2024
Novel Mechanical Aspiration Thrombectomy in Patients With Acute Pulmonary Embolism: Results From the Prospective APEX-AV Trial
Ranade M, Foster M, Brady P, Sokol S, Butty S, Klein A, Maholic R, Safar A, Patel T, Zlotnick D, Gans D, Pollak J, Ferrera D, Stegman B, Basra S, Moriarty J, Keeling B, Investigators A. Novel Mechanical Aspiration Thrombectomy in Patients With Acute Pulmonary Embolism: Results From the Prospective APEX-AV Trial. Journal Of The Society For Cardiovascular Angiography & Interventions 2024, 4: 102463. PMID: 40061412, PMCID: PMC11887559, DOI: 10.1016/j.jscai.2024.102463.Peer-Reviewed Original ResearchAcute intermediate-risk PEMechanical aspiration thrombectomyIntermediate-risk PEPulmonary embolismAspiration thrombectomyRV/LV ratioClot burdenAdverse eventsMm HgLow rate of adverse eventsMean pulmonary artery pressureEnd pointsRate of adverse eventsAcute pulmonary embolismPulmonary artery pressureSafety end pointDevice-related deathsTreat pulmonary embolismSingle-arm studyEffectiveness end pointAccess site bleedingStatistically significant reductionCardiac injuryClinical deteriorationArterial pressureMechanical clot disruption during pulmonary thromboembolectomy is safe: A propensity score-matched analysis
Thomas S, Deshmukh A, Mojibian H, Marino A, Lozada J, Cornman-Homonoff J. Mechanical clot disruption during pulmonary thromboembolectomy is safe: A propensity score-matched analysis. Clinical Imaging 2024, 118: 110381. PMID: 39637758, DOI: 10.1016/j.clinimag.2024.110381.Peer-Reviewed Original ResearchPulmonary thromboembolectomyPulmonary emboliPulmonary arteryRight pulmonary arteryLeft pulmonary arteryPulmonary artery pressureAdministration of anticoagulantsDuration of hospitalizationMechanical clot disruptionPropensity-score matchingSPESI scorePulmonary vasculatureArterial pressureClinical effectsOrganized thrombusThromboembolectomyPropensity-scoreClot disruptionInclusion criteriaPatientsMortality rateRisk categoriesCompare groupsStudy periodArteryContinuous versus Intermittent Blood Pressure Monitoring in Postpartum Preeclampsia with Severe Features
Martinez H, Haghighi N, van Wingerden A, Kirschner M, Booker W, Bello N, Petersen N, Miller E. Continuous versus Intermittent Blood Pressure Monitoring in Postpartum Preeclampsia with Severe Features. American Journal Of Perinatology 2024 PMID: 39486401, PMCID: PMC12103628, DOI: 10.1055/a-2457-2781.Peer-Reviewed Original ResearchPostpartum patientsBlood pressureProportion of patientsSevere featuresBlood pressure monitoringIntermittent monitoringPostpartum preeclampsiaPaired t-testArterial pressureFinger plethysmographyPreeclampsiaBP measurement methodsClinical protocolsMcNemar testBP valuesBP monitoringBrachial BPPatientsPressure monitoringBP measurementsOscillometric devicePostpartumMmHgT-testSBPAcute kidney injury in severe alcohol-associated hepatitis treated with anakinra plus zinc or prednisone
Patidar K, Tu W, Cotter T, Simonetto D, Asgharpour A, Jan M, Tang Q, Yu Y, Li Y, Taiwo M, Nagesh P, Dasarathy S, Kamath P, McClain C, Chalasani N, Szabo G, Bataller R, Mitchell M, Mehal W, Nagy L, Shah V, Gawrieh S, Sanyal A, Investigators F. Acute kidney injury in severe alcohol-associated hepatitis treated with anakinra plus zinc or prednisone. Hepatology 2024, 81: 1256-1268. PMID: 39028887, PMCID: PMC11829732, DOI: 10.1097/hep.0000000000001019.Peer-Reviewed Original ResearchMultivariable competing-risk analysisCompeting-risk analysisTreatment armsKidney injuryRisk factorsWhite blood cell countMulticenter randomized clinical trialAcute kidney injuryKidney injury biomarkersBaseline risk factorsBlood cell countRandomized clinical trialsAKI developmentClinical factorsPrednisoneFollow-upHepatic encephalopathyArterial pressureClinical trialsDay 7Cell countPatientsTrialsBaselineLower survivalPeak Tricuspid Regurgitation Jet Velocity and Kidney Outcomes in Patients With Heart Failure With Preserved Ejection Fraction
Oka T, Tighiouart H, McCallum W, Tuttle M, Testani J, Sarnak M. Peak Tricuspid Regurgitation Jet Velocity and Kidney Outcomes in Patients With Heart Failure With Preserved Ejection Fraction. Kidney International Reports 2024, 9: 3035-3044. PMID: 39430198, PMCID: PMC11489825, DOI: 10.1016/j.ekir.2024.07.009.Peer-Reviewed Original ResearchLeft ventricular ejection fractionPulmonary artery pressureCreatinine doublingEGFR declineEjection fractionKidney outcomesHeart failurePeak tricuspid regurgitant jet velocityDoubling of serum creatinineTricuspid regurgitant jet velocityElevated pulmonary artery pressureAssociated with lower eGFRWorsening kidney functionVentricular ejection fractionRegurgitant jet velocityCox proportional hazards modelsProportional hazards modelPost hoc analysisBaseline eGFRSerum creatinineLow eGFRTOPCAT trialFollow-upKidney functionArterial pressureThe Predictive Value of Qanadli and Miller Index Scores in Patients with Intermediate-High–Risk and High-Risk Pulmonary Emboli Undergoing Aspiration Thrombectomy
Fish A, Knight E, Mutonga M, Moulton J, Gathagan R, Andreca M, Sare A, Cornman-Homonoff J. The Predictive Value of Qanadli and Miller Index Scores in Patients with Intermediate-High–Risk and High-Risk Pulmonary Emboli Undergoing Aspiration Thrombectomy. Journal Of Vascular And Interventional Radiology 2024, 35: 1457-1463. PMID: 38969337, DOI: 10.1016/j.jvir.2024.06.031.Peer-Reviewed Original ResearchPulmonary artery pressureIntensive care unitMiller scoreHigh-risk patientsArterial pressureInstitutional review boardPulmonary pressureClot burdenB-type natriuretic peptideIntensive care unit length of stayAssociated with ICU lengthIntensive care unit lengthLength of stayFlowTriever SystemConsecutive patientsEchocardiographic findingsPulmonary emboliCreatinine levelsPulmonary embolismNatriuretic peptideStratify patientsRetrospective studyClinical outcomesAspiration thrombectomyICU lengthEffect of Filtered Blood Return on Outcomes of Pulmonary Aspiration Thrombectomy
Bitar R, Bozal S, Sisti A, Mojibian H, Marino A, Cornman-Homonoff J. Effect of Filtered Blood Return on Outcomes of Pulmonary Aspiration Thrombectomy. Journal Of Vascular And Interventional Radiology 2024, 35: 1447-1456. PMID: 38950819, DOI: 10.1016/j.jvir.2024.06.026.Peer-Reviewed Original ResearchPulmonary artery pressureAspiration thrombectomyPulmonary embolismArterial pressureDuration of intensive care unitSeverity of adverse eventsLength of hospital stayHigh-risk PEProcedure-related complicationsAdverse event ratesIntensive care unitMarker of procedural successFluoroscopy timeTransfusion requirementsBlood lossNo significant differenceTransfusion needsHospital stayPost-procedureProcedural successAdverse eventsSurrogate markerLaboratory valuesProcedural outcomesProcedural detailsRight Ventricular Pressure Waveform Analysis—Clinical Relevance and Future Directions
Heerdt P, Kheyfets V, Oakland H, Joseph P, Singh I. Right Ventricular Pressure Waveform Analysis—Clinical Relevance and Future Directions. Journal Of Cardiothoracic And Vascular Anesthesia 2024, 38: 2433-2445. PMID: 39025682, PMCID: PMC11580041, DOI: 10.1053/j.jvca.2024.06.022.Peer-Reviewed Original ResearchRight ventricular pressureRight ventricular functionVentricular pressureVentricular functionMeasuring right ventricular pressureMeasurements of right ventricular pressurePeak right ventricular pressurePulmonary artery pressureEvaluate cardiac functionPulmonary arteryStroke volume measurementsRight atriumCardiac functionDiastolic fillingSurgical patientsArterial pressureClinical valueDemonstrating utilityVolume measurementsMeasurements of pressurePressure waveformAccurate surrogateContinuous measurement of pressurePhysiological factorsEchocardiographyThe effect of acute estrogen suppression on cutaneous endothelium-dependent vasodilation in women with endometriosis
Colburn A, Leone C, Alexander L, Stachenfeld N. The effect of acute estrogen suppression on cutaneous endothelium-dependent vasodilation in women with endometriosis. Physiology 2024, 39: 421. DOI: 10.1152/physiol.2024.39.s1.421.Peer-Reviewed Original ResearchEndothelium-dependent vasodilationEstrogen suppressionHealthy controlsLDF/mean arterial pressureSodium nitroprusside perfusionDose-response curveLaser Doppler flowmetryCardiovascular disease riskCutaneous vascular conductanceACh doseEndometriosis patientsPerfusion of acetylcholineMenstrual cycleIntradermal microdialysisSuppress estrogenEndothelial functionArterial pressureEndometriosisVasodilatory functionDoppler flowmetryVascular conductanceVasodilationMaximal vasodilationGraded perfusionEstrogenRecurrence of Pulmonary Arteriovenous Malformation after Embolization in Patients with Pulmonary Hypertension
Fish A, Wang D, Knight E, Pollak J, Schlachter T. Recurrence of Pulmonary Arteriovenous Malformation after Embolization in Patients with Pulmonary Hypertension. Journal Of Vascular And Interventional Radiology 2024, 35: 1148-1153. PMID: 38692392, DOI: 10.1016/j.jvir.2024.04.017.Peer-Reviewed Original ResearchPulmonary arteriovenous malformationsPulmonary hypertensionArteriovenous malformationsRecurrence of pulmonary arteriovenous malformationsFollow-upChest CT follow-upPresence of pulmonary hypertensionCT follow-upShorter surveillance intervalsPulmonary artery pressureHistory of smokingPresence of PHCuracao criteriaSurveillance intervalsSmoking historyArterial pressureMultivariate analysisRecurrenceGenetic testingOdds ratioHypertensionPatientsStratified analysisGeneral demographicsStudy periodPulmonary Hypertension and the Risk of 30-Day Postoperative Pulmonary Complications after Gastrointestinal Surgical or Endoscopic Procedures: A Retrospective Propensity Score-Weighted Cohort Analysis
Tatsuoka Y, Carr Z, Jayakumar S, Lin H, He Z, Farroukh A, Heerdt P. Pulmonary Hypertension and the Risk of 30-Day Postoperative Pulmonary Complications after Gastrointestinal Surgical or Endoscopic Procedures: A Retrospective Propensity Score-Weighted Cohort Analysis. Journal Of Clinical Medicine 2024, 13: 1996. PMID: 38610760, PMCID: PMC11012853, DOI: 10.3390/jcm13071996.Peer-Reviewed Original ResearchPostoperative pulmonary complicationsLength of stayPulmonary hypertensionPulmonary complicationsPulmonary embolismRespiratory failureEndoscopic proceduresRisk of postoperative complicationsPulmonary artery pressurePreoperative risk assessmentProlonged length of stayRetrospective cohort studySub-cohort analysisIncreased LOSPropensity score overlap weightingOverlap weightingAssociation of PHPH cohortPH patientsPostoperative complicationsAbdominal surgeryRate of RFCohort studyControl cohortArterial pressure
2023
Association of Blood Pressure Variability With Death and Discharge Destination Among Critically Ill Patients With and Without Stroke
Stulberg E, Harris B, Zheutlin A, Delic A, Sheibani N, Anadani M, Yaghi S, Petersen N, de Havenon A. Association of Blood Pressure Variability With Death and Discharge Destination Among Critically Ill Patients With and Without Stroke. Neurology 2023, 101: e1145-e1157. PMID: 37487742, PMCID: PMC10513881, DOI: 10.1212/wnl.0000000000207599.Peer-Reviewed Original ResearchConceptsAverage real variabilityNonstroke patientsDischarge destinationHospital deathIschemic strokeIll patientsIllness severityWorse outcomesAdult intensive care unit patientsMinimum mean arterial pressureIntensive care unit patientsIntensive Care III databaseBlood pressure goalsAcute ischemic strokeMean arterial pressureBlood pressure variabilityCare unit patientsRisk of deathMedical Information MartUnit patientsArterial pressureIntracerebral hemorrhageSubarachnoid hemorrhageRisk factorsEffect modificationThe importance of forward flow and venous congestion in diuretic response in acute heart failure: Insights from the ESCAPE trial
Eder M, Griffin M, Moreno-Villagomez J, Bellumkonda L, Maulion C, Asher J, Wilson F, Cox Z, Ivey-Miranda J, Rao V, Butler J, Borlaug B, McCallum W, Ramos-Mastache D, Testani J. The importance of forward flow and venous congestion in diuretic response in acute heart failure: Insights from the ESCAPE trial. International Journal Of Cardiology 2023, 381: 57-61. PMID: 37023862, DOI: 10.1016/j.ijcard.2023.04.002.Peer-Reviewed Original ResearchConceptsRight atrial pressureDiuretic efficiencyRight atrial areaDiuretic responseVenous congestionHeart failureCardio-renal interactionsLoop diuretic doseAcute heart failureRenal perfusion pressureLow cardiac outputMean arterial pressureRight ventricular systolicCongestive heart failureVentricular ejection fractionNet fluid outputForward flowDiuretic doseDiuretic resistanceTTE parametersCardiac indexVentricular systolicArterial pressureAtrial pressureEjection fractionResponsiveness to Vasoconstrictor Therapy in Hepatorenal Syndrome Type 1
Velez J, Karakala N, Tayebi K, Wickman T, Mohamed M, Kovacic R, Therapondos G, Kanduri S, Allegretti A, Belcher J, Regner K, Wentowski C. Responsiveness to Vasoconstrictor Therapy in Hepatorenal Syndrome Type 1. Kidney360 2023, 4: e448-e456. PMID: 36763632, PMCID: PMC10278824, DOI: 10.34067/kid.0000000000000068.Peer-Reviewed Original ResearchConceptsHepatorenal syndrome type 1Mean arterial pressureSyndrome type 1HRS-1Baseline SCrMAP riseType 1Serum creatinineArterial pressureKidney functionDay 14Baseline mean arterial pressureMean mean arterial pressureMedian mean arterial pressureEnd-stage liver diseaseMultivariate logistic regression analysisFavorable renal outcomeOptimal MAP targetsUse of norepinephrineLogistic regression analysisGreater reductionMedian sCrNorepinephrine useVasoconstrictor therapyRenal outcomes
2022
Interaction of Mean Arterial Pressure and Blood Pressure Variability in Critically Ill Brain Injured Patients
de Havenon A, Petersen N, Stulberg E, Anadani M, Biffi A, Sheth K. Interaction of Mean Arterial Pressure and Blood Pressure Variability in Critically Ill Brain Injured Patients. Stroke 2022, 53: e512-e514. PMID: 36367101, PMCID: PMC9712254, DOI: 10.1161/strokeaha.122.041274.Peer-Reviewed Original ResearchGraft flow evaluation with intraoperative transit-time flow measurement in off-pump versus on-pump coronary artery bypass grafting
Leviner D, Rosati C, von Mücke Similon M, Amabile A, Thuijs D, Di Giammarco G, Wendt D, Trachiotis G, Kieser T, Kappetein A, Head S, Taggart D, Puskas J. Graft flow evaluation with intraoperative transit-time flow measurement in off-pump versus on-pump coronary artery bypass grafting. JTCVS Techniques 2022, 15: 95-106. PMID: 36276694, PMCID: PMC9579515, DOI: 10.1016/j.xjtc.2022.05.002.Peer-Reviewed Original ResearchMean graft flowMean arterial pressureONCAB groupPulsatility indexDiastolic fractionOPCAB groupIntraoperative transit time flow measurementPump coronary artery bypass proceduresPump coronary artery bypassPropensity score-matched comparisonCoronary artery bypass proceduresCoronary artery bypassPrimary end pointTransit-time flow measurementArtery bypass proceduresArtery bypassOPCAB proceduresOPCAB surgeryVenous graftsArterial pressureBypass proceduresGraft flowSurgery StudyArterial graftsSingle graftSympathetic Responses to Isometric Handgrip Exercise in Women following Preeclamptic Pregnancies
Orr H, Adler T, Leone C, Paidas M, Stachenfeld N, Usselman C. Sympathetic Responses to Isometric Handgrip Exercise in Women following Preeclamptic Pregnancies. The FASEB Journal 2022, 36 DOI: 10.1096/fasebj.2022.36.s1.r4218.Peer-Reviewed Original ResearchMuscle sympathetic nerve activityPost-exercise circulatory occlusionHand-grip exerciseElevated muscle sympathetic nerve activityHP womenMSNA responsesPreeclamptic pregnanciesBaseline muscle sympathetic nerve activityIsometric hand-grip exerciseSympathetic nerve activityIsometric handgrip exerciseTotal peripheral resistanceHG exerciseSympathetic dysregulationCardiovascular outcomesCirculatory occlusionHandgrip exerciseArterial pressureHealthy pregnancyNerve activityPE pregnanciesPeripheral resistanceGrip exercisePE womenCardiovascular diseaseCardiovascular effects of hyoscine butylbromide in patients under general anaesthesia
Quintero C, Molano M, Amaya S, Maya J, Andrade M. Cardiovascular effects of hyoscine butylbromide in patients under general anaesthesia. Journal Of Perioperative Practice 2022, 33: 211-216. PMID: 35285310, DOI: 10.1177/17504589211072698.Peer-Reviewed Original ResearchConceptsHyoscine butylbromideGeneral anesthesiaCardiovascular effectsBlood pressureIntraoperative bradycardiaPerioperative riskHeart rateAdministration of hyoscine butylbromideEffect of hyoscine butylbromideDose-related cardiovascular effectsBlood pressure of patientsPressure of patientsMicrosoft Excel databaseRetrospective studyAverage doseOutpatient basisElective surgeryArterial pressurePatientsButylbromideAnesthesiaBloodBradycardiaHeartDoseSevere inpatient hypertension prevalence and blood pressure response to antihypertensive treatment
Ghazi L, Li F, Chen X, Simonov M, Yamamoto Y, Biswas A, Hanna J, Shah T, Townsend R, Peixoto A, Wilson FP. Severe inpatient hypertension prevalence and blood pressure response to antihypertensive treatment. Journal Of Clinical Hypertension 2022, 24: 339-349. PMID: 35174627, PMCID: PMC8925013, DOI: 10.1111/jch.14431.Peer-Reviewed Original ResearchConceptsSevere hypertensionBlood pressure responseBP elevationUntreated patientsCox proportional hazards modelRetrospective cohort studyPressure responseProportional hazards modelAntihypertensive treatmentInpatient hypertensionMore comorbiditiesPossible overtreatmentHospitalized adultsCohort studyHypertension prevalenceArterial pressureHospitalized patientsTreatment guidelinesHypertensionGreater rateHazards modelPatientsAntihypertensivesTreatmentAdmissionSex differences and altered mitophagy in experimental pulmonary hypertension
Bazan IS, Kim SJ, Ardito TA, Zhang Y, Shan P, Sauler M, Lee P. Sex differences and altered mitophagy in experimental pulmonary hypertension. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2022, 322: l761-l769. PMID: 35137625, PMCID: PMC9076415, DOI: 10.1152/ajplung.00019.2020.Peer-Reviewed Original ResearchConceptsPulmonary hypertensionPathogenesis of PHFemale-predominant diseaseRight heart failurePulmonary arterial pressureExperimental pulmonary hypertensionMitochondrial dysfunctionLung endothelial cellsSex differencesMouse lung endothelial cellsInhibition of ParkinArterial pressureHeart failurePulmonary arteryMitochondrial respiratory capacityPoor outcomeHigh prevalenceSevere diseaseAnimal modelsEndothelial cellsParkin expressionOxidative stressCell proliferationHypertensionSex
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