2025
Sustained tenascin-C expression drives neointimal hyperplasia and promotes aortocaval fistula failure
Gonzalez L, Zhang W, Bai H, Taniguchi R, Ramachandra A, Jovin D, Ohashi Y, Nguyen M, Thaxton C, Yatsula B, Vazquez-Padron R, Humphrey J, Martin K, Kyriakides T, Dardik A. Sustained tenascin-C expression drives neointimal hyperplasia and promotes aortocaval fistula failure. AJP Heart And Circulatory Physiology 2025, 328: h1147-h1167. PMID: 40247455, PMCID: PMC12150301, DOI: 10.1152/ajpheart.00661.2024.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArteriovenous Shunt, SurgicalDisease Models, AnimalGraft Occlusion, VascularHuman Umbilical Vein Endothelial CellsHumansHyperplasiaMacrophagesMaleMiceMice, Inbred C57BLMice, KnockoutMyocytes, Smooth MuscleNeointimaNF-kappa BTenascinThrombomodulinVascular PatencyVascular RemodelingVena Cava, InferiorConceptsArteriovenous fistula patencyTenascin-C expressionArteriovenous fistulaTissue factor expressionEnd-stage kidney diseaseAnti-inflammatory macrophage polarizationNeointimal hyperplasiaWT miceTenascin-CInflammatory microenvironmentWild-typeFactor expressionMacrophage polarizationArteriovenous fistula outcomesArteriovenous fistula failurePatent arteriovenous fistulaVein smooth muscle cellsArteriovenous fistula maturationSmooth muscle cellsOccluded arteriovenous fistulaHuman umbilical vein smooth muscle cellsImprove dialysis outcomesHuman umbilical vein endothelial cellsRegulation of inflammationNF-kB activationSurgical Management of Tumours Invading the Inferior Vena Cava: A Delphi Consensus Document
Balaz P, Whitley A, Heinola I, Gargiulo M, Vikatmaa P, Group O, Ancetti S, Berard X, Cananzi F, Cardella J, Dawson J, Debus S, D'Oria M, Kantonen I, Langenskiöld M, Molacek J, Min S, Kuntz S, Todorov A. Surgical Management of Tumours Invading the Inferior Vena Cava: A Delphi Consensus Document. European Journal Of Vascular And Endovascular Surgery 2025 PMID: 40185394, DOI: 10.1016/j.ejvs.2025.03.034.Peer-Reviewed Original ResearchInferior vena cavaInferior vena cava resectionSurgical management of tumorsManagement of tumorsComputed tomographySurgical managementVena cavaSuprarenal inferior vena cavaInferior vena cava filterAbdominal computed tomographyGold standard imaging methodMechanical compression devicesStandard imaging methodTumour embolisationRetroperitoneal tumorMalignant thrombusRetroperitoneal malignanciesCT angiographyArteriovenous fistulaCollateral circulationTumorThrombosis preventionResponse rateGraft materialConsensus documentAnatomy of Endovascular Arteriovenous Fistula Creation
Cornman-Homonoff J, Razdan R, Lozada J. Anatomy of Endovascular Arteriovenous Fistula Creation. Seminars In Interventional Radiology 2025, 42: 176-181. PMID: 40376219, PMCID: PMC12077948, DOI: 10.1055/s-0045-1805040.Peer-Reviewed Original ResearchChanges in vascular identity during vascular remodeling
Aoyagi Y, Schwartz A, Li Z, Bai H, Gonzalez L, Etchebarne C, Ohashi Y, Kano M, Ho B, Martin K, Dardik A. Changes in vascular identity during vascular remodeling. JVS Vascular Science 2025, 6: 100282. PMID: 40213096, PMCID: PMC11985068, DOI: 10.1016/j.jvssci.2025.100282.Peer-Reviewed Original ResearchArteriovenous fistulaVascular remodelingArterial identityVenous identityVascular identityVascular diseaseCell phenotypeMolecular regulatory pathwaysCellular identityVascular cell phenotypeCellular phenotypesRegulatory pathwaysMolecular markersCOUP-TFIIPotential therapeutic targetPathological vascular remodelingRecent Innovations and Advances in Arteriovenous Fistula Creation: A Narrative Review.
Lazcano-Etchebarne C, Aboian E, Strosberg D, Sadaghianloo N, Schwartz A, Ho B, Ohashi Y, Kano M, Gonzalez L, Bai H, Dardik A. Recent Innovations and Advances in Arteriovenous Fistula Creation: A Narrative Review. Vascular Investigation And Therapy 2025, 8: 7-17. PMID: 40417719, PMCID: PMC12103191, DOI: 10.4103/vit.vit_2_25.Peer-Reviewed Original ResearchArteriovenous fistulaAVF maturationVascular accessEndovascular arteriovenous fistulaImprove AVF patencyLonger-term patencyRadial artery deviationNeointimal hyperplasiaArteriovenous fistula creationCentral vein stenosisRates of AVF failureArteriovenous fistula maturationStem cell therapyImprove AVF maturationImmune system modulationReducing neointimal hyperplasiaVein stenosisAVF patencyFistula creationAVF failureCell therapyDialysis accessPercutaneous approachDistal ischemiaImprove outcomes
2024
Endothelial TGF-β Signaling Regulates Endothelial-Mesenchymal Transition During Arteriovenous Fistula Remodeling in Mice With Chronic Kidney Disease
Zhang W, Gonzalez L, Li X, Bai H, Li Z, Taniguchi R, Langford J, Ohashi Y, Thaxton C, Aoyagi Y, Yatsula B, Martin K, Goodwin J, Tellides G, Long X, Shu C, Dardik A. Endothelial TGF-β Signaling Regulates Endothelial-Mesenchymal Transition During Arteriovenous Fistula Remodeling in Mice With Chronic Kidney Disease. Arteriosclerosis Thrombosis And Vascular Biology 2024, 44: 2509-2526. PMID: 39297205, PMCID: PMC11593991, DOI: 10.1161/atvbaha.124.320933.Peer-Reviewed Original ResearchChronic kidney diseaseTGF-b signalingArteriovenous fistula patencyArteriovenous fistulaKidney diseaseAVF patencyEndothelial cellsAssociated with endothelial injuryArteriovenous fistula diameterImprove AVF patencyIncreased outward remodelingReduced patencyInduced endothelial-to-mesenchymal transitionAortocaval fistula modelSmooth muscle cell proliferationArteriovenous fistula failureAttenuated EndMTEnd-stage kidney diseaseHuman arteriovenous fistulaeSmooth muscle cellsMuscle cell proliferationEndothelial-to-mesenchymal transitionMouse endothelial cellsInhibition of EndMTEndothelial-mesenchymal transitionEarly thrombus formation is required for eccentric and heterogeneous neointimal hyperplasia under disturbed flow
Bai H, Li Z, Zhang W, Thaxton C, Ohashi Y, Gonzalez L, Kano M, Yatsula B, Hwa J, Dardik A. Early thrombus formation is required for eccentric and heterogeneous neointimal hyperplasia under disturbed flow. Journal Of Thrombosis And Haemostasis 2024, 22: 3614-3628. PMID: 39173878, PMCID: PMC11608155, DOI: 10.1016/j.jtha.2024.07.028.Peer-Reviewed Original ResearchEndothelial cell lossArteriovenous fistulaSmooth muscle cellsNeointimal hyperplasiaHeterogeneous neointimaCell lossThrombus formationMT/mG reporter miceHuman arteriovenous fistulaeInhibit neointimal hyperplasiaEarly thrombus formationAntiplatelet therapyC57BL/6 miceReporter miceAVF failureWistar ratsVenous systemJuxta-anastomotic areaMuscle cellsAnimal modelsVenous outflowEarly thrombusEndothelial cellsArterial inflowThrombusHeterogeneous gene expression during early arteriovenous fistula remodeling suggests that downregulation of metabolism predicts adaptive venous remodeling
Ohashi Y, Protack C, Aoyagi Y, Gonzalez L, Thaxton C, Zhang W, Kano M, Bai H, Yatsula B, Alves R, Hoshina K, Schneider E, Long X, Perry R, Dardik A. Heterogeneous gene expression during early arteriovenous fistula remodeling suggests that downregulation of metabolism predicts adaptive venous remodeling. Scientific Reports 2024, 14: 13287. PMID: 38858395, PMCID: PMC11164895, DOI: 10.1038/s41598-024-64075-8.Peer-Reviewed Original ResearchConceptsGene expression patternsArteriovenous fistula groupArteriovenous fistulaExpression patternsHeterogeneous gene expressionGene expression changesOutcomes of arteriovenous fistulaVenous remodelingArteriovenous fistula maturationPostoperative day 7Reduce patient morbidityRNA sequencingUpregulation of metabolismBioinformatics analysisGene expressionDownregulation of metabolismMetabolic pathwaysExpression changesGenesAVF maturationAVF remodelingFistula creationC57BL/6 miceClinical outcomesPatient morbidityPrevalence and Associations of Dural Arteriovenous Fistulae in Cerebral Venous Thrombosis: Analysis of ACTION-CVT
Shoskes A, Shu L, Nguyen T, Abdalkader M, Giles J, Amar J, Siegler J, Henninger N, ElNazeir M, Al Kasab S, Klein P, Heldner M, Antonenko K, Psychogios M, Liebeskind D, Field T, Liberman A, Esenwa C, Simpkins A, Li G, Frontera J, Kuohn L, Rothstein A, Khazaal O, Aziz Y, Mistry E, Khatri P, Omran S, Zubair A, Sharma R, Starke R, Morcos J, Romano J, Yaghi S, Asdaghi N. Prevalence and Associations of Dural Arteriovenous Fistulae in Cerebral Venous Thrombosis: Analysis of ACTION-CVT. Journal Of Stroke 2024, 26: 325-329. PMID: 38836280, PMCID: PMC11164588, DOI: 10.5853/jos.2023.02264.Peer-Reviewed Original Research#2598 Risk of vascular access complications in haemodialysis patients initiating dialysis with arteriovenous fistula or arteriovenous graft
Willetts J, Usvyat L, Chaudhuri S, Niklason L, Maddux F. #2598 Risk of vascular access complications in haemodialysis patients initiating dialysis with arteriovenous fistula or arteriovenous graft. Nephrology Dialysis Transplantation 2024, 39: gfae069-1550-2598. DOI: 10.1093/ndt/gfae069.1550.Peer-Reviewed Original ResearchVascular access complication ratesArteriovenous fistulaEnd-stage kidney diseaseArteriovenous graftsVA complicationsVascular accessIn-center hemodialysisInitial VAComorbid conditionsDuration of follow-upAssociated with increased riskComplication eventsHistory of myocardial infarctionCongestive heart failureVascular access complicationsDiabetic ptsRisk of vascular access complicationsComplication rateDemographic characteristicsIncreased BMIDocumented thrombosisIn-center hemodialysis patientsContinuous hemodialysisHigher BMIHaemodialysis patientsDisturbed flow in the juxta-anastomotic area of an arteriovenous fistula correlates with endothelial loss, acute thrombus formation, and neointimal hyperplasia
Bai H, Varsanik M, Thaxton C, Ohashi Y, Gonzalez L, Zhang W, Aoyagi Y, Kano M, Yatsula B, Li Z, Pocivavsek L, Dardik A. Disturbed flow in the juxta-anastomotic area of an arteriovenous fistula correlates with endothelial loss, acute thrombus formation, and neointimal hyperplasia. AJP Heart And Circulatory Physiology 2024, 326: h1446-h1461. PMID: 38578237, PMCID: PMC11380968, DOI: 10.1152/ajpheart.00054.2024.Peer-Reviewed Original ResearchConceptsEndothelial cell lossOutflow veinChronic kidney diseaseJuxta-anastomotic areaMouse AVF modelNeointimal hyperplasiaThrombus formationAcute thrombus formationCell lossHuman AVF maturationGene OntologyAVF maturationAVF patencyEarly thrombus formationArteriovenous fistulaC57BL/6 miceClinical failureWistar ratsEndothelial lossKidney diseaseImmune responseEndothelial cellsHyperplasiaMiceAVFA central arteriovenous fistula reduces systemic hypertension in a mouse model
Brahmandam A, Alves R, Liu H, Gonzalez L, Aoyagi Y, Ohashi Y, Langford J, Thaxton C, Taniguchi R, Zhang W, Bai H, Yatsula B, Dardik A. A central arteriovenous fistula reduces systemic hypertension in a mouse model. JVS Vascular Science 2024, 5: 100191. PMID: 38510938, PMCID: PMC10951512, DOI: 10.1016/j.jvssci.2024.100191.Peer-Reviewed Original ResearchCentral arteriovenous fistulaArteriovenous fistulaBlood pressureAng IISystemic hypertensionVenous remodelingArteriovenous fistula creationPCNA-positive cellsPostoperative day 7Systemic blood pressureSystolic blood pressureCollagen I depositionNormotensive miceRefractory hypertensionHypertensive miceC57BL6/J miceHypertensive environmentTreated patientsAngiotensin IIMouse modelDay 7HypertensionMiceFistulaAng
2023
Sex hormones impact early maturation and immune response in the arteriovenous fistula mouse model
Satam K, Ohashi Y, Thaxton C, Gonzalez L, Setia O, Bai H, Aoyagi Y, Xie Y, Zhang W, Yatsula B, Martin K, Cai Y, Dardik A. Sex hormones impact early maturation and immune response in the arteriovenous fistula mouse model. AJP Heart And Circulatory Physiology 2023, 325: h77-h88. PMID: 37145957, PMCID: PMC10243550, DOI: 10.1152/ajpheart.00049.2023.Peer-Reviewed Original ResearchConceptsIntact female miceAVF maturationSex hormonesT cellsFemale miceArteriovenous fistulaMale miceMouse modelHigher IL-10Arteriovenous fistula creationImmune cell recruitmentSex-specific therapiesHormone receptor signalingSex differencesHuman AVF maturationAVF surgeryMale patientsClinical outcomesFemale patientsFistula maturationIL-10C57BL/6 miceInferior outcomesVenous adaptationFistula creationProspective, randomized, multicenter clinical study comparing a self-expanding covered stent to percutaneous transluminal angioplasty for treatment of upper extremity hemodialysis arteriovenous fistula stenosis
Dolmatch B, Cabrera T, Pergola P, Balamuthusamy S, Makris A, Cooper R, Moore E, Licht J, Macaulay E, Maleux G, Pfammatter T, Settlage R, Cristea E, Lansky A, Investigators A, Dolmatch B, Goh G, Hawkins S, Macaulay E, Spark I, de Graff R, Deutschmann H, Kickuth R, Maleux G, Pfammatter T, Kirksey L, Mendes R, Aruny J, Ali V, Cabrera T, Pergola P, Sharma D, Moore E, Shah H, Dwyer A, Yee D, Teng W, Cooper R, Balamuthusamy S, Lipkowitz G, Saad T, Licht J, Makris A, Rogers T, Burgess J, Hoggard J. Prospective, randomized, multicenter clinical study comparing a self-expanding covered stent to percutaneous transluminal angioplasty for treatment of upper extremity hemodialysis arteriovenous fistula stenosis. Kidney International 2023, 104: 189-200. PMID: 36990214, DOI: 10.1016/j.kint.2023.03.015.Peer-Reviewed Original ResearchConceptsTarget lesion primary patencyAccess circuit primary patencyPercutaneous transluminal angioplastyTarget lesion reinterventionPrimary patencyTransluminal angioplastyArteriovenous fistulaAVF stenosisAdditional clinical outcomesCircuit primary patencyCovered stent groupLesion primary patencyMulticenter clinical studyHemodialysis arteriovenous fistula stenosisArteriovenous fistula stenosisHemodialysis patientsPrimary outcomeRandomized studyClinical outcomesAVF dysfunctionStent groupClinical studiesFistula stenosisSix monthsPatientsArterial Diameter and Percentage of Monocytes are Sex-Dependent Predictors of Early Arteriovenous Fistula Maturation
Satam K, Setia O, Moore M, Schneider E, Chaar C, Dardik A. Arterial Diameter and Percentage of Monocytes are Sex-Dependent Predictors of Early Arteriovenous Fistula Maturation. Annals Of Vascular Surgery 2023, 93: 128-136. PMID: 36812979, PMCID: PMC10277224, DOI: 10.1016/j.avsg.2023.01.052.Peer-Reviewed Original ResearchConceptsFistula maturationArteriovenous fistula maturationArterial diameterArteriovenous fistulaFistula creationBrachial artery diameterPrimary arteriovenous fistulaPercentage of neutrophilsPeak systolic velocityPercentage of monocytesBrachial-cephalic fistulaElectronic medical recordsSex differencesFistula utilizationInferior patencyPostoperative ultrasoundUnassisted maturationYears postprocedureSingle centerArtery diameterArterial inflowArterial velocitySystolic velocityMedical recordsMonocyte percentage
2022
Endothelial Cell TGF-β (Transforming Growth Factor-Beta) Signaling Regulates Venous Adaptive Remodeling to Improve Arteriovenous Fistula Patency
Taniguchi R, Ohashi Y, Lee JS, Hu H, Gonzalez L, Zhang W, Langford J, Matsubara Y, Yatsula B, Tellides G, Fahmy TM, Hoshina K, Dardik A. Endothelial Cell TGF-β (Transforming Growth Factor-Beta) Signaling Regulates Venous Adaptive Remodeling to Improve Arteriovenous Fistula Patency. Arteriosclerosis Thrombosis And Vascular Biology 2022, 42: 868-883. PMID: 35510552, PMCID: PMC9233042, DOI: 10.1161/atvbaha.122.317676.Peer-Reviewed Original ResearchConceptsArteriovenous fistulaSMC proliferationAVF patencyCollagen densityMouse aortocaval fistula modelTGF-β receptor IArteriovenous fistula patencyAortocaval fistula modelInhibition of TGFPredetermined time pointsTGF-β inhibitionTGF-β signalingTGF-β receptorDisruption of TGFFistula patencyAVF failureWall thicknessVascular accessVenous remodelingSuccessful hemodialysisDoppler ultrasoundFistula modelReceptor IPatencyTGF
2021
PD-L1 (Programmed Death Ligand 1) Regulates T-Cell Differentiation to Control Adaptive Venous Remodeling
Matsubara Y, Gonzalez L, Kiwan G, Liu J, Langford J, Gao M, Gao X, Taniguchi R, Yatsula B, Furuyama T, Matsumoto T, Komori K, Mori M, Dardik A. PD-L1 (Programmed Death Ligand 1) Regulates T-Cell Differentiation to Control Adaptive Venous Remodeling. Arteriosclerosis Thrombosis And Vascular Biology 2021, 41: 2909-2922. PMID: 34670406, PMCID: PMC8664128, DOI: 10.1161/atvbaha.121.316380.Peer-Reviewed Original ResearchConceptsPD-L1AVF maturationPD-L1 activityVenous remodelingT cellsL1 antibodyArteriovenous fistulaNude miceMouse aortocaval fistula modelEnd-stage renal diseaseT helper type 2 cellsT helper type 1 (Th1) cellsPrimary success rateSmooth muscle cell proliferationRegulatory T cellsT cell activityT-cell transferAortocaval fistula modelPreferred vascular accessVascular wall thickeningM1-type macrophagesM2-type macrophagesPotential therapeutic targetMuscle cell proliferationType 1 cellsSex Differences in Inflammation During Venous Remodeling of Arteriovenous Fistulae
Chan SM, Weininger G, Langford J, Jane-Wit D, Dardik A. Sex Differences in Inflammation During Venous Remodeling of Arteriovenous Fistulae. Frontiers In Cardiovascular Medicine 2021, 8: 715114. PMID: 34368264, PMCID: PMC8335484, DOI: 10.3389/fcvm.2021.715114.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsAVF maturationVenous remodelingSex differencesPre-menopausal womenArteriovenous fistula maturationFistula environmentFistula utilizationCardiovascular eventsArterial diseaseClinical presentationFistula maturationArteriovenous fistulaVascular accessArterial remodelingVascular disordersClinical studiesVascular remodelingAnimal modelsInflammationAVF successVessel dilationWall thickeningVascular therapyWomenRemodelingArteriovenous fistula-induced cardiac remodeling shows cardioprotective features in mice
Lee SR, Thorn S, Guerrera N, Gonzalez L, Taniguchi R, Langford J, Sinusas AJ, Dardik A. Arteriovenous fistula-induced cardiac remodeling shows cardioprotective features in mice. JVS Vascular Science 2021, 2: 110-128. PMID: 34423320, PMCID: PMC8375600, DOI: 10.1016/j.jvssci.2021.05.002.Peer-Reviewed Original ResearchArteriovenous fistulaCardiac hypertrophyCardioprotective featuresRelative LV wall thicknessPoor cardiac outcomesRight heart functionSham-operated miceAdaptive cardiac hypertrophyLV wall thicknessSignificant sex-dependent differencesAreas of fibrosisInflammation-related genesPhysiologic cardiac hypertrophyCardiac chamber sizeCardiac fetal genesWild-type miceSex-dependent differencesSimilar body weightIngenuity Pathway AnalysisArrhythmogenic featuresAVF miceSerial echocardiographyCardiac outcomesDiastolic functionLV systolicInhibition of T-Cells by Cyclosporine A Reduces Macrophage Accumulation to Regulate Venous Adaptive Remodeling and Increase Arteriovenous Fistula Maturation
Matsubara Y, Kiwan G, Liu J, Gonzalez L, Langford J, Gao M, Gao X, Taniguchi R, Yatsula B, Furuyama T, Matsumoto T, Komori K, Dardik A. Inhibition of T-Cells by Cyclosporine A Reduces Macrophage Accumulation to Regulate Venous Adaptive Remodeling and Increase Arteriovenous Fistula Maturation. Arteriosclerosis Thrombosis And Vascular Biology 2021, 41: e160-e174. PMID: 33472405, PMCID: PMC7904667, DOI: 10.1161/atvbaha.120.315875.Peer-Reviewed Original ResearchConceptsVascular wall thickeningT helper type 1 (Th1) cellsSuccessful AVF maturationAVF maturationRegulatory T cellsMacrophage accumulationT cellsType 1 cellsArteriovenous fistulaVenous remodelingWall thickeningMouse aortocaval fistula modelT helper type 2T helper type 2 cellsAdaptive remodelingM2 macrophage accumulationPrimary success rateAortocaval fistula modelArteriovenous fistula maturationPreferred vascular accessAnti-inflammatory macrophagesT cell functionWild-type miceEffect of CsAType 2 cells
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