2025
Addressing Peri-Device Leaks in Next-Generation Transcatheter Left Atrial Appendage Occluders: An Open Question
Roshanfar M, Jang S, Sinusas A, Wong S, Mosadegh B. Addressing Peri-Device Leaks in Next-Generation Transcatheter Left Atrial Appendage Occluders: An Open Question. Surgeries 2025, 6: 15. DOI: 10.3390/surgeries6010015.Peer-Reviewed Original ResearchPeri-device leakLeft atrial appendageFDA-approved devicesRisk of thrombo-embolic eventsNon-valvular atrial fibrillationLeft atrial appendage anatomyLong-term anticoagulationPercutaneous LAA occlusionCHA2DS2-VASc scoreThrombo-embolic eventsIncreased risk of strokeRisk of strokeCircular cross-sectionLeft atrial appendage occluderSystemic embolismAnticoagulant therapyLAA occlusionObservational registryCHA2DS2-VAScNon-pharmacological alternativeAdverse eventsAtrial fibrillationAtrial appendageClinical dataIncreased riskNatriuretic peptide testing in veterans hospitalized with heart failure: Potential differences by sex
Gandhi P, Runels T, Han L, Skanderson M, Bastian L, Brandt C, Hauser R, Feder S, Rodwin B, Farmer M, Bean-Mayberry B, Placide S, Gaffey A, Akgün K. Natriuretic peptide testing in veterans hospitalized with heart failure: Potential differences by sex. Heart & Lung 2025, 71: 25-31. PMID: 39970822, DOI: 10.1016/j.hrtlng.2025.02.001.Peer-Reviewed Original ResearchConceptsNatriuretic peptide testingHeart failure hospitalizationFacility characteristicsVeterans Affairs Healthcare SystemPeptide testingSex-based differencesFacility-related factorsSex-stratified modelsAssociated with increased likelihoodAssociated with decreased likelihoodHealthcare systemHF diagnosisEjection fractionCardiac comorbiditiesFailure hospitalizationClinical outcomesLogistic regressionAtrial fibrillationHeart failureVeteransClinical covariatesPatientsAdmissionSexAssociationA comprehensive evaluation of the left atrium using cardiovascular magnetic resonance
Pradella M, Elbaz M, Lee D, Hong K, Passman R, Kholmovski E, Peters D, Baraboo J, Herzka D, Nezafat R, Edelman R, Kim D. A comprehensive evaluation of the left atrium using cardiovascular magnetic resonance. Journal Of Cardiovascular Magnetic Resonance 2025, 27: 101852. PMID: 39920924, PMCID: PMC11889362, DOI: 10.1016/j.jocmr.2025.101852.Peer-Reviewed Original ResearchCardiovascular magnetic resonanceLeft atriumCardiac imaging modalitiesLeft atrial appendageContext of atrial fibrillationAtrial fibrillationAtrial appendageHeart failureAtrial diseaseAtrial myopathyImaging modalitiesMagnetic resonanceCardiovascular medicineClinical applicationImaging parametersAtriumMyopathyTissue characterizationMechanical thrombectomy in elderly stroke patients with low ASPECTS: insights from STAR
Cunningham C, Hubbard Z, Kasem R, Elawady S, Sowlat M, Matsukawa H, Maier I, Jabbour P, Kim J, Wolfe S, T A, Starke R, Psychogios M, Samaniego E, Goyal N, Yoshimura S, Cuellar H, Howard B, Alawieh A, Alaraj A, Ezzeldin M, Romano D, Tanweer O, Mascitelli J, Fragata I, Polifka A, Siddiqui F, Osbun J, Grandhi R, Crosa R, Matouk C, Park M, Levitt M, Brinjikji W, Moss M, Daglioglu E, Williamson R, Navia P, Kan P, De Leacy R, Chowdhry S, Altschul D, Al Kasab S, Spiotta A. Mechanical thrombectomy in elderly stroke patients with low ASPECTS: insights from STAR. Journal Of NeuroInterventional Surgery 2025, jnis-2024-022677. PMID: 39855673, DOI: 10.1136/jnis-2024-022677.Peer-Reviewed Original ResearchAlberta Stroke Program Early CT ScoreLow Alberta Stroke Program Early CT ScorePropensity score matchingSymptomatic intracranial hemorrhageEndovascular thrombectomyAnterior circulation large vessel occlusion acute ischemic strokeElderly patientsLVO-AISAssociated with 90-day mortalityRate of atrial fibrillationScore matchingLarge vessel occlusion acute ischemic strokeFirst-pass reperfusionAcute ischemic strokeCT scoreIntracranial hemorrhagePatient selectionMRS scoreAtrial fibrillationClinical factorsFavorable outcomeRecanalization ratePrimary outcomeMechanical thrombectomyPatientsA Bayesian Interpretation of CABANA and Other Randomized Controlled Trials for Catheter Ablation in Patients With Atrial Fibrillation
Nogueira A, Felix N, Kalil F, Tramujas L, Godoi A, Miyawaki I, Bellavia A, Moura F, Cardoso R, d'Avila A, Fernandes G. A Bayesian Interpretation of CABANA and Other Randomized Controlled Trials for Catheter Ablation in Patients With Atrial Fibrillation. Journal Of Cardiovascular Electrophysiology 2025, 36: 617-624. PMID: 39834105, DOI: 10.1111/jce.16552.Peer-Reviewed Original ResearchConceptsBayesian analysisTreatment effect distributionAdverse cardiovascular outcomesAll-cause mortalityCardiovascular outcomesRandomized controlled trialsFrequentist estimatorsCatheter ablationMedical therapyAtrial fibrillationBayesian interpretationImpact of catheter ablationControlled trialsAnalysis of randomized controlled trialsProbability distributionAtrial fibrillation patientsReduce adverse cardiovascular outcomesImpact of ablationEffective distributionRandom-effects modelBayes' theoremTrial-level dataProbabilistic understandingSurvival outcomesFibrillation patientsState of the Art in Left Atrial Appendage Occlusion
Garg J, Kabra R, Gopinathannair R, Di Biase L, Wang D, Saw J, Hahn R, Freeman J, Ellis C, Lakkireddy D. State of the Art in Left Atrial Appendage Occlusion. JACC Clinical Electrophysiology 2025, 11: 602-641. PMID: 39797854, DOI: 10.1016/j.jacep.2024.10.024.Peer-Reviewed Original ResearchConceptsLeft atrial appendage occlusionAppendage occlusionStroke preventionLeft atrial appendage occlusion devicesNonvalvular atrial fibrillationOptimal patient selectionDevice-related thrombusLeft atrial appendagePericardial effusionPostprocedural complicationsPatient selectionAtrial fibrillationAtrial appendageArrhythmia therapyDevice leakTherapeutic targetClinical needOcclusionPreventionStrokeEffects of sex on imaging-based intravenous thrombolysis for ischaemic stroke with unknown onset time: a pooled analysis of clinical trials.
Fukuda-Doi M, Koga M, Thomalla G, Jensen M, Inoue M, Yoshimura S, Miwa K, Gerloff C, Davis S, Donnan G, Ma H, Hacke W, Ringleb P, Wu O, Schwamm L, Warach S, Toyoda K. Effects of sex on imaging-based intravenous thrombolysis for ischaemic stroke with unknown onset time: a pooled analysis of clinical trials. European Stroke Journal 2025, 23969873241309512. PMID: 39749428, PMCID: PMC11696941, DOI: 10.1177/23969873241309512.Peer-Reviewed Original ResearchFavorable outcomeIntravenous thrombolysisPooled analysis of individual patient-level dataPooled analysisClinical trialsBaseline National Institutes of Health Stroke Scale scoreSex-based differencesPooled analysis of clinical trialsIschaemic strokeNational Institutes of Health Stroke Scale scoreSevere clinical statusIndividual patient-level dataStroke Scale scorePatient-level dataAnalysis of clinical trialsOrdinal regression modelAtrial fibrillationPatient sexClinical statusMultivariable adjustmentFemale sexThrombolysis trialsOnset timePrimary outcomeFunctional outcomesPerioperative Atrial Fibrillation and Anticoagulation Management
Tao J, Oprea A. Perioperative Atrial Fibrillation and Anticoagulation Management. 2025, 148-161. DOI: 10.1093/med/9780190902001.003.0013.Peer-Reviewed Original ResearchRisk of thrombosisAbstract Atrial fibrillationOral anticoagulantsPreoperative evaluation of surgical patientsCerebral vascular accidentClasses of oral anticoagulantsPatient's risk of thrombosisRisk of surgical bleedingEvaluation of surgical patientsVitamin K antagonistsPerioperative anticoagulation managementK antagonistsSurgical bleedingPreoperative evaluationAnticoagulation managementAtrial fibrillationSurgical patientsCardiac arrhythmiasPatient riskPatientsVascular accidentAnticoagulationRisk
2024
Racial and Ethnic Disparities in the Use and Outcomes With WATCHMAN FLX: A SURPASS Analysis of the NCDR Left Atrial Appendage Occlusion Registry
Alli O, Garg J, Boursiquot B, Kapadia S, Yeh R, Price M, Piccini J, Nair D, Hsu J, Gibson D, Allocco D, Christen T, Sutton B, Freeman J. Racial and Ethnic Disparities in the Use and Outcomes With WATCHMAN FLX: A SURPASS Analysis of the NCDR Left Atrial Appendage Occlusion Registry. Journal Of The American Heart Association 2024, 13: e036406. PMID: 39575715, PMCID: PMC11681556, DOI: 10.1161/jaha.124.036406.Peer-Reviewed Original ResearchLeft atrial appendage occlusionWatchman FLX implantationBlack patientsHispanic patientsOral anticoagulantsProcedural successRates of 1-year deathWhite patientsAlternative to oral anticoagulationRate of procedural successEthnic minority groupsEthnic minority individualsRate of deathSignificant bleedingWatchman FLXMinority individualsAppendage occlusionAntiplatelet therapyBaseline characteristicsAtrial fibrillationAnalyses assessed differencesMinority groupsPatientsStroke preventionBleedingEffect of apixaban versus vitamin K antagonist and aspirin versus placebo on days alive and out of hospital: An analysis from AUGUSTUS
Fanaroff A, Vora A, Wojdyla D, Mehran R, Granger C, Goodman S, Aronson R, Windecker S, Alexander J, Lopes R. Effect of apixaban versus vitamin K antagonist and aspirin versus placebo on days alive and out of hospital: An analysis from AUGUSTUS. American Heart Journal 2024, 280: 60-69. PMID: 39557109, DOI: 10.1016/j.ahj.2024.11.005.Peer-Reviewed Original ResearchConceptsAcute coronary syndromeTime-to-event analysisAtrial fibrillationCoronary syndromeClinical trialsEffect of antithrombotic therapyVitamin K antagonistsProportion of patientsRobust variance estimationRandomized clinical trialsClinical trial endpointsPercutaneous coronary interventionK antagonistsAntithrombotic therapyPoisson regressionTreatment armsFollow-upIschemic eventsPlaceboRate ratiosAntithrombotic agentsTrial endpointsWarfarinCoronary interventionIntervention methodsProteomic and phosphoproteomic identified structural and functional changes in the aorta associate with age-dependent hypertension in male Sprague-Dawley rats
Amraei R, Lampl N, Nist K, Zhang Y, Wainford R. Proteomic and phosphoproteomic identified structural and functional changes in the aorta associate with age-dependent hypertension in male Sprague-Dawley rats. Physiological Genomics 2024, 57: 16-27. PMID: 39548828, DOI: 10.1152/physiolgenomics.00052.2024.Peer-Reviewed Original ResearchIncreased risk of HFRisk of HFMendelian randomizationMR analysisCardiovascular diseaseTwo-sample bidirectional Mendelian randomizationBidirectional MR analysisBidirectional Mendelian randomizationInstrumental variablesIncreased riskUnited Kingdom BiobankCoronary artery diseaseCausal effectsHorizontal pleiotropyPleiotropy testConfounding factorsHeart failureObservational studyGenetic variantsAtrial fibrillationPotential associationManagement of patientsEuropean populationsClinical management of patientsReverse causal effectPATCH (Preferred Attachment Strategy for Optimal Electrocardiograms)-1 Study
Becker R, Harnett B, Wayne D, Mardis R, Meganathan K, Steen D. PATCH (Preferred Attachment Strategy for Optimal Electrocardiograms)-1 Study. Clinical Research In Cardiology 2024, 114: 497-506. PMID: 39527276, DOI: 10.1007/s00392-024-02572-6.Peer-Reviewed Original ResearchStable cardiovascular diseaseAmbulatory clinic visitsAmbulatory clinic settingCardiovascular diseaseS-ECGClinical research coordinatorsClinical indicationsClinic visitsResearch coordinatorsValvular heart diseaseCoronary artery diseaseMedical practiceParticipantsEssential hypertensionClinical settingLead placementAtrial fibrillationHeart diseaseHeart failureTreatment decisionsArtery diseaseST-TElectrocardiographyBaselineHeart rhythmAssociation of Chronic Kidney Disease and Kidney Failure with Replacement Therapy with Procedural and Long-Term Outcomes after First Generation Watchman Device: Insights from the NCDR LAAO Registry
Munir M, Tan Z, Pun P, Wang Y, Tandar A, Darden D, Hsu J, Friedman D, Curtis J, Freeman J. Association of Chronic Kidney Disease and Kidney Failure with Replacement Therapy with Procedural and Long-Term Outcomes after First Generation Watchman Device: Insights from the NCDR LAAO Registry. Heart Rhythm 2024 PMID: 39515495, DOI: 10.1016/j.hrthm.2024.10.071.Peer-Reviewed Original ResearchChronic kidney diseaseLong-term outcomesLeft atrial appendage occlusionAssociation of chronic kidney diseaseNational Cardiovascular Data Registry LAAO RegistryReplacement therapyAdverse eventsAtrial fibrillationKidney diseaseKidney failureAssociated with higher ratesIn-hospital deathRisk of strokeRate of strokeBilling claimsAF patientsProcedural complicationsAppendage occlusionWatchman deviceMultivariate analysisKFRTHigh riskPatientsRegistryComplicationsThe Impact of Frailty on Patients With AF and HFrEF Undergoing Catheter Ablation A Nationwide Population Study
Mark J, Colombo R, Alfonso C, Llanos A, Collado E, Larned J, Giese G, Dyal M, Nanna M, Damluji A. The Impact of Frailty on Patients With AF and HFrEF Undergoing Catheter Ablation A Nationwide Population Study. JACC Advances 2024, 3: 101358. PMID: 39600986, PMCID: PMC11588852, DOI: 10.1016/j.jacadv.2024.101358.Peer-Reviewed Original ResearchAdverse cardiovascular eventsCatheter ablationAtrial fibrillationCardiovascular eventsHeart failureFrail patientsHospital lengthNonfrail patientsReducing major adverse cardiovascular eventsAssociated with worse outcomesMajor adverse cardiovascular eventsReduced ejection fractionHospital length of stayIn-hospital mortalityLonger hospital lengthAssociated with increased oddsDischarge dispositionInfluence of frailtyMultivariate regression analysisNationwide Inpatient SampleImpact of frailtyLength of stayPrevalence of frailtyEjection fractionJohns Hopkins Adjusted Clinical GroupsAssociation of Physician Certification and Outcomes Among Patients Undergoing Left Atrial Appendage Occlusion
Vora A, Pereira L, Du C, Tan Z, Huang C, Friedman D, Wang Y, Faridi K, Lakkireddy D, Zimmerman S, Higgins A, Kapadia S, Curtis J, Freeman J. Association of Physician Certification and Outcomes Among Patients Undergoing Left Atrial Appendage Occlusion. JACC Cardiovascular Interventions 2024, 18: 591-602. PMID: 39474982, DOI: 10.1016/j.jcin.2024.10.020.Peer-Reviewed Original ResearchPhysician certificationAppendage occlusionAdverse eventsPercutaneous left atrial appendage occlusionLong-term oral anticoagulationDischarged patientsMultivariate Cox proportional hazards regression analysisRate of procedural complicationsLeft atrial appendage occlusionCox proportional hazards regression analysisProportional hazards regression analysisRisk of adverse eventsHazards regression analysisIn-hospital deathOral anticoagulantsWatchman FLXNo significant differenceLAAO devicesProcedural complicationsStratify patientsIntracardiac echocardiographyAtrial fibrillationEligible patientsIdentified patientsMultivariable adjustmentMigraine May Represent an Independent Risk Factor for Retinal Stroke: A Population-Based Cohort Study
Lusk J, Song A, Unnithan S, Al-Khalidi H, de Havenon A, Biousse V, Schrag M, Solopova E, Poli S, Osazuwa-Peters N, Xian Y, O'Brien E, Mac Grory B. Migraine May Represent an Independent Risk Factor for Retinal Stroke: A Population-Based Cohort Study. Clinical Neurology And Neurosurgery 2024, 246: 108587. PMID: 39405806, PMCID: PMC11527560, DOI: 10.1016/j.clineuro.2024.108587.Peer-Reviewed Original ResearchRetinal artery occlusionRetinal strokeRisk factorsCohort studyPopulation-based cohort studyState Emergency Department DatabasesPopulation-based dataEmergency Department DatabasesCause-specific hazard modelBurden of atrial fibrillationCongestive cardiac failureIndependent risk factorChronic kidney diseasePrimary exposureDepartment databasePrimary endpointSecondary endpointsCardiac failureAtrial fibrillationHazards modelRobust associationsArtery occlusionKidney diseaseMigraineDiagnostic positionsCerebrovascular Events in Patients Undergoing Transcatheter Aortic Valve Replacement: A Review
Patel K, Rathod K, Lansky A, Prendergast B, Kharbanda R, Mathur A, Perry R, Baumbach A. Cerebrovascular Events in Patients Undergoing Transcatheter Aortic Valve Replacement: A Review. Stroke 2024, 55: 2754-2764. PMID: 39371005, DOI: 10.1161/strokeaha.124.047149.Peer-Reviewed Original ResearchTranscatheter aortic valve replacementAortic valve replacementCerebrovascular eventsValve replacementAtrial fibrillationLow operative risk patientsAdvent of transcatheter aortic valve replacementNew-onset atrial fibrillationComplication of transcatheter aortic valve replacementIncreased risk of bleedingHigher risk of cerebrovascular eventsAssociated with significant mortalityTranscatheter aortic valve replacement procedureRisk of cerebrovascular eventsOperative risk patientsResults of embolizationRisk of bleedingRisk of thromboembolismHypoattenuated leaflet thickeningImprove risk stratificationCerebral lesion volumeAssociated with cerebrovascular eventsTherapy to patientsOverall stroke rateSeverity of comorbiditiesSequencing Quadruple Therapy for Heart Failure with Reduced Ejection Fraction: Does It Really Matter?
Hu J, Schwann A, Tan J, Nuqali A, Riello R, Beasley M. Sequencing Quadruple Therapy for Heart Failure with Reduced Ejection Fraction: Does It Really Matter? Heart Failure Clinics 2024, 20: 373-386. PMID: 39216923, DOI: 10.1016/j.hfc.2024.06.004.Peer-Reviewed Original ResearchEsophageal damage following left atrial ablation in a patient on dabigatran: adding insult to injury
Jalloul S, Jreij C, Karam K, Salem J, Chaptini L. Esophageal damage following left atrial ablation in a patient on dabigatran: adding insult to injury. European Journal Of Case Reports In Internal Medicine 2024, 11: 004832. PMID: 39372148, PMCID: PMC11451853, DOI: 10.12890/2024_004832.Peer-Reviewed Original ResearchAtrial Fibrillation: Prevalence and Association With Outcome in Patients With Stroke Undergoing Mechanical Thrombectomy in the United States
Otite F, Patel S, Hoffman H, Aneni E, Anikpezie N, Akano E, Wee C, Burke D, Albright K, Beutler T, Latorre J, Sonig A, Singla A, Morris N, Chaturvedi S, Khandelwal P. Atrial Fibrillation: Prevalence and Association With Outcome in Patients With Stroke Undergoing Mechanical Thrombectomy in the United States. Stroke Vascular And Interventional Neurology 2024, 4 DOI: 10.1161/svin.123.001248.Peer-Reviewed Original ResearchAcute ischemic strokeAF prevalenceJoinpoint regressionAtrial fibrillationIn-hospital deathIn-hospital outcomesMechanical thrombectomyDemographic subgroupsMultivariable-adjusted generalized linear modelsDemographic subgroups of patientsOdds of in-hospital deathCross-sectional studyNegative binomial regressionPrevalence of atrial fibrillationRoutine home dischargeNational Inpatient SampleAcute ischemic stroke populationAssociation of AFUnited StatesSubgroup of patientsHome dischargeBinomial regressionMultivariable adjustmentRacial subgroupsInpatient Sample
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