2025
Interventional treatment strategies for arteriovenous malformations of the mandible and maxilla: 30-year institutional case series.
Sujijantarat N, Padmanaban V, Larson A, Troulis M, Kaban L, Curtin H, Rabinov J. Interventional treatment strategies for arteriovenous malformations of the mandible and maxilla: 30-year institutional case series. Interventional Neuroradiology 2025, 15910199251343000. PMID: 40398476, PMCID: PMC12095211, DOI: 10.1177/15910199251343000.Peer-Reviewed Original ResearchArteriovenous malformationsFollow-up angiographyDental extractionTreatment strategiesAV shuntsConsecutive series of patientsHigh-flow arteriovenous malformationsHistory of hemorrhageInstitutional case seriesTime of biopsyRisk of hemorrhageOutcomes of patientsSeries of patientsEvaluate treatment strategiesArteriovenous (AVInterventional treatment strategiesConclusionsMultidisciplinary treatmentFocused surgeryRefractory bleedingResultsNine patientsAngiographic closureBleeding episodesAlveolar ridgeSpontaneous regressionTrans-arterialEndovascular Embolization versus Observation of Congenital Renal Arteriovenous Malformations: A Retrospective Study
Hufnagle J, Fish A, Schlachter T. Endovascular Embolization versus Observation of Congenital Renal Arteriovenous Malformations: A Retrospective Study. Journal Of Vascular And Interventional Radiology 2025, 36: 988-993.e1. PMID: 39938714, DOI: 10.1016/j.jvir.2025.02.001.Peer-Reviewed Original ResearchCongenital renal arteriovenous malformationRenal arteriovenous malformationType I AVMArteriovenous malformationsEndovascular embolizationAdverse eventsImaging review of patientsReview of patientsArteriovenous malformation ruptureFollow-up dataYakes classificationTransarterial embolizationEmbolization groupPresenting symptomsPatient demographicsRetrospective studyProcedural imagingImaging reviewEmbolizationPatientsObservation groupMalformationsComplicationsVessel sizeNephrectomy
2024
Akt is a mediator of artery specification during zebrafish development
Zhou W, Ghersi J, Ristori E, Semanchik N, Prendergast A, Zhang R, Carneiro P, Baldissera G, Sessa W, Nicoli S. Akt is a mediator of artery specification during zebrafish development. Development 2024, 151: dev202727. PMID: 39101673, PMCID: PMC11441982, DOI: 10.1242/dev.202727.Peer-Reviewed Original ResearchArterial specificationEndothelial cellsVascular endothelial growth factor ADorsal aortaEndothelial growth factor ASingle-cell RNA sequencing analysisGrowth factor AArtery endothelial cellsEmbryonic cardiovascular systemConstitutively active Akt1Ligand-independent activationActivation of NotchArteriovenous malformationsCongenital malformationsRNA sequencing analysisVEGF-AProtein kinase BUpstream of NotchSequence analysisCardiovascular developmentSpecific expressionAkt kinaseActive Akt1Zebrafish developmentCardiovascular systemPulmonary Angiography: Arteriovenous Malformation and Pseudoaneurysm
Luhar A, Pollak J. Pulmonary Angiography: Arteriovenous Malformation and Pseudoaneurysm. 2024, 311-324. DOI: 10.1007/978-3-031-52546-9_25.Peer-Reviewed Original ResearchPulmonary arteriovenous malformationsRight-to-left shuntHereditary hemorrhagic telangiectasiaTransient ischemic attackChest painSize of pulmonary arteriovenous malformationsAssociated with hereditary hemorrhagic telangiectasiaDegree of right-to-left shuntingTreatment of pulmonary arteriovenous malformationsAssociated with paradoxical emboliIntrapulmonary right-to-left shuntFeeding artery diameterPulmonary artery pseudoaneurysmLocal mass effectBrain abscessPeripheral emboliIntrapulmonary hemorrhageArteriovenous malformationsHemorrhagic telangiectasiaSymptomatic hypoxemiaPulmonary arterySerious complicationsEndovascular treatmentArtery pseudoaneurysmParadoxical emboliRecurrence of Pulmonary Arteriovenous Malformation after Embolization in Patients with Pulmonary Hypertension
Fish A, Wang D, Knight E, Pollak J, Schlachter T. Recurrence of Pulmonary Arteriovenous Malformation after Embolization in Patients with Pulmonary Hypertension. Journal Of Vascular And Interventional Radiology 2024, 35: 1148-1153. PMID: 38692392, DOI: 10.1016/j.jvir.2024.04.017.Peer-Reviewed Original ResearchPulmonary arteriovenous malformationsPulmonary hypertensionArteriovenous malformationsRecurrence of pulmonary arteriovenous malformationsFollow-upChest CT follow-upPresence of pulmonary hypertensionCT follow-upShorter surveillance intervalsPulmonary artery pressureHistory of smokingPresence of PHCuracao criteriaSurveillance intervalsSmoking historyArterial pressureMultivariate analysisRecurrenceGenetic testingOdds ratioHypertensionPatientsStratified analysisGeneral demographicsStudy periodBrain AVM compactness score in children with hereditary hemorrhagic telangiectasia
Beslow L, Vossough A, Kim H, Nelson J, Lawton M, Pollak J, Lin D, Ratjen F, Hammill A, Hetts S, Gossage J, Whitehead K, Faughnan M, Krings T. Brain AVM compactness score in children with hereditary hemorrhagic telangiectasia. Child's Nervous System 2024, 40: 2101-2108. PMID: 38517485, PMCID: PMC11179972, DOI: 10.1007/s00381-024-06366-z.Peer-Reviewed Original ResearchBrain arteriovenous malformationsSporadic brain arteriovenous malformationsHereditary hemorrhagic telangiectasiaHemorrhagic riskHemorrhagic telangiectasiaBrain arteriovenous malformation treatmentBrain vascular malformationsCompact nidusSurgical resectionArteriovenous malformationsIntracranial hemorrhageVascular malformationsRecurrence riskResultsForty-eightInterventional neuroradiologistsAngiographic measurementsHemorrhageNidusAngiogramMalformationsRecurrenceTelangiectasiaRiskChildrenBrain
2023
Mutation of key signaling regulators of cerebrovascular development in vein of Galen malformations
Zhao S, Mekbib K, van der Ent M, Allington G, Prendergast A, Chau J, Smith H, Shohfi J, Ocken J, Duran D, Furey C, Hao L, Duy P, Reeves B, Zhang J, Nelson-Williams C, Chen D, Li B, Nottoli T, Bai S, Rolle M, Zeng X, Dong W, Fu P, Wang Y, Mane S, Piwowarczyk P, Fehnel K, See A, Iskandar B, Aagaard-Kienitz B, Moyer Q, Dennis E, Kiziltug E, Kundishora A, DeSpenza T, Greenberg A, Kidanemariam S, Hale A, Johnston J, Jackson E, Storm P, Lang S, Butler W, Carter B, Chapman P, Stapleton C, Patel A, Rodesch G, Smajda S, Berenstein A, Barak T, Erson-Omay E, Zhao H, Moreno-De-Luca A, Proctor M, Smith E, Orbach D, Alper S, Nicoli S, Boggon T, Lifton R, Gunel M, King P, Jin S, Kahle K. Mutation of key signaling regulators of cerebrovascular development in vein of Galen malformations. Nature Communications 2023, 14: 7452. PMID: 37978175, PMCID: PMC10656524, DOI: 10.1038/s41467-023-43062-z.Peer-Reviewed Original ResearchConceptsEphrin receptor B4Galen malformationBrain arteriovenous malformationsP120 RasGAPTransmitted variantsArteriovenous malformationsDe novo variantsSingle-cell transcriptomesSignificant burdenCerebrovascular developmentIntegrative genomic analysisEndothelial cellsVenous networkAdditional probandsMalformationsNovo variantsMissense variantsGenomic analysisDevelopmental angiogenesisVascular developmentDamaging variantsVeinRasGAPIntegrated analysisPatients345 Structural Cardiac Defects and Vascular Anomalies in Vein of Galen Malformation Patients: A Multi-Institutional Cohort With Genetic Sequencing
Piwowarczyk P, Moyer Q, Mekbib K, Kappel A, Zhao S, Shohfi J, Smith H, Orbach D, See A, Smith E, Kahle K. 345 Structural Cardiac Defects and Vascular Anomalies in Vein of Galen Malformation Patients: A Multi-Institutional Cohort With Genetic Sequencing. Neurosurgery 2023, 69: 55-55. DOI: 10.1227/neu.0000000000002375_345.Peer-Reviewed Original ResearchCapillary malformation-arteriovenous malformation syndromeHereditary hemorrhagic telangiectasiaStructural cardiac defectsCutaneous vascular lesionsCardiac defectsWhole-exome sequencingRecurrent epistaxisVascular abnormalitiesVascular lesionsArteriovenous malformationsGeneral populationExome sequencingRole of EphB4Patent ductus arteriosusBrain arteriovenous malformationsAtrial septal defectGalen malformationDuctus arteriosusClinical featuresInstitutional cohortMoyamoya diseaseVascular anomaliesSeptal defectVascular disordersNeurovascular disorderPreliminary dosimetric comparison between fixed and rotating source stereotactic radiosurgery systems
Draeger E, Chen Z, Hansen J, Chiang V, Tien C. Preliminary dosimetric comparison between fixed and rotating source stereotactic radiosurgery systems. Journal Of Applied Clinical Medical Physics 2023, 24: e13907. PMID: 36660774, PMCID: PMC10161057, DOI: 10.1002/acm2.13907.Peer-Reviewed Original ResearchConceptsConformity indexRadiation Therapy Oncology Group conformity indexGK plansSuperior conformity indexNon-metastatic casesPaddick conformity indexDosimetric plan qualityGK patientsBrain metastasesRadiosurgery systemTrigeminal neuralgiaPrescription dosesGamma Knife systemMetastatic casesArteriovenous malformationsPituitary adenomasConformality indexLarge cohortDosimetric comparisonStereotactic radiosurgery systemGK IconPatientsCohortTreatment timeDosimetric resultsTransfrontal Approach to the Amygdala for Ablation With Laser Interstitial Thermal Therapy: An Epilepsy Case Report
Lamsam L, Brigido M, Sivaraju A, Hirsch L, Spencer D, Chiang V, Damisah E. Transfrontal Approach to the Amygdala for Ablation With Laser Interstitial Thermal Therapy: An Epilepsy Case Report. Operative Neurosurgery 2023, 24: e381-e384. PMID: 36715982, PMCID: PMC10158899, DOI: 10.1227/ons.0000000000000576.Peer-Reviewed Original ResearchConceptsStereotactic laser amygdalohippocampotomyLaser interstitial thermal therapyEntorhinal cortexInterstitial thermal therapyComplete ablationMesial temporal lobe epilepsyTemporal arteriovenous malformationTemporal lobe epilepsyLeft temporal arteriovenous malformationMiddle frontal gyrusPrior craniotomyOpen resectionLobe epilepsyCase reportMedial amygdalaArteriovenous malformationsAnterior entorhinal cortexTransfrontal approachAmygdalaInvasive surgeryFrontal gyrusThermal therapyIntracranial electroencephalographyResection
2022
Mitochondrial dysfunction induces ALK5-SMAD2-mediated hypovascularization and arteriovenous malformations in mouse retinas
Zhang H, Li B, Huang Q, López-Giráldez F, Tanaka Y, Lin Q, Mehta S, Wang G, Graham M, Liu X, Park I, Eichmann A, Min W, Zhou J. Mitochondrial dysfunction induces ALK5-SMAD2-mediated hypovascularization and arteriovenous malformations in mouse retinas. Nature Communications 2022, 13: 7637. PMID: 36496409, PMCID: PMC9741628, DOI: 10.1038/s41467-022-35262-w.Peer-Reviewed Original ResearchConceptsMitochondrial dysfunctionThioredoxin 2Single-cell RNA-seq analysisRNA-seq analysisMutant miceNuclear genesMitochondrial proteinsMitochondrial localizationHuman retinal diseasesTranscriptional factorsGene expressionMutant retinasMitochondrial activityExtracellular matrixNovel mechanismVascular maturationArteriovenous malformationsGenetic deficiencyVessel growthSmad2Mouse retinaVascular malformationsMechanistic studiesBasement membraneRetinal vascular malformationsTranspleural Systemic Artery-to-Pulmonary Artery Shunts: A Potential Mimicker of Pulmonary Arteriovenous Malformations
Fish A, Chan SM, Pollak J, Schlachter T. Transpleural Systemic Artery-to-Pulmonary Artery Shunts: A Potential Mimicker of Pulmonary Arteriovenous Malformations. Journal Of Vascular And Interventional Radiology 2022, 34: 300-303. PMID: 36283590, DOI: 10.1016/j.jvir.2022.10.028.Peer-Reviewed Original ResearchConceptsPulmonary artery shuntPulmonary arteriovenous malformationsPotential mimickersSystemic arteriesArteriovenous malformations
2021
Adverse radiation effects in volume-staged radiosurgery for large arteriovenous malformations: a multiinstitutional study.
Seymour ZA, Chan JW, McDermott MW, Grills I, Ye H, Kano H, Lehocky CA, Jacobs RC, Lunsford LD, Chytka T, Liščák R, Lee CC, Yang HC, Ding D, Sheehan JP, Feliciano CE, Rodriguez-Mercado R, Chiang VL, Hess JA, Sommaruga S, McShane B, Lee JYK, Vasas LT, Kaufmann AM, Sneed PK. Adverse radiation effects in volume-staged radiosurgery for large arteriovenous malformations: a multiinstitutional study. Journal Of Neurosurgery 2021, 136: 503-511. PMID: 34450589, DOI: 10.3171/2020.12.jns201866.Peer-Reviewed Original ResearchConceptsAdverse radiation effectsLarge arteriovenous malformationsArteriovenous malformationsVS-SRSLobe involvementSymptomatic adverse radiation effectsVolume-staged stereotactic radiosurgeryMedian margin doseOptimal treatment paradigmAVM nidus volumeTemporal lobe involvementVolume-staged radiosurgeryParietal lobe involvementMultiinstitutional cohortRadiosurgical centersMargin doseMedian ageRetrospective reviewEntire nidusMaximal linear dimensionMultiinstitutional studyNidus volumeTreatment paradigmStereotactic radiosurgeryPatientsDefective Flow-Migration Coupling Causes Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia
Park H, Furtado J, Poulet M, Chung M, Yun S, Lee S, Sessa WC, Franco CA, Schwartz MA, Eichmann A. Defective Flow-Migration Coupling Causes Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia. Circulation 2021, 144: 805-822. PMID: 34182767, PMCID: PMC8429266, DOI: 10.1161/circulationaha.120.053047.Peer-Reviewed Original ResearchConceptsActivin receptor-like kinase 1Hereditary hemorrhagic telangiectasiaHemorrhagic telangiectasiaVascular malformationsArteriovenous malformationsBlood flowGrowth factor receptor 2Endothelial growth factor receptor 2Vascular endothelial growth factor receptor 2Factor receptor 2Receptor-like kinase 1New potential targetsYAP/TAZ nuclear translocationDeficient miceTransmembrane serine-threonine kinase receptorsDevastating disorderAlk1 deletionReceptor 2Pharmacologic inhibitionCre linesPostnatal retinaMalformationsSerine-threonine kinase receptorsEndothelial cell migrationNuclear translocationSa093 IMPROVING QUALITY OF CARE FOR PATIENTS WITH GASTROINTESTINAL BLEEDING DUE TO SMALL BOWEL ARTERIOVENOUS MALFORMATIONS
Szafron D, Chatterjee R, Bushan S, Ketwaroo G. Sa093 IMPROVING QUALITY OF CARE FOR PATIENTS WITH GASTROINTESTINAL BLEEDING DUE TO SMALL BOWEL ARTERIOVENOUS MALFORMATIONS. Gastroenterology 2021, 160: s-418. DOI: 10.1016/s0016-5085(21)01706-6.Peer-Reviewed Original ResearchFever, pancytopenia, and elevated D-dimer in a 95‐year‐old woman with ehrlichiosis: a case report
Radcliffe C, Tsay C, Glerum K, Liao J, Goshua G, Kerins G. Fever, pancytopenia, and elevated D-dimer in a 95‐year‐old woman with ehrlichiosis: a case report. BMC Geriatrics 2021, 21: 178. PMID: 33711942, PMCID: PMC7953191, DOI: 10.1186/s12877-021-02129-6.Peer-Reviewed Original ResearchConceptsD-dimerPulmonary emboliSevere coronavirus disease 2019Hospital day 7Computed tomography angiogramSignificant clinical findingsPeripheral blood smearCoronavirus disease 2019Concurrent ehrlichiosisDoxycycline monotherapyHospital stayHigh feverSymptomatic improvementTomography angiogramCase presentationWeClinical findingsLarge academic institutionCase reportArteriovenous malformationsAppropriate treatmentDifferential diagnosisUnexpected presentationDisease 2019Hematological malignanciesDay 7Stop the Divide and Build Coronary Arteries
Zarkada G, Eichmann A. Stop the Divide and Build Coronary Arteries. Developmental Cell 2021, 56: 255-256. PMID: 33561420, PMCID: PMC12128094, DOI: 10.1016/j.devcel.2021.01.008.Commentaries, Editorials and Letters
2020
Genotype–Phenotype Correlations in Children with HHT
Kilian A, Latino GA, White AJ, Clark D, Chakinala MM, Ratjen F, McDonald J, Whitehead K, Gossage JR, Lin D, Henderson K, Pollak J, McWilliams JP, Kim H, Lawton MT, Faughnan ME, . Genotype–Phenotype Correlations in Children with HHT. Journal Of Clinical Medicine 2020, 9: 2714. PMID: 32842615, PMCID: PMC7565052, DOI: 10.3390/jcm9092714.Peer-Reviewed Original ResearchBrain vascular malformationsHereditary hemorrhagic telangiectasiaPulmonary arteriovenous malformationsGenotype-phenotype correlationVascular malformationsArteriovenous malformationsHHT patientsCentral nervous systemRare autosomal dominant diseaseChi-square testAutosomal dominant diseaseGastrointestinal bleedingPediatric patientsMucocutaneous telangiectasiaHemorrhagic telangiectasiaGreater prevalenceNervous systemPatientsPhenotypic presentationDominant diseaseMalformationsAdultsChildrenTelangiectasiaMutationsMRI-Guided Laser Interstitial Thermal Therapy for Radiation Necrosis in Previously Irradiated Brain Arteriovenous Malformations
Hong CS, Cord BJ, Kundishora AJ, Elsamadicy AA, Beckta JM, Huttner A, Chiang VL, Matouk CC. MRI-Guided Laser Interstitial Thermal Therapy for Radiation Necrosis in Previously Irradiated Brain Arteriovenous Malformations. Practical Radiation Oncology 2020, 10: e298-e303. PMID: 32068154, DOI: 10.1016/j.prro.2020.02.003.Peer-Reviewed Original Research
2019
Dose response and architecture in volume staged radiosurgery for large arteriovenous malformations: A multi-institutional study
Seymour ZA, Chan JW, Sneed PK, Kano H, Lehocky CA, Jacobs RC, Ye H, Chytka T, Liscak R, Lee CC, Yang HC, Ding D, Sheehan J, Feliciano CE, Rodriguez-Mercado R, Chiang VL, Hess JA, Sommaruga S, McShane B, Lee J, Vasas LT, Kaufmann AM, Grills I, McDermott MW. Dose response and architecture in volume staged radiosurgery for large arteriovenous malformations: A multi-institutional study. Radiotherapy And Oncology 2019, 144: 180-188. PMID: 31835173, DOI: 10.1016/j.radonc.2019.09.019.Peer-Reviewed Original ResearchConceptsLarge arteriovenous malformationsArteriovenous malformationsVS-SRSMargin doseObliteration rateVolume-staged stereotactic radiosurgeryMedian margin doseHigh-risk lesionsOptimal treatment paradigmAVM nidus volumeMulti-institutional studyImproved ratesCompact nidusEvaluable patientsMedian followRadiosurgical centersOverall survivalUpfront treatmentComplete responseMedian ageRetrospective reviewCure rateRare lesionsPrior embolizationTreatment paradigm
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