2025
Addressing Peri-Device Leaks in Next-Generation Transcatheter Left Atrial Appendage Occluders: An Open Question
Roshanfar M, Jang S, Sinusas A, Wong S, Mosadegh B. Addressing Peri-Device Leaks in Next-Generation Transcatheter Left Atrial Appendage Occluders: An Open Question. Surgeries 2025, 6: 15. DOI: 10.3390/surgeries6010015.Peer-Reviewed Original ResearchPeri-device leakLeft atrial appendageFDA-approved devicesRisk of thrombo-embolic eventsNon-valvular atrial fibrillationLeft atrial appendage anatomyLong-term anticoagulationPercutaneous LAA occlusionCHA2DS2-VASc scoreThrombo-embolic eventsIncreased risk of strokeRisk of strokeCircular cross-sectionLeft atrial appendage occluderSystemic embolismAnticoagulant therapyLAA occlusionObservational registryCHA2DS2-VAScNon-pharmacological alternativeAdverse eventsAtrial fibrillationAtrial appendageClinical dataIncreased riskA comprehensive evaluation of the left atrium using cardiovascular magnetic resonance
Pradella M, Elbaz M, Lee D, Hong K, Passman R, Kholmovski E, Peters D, Baraboo J, Herzka D, Nezafat R, Edelman R, Kim D. A comprehensive evaluation of the left atrium using cardiovascular magnetic resonance. Journal Of Cardiovascular Magnetic Resonance 2025, 27: 101852. PMID: 39920924, PMCID: PMC11889362, DOI: 10.1016/j.jocmr.2025.101852.Peer-Reviewed Original ResearchCardiovascular magnetic resonanceLeft atriumCardiac imaging modalitiesLeft atrial appendageContext of atrial fibrillationAtrial fibrillationAtrial appendageHeart failureAtrial diseaseAtrial myopathyImaging modalitiesMagnetic resonanceCardiovascular medicineClinical applicationImaging parametersAtriumMyopathyTissue characterizationState of the Art in Left Atrial Appendage Occlusion
Garg J, Kabra R, Gopinathannair R, Di Biase L, Wang D, Saw J, Hahn R, Freeman J, Ellis C, Lakkireddy D. State of the Art in Left Atrial Appendage Occlusion. JACC Clinical Electrophysiology 2025, 11: 602-641. PMID: 39797854, DOI: 10.1016/j.jacep.2024.10.024.Peer-Reviewed Original ResearchConceptsLeft atrial appendage occlusionAppendage occlusionStroke preventionLeft atrial appendage occlusion devicesNonvalvular atrial fibrillationOptimal patient selectionDevice-related thrombusLeft atrial appendagePericardial effusionPostprocedural complicationsPatient selectionAtrial fibrillationAtrial appendageArrhythmia therapyDevice leakTherapeutic targetClinical needOcclusionPreventionStroke
2024
Unforeseen and Immediate: A Case of a Post-Watchman Device-Related Thrombus
Sethi S, Stolear A, Dulgher M, Nwokeocha N, Mejia V, Shkolnik E. Unforeseen and Immediate: A Case of a Post-Watchman Device-Related Thrombus. Cureus 2024, 16: e63442. PMID: 39077225, PMCID: PMC11284824, DOI: 10.7759/cureus.63442.Peer-Reviewed Original ResearchDevice-related thrombusLeft atrial appendageOral anticoagulantsLAA occlusionLong-term oral anticoagulationAssociated with increased morbidityLeft atrial appendage occlusionHeparin dripPeriprocedural managementPrompt diagnosisThrombus resolutionSafety profileRare caseWatchman deviceArterial thromboembolismAtrial fibrillationAtrial appendageLeft atriumPersistent AFibAtrial sideRisk factorsBlood clot formationThrombusPatientsTherapeutic interventions
2023
The Left Atrial Appendage and Atrial Fibrillation—A Contemporary Review
Sulague R, Whitham T, Danganan L, Effiom V, Candelario K, Latif N, Hameed I. The Left Atrial Appendage and Atrial Fibrillation—A Contemporary Review. Journal Of Clinical Medicine 2023, 12: 6909. PMID: 37959374, PMCID: PMC10650862, DOI: 10.3390/jcm12216909.Peer-Reviewed Original ResearchLeft atrial appendageAtrial appendageAtrial fibrillationClinical utilityThrombus formationAtrial appendage occlusionGood alternative treatmentProcedure's clinical utilityThromboembolism prophylaxisThromboembolic eventsAppendage occlusionAlternative treatmentPatientsFibrillationContemporary reviewProphylaxisSCAI/HRS Expert Consensus Statement on Transcatheter Left Atrial Appendage Closure
Saw J, Holmes D, Cavalcante J, Freeman J, Goldsweig A, Kavinsky C, Moussa I, Munger T, Price M, Reisman M, Sherwood M, Turi Z, Wang D, Whisenant B. SCAI/HRS Expert Consensus Statement on Transcatheter Left Atrial Appendage Closure. Journal Of The Society For Cardiovascular Angiography & Interventions 2023, 2: 100577. PMID: 39130704, PMCID: PMC11307869, DOI: 10.1016/j.jscai.2022.100577.Peer-Reviewed Original ResearchAtrial appendage closureAppendage closureConsensus statementTranscatheter Left Atrial Appendage ClosureLeft atrial appendage closureImportant clinical trialsExpert consensus statementLeft atrial appendageCardiovascular Computed TomographyDrug Administration approvalEvidence-based best practicesThromboembolic riskWatchman deviceLAAC procedureAtrial fibrillationAtrial appendageAdministration approvalClinical trialsCardiovascular AngiographyAmerican CollegeComputed tomographyClinical developmentClinical practiceEndovascular devices
2022
Abnormal left atrial body stiffness is predicted by appendage size: impact of appendage occlusion on left atrial mechanics assessed by pressure-volume analysis
Bregasi A, Freeman JV, Curtis JP, Akar JG, Ortiz-Leon XA, Maia JH, Higgins AY, Matthews RV, Sinusas AJ, McNamara RL, Sugeng L, Lin BA. Abnormal left atrial body stiffness is predicted by appendage size: impact of appendage occlusion on left atrial mechanics assessed by pressure-volume analysis. AJP Heart And Circulatory Physiology 2022, 323: h559-h568. PMID: 35960632, PMCID: PMC9576173, DOI: 10.1152/ajpheart.00083.2022.Peer-Reviewed Original ResearchConceptsLeft atrial appendage occlusionLA stiffnessAppendage occlusionLA appendageLA mechanicsTransesophageal echocardiographyPressure-volume analysisPercutaneous left atrial appendage occlusionAdverse atrial remodelingAtrial appendage occlusionLeft atrial appendageLA volume measurementsAtrial cardiomyopathyBaseline characteristicsLA complianceAtrial remodelingClinical outcomesAtrial appendageAtrial mechanicsCardiac performancePathophysiological roleBaseline parametersMagnitude of increaseAppendage sizeOcclusionRegional heterogeneity in determinants of atrial matrix remodeling and association with atrial fibrillation vulnerability postmyocardial infarction
Stacy MR, Lin BA, Thorn SL, Lobb DC, Maxfield MW, Novack C, Zellars KN, Freeburg L, Akar JG, Sinusas AJ, Spinale FG. Regional heterogeneity in determinants of atrial matrix remodeling and association with atrial fibrillation vulnerability postmyocardial infarction. Heart Rhythm 2022, 19: 847-855. PMID: 35066183, PMCID: PMC9064890, DOI: 10.1016/j.hrthm.2022.01.022.Peer-Reviewed Original ResearchConceptsAtrial fibrillationMyocardial infarctionRight atrial regionsAtrial regionsPost-MIMMP activityMatrix metalloproteinasesMMP/TIMP profilesNew-onset atrial fibrillationLeft atrial regionsMMP/TIMP expressionLeft atrial appendageMatrix remodelingElectrical stimulation protocolFibrillar collagen contentExtracellular matrix remodelingAF vulnerabilityTIMP profilesAtrial appendagePostmyocardial infarctionMyocardial substrateStimulation protocolNoninvasive molecular imagingTIMP expressionTissue inhibitorIntraoperative echocardiographic contrast opacifies the left atrial appendage and assists in surgical exclusion
Santana J, Rosell F, Dave B, Manafi A. Intraoperative echocardiographic contrast opacifies the left atrial appendage and assists in surgical exclusion. Annals Of Cardiac Anaesthesia 2022, 25: 77-80. PMID: 35075025, PMCID: PMC8865348, DOI: 10.4103/aca.aca_192_20.Peer-Reviewed Original Research
2020
Pulmonary Venoatrial Connection Using a Ringed Tube Graft to Repair Partial Anomalous Pulmonary Venous Return
Ong CS, D’Alessandro DA, Cameron DE, Melnitchouk S. Pulmonary Venoatrial Connection Using a Ringed Tube Graft to Repair Partial Anomalous Pulmonary Venous Return. World Journal For Pediatric And Congenital Heart Surgery 2020, 11: 672-674. PMID: 32853065, DOI: 10.1177/2150135120918785.Peer-Reviewed Original ResearchConceptsPartial anomalous pulmonary venous returnAnomalous pulmonary venous returnPulmonary venous returnTube graftVenous returnLeft-sided partial anomalous pulmonary venous returnPolytetrafluoroethylene tube graftLeft atrial appendageTension-free anastomosisPulmonary veinsAtrial appendageVenoatrial connectionsVertical veinGraftVeinPatientsAnastomosisCHANGES OF LEFT ATRIAL APPENDAGE ORIFICE FOLLOWING PERCUTANEOUS LEFT ATRIAL APPENDAGE CLOSURE USING THREE-DIMENSIONAL ECHOCARDIOGRAPHY
Ortiz-Leon X, Posada E, Chen W, Bregasi A, Crandall I, Pereira J, Miranda J, Akar J, Lin B, McNamara R, Freeman J, Curtis J, Arias-Godínez J, Sugeng L. CHANGES OF LEFT ATRIAL APPENDAGE ORIFICE FOLLOWING PERCUTANEOUS LEFT ATRIAL APPENDAGE CLOSURE USING THREE-DIMENSIONAL ECHOCARDIOGRAPHY. Journal Of The American College Of Cardiology 2020, 75: 1708. DOI: 10.1016/s0735-1097(20)32335-4.Peer-Reviewed Original Research
2019
Interatrial Septum and Appendage Ostium in Atrial Fibrillation Patients: A Population Study
Goparaju A, Morris A, Csecs I, Bhalodia R, Ditter T, Fuimaono K, Kholmovski E, Marrouche N, Cates J, Elhabian S. Interatrial Septum and Appendage Ostium in Atrial Fibrillation Patients: A Population Study. 2016 Computing In Cardiology Conference (CinC) 2019, 46: 1-3. PMID: 32632372, PMCID: PMC7338039, DOI: 10.22489/cinc.2019.439.Peer-Reviewed Original ResearchLeft atrial appendageLeft atrial appendage closureAtrial fibrillationInteratrial septumAtrial fibrillation patientsFibrillation patientsPatient-specific implant selectionImage guidanceOstium planeAtrial appendagePopulation studiesImplant choiceImplant selectionPrevent strokeAppendage ostiumPatientsCatheter designSeptumOstiumOcclusionDifferentiating spontaneous echo contrast, sludge, and thrombus in the left atrial appendage: Can ultrasound enhancing agents help?
Posada‐Martinez E, Trejo‐Paredes C, Ortiz‐Leon X, Ivey‐Miranda J, Lin BA, McNamara RL, Arias‐Godinez J, Lombo B, Sugeng L. Differentiating spontaneous echo contrast, sludge, and thrombus in the left atrial appendage: Can ultrasound enhancing agents help? Echocardiography 2019, 36: 1413-1417. PMID: 31260135, DOI: 10.1111/echo.14405.Peer-Reviewed Original ResearchMastering the art of epicardial access in cardiac electrophysiology
Romero J, Shivkumar K, Di Biase L, Avendano R, Anderson R, Natale A, Kumar S. Mastering the art of epicardial access in cardiac electrophysiology. Heart Rhythm 2019, 16: 1738-1749. PMID: 31015022, DOI: 10.1016/j.hrthm.2019.04.038.Peer-Reviewed Original ResearchConceptsVentricular arrhythmiasEpicardial accessEpicardial spaceRight ventricular perforationAtrial appendage occlusionAtrial fibrillation proceduresRight atrial appendageCardiac magnetic resonanceEpicardial pacing leadsVentricular perforationCoronary sinusAppendage occlusionCatheter ablationEsophageal protectionCardiac proceduresAccessory pathwayAtrial appendageNerve displacementTraditional indicationsPacing leadsSafe ablationCardiac anatomyNovel indicationsMultiple technological advancesAccess success
2018
Periprocedural Use of Oral Anticoagulation Therapy in Patients Undergoing Atrial Fibrillation Ablation
Maraj I, Gonzalez MD, Naccarelli GV. Periprocedural Use of Oral Anticoagulation Therapy in Patients Undergoing Atrial Fibrillation Ablation. Journal Of Innovations In Cardiac Rhythm Management 2018, 9: 3274-3281. PMID: 32477818, PMCID: PMC7252752, DOI: 10.19102/icrm.2018.090801.Peer-Reviewed Original ResearchAtrial fibrillationStroke preventionCatheter ablationLeft atrial appendage occlusion devicesAtrial appendage occlusion devicesRhythm control strategyOral anticoagulation therapyImportant treatment strategyRisk of strokeAtrial fibrillation ablationCommon sustained arrhythmiaLeft atrial appendageClinical practice todayOral anticoagulationPeriprocedural useAnticoagulation therapySurgical exclusionFibrillation ablationSustained arrhythmiaDrug optionsAtrial appendageTreatment strategiesHigh riskOcclusion devicePatientsLeft Atrial Appendage Morphology and Embolic Stroke of Undetermined Source: A Cross-Sectional Multicenter Pilot Study
Yaghi S, Chang AD, Hung P, Mac Grory B, Collins S, Gupta A, Reynolds J, Finn CB, Hemendinger M, Cutting SM, McTaggart RA, Jayaraman M, Leasure A, Sansing L, Panda N, Song C, Chu A, Merkler A, Gialdini G, Sheth KN, Kamel H, Elkind MSV, Greer D, Furie K, Atalay M. Left Atrial Appendage Morphology and Embolic Stroke of Undetermined Source: A Cross-Sectional Multicenter Pilot Study. Journal Of Stroke And Cerebrovascular Diseases 2018, 27: 1497-1501. PMID: 29398537, DOI: 10.1016/j.jstrokecerebrovasdis.2017.12.036.Peer-Reviewed Original ResearchConceptsLeft atrial appendageNoncardioembolic strokeLAA morphologyIschemic strokeEmbolic strokeStroke subtypesChest CTUndetermined sourcePilot studyComprehensive stroke centerMulticenter pilot studyNon-chicken wing LAA morphologyRetrospective pilot studyAtrial appendage morphologyInpatient diagnostic evaluationESUS criteriaClinical chest CTCardioembolic strokeCE strokeStroke centersConsecutive patientsAtrial fibrillationMean ageAtrial appendageDiagnostic evaluation
2017
Endothelial and smooth muscle cells derived from human cardiac explants demonstrate angiogenic potential and suitable for design of cell-containing vascular grafts
Zakharova I, Zhiven’ M, Saaya S, Shevchenko A, Smirnova A, Strunov A, Karpenko A, Pokushalov E, Ivanova L, Makarevich P, Parfyonova Y, Aboian E, Zakian S. Endothelial and smooth muscle cells derived from human cardiac explants demonstrate angiogenic potential and suitable for design of cell-containing vascular grafts. Journal Of Translational Medicine 2017, 15: 54. PMID: 28257636, PMCID: PMC5336693, DOI: 10.1186/s12967-017-1156-1.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood Vessel ProsthesisCell DifferentiationCell ProliferationCell SeparationCell SurvivalCells, CulturedChitosanEndothelial CellsHumansMice, SCIDMyocardiumMyocytes, Smooth MuscleNeovascularization, PhysiologicPlatelet Endothelial Cell Adhesion Molecule-1PolyestersProsthesis DesignWeibel-Palade BodiesConceptsSmooth muscle cellsRight atrial appendageMuscle cellsCardiac explantsAtrial appendageHuman right atrial appendagesEndothelial cellsHuman cardiac explantsAngiogenic potentialRight ventricular myocardiumAcetylated low-density lipoproteinLow-density lipoproteinSmooth muscle cell culturesReplacement therapyCell replacement therapyPrimary cell culturesImmunodeficient miceVentricular myocardiumAngiogenic cytokinesCell culturesWeibel-Palade bodiesMyosin heavy chainAngiogenic potencySpecific pathologyVascular cells
2016
The Use of Standard Gastrointestinal Endoscopic Ultrasound to Assess Cardiac Anatomy
Sentissi K, Sawhney M, Pleskow D, Sepe P, Mella J, Kwittken B, Ketwaroo G, Subramaniam B. The Use of Standard Gastrointestinal Endoscopic Ultrasound to Assess Cardiac Anatomy. Anesthesia & Analgesia 2016, 123: 547-550. PMID: 27541718, DOI: 10.1213/ane.0000000000001380.Peer-Reviewed Original ResearchConceptsVentricular functionAortic valveMitral valveRight ventricular systolic functionLinear echoendoscopeCardiovascular Anesthesiologists guidelinesEchocardiography/SocietyDepressed ventricular functionProspective observational studyVentricular systolic functionTransesophageal echocardiography examinationStandard clinical indicationsAcademic medical centerEarly diagnostic toolFormal echocardiographyPericardial effusionSystolic functionAortic dissectionAortic stenosisPulmonic valveTricuspid valveEchocardiography examinationAtrial appendageCardiac assessmentClinical indicationsTranscatheter valve implantation for right atrium‐to‐right ventricle conduit obstruction or regurgitation after modified Björk–fontan procedure
Shah AH, Horlick EM, Eicken A, Asnes JD, Bocks ML, Boudjemline Y, Cabalka AK, Fagan TE, Schubert S, Mahadevan VS, Dvir D, Osten M, McElhinney DB. Transcatheter valve implantation for right atrium‐to‐right ventricle conduit obstruction or regurgitation after modified Björk–fontan procedure. Catheterization And Cardiovascular Interventions 2016, 89: 298-305. PMID: 27465501, DOI: 10.1002/ccd.26648.Peer-Reviewed Original ResearchMeSH KeywordsAdultBioprosthesisBlood Vessel ProsthesisBlood Vessel Prosthesis ImplantationCanadaCardiac CatheterizationEuropeFemaleFontan ProcedureGraft Occlusion, VascularHeart Defects, CongenitalHeart Valve DiseasesHeart Valve ProsthesisHeart Valve Prosthesis ImplantationHemodynamicsHumansMaleMiddle AgedNorth AmericaProsthesis DesignProsthesis FailureRecovery of FunctionRegistriesRetrospective StudiesStentsTime FactorsTreatment OutcomeConceptsRight ventricleBjörk modificationFontan procedureValve implantationExtra-anatomic graftRetrospective multicenter registrySapien valve implantationLow procedural riskTranscatheter valve implantationRight atrial appendageCardiovascular causesPercutaneous transcatheterRA-RVUncomplicated implantationMulticenter registrySAPIEN 3Clinical improvementValve dysfunctionConduit dysfunctionFontan circulationPulmonary circulationAtrial appendageFontan pathwayTranscatheter implantationProcedural riskCost-Effectiveness of Percutaneous Closure of the Left Atrial Appendage in Atrial Fibrillation Based on Results From PROTECT AF Versus PREVAIL
Freeman JV, Hutton DW, Barnes GD, Zhu RP, Owens DK, Garber AM, Go AS, Hlatky MA, Heidenreich PA, Wang PJ, Al-Ahmad A, Turakhia MP. Cost-Effectiveness of Percutaneous Closure of the Left Atrial Appendage in Atrial Fibrillation Based on Results From PROTECT AF Versus PREVAIL. Circulation Arrhythmia And Electrophysiology 2016, 9: e003407. PMID: 27307517, PMCID: PMC4911813, DOI: 10.1161/circep.115.003407.Peer-Reviewed Original ResearchConceptsLAA closureLeft atrial appendageQuality-adjusted life yearsPROTECT AFAtrial fibrillationPercutaneous closureWatchman deviceAtrial appendageLife yearsTrial dataWATCHMAN LAA closure devicePROTECT AF trialIncremental cost-effectiveness ratioMajor adverse eventsPrevention of strokeAtrial appendage closureProspective Randomized EvaluationLAA closure deviceLong-term trial resultsQuality-adjusted survivalCost-effectiveness ratioCost-effectiveness resultsMedical anticoagulationAF trialAdverse events
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