2025
Systematic Review and Meta‐Analysis of Dual‐Layered Stents Versus Single‐Layered Stents for Carotid Artery Stenosis
Mari T, Moeed A, Siddiqui A, Abbasi A, Arif Z, Jannat A, Akman Z, Rossi R, Unnar H, Bhatti H, Batool R, Khan M, Ali M, Batool F, Minahil, Iqbal J, Mena‐Hurtado C, Nanna M. Systematic Review and Meta‐Analysis of Dual‐Layered Stents Versus Single‐Layered Stents for Carotid Artery Stenosis. Catheterization And Cardiovascular Interventions 2025 PMID: 40518749, DOI: 10.1002/ccd.31684.Peer-Reviewed Original ResearchCarotid artery stentingCarotid artery stenosisSingle-layer stentsDual-layer stentsAll-cause mortalityPost-procedural strokeArtery stenosisRandomized controlled trialsStent occlusionHigher risk of peri-procedural strokePostprocedural strokeMeta-analysisRisk of peri-procedural strokeRisk ratioHigh riskCarotid artery stenting proceduresStroke riskPeri-procedural strokeRandom-effects meta-analysisPredictors of strokeTreat carotid artery stenosisLipid-rich carotid plaquesTreatment optionsArtery stentingPrimary outcomeValidación experimental de la gravedad de la estenosis coronaria y el desarrollo de miocardio isquémico
Lee J, Lee S, Kwon W, Kim H, Hong D, Kim H, Cho S, Shin D, Park K, Kim J, Moon J, Song H, Lee S, Ha D, Jang J, Ahn Y, Jeong M, Choi K, Park T, Yang J, Bin Song Y, Hahn J, Choi S, Gwon H, Hong Y. Validación experimental de la gravedad de la estenosis coronaria y el desarrollo de miocardio isquémico. Revista Española De Cardiología 2025, 78: 521-532. DOI: 10.1016/j.recesp.2024.10.006.Peer-Reviewed Original ResearchStress perfusion defectsFractional flow reservePositron emission tomographyLeft anterior descending arteryHemodynamically significant stenosisAnterior descending arteryPerfusion defectsVascular occluderNecrotic myocardiumSignificant stenosisDescending arteryTTC stainingSignificantly higher areaMedian diameter stenosisExperimental animal modelsCoronary artery stenosisHyperemic stenosis resistanceOccluder implantationArtery stenosisDiameter stenosisFlow reserveAnimal modelsStenosisCoronary stenosisOcclusion severityThe future in the management of patients with asymptomatic carotid artery stenosis.
Paraskevas K, Sultan S, Aburahma A, Moore W, Blecha M, Myrcha P, Zeebregts C, Blinc A, Davies A, D'Oria M, Gargiulo M, Poredos P, Svetlikov A, Perler B, Chaturvedi S, Sufali G, Saba L, Eldrup-Jorgensen J, Lyden S, Setacci C, DI Lazzaro V, Reiff T, Sawicka A, Liapis C, Lanza G, Spinetti G, Bruno A, Nicolaides A, Thapar A, Uyttenboogaart M, Jawien A, Mikhailidis D, Spinelli F, Stilo F, Musialek P, Gurevich V, Silvestrini M, Erben Y, Schneider P, Lip G, White C, Dardik A, Meschia J, Malas M, Gloviczki P, Schermerhorn M, Mansilha A. The future in the management of patients with asymptomatic carotid artery stenosis. International Angiology 2025 PMID: 40192320, DOI: 10.23736/s0392-9590.25.05401-x.Peer-Reviewed Original ResearchManagement of patientsOptimal management of patientsAsymptomatic carotid artery stenosisSymptomatic carotid stenosisContrast-enhanced ultrasoundCarotid artery stenosisArtery stenosisCarotid stenosisEarly diagnosisContinuous non-invasive monitoringOptimal managementStroke preventionPatientsNon-invasive monitoringStenosisPlaque morphologyRisk predictionDiagnosisStroke risk predictionStrokeMachine learning and computational fluid dynamics derived FFRCT demonstrate comparable diagnostic performance in patients with coronary artery disease; A Systematic Review and Meta-Analysis
Narimani-Javid R, Moradi M, Mahalleh M, Najafi-Vosough R, Arzhangzadeh A, Khalique O, Mojibian H, Kuno T, Mohsen A, Alam M, Shafiei S, Khansari N, Shaghaghi Z, Nozhat S, Hosseini K, Hosseini S. Machine learning and computational fluid dynamics derived FFRCT demonstrate comparable diagnostic performance in patients with coronary artery disease; A Systematic Review and Meta-Analysis. Journal Of Cardiovascular Computed Tomography 2025, 19: 232-246. PMID: 39988511, DOI: 10.1016/j.jcct.2025.02.004.Peer-Reviewed Original ResearchArea under the curveDiagnostic odds ratioDiagnostic performanceComputed tomography-derived fractional flow reserveDiagnostic performance of FFRCTHemodynamically significant coronary artery stenosisSignificant coronary artery stenosisMeta-analysisPer-patient levelReceiver operating characteristic curveCoronary artery diseaseCoronary artery stenosisPer-vessel levelFractional flow reserveNoninvasive diagnostic techniquesMachine learningInvasive FFRPooled specificityArtery diseaseArtery stenosisFlow reserveOdds ratioCochrane LibraryFFRCTPatients
2024
New horizons in nuclear cardiology: Imaging of peripheral arterial disease
Callegari S, Mena-Hurtado C, Smolderen K, Thorn S, Sinusas A. New horizons in nuclear cardiology: Imaging of peripheral arterial disease. Journal Of Nuclear Cardiology 2024, 46: 102079. PMID: 39549830, DOI: 10.1016/j.nuclcard.2024.102079.Peer-Reviewed Original ResearchPeripheral arterial diseaseDiagnostic modalitiesRisk stratificationArtery diseaseEarly diagnosisImprove risk stratificationAssociated with higher ratesLower extremity peripheral arterial diseaseEvaluation of therapyClinically relevant areasPreclinical modelsObstructive atherosclerotic diseaseClinical studiesArtery stenosisMicrovascular diseasePreprocedural assessmentPeripheral vasculaturePET imagingAtherosclerotic diseaseNuclear cardiologyTherapeutic interventionsClinical diseaseDiseaseComplex physiologyPerfusionExperimental validation of coronary stenosis severity and development of ischemic myocardium
Lee J, Lee S, Kwon W, Kim H, Hong D, Kim H, Cho S, Shin D, Park K, Kim J, Moon J, Song H, Lee S, Ha D, Jang J, Ahn Y, Jeong M, Choi K, Park T, Yang J, Song Y, Hahn J, Choi S, Gwon H, Hong Y. Experimental validation of coronary stenosis severity and development of ischemic myocardium. Revista Española De Cardiología (English Edition) 2024, 78: 521-532. PMID: 39490529, DOI: 10.1016/j.rec.2024.10.006.Peer-Reviewed Original ResearchStress perfusion defectsFractional flow reserveLeft anterior descending arteryHemodynamically significant stenosisAnterior descending arteryPerfusion defectsVascular occluderNecrotic myocardiumSignificant stenosisDescending arteryTTC stainingIschemic myocardiumStenosis severitySignificantly higher areaMedian diameter stenosisExperimental animal modelsCoronary artery stenosisCoronary stenosis severityHyperemic stenosis resistanceOccluder implantationArtery stenosisDiameter stenosisFlow reserveAnimal modelsStenosisCarotid artery stenting versus carotid endarterectomy for symptomatic or asymptomatic extracranial carotid stenosis: A national cohort study
Krittanawong C, Ang S, Tangsrivimol J, Qadeer Y, Wang Z, Virk H, Khalid U, Sharma S, Dardik A. Carotid artery stenting versus carotid endarterectomy for symptomatic or asymptomatic extracranial carotid stenosis: A national cohort study. Journal Of Stroke And Cerebrovascular Diseases 2024, 33: 108094. PMID: 39424210, DOI: 10.1016/j.jstrokecerebrovasdis.2024.108094.Peer-Reviewed Original ResearchAsymptomatic carotid stenosisCarotid artery stenosisCarotid stenosisArtery stenosisAdverse eventsCohort studyAsymptomatic extracranial carotid stenosisNational population-based cohort studyPopulation-based cohort studyAssociated with lower adverse eventsAssociated with high mortalityAlternative to CEAExtracranial carotid stenosisSymptomatic carotid stenosisMortality of patientsCarotid artery stentingLower adverse eventsNational cohort studyAsymptomatic patientsClinical characteristicsArtery stentingPatient populationCarotid endarterectomyStenosisPatientsAn International, Expert-Based Delphi Consensus Document on Controversial Issues about TransCarotid Artery Revascularization (TCAR)
Paraskevas K, AbuRahma A, Abularrage C, Clair D, Eldrup-Jorgensen J, Kashyap V, Dardik A, de Borst G, Dermody M, Faggioli G, Hicks C, Kwolek C, Lyden S, Mansilha A, Van Herzeele I, Myrcha P, Leal Lorenzo J, Jim J, Pini R, Secemsky E, Spinelli F, Capoccia L, Stone D, Stoner M, Zeebregts C, Lal B, Schneider P, Malas M, Schermerhorn M. An International, Expert-Based Delphi Consensus Document on Controversial Issues about TransCarotid Artery Revascularization (TCAR). Annals Of Vascular Surgery 2024, 110: 42-53. PMID: 39413993, DOI: 10.1016/j.avsg.2024.09.048.Peer-Reviewed Original ResearchTransfemoral carotid artery stentingTranscarotid artery revascularizationRandomized controlled trialsCarotid endarterectomyConsensus documentArtery revascularizationAlternative therapeutic modalityManagement of patientsCarotid artery stentingCarotid artery stenosisTreatment of restenosisCarotid stenosis patientsSymptomatic patientsStenosis patientsTherapeutic modalitiesCerebrovascular eventsArtery stenosisArtery stentingControlled trialsDelphi consensus processPatientsContraindicationsRevascularizationTranscarotidTrialsImpact Of Ultra-high-resolution On Cardiac CT Assessment Of Coronary Artery Stenoses, Plaque Burden/composition, And Pericoronary Adipose Tissue Attenuation
Matuck B, Matheson M, Latina J, Shabani M, Hoballah M, Ostovaneh A, Abdollahi A, Ebrahimihoor E, Trost J, Mashes M, Lima J, Arbab-Zadeh A. Impact Of Ultra-high-resolution On Cardiac CT Assessment Of Coronary Artery Stenoses, Plaque Burden/composition, And Pericoronary Adipose Tissue Attenuation. Journal Of Cardiovascular Computed Tomography 2024, 18: s67-s68. DOI: 10.1016/j.jcct.2024.05.159.Peer-Reviewed Original ResearchMacro- and microvascular contributions to cerebral structural alterations in patients with asymptomatic carotid artery stenosis
Schmitzer L, Kaczmarz S, Göttler J, Hoffmann G, Kallmayer M, Eckstein H, Hedderich D, Kufer J, Zimmer C, Preibisch C, Hyder F, Sollmann N. Macro- and microvascular contributions to cerebral structural alterations in patients with asymptomatic carotid artery stenosis. Cerebrovascular And Brain Metabolism Reviews 2024, 44: 1629-1642. PMID: 38506325, PMCID: PMC11418673, DOI: 10.1177/0271678x241238935.Peer-Reviewed Original ResearchInternal carotid artery stenosisInternal carotid artery stenosis patientsCerebral blood flowCarotid artery stenosisPeak width of skeletonized mean diffusivitySmall vessel diseaseContralateral alterationsArtery stenosisAsymptomatic internal carotid artery stenosisWhite matterAsymptomatic carotid artery stenosisCapillary transit time heterogeneityCerebral structural alterationsCortical thicknessMagnetic resonance imagingHemodynamic alterationsRisk factorsPatientsDTI metricsResonance imagingDorsal cingulate cortexBlood flowIschemic strokeMean diffusivityStenosisLongitudinal changes in the carotid arteries of head and neck cancer patients following radiation therapy: Results from a prospective serial imaging biomarker characterization study
Koutroumpakis E, Mohamed A, Chaftari P, Rosenthal D, Gujral D, Nutting C, Kamel S, Naser M, Kim P, Bassett R, Fuller C, Mouhayar E, Group A. Longitudinal changes in the carotid arteries of head and neck cancer patients following radiation therapy: Results from a prospective serial imaging biomarker characterization study. Radiotherapy And Oncology 2024, 195: 110220. PMID: 38467343, PMCID: PMC11380547, DOI: 10.1016/j.radonc.2024.110220.Peer-Reviewed Original ResearchIntima-media thicknessGlobal circumferential strainRadiation therapyCarotid arteryHead and neck RTHead and neck cancer patientsHead and neck cancerNeck radiation therapyCircumferential strainNeck cancer patientsCarotid intima-media thicknessCarotid artery injuryArtery duplex studiesCarotid artery stenosisNeck RTNo significant differenceNeck cancerDuplex studiesArterial injuryArtery stenosisCancer patientsMedia thicknessCarotid ultrasoundArterial elastanceCarotid
2023
Inflammation, anti-inflammatory agents, and the role of colchicine in carotid artery stenosis.
Chlorogiannis D, Pargaonkar S, Papanagiotou P, Bakogiannis N, Bakoyiannis C, Kokkinidis D. Inflammation, anti-inflammatory agents, and the role of colchicine in carotid artery stenosis. Vasa 2023, 53: 4-12. PMID: 38079179, DOI: 10.1024/0301-1526/a001104.Peer-Reviewed Original ResearchConceptsCarotid artery stenosisArtery stenosisAnti-inflammatory medicationsRole of inflammationCoronary artery diseaseAnti-inflammatory agentsRole of colchicineArtery diseaseOngoing trialsOptimal treatmentCardiovascular diseaseStenosis developmentMedicationsInflammationAvailable evidenceMajor causeStenosisDiseaseColchicineMorbidityPatientsMortalityProgressionTrialsWhat are the benefits and drawbacks of statins in carotid artery disease? A perspective review
Said S, Dardik A, Chaar C. What are the benefits and drawbacks of statins in carotid artery disease? A perspective review. Expert Review Of Cardiovascular Therapy 2023, 21: 763-777. PMID: 37994875, PMCID: PMC11493559, DOI: 10.1080/14779072.2023.2286011.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCarotid artery diseaseCarotid artery stenosisSide effectsArtery diseaseArtery stenosisAlternative therapiesSymptomatic carotid artery stenosisAtherosclerotic carotid artery diseaseMultiple international guidelinesAcute ischemic strokeImpact of statinsGenetic polymorphismsStatin side effectsWarrants close monitoringDrug of choiceSerious side effectsMechanism of statinStatin therapyCarotid revascularizationIschemic strokePCSK9 inhibitorsLipid controlStroke incidencePatient selectionClinical efficacyCarotid Artery Operation Delay During the Covid-19 Pandemic: Results of a Multicenter International Study
Kabeil M, Wohlauer M, D'Oria M, Khetarpaul V, Gillette R, Moore E, Colborn K, Cuff R, O'Banion L, Koleilat I, Aziz F, Mouawad N, Kabeil M, Wohlauer M, D’Oria M, Khetarpaul V, Gillette R, Moore E, Colborn K, Cuff R, O’Banion L, Ali A, Lucero L, Costanza M, Hammond E, Motaganahalli R, Samra H, Westin G, Allen K, Sachdev U, Andraska E, Sharafuddin M, Pena-Quevedo J, Koleilat I, Carnevale M, Batarseh P, Tonnessen B, Harroun N, Sataviciute A, Aziz F, Tinelli G, Chuen J, Bath J, Mills J, Afifi R, Coscas R, Shalhub S, Nkansah R, Beck A, St. John R, Malekpour F, Siah M, Kim S, Davies M, Todd G, Busby C, Nelson P, Wyatt S, Ahmed S, Cosentino A, Ghosh A, Miranda J, Torres I, Fakhradiyev I, Kota A, Mier y Teran-Ellis S, Lopez G, Hinojosa C, Gunawansa N, Mouawad N, Singh K. Carotid Artery Operation Delay During the Covid-19 Pandemic: Results of a Multicenter International Study. Annals Of Vascular Surgery 2023, 96: 44-56. PMID: 37355018, DOI: 10.1016/j.avsg.2023.05.041.Peer-Reviewed Original ResearchConceptsCarotid artery stenosisArtery stenosisCarotid stenosisCOVID-19 pandemicCohort of patientsManagement of patientsSignificant carotid stenosisCarotid artery operationsMulticenter international studyCarotid operationsEmergency surgeryMost patientsNeurological deteriorationSurgical delayUrgent operationCarotid endarterectomyMedian lengthOperative delayMedian delayVascular operationsPatientsHospital policiesStenosisCOVID-19International studiesMultivariate analysis of perfusion and oxygenation patterns in asymptomatic unilateral carotid artery stenosis
Kufer J, Göttler J, Hoffmann G, Schmitzer L, Zimmer C, Hyder F, Preibisch C, Kaczmarz S. Multivariate analysis of perfusion and oxygenation patterns in asymptomatic unilateral carotid artery stenosis. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2023 DOI: 10.58530/2023/0878.Peer-Reviewed Original ResearchInternal carotid artery stenosisCarotid artery stenosisArtery stenosisInternal carotid artery stenosis patientsAsymptomatic internal carotid artery stenosisUnilateral carotid artery stenosisSystemic blood pressureAnalysis of perfusionIncreased stroke riskCerebral hemodynamic changesDegree of stenosisPhysiologic MRICerebral perfusionComplex pathophysiologyMultivariate analysisHemodynamic changesBlood pressureCarotid arteryTreatment decisionsStenosisDisease-specific patternsStroke risk
2022
Coronary artery disease and revascularization associated with immune checkpoint blocker myocarditis: Report from an international registry
Nowatzke J, Guedeney P, Palaskas N, Lehmann L, Ederhy S, Zhu H, Cautela J, Francis S, Courand PY, Deswal A, Ewer SM, Aras M, Arangalage D, Ghafourian K, Fenioux C, Finke D, Peretto G, Zaha V, Zadok O, Tajiri K, Akhter N, Levenson J, Baldassarre L, Power J, Huang S, Collet JP, Moslehi J, Salem JE, contributors I, Aghel N, Alexandre J, Aonuma K, Asnani A, Behling J, Bilen M, Bottinor W, Cariou E, Chahine J, Chan W, Chauhan A, Cohen M, Crusz S, Fernando S, Florido R, Frigeri M, Fukushima S, Gaughan E, Geisler B, Gilstrap L, Grohe C, Guha A, Habib M, Haegler-Laube E, Haydon A, Hayek S, Hughes A, Imai R, Katsume Y, Kimura H, Lin L, Lenneman C, Leong D, Makker V, Martinez-Calle N, Moey M, Mohri M, Morimoto R, Moritoki Y, Narezkina A, Nicol M, Nooka A, Orimoloye O, Patel M, Perl M, Piriou N, Raikhelkar J, Raza Y, Rao A, Reddy S, Seki N, Stangl K, Stewart A, Stringer B, Tamarappoo B, Tamura Y, Thuny F, Tierney S, Tresorier R, Ullah W, Von Hunolstein J, Warner E, Weppler A. Coronary artery disease and revascularization associated with immune checkpoint blocker myocarditis: Report from an international registry. European Journal Of Cancer 2022, 177: 197-205. PMID: 36030143, PMCID: PMC10165738, DOI: 10.1016/j.ejca.2022.07.018.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseImmune checkpoint blockersCoronary revascularizationArtery diseaseCAD groupInternational registryPrompt clinical diagnosisAcute coronary syndromeCoronary artery stenosisAdjustment of ageCause deathCoronary syndromeIndex hospitalisationSteroid administrationCheckpoint blockersCoronary angiographyArtery stenosisCoronary angiogramPoor outcomeSevere presentationRevascularizationPatientsCardiac pathologyClinical diagnosisMyocarditis
2021
Impaired Distal Perfusion Predicts Length of Hospital Stay in Patients with Symptomatic Middle Cerebral Artery Stenosis
Yaghi S, de Havenon A, Honda T, Hinman JD, Raychev R, Sharma LK, Kim S, Feldmann E, Romano JG, Prabhakaran S, Liebeskind DS. Impaired Distal Perfusion Predicts Length of Hospital Stay in Patients with Symptomatic Middle Cerebral Artery Stenosis. Journal Of Neuroimaging 2021, 31: 475-479. PMID: 33565162, PMCID: PMC8119309, DOI: 10.1111/jon.12839.Peer-Reviewed Original ResearchConceptsTransient ischemic attackMCA stenosisPerfusion delayPerfusion imagingSymptomatic middle cerebral artery stenosisMiddle cerebral artery stenosisSymptomatic MCA stenosisComprehensive stroke centerSymptomatic intracranial stenosisCerebral artery stenosisContinuous variablesHospital stayIschemic attackIschemic strokeStenosis patientsStroke centersSymptom onsetConsecutive patientsArtery stenosisIntracranial stenosisProspective studyRetrospective studyPredicts LengthInclusion criteriaMismatch volume
2020
Vertebral Artery Stenosis
Brooks D, Schindler J. Vertebral Artery Stenosis. Current Treatment Options In Cardiovascular Medicine 2020, 22: 35. DOI: 10.1007/s11936-020-00832-y.Peer-Reviewed Original ResearchVertebral artery stenosisArtery stenosisEndovascular therapyAggressive risk factor controlExtracranial vertebral artery stenosisHigh-intensity statin therapyIntracranial vertebral artery stenosisSymptomatic vertebral artery stenosisDual antiplatelet therapyLipid-Lowering TherapyRisk factor controlLipid-lowering agentsRisk of strokeNovel lipid-lowering agentsAggressive initiationAntiplatelet therapyStatin therapyCommon conditionHigh riskStenosisMedical careTherapyNatural historyTherapy protocolsStrokeIntravascular Lithotripsy for Treatment of Calcified Lesions During Carotid Artery Stenting
Giannopoulos S, Speziale F, Vadalà G, Soukas P, Kuhn BA, Stoltz CL, Foteh MI, Mena-Hurtado C, Armstrong EJ. Intravascular Lithotripsy for Treatment of Calcified Lesions During Carotid Artery Stenting. Journal Of Endovascular Therapy 2020, 28: 93-99. PMID: 32869718, DOI: 10.1177/1526602820954244.Peer-Reviewed Original ResearchConceptsCarotid artery lesionsIntravascular lithotripsyArtery lesionsCarotid duplex ultrasound examinationAortic arch manipulationDual antiplatelet therapyCarotid artery stentingEmbolic protection devicesDuplex ultrasound examinationCarotid artery stenosisLong-term safetyArch manipulationBaseline stenosisAntiplatelet therapyAsymptomatic patientsSignificant restenosisIschemic strokeISR lesionsRisk patientsStent restenosesTransfemoral accessAdverse eventsArtery stentingArtery stenosisSymptomatic bradycardiaAssessment of Intracranial Atherosclerotic Plaques Using 3D Black‐Blood MRI: Comparison With 3D Time‐of‐Flight MRA and DSA
Tian X, Tian B, Shi Z, Wu X, Peng W, Zhang X, Malhotra A, Mossa‐Basha M, Sekhar L, Liu Q, Lu J, Hu C, Zhu C. Assessment of Intracranial Atherosclerotic Plaques Using 3D Black‐Blood MRI: Comparison With 3D Time‐of‐Flight MRA and DSA. Journal Of Magnetic Resonance Imaging 2020, 53: 469-478. PMID: 32864816, DOI: 10.1002/jmri.27341.Peer-Reviewed Original ResearchConceptsTransient ischemic attackDigital subtraction angiographyMagnetic resonance angiographyPosterior circulation strokeInterclass correlation coefficientDegree of stenosisBlack blood MRINonstenotic plaquesIntracranial stenosisPlaque assessmentIntracranial vessel wall imagingIschemic stroke patientsIntracranial artery stenosisIntracranial atherosclerotic plaquesFlight magnetic resonance angiographyMann-Whitney U testAtherosclerotic plaque assessmentStage 2 J. MagnT-testStudent's t-testVessel wall imagingIschemic attackCohort studyArtery stenosisStroke patients
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