2025
Significance of Coronary Artery Calcifications and Ischemic Electrocardiographic Changes Among Patients Undergoing Myocardial Perfusion Imaging
Kokkinidis D, Kyriakoulis I, Chui P, Agarwal R, Liu Y, Khera R, Sinusas A, Velazquez E, Miller E, Feher A. Significance of Coronary Artery Calcifications and Ischemic Electrocardiographic Changes Among Patients Undergoing Myocardial Perfusion Imaging. JACC Advances 2025, 4: 101618. PMID: 39983619, PMCID: PMC11891677, DOI: 10.1016/j.jacadv.2025.101618.Peer-Reviewed Original ResearchCoronary artery calcificationMyocardial perfusion imagingIschemic ECG changesLow event ratesECG changesNormal perfusionArtery calcificationPerfusion imagingSingle-photon emission computed tomography/computed tomographyStress ECGCAC evaluationPresence of coronary artery calcificationSuspected coronary artery diseaseMedian follow-upEvent ratesIschemic electrocardiographic changesAnalysis to patientsComposite endpoint rateCoronary artery diseaseTomography/computed tomographyPrognostic informationMACE rateFollow-upSubgroup analysisAdverse outcomesLung Cancer Screening and Incidental Findings: A Research Agenda: An Official American Thoracic Society Research Statement.
Henderson L, Kim R, Tanner N, Tsai E, Begnaud A, Dako F, Gieske M, Kallianos K, Richman I, Sakoda L, Schwartz R, Yeboah J, Fong K, Lam S, Lee P, Pasquinelli M, Smith R, Triplette M, Tanoue L, Rivera M. Lung Cancer Screening and Incidental Findings: A Research Agenda: An Official American Thoracic Society Research Statement. American Journal Of Respiratory And Critical Care Medicine 2025, 211: 436-451. PMID: 39928329, PMCID: PMC11936151, DOI: 10.1164/rccm.202501-0011st.Peer-Reviewed Original ResearchConceptsLow-dose computed tomographyManagement of incidental findingsLung cancer screeningCancer screeningThree-round modified Delphi processReporting of incidental findingsClinically significant IFsPrioritized questionsDelphi processIncidental findingClinicians' effortsMultidisciplinary panelPatient anxietyResearch questionsPotential harmLDCT examinationsCoronary artery calcificationIncreased awarenessSignificant IFsExcess costsHarmPotential benefitsArtery calcificationKnowledge gapsComputed tomography
2024
Refining Cardiovascular Calcification in the Appraisal of Ischemic Heart
Nguyen V, Fan J, Hafeez I, Nguyen A, Mojibian H. Refining Cardiovascular Calcification in the Appraisal of Ischemic Heart. Cureus 2024, 16: e64328. PMID: 39130835, PMCID: PMC11316457, DOI: 10.7759/cureus.64328.Peer-Reviewed Original ResearchCoronary artery calcificationCardiovascular calcificationPositron emission tomographySuspected ischemiaPerfusion defectsArtery calcificationMedical historyPredictor of myocardial ischemiaNon-contrast computed tomographyRate of cardiovascular eventsAssociation of ischemiaCT attenuation correctionChest computed tomography imagesNegative predictive valueSignificant perfusion defectsAtherosclerotic coronary artery diseaseNuclear stress testingMyocardial perfusion defectsMyocardial perfusion imagingMyocardial perfusion scanCoronary artery diseaseFollow-up dataPatient's medical historyCoronary CTAInvasive angiographyAbstract 146: Phosphodiesterase 10A Mediates Arterial Calcification Through A P38/MAPK-MMP3 Signaling
Jin Y, Xie Y, Berezowitz A, Davis S, Flores A, Wang X, Guzman R, Cai Y. Abstract 146: Phosphodiesterase 10A Mediates Arterial Calcification Through A P38/MAPK-MMP3 Signaling. Arteriosclerosis Thrombosis And Vascular Biology 2024, 44: a146-a146. DOI: 10.1161/atvb.44.suppl_1.146.Peer-Reviewed Original ResearchVascular smooth muscle cellsChronic kidney diseasePeripheral arterial diseaseArtery calcificationInhibition of PDE10AMedial arterial calcificationVascular calcificationAssociated with increased cardiovascular morbidityCalcifying vascular smooth muscle cellsMatrix metallopeptidaseSmooth muscle cellsVSMCs in vitroCyclic nucleotides cAMPArteries in vivoMMP-3 upregulationCardiovascular morbidityCalcification in vivoArtery diseaseVon Kossa stainingKidney diseaseMuscle cellsRodent modelsVSMC calcificationInducible isoformCalcium assayAtherectomy – The Options, the Evidence, and When Should It Be Used
Pinto P, Ochoa Chaar C. Atherectomy – The Options, the Evidence, and When Should It Be Used. Annals Of Vascular Surgery 2024, 107: 127-135. PMID: 38583766, DOI: 10.1016/j.avsg.2023.12.104.Peer-Reviewed Original ResearchPeripheral vascular interventionsEndovascular techniquesLack of level 1 evidenceFirst-line therapyLevel 1 evidenceOffice-based laboratoriesComplex atherosclerotic lesionsProspective studyDissection riskEndovascular technologyBailout stentingArtery calcificationAmbulatory surgery centersSurgery centersModerate disease burdenVascular interventionsPlaque modificationDisease burdenAtherectomyAtherosclerotic lesionsPatientsTheoretical benefitsPractitioner preferencesAtherectomy technologiesTherapySmooth muscle cell-specific matrix metalloproteinase 3 deletion reduces osteogenic transformation and medial artery calcification
Xie Y, Lin T, Jin Y, Berezowitz A, Wang X, Lu J, Cai Y, Guzman R. Smooth muscle cell-specific matrix metalloproteinase 3 deletion reduces osteogenic transformation and medial artery calcification. Cardiovascular Research 2024, 120: 658-670. PMID: 38454645, PMCID: PMC11074797, DOI: 10.1093/cvr/cvae035.Peer-Reviewed Original ResearchSmooth muscle cellsPeripheral arterial diseaseVascular smooth muscle cellsMedial calcificationMMP-3Osteogenic transformationRodent modelsAssociated with increased morbiditySmooth muscle cell calcificationChronic kidney diseaseEx vivo organ culture modelMMP-3 expressionOrgan culture modelMedial arterial calcificationTargeting MMP-3Matrix metalloproteinase 3MMP-3 proteinArtery calcificationArtery diseaseKidney diseaseVascular calcificationMuscle cellsTherapeutic strategiesCalcification mediumVitamin D3Automated vessel-specific coronary artery calcification quantification with deep learning in a large multi-centre registry
Williams M, Shanbhag A, Zhou J, Michalowska A, Lemley M, Miller R, Killekar A, Waechter P, Gransar H, Van Kriekinge S, Builoff V, Feher A, Miller E, Bateman T, Dey D, Berman D, Slomka P. Automated vessel-specific coronary artery calcification quantification with deep learning in a large multi-centre registry. European Heart Journal - Cardiovascular Imaging 2024, 25: 976-985. PMID: 38376471, DOI: 10.1093/ehjci/jeae045.Peer-Reviewed Original ResearchCoronary artery calcificationRight coronary arteryAttenuation correction CTGated CTAgatston unitsLeft circumflexHazard ratioCoronary artery calcification quantificationMulti-center registryAdverse cardiovascular eventsYear follow-upConfidence intervalsLinear weighted Cohen's kappaPrognostic implicationsMulticenter registryPrognostic assessmentCardiovascular eventsArtery calcificationCoronary arteryAttenuation correctionCohen's kappaLM/LADRegistry
2023
Whole-genome sequencing uncovers two loci for coronary artery calcification and identifies ARSE as a regulator of vascular calcification
de Vries P, Conomos M, Singh K, Nicholson C, Jain D, Hasbani N, Jiang W, Lee S, Lino Cardenas C, Lutz S, Wong D, Guo X, Yao J, Young E, Tcheandjieu C, Hilliard A, Bis J, Bielak L, Brown M, Musharoff S, Clarke S, Terry J, Palmer N, Yanek L, Xu H, Heard-Costa N, Wessel J, Selvaraj M, Li R, Sun X, Turner A, Stilp A, Khan A, Newman A, Rasheed A, Freedman B, Kral B, McHugh C, Hodonsky C, Saleheen D, Herrington D, Jacobs D, Nickerson D, Boerwinkle E, Wang F, Heiss G, Jun G, Kinney G, Sigurslid H, Doddapaneni H, Hall I, Bensenor I, Broome J, Crapo J, Wilson J, Smith J, Blangero J, Vargas J, Mosquera J, Smith J, Viaud-Martinez K, Ryan K, Young K, Taylor K, Lange L, Emery L, Bittencourt M, Budoff M, Montasser M, Yu M, Mahaney M, Mahamdeh M, Fornage M, Franceschini N, Lotufo P, Natarajan P, Wong Q, Mathias R, Gibbs R, Do R, Mehran R, Tracy R, Kim R, Nelson S, Damrauer S, Kardia S, Rich S, Fuster V, Napolioni V, Zhao W, Tian W, Yin X, Min Y, Manning A, Peloso G, Kelly T, O’Donnell C, Morrison A, Curran J, Zapol W, Bowden D, Becker L, Correa A, Mitchell B, Psaty B, Carr J, Pereira A, Assimes T, Stitziel N, Hokanson J, Laurie C, Rotter J, Vasan R, Post W, Peyser P, Miller C, Malhotra R. Whole-genome sequencing uncovers two loci for coronary artery calcification and identifies ARSE as a regulator of vascular calcification. Nature Cardiovascular Research 2023, 2: 1159-1172. PMID: 38817323, PMCID: PMC11138106, DOI: 10.1038/s44161-023-00375-y.Peer-Reviewed Original ResearchGenome-wide association studiesMultiple ancestral groupsWhole-genome sequencingPotential drug targetsNovel lociAncestral groupsLociCoronary artery calcificationVascular smooth muscle cellsDrug targetsFunctional assaysPhenotypic switchingCoronary artery diseaseVascular smooth muscle cell phenotypic switchingHuman vascular smooth muscle cellsARSEG alleleArtery calcificationVascular calcificationPredictor of coronary artery diseaseReplicate analysesRegulation of vascular calcificationSmooth muscle cellsCalcifiersSequenceAn ultrasound-based femoral artery calcification score
Maahs E, Schwartz A, Berezowitz A, Davis S, Guzman R. An ultrasound-based femoral artery calcification score. Journal Of Vascular Surgery Cases And Innovative Techniques 2023, 10: 101381. PMID: 38130366, PMCID: PMC10731664, DOI: 10.1016/j.jvscit.2023.101381.Peer-Reviewed Original ResearchPeripheral arterial diseaseCalcification scoreArterial diseaseLower extremitiesFemoral calcificationCalcium scoreDuplex ultrasoundFemoral arteryChronic limb threatening ischemiaArterial duplex ultrasoundFemoral artery calcificationLimb-specific outcomesAmputation-free survivalLimb threatening ischemiaLower extremity atherosclerosisStandard computed tomographyNew scoring systemArtery calcificationLimb outcomesRenal failureCT evaluationArterial calcificationInclusion criteriaComputed tomographyUS scoreComparison of the prognostic value between quantification and visual estimation of coronary calcification from attenuation CT in patients undergoing SPECT myocardial perfusion imaging
Feher A, Pieszko K, Shanbhag A, Lemley M, Miller R, Huang C, Miras L, Liu Y, Gerber J, Sinusas A, Miller E, Slomka P. Comparison of the prognostic value between quantification and visual estimation of coronary calcification from attenuation CT in patients undergoing SPECT myocardial perfusion imaging. The International Journal Of Cardiovascular Imaging 2023, 40: 185-193. PMID: 37845406, PMCID: PMC466934, DOI: 10.1007/s10554-023-02980-1.Peer-Reviewed Original ResearchConceptsMajor adverse cardiovascular eventsCoronary artery calcificationMyocardial perfusion imagingCT myocardial perfusion imagingSPECT/CT myocardial perfusion imagingArtery calcificationPrognostic valuePrior coronary stentingAdverse cardiovascular eventsSimilar prognostic valueSPECT myocardial perfusionREFINE SPECT registrySPECT/CTCardiovascular eventsCAC scoringCalcium scoreCoronary calcificationCoronary stentingPrognostic utilitySingle centerCoronary arteryLow doseMyocardial perfusionPerfusion imagingSurvival analysisEffect of Doxycycline on Progression of Arterial Calcification in the Noninvasive Treatment of Abdominal Aortic Aneurysm Clinical Trial (N-TA(3)CT)
Kim T, Kostiuk V, Olson S, Curci J, Matsumura J, Baxter B, Blackwelder W, Terrin M, Guzman R. Effect of Doxycycline on Progression of Arterial Calcification in the Noninvasive Treatment of Abdominal Aortic Aneurysm Clinical Trial (N-TA(3)CT). Annals Of Vascular Surgery 2023, 104: 1-9. PMID: 37356652, PMCID: PMC10748791, DOI: 10.1016/j.avsg.2023.06.019.Peer-Reviewed Original ResearchAbdominal Aortic Aneurysm Clinical TrialSerum MMP-3MMP-9 levelsArterial calcificationEffect of doxycyclineNon-invasive treatmentMMP-3Clinical trialsTomography scanMatrix metalloproteinasesSmall aortic aneurysmsArtery calcificationBaseline characteristicsPlacebo armCalcium scoreStudy armsAortic aneurysmPreclinical modelsMean changeAbdominal vesselsPatientsIndividual arteriesMatrix degradingDoxycyclineCalcificationCORONARY ARTERY CALCIFICATIONS ARE A BETTER PREDICTOR OF CARDIOVASCULAR OUTCOMES THAN ISCHEMIC ECG CHANGES IN PATIENTS WITH NORMAL PERFUSION ON EXERCISE SPECT
Shi T, Kokkinidis D, Agarwal R, Liu Y, Sinusas A, Miller E, Feher A. CORONARY ARTERY CALCIFICATIONS ARE A BETTER PREDICTOR OF CARDIOVASCULAR OUTCOMES THAN ISCHEMIC ECG CHANGES IN PATIENTS WITH NORMAL PERFUSION ON EXERCISE SPECT. Journal Of The American College Of Cardiology 2023, 81: 1498. DOI: 10.1016/s0735-1097(23)01942-3.Peer-Reviewed Original Research
2022
Next Generation Risk Markers in Preventive Cardio-oncology
Lamberg M, Rossman A, Bennett A, Painter S, Goodman R, MacLeod J, Maddula R, Rayan D, Doshi K, Bick A, Bailey S, Brown S. Next Generation Risk Markers in Preventive Cardio-oncology. Current Atherosclerosis Reports 2022, 24: 443-456. PMID: 35441347, PMCID: PMC10026729, DOI: 10.1007/s11883-022-01021-x.Peer-Reviewed Original ResearchConceptsClonal hematopoiesis of indeterminate potentialBreast arterial calcificationCoronary artery calcificationPurpose of reviewCardiovascular diseaseCoronary artery diseaseRisk stratificationRisk markersCVD risk assessmentCancer treatmentArtery calcificationImprove CV risk stratificationPresence of clonal hematopoiesis of indeterminate potentialAtherosclerotic CVDIndependent of traditional CV risk factorsLong-term CVD outcomesIncreased risk of CVDTraditional CV risk factorsCV risk markersPrediction of coronary artery diseaseCardio-oncology practiceLung cancer screeningCV risk factorsCVD risk calculatorsCV risk stratificationCoronary artery stenosis
2021
Recovery of limb perfusion and function after hindlimb ischemia is impaired by arterial calcification
Zettervall SL, Wang X, Monk S, Lin T, Cai Y, Guzman RJ. Recovery of limb perfusion and function after hindlimb ischemia is impaired by arterial calcification. Physiological Reports 2021, 9: e15008. PMID: 34405571, PMCID: PMC8371346, DOI: 10.14814/phy2.15008.Peer-Reviewed Original ResearchConceptsPeripheral artery diseaseMedial artery calcificationFemoral artery ligationVehicle-injected ratsMedial calcificationHindlimb ischemiaArtery calcificationLimb ischemiaArtery ligationFunctional recoveryArterial calcificationLaser Doppler perfusion imagingAcute limb ischemiaChronic kidney diseaseRecovery of perfusionVascular smooth muscle cellsSmooth muscle cellsLower extremity vesselsAmputation rateArtery diseaseArterial stiffnessClinical outcomesImpaired perfusionKidney diseaseLimb perfusion
2020
Efficacy and safety of intravascular lithotripsy for the treatment of peripheral arterial disease: An individual patient‐level pooled data analysis
Madhavan MV, Shahim B, Mena‐Hurtado C, Garcia L, Crowley A, Parikh SA. Efficacy and safety of intravascular lithotripsy for the treatment of peripheral arterial disease: An individual patient‐level pooled data analysis. Catheterization And Cardiovascular Interventions 2020, 95: 959-968. PMID: 31957955, PMCID: PMC7187419, DOI: 10.1002/ccd.28729.Peer-Reviewed Original ResearchConceptsIndividual patient-level dataPeripheral arterial diseaseUse of IVLIntravascular lithotripsyArterial diseaseProspective studyTreatment of PADSafety of IVLPeripheral arterial calcificationPeripheral artery calcificationPeripheral intravascular lithotripsyProcedural angiographic complicationsFlow-limiting dissectionIndependent core laboratoryTreatment of patientsPercent diameter stenosisLong-term patencyPatient-level dataAngiographic complicationsAcute successEfficacy endpointEndovascular revascularizationSafety endpointArtery calcificationDistal embolization
2019
Absence of Coronary Artery Calcification in Middle-Aged Familial Hypercholesterolemia Patients Without Atherosclerotic Cardiovascular Disease
Mszar R, Grandhi GR, Valero-Elizondo J, Virani SS, Blankstein R, Blaha M, Mata P, Miname MH, Al Rasadi K, Krumholz HM, Santos RD, Nasir K. Absence of Coronary Artery Calcification in Middle-Aged Familial Hypercholesterolemia Patients Without Atherosclerotic Cardiovascular Disease. JACC Cardiovascular Imaging 2019, 13: 1090-1092. PMID: 31843585, DOI: 10.1016/j.jcmg.2019.11.001.Peer-Reviewed Original ResearchMedial artery calcification increases neointimal hyperplasia after balloon injury
Marshall AP, Luo W, Wang XL, Lin T, Cai Y, Guzman RJ. Medial artery calcification increases neointimal hyperplasia after balloon injury. Scientific Reports 2019, 9: 8193. PMID: 31160618, PMCID: PMC6547750, DOI: 10.1038/s41598-019-44668-4.Peer-Reviewed Original ResearchMeSH KeywordsAngioplasty, BalloonAnimalsBone Morphogenetic Protein 2CalcinosisCalcium ChlorideCarotid ArteriesCarotid Artery InjuriesCell ProliferationCoronary RestenosisDisease Models, AnimalHyperplasiaMaleMuscle, Smooth, VascularMyocytes, Smooth MuscleNeointimaProliferating Cell Nuclear AntigenRatsRats, Sprague-DawleyTunica IntimaConceptsSmooth muscle cellsNeointimal hyperplasiaBalloon injuryArterial calcificationCalcified arteriesMedial smooth muscle cellsCell nuclear antigen stainingBalloon catheter injuryMedial artery calcificationTime of injuryVascular smooth muscle cellsNeointimal cell proliferationCell proliferationCatheter injuryArtery calcificationMedial calcificationSubcutaneous injectionAntigen stainingVitamin D3Rat carotidEffect of calcificationArteryHyperplasiaAdventitial applicationInjuryReclassification of coronary heart disease risk in a primary prevention setting: traditional risk factor assessment vs . coronary artery calcium scoring
Alashi A, Lang R, Seballos R, Feinleib S, Sukol R, Cho L, Schoenhagen P, Griffin BP, Flamm SD, Desai MY. Reclassification of coronary heart disease risk in a primary prevention setting: traditional risk factor assessment vs . coronary artery calcium scoring. Cardiovascular Diagnosis And Therapy 2019, 9: 214-220. PMID: 31275811, PMCID: PMC6603493, DOI: 10.21037/cdt.2019.04.05.Peer-Reviewed Original ResearchReynolds Risk ScoreC-reactive proteinCoronary heart disease riskHeart disease riskPrimary preventionCHD riskAsymptomatic middle-aged patientsAsymptomatic middle-aged subjectsAtherosclerotic cardiovascular disease (ASCVD) scoreTraditional risk factor assessmentDisease riskMean C-reactive proteinCoronary artery calcium scoringConsecutive asymptomatic subjectsSignificant risk reclassificationCoronary artery calcificationMiddle-aged patientsRisk factor assessmentMiddle-aged subjectsStandard risk factorsASCVD scorePrevention clinicArtery calcificationCAC scoringAsymptomatic subjects
2018
Lipoprotein Sub-Fractions by Ion-Mobility Analysis and Its Association with Subclinical Coronary Atherosclerosis in High-Risk Individuals
Aneni EC, Osondu CU, De La Cruz J, Martin SS, Blaha MJ, Younus A, Feldman T, Agatston AS, Veledar E, Nasir K. Lipoprotein Sub-Fractions by Ion-Mobility Analysis and Its Association with Subclinical Coronary Atherosclerosis in High-Risk Individuals. Journal Of Atherosclerosis And Thrombosis 2018, 26: 50-63. PMID: 30224606, PMCID: PMC6308270, DOI: 10.5551/jat.40741.Peer-Reviewed Original ResearchConceptsCoronary artery calcificationLipoprotein subfractionsCoronary atherosclerosisRisk of CACLipoprotein particlesLipoprotein subfraction analysisSubclinical coronary atherosclerosisBaptist Health South FloridaLarge LDL particlesHigh-risk personsHigh-risk populationHigh-risk individualsTriglyceride-rich lipoproteinsHigh-risk workersArtery calcificationIDL particlesMetabolic syndromeLipoprotein profileHDL lipoproteinsMean ageLipoprotein subclassesMedium LDLStudy populationRisk individualsVLDL particlesMultifactorial Analysis of Mortality in Screening Detected Lung Cancer
Digumarthy SR, De Man R, Canellas R, Otrakji A, Wang G, Kalra MK. Multifactorial Analysis of Mortality in Screening Detected Lung Cancer. Journal Of Oncology 2018, 2018: 1296246. PMID: 29861726, PMCID: PMC5976935, DOI: 10.1155/2018/1296246.Peer-Reviewed Original ResearchCoronary artery calcificationNational Lung Screening TrialLow-dose CTBody mass indexLung cancerFat attenuationMuscle massLow-dose chest CTLung cancer mortalitySeverity of emphysemaLung cancer stageNLST trialNonsurvivor groupArtery calcificationSmoking historyMass indexCancer mortalityChest CTCancer stageSurvivor groupScreening TrialSurvival timeEmphysemaPatientsCancer
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