2024
Ferroptosis in Osteoarthritis: Towards Novel Therapeutic Strategy
Zhang Y, Li J, Liu J, Gao Y, Li K, Zhao X, Liu Y, Wang D, Hu X, Wang Z. Ferroptosis in Osteoarthritis: Towards Novel Therapeutic Strategy. Cell Proliferation 2024, 58: e13779. PMID: 39624950, PMCID: PMC11882765, DOI: 10.1111/cpr.13779.Peer-Reviewed Original ResearchArticular cartilageTherapeutic strategiesChondrocyte viabilityCell deathMechanical stressNovel therapeutic strategiesOA cartilagePotential therapeutic strategyIron-dependent formPersistent painRegulated cell deathAutophagic cell deathIron overloadPathogenetic mechanismsExtracellular matrix integrityInflammatory responseSurgical Approach to Patellofemoral Pain
Schneble C, Fulkerson J. Surgical Approach to Patellofemoral Pain. 2024, 1-17. DOI: 10.1007/978-3-030-82869-1_69-1.ChaptersPatellofemoral painSurgical treatmentTreatment of patellofemoral painPeripatellar soft tissuesAnterior knee painSource of painPain improvementPersistent painPain sourceSurgical approachNonsurgical treatmentSurgical interventionKnee painOrthopedic providersPainPatellofemoral syndromeRealignment proceduresAlleviate symptomsSoft tissue releaseSoft tissuePatellofemoral jointTissue releaseArticular cartilageTreatmentSubchondral bone
2023
Three-Dimensional Printing of Models of Patellofemoral Joint Articular Cartilage in Patients With Patella Instability for Observing Joint Congruity
Beitler B, Kunsel K, Yu K, Wang A, Tommasini S, Wiznia D, Fulkerson J. Three-Dimensional Printing of Models of Patellofemoral Joint Articular Cartilage in Patients With Patella Instability for Observing Joint Congruity. Arthroscopy Techniques 2023, 12: e1853-e1858. PMID: 37942111, PMCID: PMC10628265, DOI: 10.1016/j.eats.2023.06.016.Peer-Reviewed Original ResearchBiomechanical Impact of Phosphate Wasting on Articular Cartilage Using the Murine Hyp Model of X‐linked hypophosphatemia
Macica C, Tommasini S. Biomechanical Impact of Phosphate Wasting on Articular Cartilage Using the Murine Hyp Model of X‐linked hypophosphatemia. JBMR Plus 2023, 7: e10796. PMID: 37808393, PMCID: PMC10556269, DOI: 10.1002/jbm4.10796.Peer-Reviewed Original ResearchWT miceHyp miceMechanical propertiesArticular cartilageTrabecular bone volumeProgression of osteoarthritisEtiology of osteoarthritisRange of motionSubchondral bone plateOral phosphateDegenerative osteoarthritisTibial articular cartilageDaily livingAC stiffnessBone volumeTherapeutic restorationOsteoarthritisStructural stiffnessCompressive loadingMicePeak loadTherapyCellular changesMineral deficitStress relaxationCartilage-Related Collagens in Osteoarthritis and Rheumatoid Arthritis: From Pathogenesis to Therapeutics
Ouyang Z, Dong L, Yao F, Wang K, Chen Y, Li S, Zhou R, Zhao Y, Hu W. Cartilage-Related Collagens in Osteoarthritis and Rheumatoid Arthritis: From Pathogenesis to Therapeutics. International Journal Of Molecular Sciences 2023, 24: 9841. PMID: 37372989, PMCID: PMC10298547, DOI: 10.3390/ijms24129841.Peer-Reviewed Original ResearchConceptsRheumatoid arthritisArticular cartilageCourse of osteoarthritisNew biochemical markersDisease progressionPathogenic factorsCartilage damageDegradation of collagenBiochemical markersProgressive destructionClinical diagnosisMechanical injuryConnective tissueDisease statesRole of collagenCollagen productionLow immunogenicityFacilitate drug developmentArthritisDrug developmentOsteoarthritisBiomechanical propertiesMechanical functionCartilageCollagenAdvances in Cartilage Repair
Azam M, Butler J, Duenes M, McAllister T, Walls R, Gianakos A, Kennedy J. Advances in Cartilage Repair. Orthopedic Clinics Of North America 2023, 54: 227-236. PMID: 36894294, DOI: 10.1016/j.ocl.2022.11.007.Peer-Reviewed Original ResearchConceptsAutologous osteochondral transplantationBone marrow stimulationPoor healing capacityAnkle painUncontained lesionsConservative managementArthroscopic debridementCystic lesionsBiological adjuvantsTraumatic etiologyOsteochondral transplantationInvasive proceduresOsteochondral lesionsLarge lesionsMarrow stimulationAnkle jointLesionsSmall lesionsScaffold-based therapiesHealing capacityPatientsArticular cartilageUnsatisfactory resultsCartilage repairDebridement
2022
Treating ‘Septic’ With Enhanced Antibiotics and ‘Arthritis’ by Mitigation of Excessive Inflammation
Kwon HK, Dussik CM, Kim SH, Kyriakides TR, Oh I, Lee FY. Treating ‘Septic’ With Enhanced Antibiotics and ‘Arthritis’ by Mitigation of Excessive Inflammation. Frontiers In Cellular And Infection Microbiology 2022, 12: 897291. PMID: 35755835, PMCID: PMC9218192, DOI: 10.3389/fcimb.2022.897291.Peer-Reviewed Original ResearchConceptsSeptic arthritisBacterial burdenAntibiotic treatmentMurine modelTherapeutic goalsConcurrent antimicrobial therapyDistinct therapeutic goalsGeneration of inflammationMRSA septic arthritisSeptic knee arthritisInflammatory joint conditionsArticular cartilageMitigation of inflammationPost-antibiotic treatmentNovel therapeutic strategiesSeptic arthritis modelArticular cartilage damageEx vivo modelArticular cartilage integrityInflammatory arthritisInhibitors of ERKInflammatory profileMRSA infectionSynovial tissueExcessive inflammationAcid-sensitive ion channel 1a mediates osteoarthritis chondrocyte senescence by promoting Lamin B1 degradation
Ding J, Chen Y, Zhao Y, Chen F, Dong L, Zhang H, Hu W, Li S, Zhou R, Hu W. Acid-sensitive ion channel 1a mediates osteoarthritis chondrocyte senescence by promoting Lamin B1 degradation. Biochemical Pharmacology 2022, 202: 115107. PMID: 35643339, DOI: 10.1016/j.bcp.2022.115107.Peer-Reviewed Original ResearchConceptsAcid-sensitive ion channel 1aChondrocyte senescenceIon channel 1aChannel 1aBeclin-1Chronic joint diseaseBeclin-1 protein expressionRat OA modelProtein Beclin 1Senescence-related markersJoint diseaseOA modelAging of chondrocytesJoint cavityPsalmotoxin-1Chondrocyte autophagyOsteoarthritisB1 expressionProtein expressionCationic channelsHairpin RNALamin B1Autophagy pathwayArticular cartilageLamin B1 expressionArthroscopic Patellar Osteochondral Transplantation
Hsu J, Linhoff J. Arthroscopic Patellar Osteochondral Transplantation. Arthroscopy Techniques 2022, 11: e475-e481. PMID: 35256994, PMCID: PMC8897650, DOI: 10.1016/j.eats.2021.11.017.Peer-Reviewed Original Research
2021
A 24-Year-Old Female with Anterior Knee Pain, Normal Looking Cartilage, and Mild Malalignment
Aitchison A, Fulkerson J, Tompkins M, Green D. A 24-Year-Old Female with Anterior Knee Pain, Normal Looking Cartilage, and Mild Malalignment. 2021, 161-164. DOI: 10.1007/978-3-030-81545-5_16.Peer-Reviewed Original ResearchInfluence of pore sizes in 3D-scaffolds on mechanical properties of scaffolds and survival, distribution, and proliferation of human chondrocytes
Abpeikar Z, Milan P, Moradi L, Anjomshoa M, Asadpour S. Influence of pore sizes in 3D-scaffolds on mechanical properties of scaffolds and survival, distribution, and proliferation of human chondrocytes. Mechanics Of Advanced Materials And Structures 2021, 29: 4911-4922. DOI: 10.1080/15376494.2021.1943077.Peer-Reviewed Original ResearchDual therapeutic targeting of intra-articular inflammation and intracellular bacteria enhances chondroprotection in septic arthritis
Kwon HK, Lee I, Yu KE, Cahill SV, Alder KD, Lee S, Dussik CM, Back J, Choi J, Song L, Kyriakides TR, Lee FY. Dual therapeutic targeting of intra-articular inflammation and intracellular bacteria enhances chondroprotection in septic arthritis. Science Advances 2021, 7: eabf2665. PMID: 34172438, PMCID: PMC8232912, DOI: 10.1126/sciadv.abf2665.Peer-Reviewed Original ResearchConceptsIntra-articular inflammationSeptic arthritisBacterial infectionsDual therapeutic targetingKnee septic arthritisPromising new therapeutic strategyArticular cartilageChallenging clinical problemNovel treatment modalitiesIntracellular bacteriaNew therapeutic strategiesAdjuvant targetingTreatment modalitiesBacterial eradicationSuccessful treatmentHost inflammationCausative bacteriaMurine modelTherapeutic strategiesArthritisTherapeutic goalsClinical problemTherapeutic targetingInflammationVital organs
2020
Current Concepts Regarding Patellofemoral Trochlear Dysplasia
Levy BJ, Tanaka MJ, Fulkerson JP. Current Concepts Regarding Patellofemoral Trochlear Dysplasia. The American Journal Of Sports Medicine 2020, 49: 1642-1650. PMID: 33021814, DOI: 10.1177/0363546520958423.Peer-Reviewed Original ResearchConceptsRecurrent patellar instabilityTrochlear dysplasiaPatellar instabilityPatellofemoral jointMedial quadriceps tendon-femoral ligamentMajority of patientsTibial tubercle transferMajority of casesArticular cartilageSurgical stabilizationMedial patellofemoralOptimal treatmentTubercle transferDysplasiaPatientsComplex structural anomaliesPatellofemoral trackingSurgical planningTrochleoplastyStructural anomaliesSpecific deficitsCartilagePatellofemoralMajority
2018
Necrostatin-1 ameliorates adjuvant arthritis rat articular chondrocyte injury via inhibiting ASIC1a-mediated necroptosis
Chen Y, Zhu C, Zhu F, Dai B, Song S, Wang Z, Feng Y, Ge J, Zhou R, Chen F. Necrostatin-1 ameliorates adjuvant arthritis rat articular chondrocyte injury via inhibiting ASIC1a-mediated necroptosis. Biochemical And Biophysical Research Communications 2018, 504: 843-850. PMID: 30219231, DOI: 10.1016/j.bbrc.2018.09.031.Peer-Reviewed Original ResearchConceptsRat articular cartilageRheumatoid arthritisNec-1Necrostatin-1Potential therapeutic strategyAcid-induced increaseChannel inhibitor amilorideArticular cartilage damageReceptor interacting protein 1Articular cartilageRIP1/RIP3Chondrocyte injuryAA ratsCartilage damageTherapeutic strategiesRA treatmentCartilage injuryPathophysiological processesPsalmotoxin-1Inhibitor necrostatin-1Expression of RIP1Inhibitor amilorideRIP1 inhibitor necrostatin-1Interacting protein 1ASIC1a
2017
Dried plum alleviates symptoms of inflammatory arthritis in TNF transgenic mice
Mirza F, Lorenzo J, Drissi H, Lee FY, Soung DY. Dried plum alleviates symptoms of inflammatory arthritis in TNF transgenic mice. The Journal Of Nutritional Biochemistry 2017, 52: 54-61. PMID: 29149648, DOI: 10.1016/j.jnutbio.2017.10.002.Peer-Reviewed Original ResearchConceptsTumor necrosis factorTransgenic miceRheumatoid arthritisNuclear factor-kappa B activationDP dietBone-preserving propertiesReduction of synovitisPresence of TNFFour-week treatmentOnset of arthritisResistant acid phosphatase-positive cellsAcid phosphatase-positive cellsDestruction of jointsHuman synovial fibroblastsTNF-transgenic miceHuman tumor necrosis factorKappa B activationActivated T cellsFormation of osteoclastsMouse bone marrow macrophagesBone marrow macrophagesArticular cartilagePostmenopausal womenInflammatory arthritisBone erosionWhole grape alleviates inflammatory arthritis through inhibition of tumor necrosis factor
Stamer D, Nizami S, Lee F, Soung Y. Whole grape alleviates inflammatory arthritis through inhibition of tumor necrosis factor. Journal Of Functional Foods 2017, 35: 458-465. DOI: 10.1016/j.jff.2017.06.018.Peer-Reviewed Original ResearchTumor necrosis factorTransgenic miceRheumatoid arthritisTg miceNecrosis factorMacrophage inflammatory protein-1 alphaInflammatory protein-1 alphaAnti-rheumatic efficacySynovitis/enthesitisGP dietProtein-1 alphaHuman tumor necrosis factorRA symptomsInflammatory arthritisRegular dietBone massOsteoclastogenic factorsPowder dietMatrix metalloproteinasesMiceArthritisDietArticular cartilageWhole grapesGPs
2014
Anteromedial Tibial Tubercle Transfer
Fulkerson J. Anteromedial Tibial Tubercle Transfer. 2014, 151-153. DOI: 10.1007/978-3-642-54965-6_20.Peer-Reviewed Original ResearchAnteromedial tibial tubercle transferTibial tubercle transferExcessive lateral pressure syndromeTubercle transferArticular cartilageChronic painArticular damageMedial patellaLateral patellaProximal aspectEarly flexionDistal aspectArticular lesionsClassic patientsLateral trochleaPatientsPatellaLateral articular cartilageLateral positionCartilageLateral facetVast majorityLateral trackingTypical patternFicat
2012
Lead induces an osteoarthritis‐like phenotype in articular chondrocytes through disruption of TGF‐β signaling
Holz JD, Beier E, Sheu T, Ubayawardena R, Wang M, Sampson ER, Rosier RN, Zuscik M, Puzas JE. Lead induces an osteoarthritis‐like phenotype in articular chondrocytes through disruption of TGF‐β signaling. Journal Of Orthopaedic Research® 2012, 30: 1760-1766. PMID: 22517267, PMCID: PMC3839422, DOI: 10.1002/jor.22117.Peer-Reviewed Original ResearchConceptsLead treatmentOsteoarthritis-like phenotypeNormal chondrocyte phenotypeDose-dependent mannerArticular chondrocytesTGF-β signalingActive caspase-3MMP13 activityLead exposureHigher level leadType II collagenVivo exposureCollagen levelsNovel targetType X collagenCaspase-3Articular surfaceEnvironmental toxinsLead toxicityII collagenReporter activityTreatmentArticular cartilageDosePhenotypic shift
2011
Genetic evidence of the regulatory role of parathyroid hormone–related protein in articular chondrocyte maintenance in an experimental mouse model
Macica C, Liang G, Nasiri A, Broadus AE. Genetic evidence of the regulatory role of parathyroid hormone–related protein in articular chondrocyte maintenance in an experimental mouse model. Arthritis & Rheumatism 2011, 63: 3333-3343. PMID: 21702022, PMCID: PMC3197958, DOI: 10.1002/art.30515.Peer-Reviewed Original ResearchConceptsHormone-related proteinDegenerative changesKO miceParathyroid hormone-related proteinMale KO miceExperimental mouse modelMouse articular cartilageTotal histologic scoreIndian hedgehogTibial articular surfaceArticular chondrocytesArticular cartilageGrowth differentiation factor 5Degenerative findingsControl miceHistologic scoresMouse modelCompensatory increaseTime-course studyDifferentiation factor 5PTHrPRegulatory roleMiceConditional deletionChondrocyte maintenance
2009
Effects of multiple chondroitinase ABC applications on tissue engineered articular cartilage
Natoli R, Responte D, Lu B, Athanasiou K. Effects of multiple chondroitinase ABC applications on tissue engineered articular cartilage. Journal Of Orthopaedic Research® 2009, 27: 949-956. PMID: 19123232, PMCID: PMC2819396, DOI: 10.1002/jor.20821.Peer-Reviewed Original ResearchConceptsCartilage tissue engineeringArticular cartilage tissue engineeringIncreased tensile propertiesTensile propertiesTissue engineeringTissue engineered articular cartilageAbundant collagen type IITensile biomechanical propertiesIncreased tensile stiffnessTensile modulusCollagen type IITensile stiffnessTensile strengthCompressive stiffnessArticular cartilageC-ABCTensileSulfated GAG compositionEngineeringStiffnessPropertiesCollagen type I.Collagen compositionCartilageBiomechanical properties
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