. African Trypanosome-Induced Blood–Brain Barrier Dysfunction under Shear Stress May Not Require ERK Activation. International Journal Of Angiology 2014, 24: 41-46. PMID: 27053915, PMCID: PMC4813428, DOI: 10.1055/s-0034-1370890.Peer-Reviewed Original ResearchHuman brain microvascular endothelial cellsBrain microvascular endothelial cellsTransendothelial electrical resistanceBlood-brain barrierBrain postcapillary venulesBrain barrier dysfunctionMicrovascular endothelial cellsPhosphorylation of ERK1/2Parasite cysteine proteasesNeurological symptomsBBB permeabilityBarrier dysfunctionExtracellular signal-regulated kinaseBrain capillariesMicrovascular permeabilityAbsence of trypanosomesHuman African trypanosomiasisSignal-regulated kinasePostcapillary venulesTransient increaseEndothelial cellsBarrier functionElectric cell-substrate impedance sensingProtozoan parasiteTrypanosome infection
1991
Recombinant human interleukin-1 induces meningitis and blood-brain barrier injury in the rat. Characterization and comparison with tumor necrosis factor.
Quagliarello V, Wispelwey B, Long W, Scheld W. Recombinant human interleukin-1 induces meningitis and blood-brain barrier injury in the rat. Characterization and comparison with tumor necrosis factor. Journal Of Clinical Investigation 1991, 87: 1360-1366. PMID: 2010549, PMCID: PMC295174, DOI: 10.1172/jci115140.Peer-Reviewed Original ResearchConceptsBlood-brain barrier injuryRIL-1 betaBBB injuryCerebrospinal fluidBarrier injuryBBB permeabilityInterleukin-1Central nervous system infectionInduction of meningitisNervous system infectionRecombinant human interleukin-1Tumor necrosis factorExperimental rat modelRIL-1 alphaHuman interleukin-1Systemic neutropeniaHost mediatorsCSF inflammationSystem infectionIgG monoclonal antibodiesNeutrophil emigrationRTNF alphaNecrosis factorRat modelIL-1
1986
Morphologic alterations of the blood-brain barrier with experimental meningitis in the rat. Temporal sequence and role of encapsulation.
Quagliarello V, Long W, Scheld W. Morphologic alterations of the blood-brain barrier with experimental meningitis in the rat. Temporal sequence and role of encapsulation. Journal Of Clinical Investigation 1986, 77: 1084-1095. PMID: 3514671, PMCID: PMC424442, DOI: 10.1172/jci112407.Peer-Reviewed Original ResearchConceptsBlood-brain barrierH. influenzae type b.Cerebral capillary endotheliumBBB permeabilityInfection durationMorphologic alterationsCapillary endotheliumEffective blood-brain barrierInduction of meningitisLonger infection durationUnencapsulated mutant strainCerebrospinal fluid bacterial concentrationsType B.Significant increaseIntercellular tight junctionsBBB injuryMeningitis inductionMeningeal pathogensExperimental meningitisHost clearanceCSF clearanceMeningitisMorphologic changesMorphologic explanationProgressive increase
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