2024
Sickle cell disease in India: the journey and hope for the future.
Gupta K, Krishnamurti L, Jain D. Sickle cell disease in India: the journey and hope for the future. Hematology 2024, 2024: 1-9. PMID: 39644008, PMCID: PMC11665512, DOI: 10.1182/hematology.2024000678.Peer-Reviewed Original ResearchConceptsSickle cell diseaseHematopoietic stem cell transplantationCell diseaseSeverity of sickle cell diseaseStem cell transplantationAcute chest syndromeVaso-occlusive crisisSurvive into adulthoodChest syndromePenicillin prophylaxisCell transplantationRenal involvementHydroxyurea therapyGene therapyClinical featuresNovel therapiesA-thalassemiaFetal HbNewborn screeningAvascular necrosisTranscranial DopplerComprehensive care programTherapyYounger ageFatal diseaseGenome-Wide Association Study Identifies Novel Genetic Variants Associated with Avascular Necrosis in Sickle Cell Disease
Sowa A, Hu Y, Gladwin M, Gordeuk V, Nouraie S, Zhang Y, Pashankar F, Krishnamurti L, Gruen J. Genome-Wide Association Study Identifies Novel Genetic Variants Associated with Avascular Necrosis in Sickle Cell Disease. Blood 2024, 144: 5297-5297. DOI: 10.1182/blood-2024-207552.Peer-Reviewed Original ResearchGenome-wide association studiesChromosome 1Enhancer regionGenome-wide significance thresholdNon-coding RNA genesLong non-coding RNA genesGenome-wide significanceGenotype call rateHardy-Weinberg equilibriumSickle cell diseaseRNA genesLinkage disequilibriumPopulation stratificationAssociation studiesDiagnosis of sickle cell diseaseRegulatory elementsAvascular necrosisCohort of individualsGene studiesAllele frequenciesMultivariate logistic regression analysisLogistic regression analysisSNPsGenetic associationCall rateStem Cells and Platelet-Rich Plasma in the Treatment of Osteochonndral Lesions of the Talus
Fraser E, Kennedy J, Gianakos A, Yasui Y. Stem Cells and Platelet-Rich Plasma in the Treatment of Osteochonndral Lesions of the Talus. 2024, 47-56. DOI: 10.1201/9781003524205-7.Peer-Reviewed Original ResearchFabricating patient-specific 3D printed drill guides to treat femoral head avascular necrosis
Bell C, Feizi A, Roytman G, Ramji A, Tommasini S, Wiznia D. Fabricating patient-specific 3D printed drill guides to treat femoral head avascular necrosis. 3D Printing In Medicine 2024, 10: 10. PMID: 38564090, PMCID: PMC10986134, DOI: 10.1186/s41205-024-00208-z.Peer-Reviewed Original ResearchUsing Computed Tomography-Based Three-dimensional Modeling and Computer Navigation for Minimally Invasive Core Decompression and Adjuvant Orthobiologic Therapy of Femoral Head Avascular Necrosis
Feizi A, Bell C, Roytman G, Park N, Wang A, Tommasini S, Wiznia D. Using Computed Tomography-Based Three-dimensional Modeling and Computer Navigation for Minimally Invasive Core Decompression and Adjuvant Orthobiologic Therapy of Femoral Head Avascular Necrosis. Arthroplasty Today 2024, 26: 101337. PMID: 38497084, PMCID: PMC10940782, DOI: 10.1016/j.artd.2024.101337.Peer-Reviewed Original ResearchFemoral head avascular necrosisAvascular necrosisSurgical techniqueCore decompressionBone marrow aspirate concentrateDelay disease progressionOutcome of core decompressionAdjuvant therapyCellular therapyAspirate concentrateDisease progressionFemoral head collapseImprove outcomesLesionsDebilitating conditionTherapyComputer navigationNecrosisDecompressionHead collapseThree-dimensional modelFemoral head
2023
Comparison of Outcomes of Hematopoietic Cell Transplantation (HCT) for Asymptomatic Patients with Sickle Cell Disease (SCD) and That of Propensity Matched Symptomatic Patients Undergoing HCT
Katoch D, Nallagatla V, Krishnamurti L. Comparison of Outcomes of Hematopoietic Cell Transplantation (HCT) for Asymptomatic Patients with Sickle Cell Disease (SCD) and That of Propensity Matched Symptomatic Patients Undergoing HCT. Blood 2023, 142: 3873. DOI: 10.1182/blood-2023-190977.Peer-Reviewed Original ResearchHematopoietic cell transplantationSickle cell diseaseComplications of SCDGraft failureOverall survivalAsymptomatic patientsAvascular necrosisSCD patientsDonor typeChronic GVHDCell transplantationCell diseaseOutcomes of HCTPost-transplant lymphoproliferative disorderSubstantial short-term morbidityCommon graft sourceExperienced graft failureHCT comorbidity indexAcute chest syndromeHLA-identical donorShort-term morbidityLong-term sequelaePotential curative optionSubset of patientsOrgan-specific complications
2021
Incremental biomarker and clinical outcomes after switch from enzyme therapy to eliglustat substrate reduction therapy in Gaucher disease
Kleytman N, Ruan J, Ruan A, Zhang B, Murugesan V, Lin H, Guo L, Klinger K, Mistry PK. Incremental biomarker and clinical outcomes after switch from enzyme therapy to eliglustat substrate reduction therapy in Gaucher disease. Molecular Genetics And Metabolism Reports 2021, 29: 100798. PMID: 34485083, PMCID: PMC8408524, DOI: 10.1016/j.ymgmr.2021.100798.Peer-Reviewed Original ResearchLong-term enzyme replacement therapyEnzyme replacement therapySubstrate reduction therapyGaucher diseaseStable patientsReduction therapySingle tertiary referral centerPhase 3 clinical trialsChronic metabolic inflammationFirst-line therapyTertiary referral centerGD type 1Primary metabolic defectLipid-laden cellsType 1 patientsGD type 1 patientsSubstrate glucosylceramideDisease activityOral therapyReferral centerAvascular necrosisMetabolic inflammationWeek infusionClinical outcomesInflammatory cascade
2020
Talar Avascular Necrosis After Calcium Phosphate Injection Treatment of Talar Bone Marrow Lesions: A Report of 2 Cases.
Kohring JM, Oh I, Baumhauer JF. Talar Avascular Necrosis After Calcium Phosphate Injection Treatment of Talar Bone Marrow Lesions: A Report of 2 Cases. JBJS Case Connector 2020, 10: e19.00389. PMID: 32649148, DOI: 10.2106/jbjs.cc.19.00389.Peer-Reviewed Original ResearchConceptsCalcium phosphate injectionBone marrow lesionsAvascular necrosisMarrow lesionsExtensive avascular necrosisBone marrow edemaTalar avascular necrosisPoor patient outcomesPhosphate injectionEquivocal improvementPatient's symptomsMarrow edemaPatient outcomesInjection treatmentAnkle jointPatientsLesionsNecrosisPoor qualityOutcomesTreatmentInjectionAvailable researchSubchondroplastyEdemaSAT-065 A Novel De Novo GATA3 Gene Mutation in an Adolescent with HDR Syndrome
Cruz-Aviles L, Bale A, Carpenter T. SAT-065 A Novel De Novo GATA3 Gene Mutation in an Adolescent with HDR Syndrome. Journal Of The Endocrine Society 2020, 4: sat-065. PMCID: PMC7208832, DOI: 10.1210/jendso/bvaa046.1845.Peer-Reviewed Original ResearchBone density Z-scorePg/Abnormal calcium levelsLeft hip painSmall right kidneyVitamin D supplementationRemoval of hardwareSensorineural hearing lossBilateral hip dysplasiaPre-op evaluationCentral nervous systemCapital femoral epiphysisTotal hip replacementGATA3 gene mutationWhole-exome sequencingFamily membersD supplementationOral calciumYo maleGastroesophageal refluxHip painChvostek's signEndocrine evaluationRenal diseaseAvascular necrosis
2019
Excellent Overall Survival and Low Incidence of Late Effects in Patients Undergoing Allogeneic Hematopoietic Cell Transplant for Sickle Cell Disease: A Report from the Center for International Blood and Marrow Transplant Research (CIBMTR)
Stenger E, Phelan R, Shaw B, Battiwalla M, Bo-Subait S, Brazauskas R, Buchbinder D, Hamilton B, Shenoy S, Krishnamurti L. Excellent Overall Survival and Low Incidence of Late Effects in Patients Undergoing Allogeneic Hematopoietic Cell Transplant for Sickle Cell Disease: A Report from the Center for International Blood and Marrow Transplant Research (CIBMTR). Blood 2019, 134: 697. DOI: 10.1182/blood-2019-128797.Peer-Reviewed Original ResearchHematopoietic cell transplantationSickle cell diseaseAcute chest syndromeMarrow Transplant ResearchLate effectsCumulative incidenceRisk factorsChest syndromeInternational BloodAvascular necrosisMultivariable analysisUnrelated donorsPatient populationTransplant ResearchCell diseaseAllogeneic hematopoietic cell transplantMyeloablative hematopoietic cell transplantationVaso-occlusive pain crisesAllogeneic hematopoietic cell transplantationDiagnosis of SCDMultivariable Cox regression analysisFirst hematopoietic cell transplantationOlder ageExcellent overall survivalHematopoietic cell transplantBisphosphonate-loaded Bone Cement as a Local Adjuvant Therapy for Giant Cell Tumor of Bone
Greenberg DD, Lee FY. Bisphosphonate-loaded Bone Cement as a Local Adjuvant Therapy for Giant Cell Tumor of Bone. American Journal Of Clinical Oncology 2019, 42: 231-237. PMID: 30811352, DOI: 10.1097/coc.0000000000000504.Peer-Reviewed Original ResearchConceptsGiant cell tumorAdjuvant therapyLocal adjuvant therapySystemic side effectsAvascular necrosisCell tumorsSide effectsMusculoskeletal Tumor Society scoreOsteoclast-like giant cellsAggressive bone resorptionTherapeutic Level IVHigh-speed burringLocal recurrence rateAtypical femur fracturesLevel of evidenceTraditional adjuvant therapyBone cementAtypical fracturesSystemic bisphosphonatesPulmonary metastasesSociety ScoreCurettage proceduresRecurrence rateFemur fracturesPolymethylmethacrylate bone cement
2017
Avascular necrosis of the humeral head following bilateral upper extremity vascular composite allotransplantation: a case report
Rinkinen J, Molway D, Carty M, Dyer G, Pomahac B, Chandraker A, Talbot S. Avascular necrosis of the humeral head following bilateral upper extremity vascular composite allotransplantation: a case report. Case Reports In Plastic Surgery And Hand Surgery 2017, 4: 60-64. PMID: 28804740, PMCID: PMC5532758, DOI: 10.1080/23320885.2017.1345635.Peer-Reviewed Original Research
2016
Scaphoid Plate Fixation and Volar Carpal Artery Vascularized Bone Graft for Recalcitrant Scaphoid Nonunions
Dodds SD, Halim A. Scaphoid Plate Fixation and Volar Carpal Artery Vascularized Bone Graft for Recalcitrant Scaphoid Nonunions. The Journal Of Hand Surgery 2016, 41: e191-e198. PMID: 27212412, DOI: 10.1016/j.jhsa.2016.04.021.Peer-Reviewed Original ResearchConceptsRecalcitrant scaphoid nonunionsScaphoid nonunionBone graftTomography scanSTUDY/LEVELVolar buttress plateVolar carpal arteryScaphoid waist nonunionHeadless screw fixationMinimal donor site morbidityComputed tomography scanVascularized bone graftsConsiderable bone lossDonor site morbidityPersistent clickingVolar incisionQuickDASH scoreRadiographic improvementMedian durationPrior surgeryRadiographic outcomesSymptomatic reliefAvascular necrosisWaist nonunionBone lossValidity and Clinical Consequences of a Rotational Mechanism for Slipped Capital Femoral Epiphysis
Liu RW, Fraley SM, Morris WZ, Cooperman DR. Validity and Clinical Consequences of a Rotational Mechanism for Slipped Capital Femoral Epiphysis. Journal Of Pediatric Orthopaedics 2016, 36: 239-246. PMID: 25812143, DOI: 10.1097/bpo.0000000000000438.Peer-Reviewed Original ResearchConceptsCapital femoral epiphysisStable SCFEVarus deformityClinical consequencesFemoral epiphysisSlipped Capital Femoral EpiphysisAxial plane deformityImmature femoraAvascular necrosisAnatomic supportLateral epiphyseal vesselsPlane deformityProtective effectRotational deformityPosterior displacementCadaveric studyVessel stretchVarus componentRetroversion deformityDeformityEpiphyseal vesselsCharacteristic deformitiesSCFEAnatomic dataEpiphysis
2015
Current concepts on osteonecrosis of the femoral head
Moya-Angeler J, Gianakos A, Villa J, Ni A, Lane J. Current concepts on osteonecrosis of the femoral head. World Journal Of Orthopedics 2015, 6: 590-601. PMID: 26396935, PMCID: PMC4573503, DOI: 10.5312/wjo.v6.i8.590.Peer-Reviewed Original ResearchMagnetic resonance imagingFemoral headCore decompressionFrog-leg lateral radiographsNatural historyFirst radiographic changeTrue natural historyLevel 1 evidenceOptimal treatment protocolTotal hip arthroplastyJoint preserving proceduresPre-collapse stageOsteonecrosis diagnosisPlain anteroposteriorSurgical treatmentAvascular necrosisPlain radiographsSclerotic changesTreatment optionsMinimal symptomsRadiographic changesTreatment modalitiesRisk factorsPharmacologic agentsSymptomatic stage
2014
Oral Rehabilitation Outcomes After Free Fibula Reconstruction of the Mandible Without Condylar Restoration
Chao J, Rohde C, Chang M, Kutler D, Friedman J, Spector J. Oral Rehabilitation Outcomes After Free Fibula Reconstruction of the Mandible Without Condylar Restoration. Journal Of Craniofacial Surgery 2014, 25: 415-417. PMID: 24621695, DOI: 10.1097/scs.0000000000000691.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnkylosisBone TransplantationDental Occlusion, CentricDietFemaleFibulaFollow-Up StudiesFree Tissue FlapsHumansMaleMandibleMandibular CondyleMandibular DiseasesMandibular NeoplasmsMiddle AgedOsteonecrosisPlastic Surgery ProceduresPostoperative ComplicationsRange of Motion, ArticularRetrospective StudiesTemporal BoneTemporomandibular Joint DisordersTreatment OutcomeTrismusConceptsFree fibula reconstructionTemporomandibular joint dysfunctionTemporomandibular jointCondylar reconstructionFibula reconstructionFibula flapGlenoid fossaMaximum interincisal openingRetrospective chart reviewVascularized fibula flapSkull base erosionInterincisal openingPosterior mandiblePostoperative trismusIpsilateral deviationSegmental mandibulectomyChart reviewCondylar headCondylar resectionReconstructed mandibleMouth openingMandibular condyleAvascular necrosisFunctional recoveryPatients
2013
Management of the 'young' patient with hip disease.
Ritterman SA, Rubin LE. Management of the 'young' patient with hip disease. Rhode Island Medical Journal 2013, 96: 26-9. PMID: 23641435.Peer-Reviewed Original ResearchConceptsHip diseaseTotal hip replacementNative bone stockOlder patientsYounger patientsAvascular necrosisGeriatric patientsHip arthritisMetabolic causesSurgical techniqueRevision arthroplastyBone stockHip replacementPatientsYoung populationDiseasePopulationArthritisOsteoarthritisArthroplastySymptomsNecrosisCare
2012
A rare but radiographically recognizable cause of an irreducible hip fracture-dislocation
Lawrence DA, Smitaman E, Baumgartner M, Haims A. A rare but radiographically recognizable cause of an irreducible hip fracture-dislocation. Clinical Imaging 2012, 37: 595-597. PMID: 23601776, DOI: 10.1016/j.clinimag.2012.06.009.Peer-Reviewed Original ResearchRisk Factors For Developing Avascular Necrosis Or Fractures In Patients With Type 1 Gaucher Disease: Analysis From The Gaucher Registry
Khan A, Hangartner T, Weinreb N, Taylor J, Mistry P. Risk Factors For Developing Avascular Necrosis Or Fractures In Patients With Type 1 Gaucher Disease: Analysis From The Gaucher Registry. Molecular Genetics And Metabolism 2012, 105: s39-s40. DOI: 10.1016/j.ymgme.2011.11.091.Peer-Reviewed Original Research
2011
Non-Cardiopulmonary Factors Affecting the Six-Minute Walk Distance in Patients with Sickle Cell Disease: Results From the Walk-PHaSST Study
Goel R, Hassell K, Machado R, Barst R, Yovetich N, Kato G, Gordeuk V, Little J, Gibbs J, Schraufnagel D, Girgis R, Rosenzweig E, Morris C, Badesch D, Lanzkron S, Onyekwere O, Nouraie M, Castro O, Sachdev V, Waclawiw M, Woolson R, Goldsmith J, Gladwin M, Krishnamurti L. Non-Cardiopulmonary Factors Affecting the Six-Minute Walk Distance in Patients with Sickle Cell Disease: Results From the Walk-PHaSST Study. Blood 2011, 118: 1074. DOI: 10.1182/blood.v118.21.1074.1074.Peer-Reviewed Original ResearchTR jet velocitySickle cell diseaseSix-minute walk distanceAvascular necrosisMultivariable linear regressionPulmonary hypertensionCell diseasePrimary endpointWalk distanceChronic painSCD patientsSevere genotypeAmerican Thoracic Society guidelinesSix-minute walk testSelf-reported medical historyThoracic Society guidelinesMulti-center studySided p valueGreater predictive valueCardiopulmonary factorsOral sildenafilPain 2NT-proBNPExercise capacityWalk test
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