2025
Multi-Center Experience with Unitary Stent Graft System for Endovascular Debranched Aortic Repair of Various Thoracoabdominal Aortopathies
Pupovac S, Restrepo-Espinosa V, Chen J, Zaky M, Answini G, Kelly P, Vallabhajosyula P, Nassiri N. Multi-Center Experience with Unitary Stent Graft System for Endovascular Debranched Aortic Repair of Various Thoracoabdominal Aortopathies. The Annals Of Thoracic Surgery 2025 PMID: 40484210, DOI: 10.1016/j.athoracsur.2025.05.026.Peer-Reviewed Original ResearchThoracoabdominal aortic aneurysmsAortic repairOpen surgeryTechnical successAortic aneurysmPatency ratesShort-neck infrarenal aneurysmsTarget vessel patency rateMedian hospital stayThirty-day mortalityClinical follow-upMajor adverse eventsStent graft systemMulti-center experienceMulti-center studyMedian followChronic dissectionInfrarenal aneurysmsReintervention rateEndoluminal bypassInfrarenal EVARThirty-dayStent graftHospital stayAdverse eventsAssociation of dilated aortic root on point-of-care ultrasound with aortic aneurysm and dissection
Hesami M, Denkewicz R, Boivin Z, Bhalodkar S, Li J, Moore C. Association of dilated aortic root on point-of-care ultrasound with aortic aneurysm and dissection. The American Journal Of Emergency Medicine 2025, 95: 89-94. PMID: 40440820, DOI: 10.1016/j.ajem.2025.05.039.Peer-Reviewed Original ResearchThoracic aortic aneurysmThoracic aortic dissectionPoint-of-care ultrasound measurementsPoint-of-care ultrasoundPositive predictive valueAortic aneurysmEfficacy of point-of-care ultrasoundAccuracy of point-of-care ultrasoundDiagnostic accuracy of point-of-care ultrasoundCardiac point-of-care ultrasoundAssociated with thoracic aortic dissectionPredictive valueDilated aortic rootAssociated with thoracic aortic aneurysmAortic root measurementsLife-threatening conditionBland-Altman plotsChest CTAortic measurementsPrompt diagnosisAortic dissectionAortic rootDiagnostic accuracyPatientsMedical recordsSpinal Cord Protection for Open Descending Thoracic and Thoracoabdominal Aorta Surgery: An STS Adult Cardiac Surgery Database Analysis
Amabile A, Bonnell L, Del Vecchio A, Basciano A, Antonios J, Kaneko T, Habib R, Di Luozzo G. Spinal Cord Protection for Open Descending Thoracic and Thoracoabdominal Aorta Surgery: An STS Adult Cardiac Surgery Database Analysis. The Annals Of Thoracic Surgery 2025 PMID: 40389192, DOI: 10.1016/j.athoracsur.2025.05.002.Peer-Reviewed Original ResearchThoracoabdominal aortic aneurysmsThoracoabdominal aortic aneurysm repairSpinal cord injuryDrain placementDTAA/TAAA repairDrain useThe Society of Thoracic Surgeons Adult Cardiac Surgery DatabaseSociety of Thoracic Surgeons Adult Cardiac Surgery DatabaseAdult Cardiac Surgery DatabaseOpen descending thoracicCardiac Surgery DatabaseSpinal cord protectionMultivariate logistic regression modelRate of spinal cord injuryArch involvementDescending thoracicPreoperative paralysisSurgery DatabaseSpinal drainAdult patientsAortic rootAortic aneurysmLogistic regression modelsSpinal injuryStudy populationAdherence to SVS Abdominal Aortic Aneurysm Guidelines Among Patients Detected by AI-Based Algorithm
Wilson E, Yao K, Kostiuk V, Bader J, Loh S, Mojibian H, Fischer U, Ochoa Chaar C, Aboian E. Adherence to SVS Abdominal Aortic Aneurysm Guidelines Among Patients Detected by AI-Based Algorithm. Annals Of Vascular Surgery 2025, 120: 108-114. PMID: 40349830, DOI: 10.1016/j.avsg.2025.05.007.Peer-Reviewed Original ResearchAbdominal aortic aneurysmAdherent patientsSurgical interventionAbdominal aortic aneurysm patientsNon-adherent patientsTertiary care centerFollow-up adherenceFollow-up algorithmSVS guidelinesImaging surveillanceSurgical criteriaAneurysm sizeAortic aneurysmIdentified patientsPati entsSurveillance adherenceVascular providersImaging scansDeceased patientsPatientsPhysician evaluationCare centerPatient outcomesStatistical significanceNo significant age differencesThoracic aortic aneurysm
Berger T, Dumfarth J, Kreibich M, Minatoya K, Ziganshin B, Czerny M. Thoracic aortic aneurysm. Nature Reviews Disease Primers 2025, 11: 34. PMID: 40341396, DOI: 10.1038/s41572-025-00617-2.Peer-Reviewed Original ResearchConceptsThoracic aortic aneurysmAortic diseasePathophysiological mechanismsTreatment of aortic diseaseThoracic aortic diseaseVascular smooth muscle cellsGold standard diagnostic toolSmooth muscle cellsCardiovascular risk factorsStandard diagnostic toolAortic medicineAdvanced imaging techniquesEmbryological factorsCT angiographyArterial hypertensionDiagnostic challengeAortic aneurysmAbnormal dilatationThoracic aortaAsymptomatic natureGenetic predispositionTreatment outcomesMuscle cellsMedical managementRisk factorsEfficacy of beta-blocker agents on clinical outcomes in patients with thoracic aortic aneurysm: A systematic review and meta-analysis of randomized controlled trials
Tanriverdi L, Barrett A, Kalyanasundaram A, Zafar M, Ziganshin B, Elefteriades J. Efficacy of beta-blocker agents on clinical outcomes in patients with thoracic aortic aneurysm: A systematic review and meta-analysis of randomized controlled trials. Vascular Pharmacology 2025, 159: 107494. PMID: 40204023, DOI: 10.1016/j.vph.2025.107494.Peer-Reviewed Original ResearchConceptsThoracic aortic aneurysmRandomized controlled trialsPooled risk ratioB-blockersAortic dissectionClinical outcomesAortic aneurysmRisk ratioRisk of aortic dissectionMeta-analysis of randomized controlled trialsControlled trialsB-blocker treatmentCompared to placeboBeta-blocking agentsCochrane Risk of Bias 2 toolRisk of Bias 2 toolRobust randomized controlled trialsInverse variance-weighted random-effects modelRisk of bias assessmentRandom-effects modelEvidence of benefitSystematic literature searchAortic eventsEvidence-based recommendationsFollow-upComparison of EndoSuture vs fenestrated aortic aneurysm repair in treatment of abdominal aortic aneurysms with unfavorable neck anatomy Presented at the Thirty-ninth Annual Meeting of the Western Vascular Society, Colorado Springs, Colorado, September 7-10, 2024.
Fereydooni A, Satam K, Dossabhoy S, Trogolo-Franco C, Sorondo S, Arya S, Ullery B, Lee J. Comparison of EndoSuture vs fenestrated aortic aneurysm repair in treatment of abdominal aortic aneurysms with unfavorable neck anatomy Presented at the Thirty-ninth Annual Meeting of the Western Vascular Society, Colorado Springs, Colorado, September 7-10, 2024. European Journal Of Vascular And Endovascular Surgery 2025, 69: e260-e261. DOI: 10.1016/j.ejvs.2025.02.050.Peer-Reviewed Original ResearchVolumetric Abdominal Aortic Aneurysm Analysis in Post EVAR Surveillance Settings
Simmons K, Weiss D, Aboian M, Lin M, Bousabarah K, Renninghoff D, Holler W, Deuschl C, Fischer U, Aboian E. Volumetric Abdominal Aortic Aneurysm Analysis in Post EVAR Surveillance Settings. Annals Of Vascular Surgery 2025, 114: 241-250. PMID: 40049548, DOI: 10.1016/j.avsg.2025.02.009.Peer-Reviewed Original ResearchAbdominal aortic aneurysmEndovascular aortic repairEarly detection of abdominal aortic aneurysmsDetection of abdominal aortic aneurysmsLong-term follow-up dataAneurysm-related mortalityVolumetric analysisAneurysm sac enlargementAssociated with older ageSubgroup of patientsFollow-up dataHigh-risk aneurysmsMaximum diameter measurementsAortic repairSac enlargementAAA enlargementCT angiogramMetformin therapyPatient cohortAortic aneurysmClinical factorsUnivariate analysisClinical variablesAneurysm volumeMedical recordsModeling thoracic aortic genetic variants in the zebrafish: useful for predicting clinical pathogenicity?
Prendergast A, Sheppard M, Famulski J, Nicoli S, Mukherjee S, Sips P, Elefteriades J. Modeling thoracic aortic genetic variants in the zebrafish: useful for predicting clinical pathogenicity? Frontiers In Cardiovascular Medicine 2025, 12: 1480407. PMID: 40066353, PMCID: PMC11892108, DOI: 10.3389/fcvm.2025.1480407.Peer-Reviewed Original ResearchPathogenicity of VUSProportion of variantsMedical genetic testingCausal genesPathogenicity assessmentClinical pathogensTested pathogensGenetic variantsCausative genesTAAD casesGenesGenetic defectsGenetic testingThoracic aortic aneurysmHeritable genetic defectsImpact cardiovascular morbidityPathogensVUSAortic aneurysmCardiovascular morbidityVariantsZebrafishTAADClinical applicationEnhance patient careRisk of aortic aneurysm or dissection following use of fluoroquinolones: a retrospective multinational network cohort study
Janetzki J, Kim J, Minty E, Lee J, Morales D, Khera R, Kim C, Alshammari T, DuVall S, Matheny M, Falconer T, Kim S, Phan T, Nguyen P, Hsu M, Hsu J, Park R, Man K, Seager S, Van Zandt M, Gilbert J, Ryan P, Schuemie M, Suchard M, Hripcsak G, Pratt N, You S. Risk of aortic aneurysm or dissection following use of fluoroquinolones: a retrospective multinational network cohort study. EClinicalMedicine 2025, 81: 103096. PMID: 39975698, PMCID: PMC11836508, DOI: 10.1016/j.eclinm.2025.103096.Peer-Reviewed Original ResearchUrinary tract infectionRisk of aortic aneurysmTreat urinary tract infectionsOutpatient settingAortic aneurysmIndex dateCohort studyHazard ratioUrinary tract infection treatmentYonsei University College of MedicineRetrospective cohort studyPropensity scoreCox proportional hazards modelsPropensity-matched pairsRandom-effects meta-analysisProportional hazards modelNational Health and Medical Research Council (NHMRCUniversity College of MedicineSystemic fluoroquinolonesTract infectionsNo significant differenceBayesian random-effects meta-analysisFollow-upPrimary outcomeIncreased riskGenetic Overlap of Thoracic Aortic Aneurysms and Intracranial Aneurysms
Changez M, Nasir A, Sonsino A, Jeoffrey S, Kalyanasundaram A, Zafar M, Ziganshin B, Elefteriades J. Genetic Overlap of Thoracic Aortic Aneurysms and Intracranial Aneurysms. Genes 2025, 16: 154. PMID: 40004483, PMCID: PMC11855647, DOI: 10.3390/genes16020154.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesThoracic aortic aneurysmGenetic overlapCell cycle pathwayIntracranial aneurysmsAortic aneurysmAssociation studiesEtiology of thoracic aortic aneurysmExtracellular matrix componentsGenetic interplayGenetic pathwaysCycle pathwayCausative genesExtracellular matrix remodelingThoracic aortic aneurysm patientsGenetic etiologyConnective tissue biologyRetrospective clinical studyMolecular mechanismsGenesIntracranial aneurysm patientsPhysiological pathwaysTissue biologyPathwayGenetic factorsPrediction of Aneurysm Sac Shrinkage After Endovascular Aortic Repair Using Machine Learning-Based Decision Tree Analysis
Nishibe T, Iwasa T, Matsuda S, Kano M, Akiyama S, Fukuda S, Koizumi J, Nishibe M, Dardik A. Prediction of Aneurysm Sac Shrinkage After Endovascular Aortic Repair Using Machine Learning-Based Decision Tree Analysis. Journal Of Surgical Research 2025, 306: 197-202. PMID: 39793306, DOI: 10.1016/j.jss.2024.11.049.Peer-Reviewed Original ResearchConceptsAneurysm sac shrinkageEndovascular aortic repairAbdominal aortic aneurysmSac shrinkageType II endoleakAortic repairII endoleakUnivariate analysisElective endovascular aortic repairTokyo Medical University HospitalMedical University HospitalDecision tree analysisPulse wave velocityAortic aneurysmUniversity HospitalCurrent smokingAneurysmPatientsStratification modelEndoleakLow likelihoodVariables of ageSmokingRepair
2024
Comparison of EndoSuture vs fenestrated aortic aneurysm repair in treatment of abdominal aortic aneurysms with unfavorable neck anatomy
Fereydooni A, Satam K, Dossabhoy S, Trogolo-Franco C, Sorondo S, Arya S, Ullery B, Lee J. Comparison of EndoSuture vs fenestrated aortic aneurysm repair in treatment of abdominal aortic aneurysms with unfavorable neck anatomy. Journal Of Vascular Surgery 2024, 81: 856-865.e1. PMID: 39603282, PMCID: PMC11967903, DOI: 10.1016/j.jvs.2024.11.020.Peer-Reviewed Original ResearchFenestrated endovascular aortic repairSac regressionInfrarenal angulationAneurysm repairNeck anatomyAortic aneurysmHostile aortic neck anatomyLong-term renal functionTreatment of abdominal aortic aneurysmsAneurysm-related reinterventionsAortic neck anatomyUnfavorable neck anatomyThoracoabdominal aortic aneurysmsAneurysm-related mortalityShorter neck lengthType Ia endoleakEndovascular aortic repairAortic aneurysm repairPre-operative eGFRKaplan-Meier analysisTreatment of AAARandomized prospective trialAssociated with reduced freedomBranch vessel patencyPropensity-matched cohortEfficacy of beta blockers in patients with thoracic aortic aneurysm: meta-analysis of randomized controlled trials
Tanriverdi L, Barrett A, Kalyanasundaram A, Zafar M, Ziganshin B, Elefteriades J. Efficacy of beta blockers in patients with thoracic aortic aneurysm: meta-analysis of randomized controlled trials. European Heart Journal 2024, 45: ehae666.2256. DOI: 10.1093/eurheartj/ehae666.2256.Peer-Reviewed Original ResearchThoracic aortic aneurysmRandomized controlled trialsPooled risk ratioB-blockersAortic aneurysmAortic dissectionControlled trialsAortic eventsRisk ratioPrimary outcomePooled risk estimatesRisk of aortic dissectionRisk of bias assessmentNo treatmentMeta-analysis of randomized controlled trialsInverse variance-weighted random-effects modelMeta-analysisLiterature searchB-blocker treatmentSystematic review protocolInternational Prospective RegisterCochrane Central Register of Controlled TrialsEfficacy of beta blockersCentral Register of Controlled TrialsSummary effect measuresRuptured Complex Aortoiliac Aneurysm in an Elderly Patient With a Kidney Transplant Presenting With Sciatica
Kostiuk V, Rodriguez P, Aboian E, Kuwayama D, Guzman R, Chaar C. Ruptured Complex Aortoiliac Aneurysm in an Elderly Patient With a Kidney Transplant Presenting With Sciatica. Vascular And Endovascular Surgery 2024, 59: 411-415. PMID: 39438778, DOI: 10.1177/15385744241296220.Peer-Reviewed Original ResearchCommon iliac artery aneurysmsIliac artery aneurysmsAbdominal aortic aneurysmArtery aneurysmRenal artery originsKidney transplantationAortic aneurysmEndovascular repairAneurysm repairArtery originLeft common iliac artery aneurysmConcomitant abdominal aortic aneurysmNon-contrast CT scanComplex aneurysm anatomyComplex aortoiliac aneurysmsIntra-abdominal aneurysmsFemoral-femoral bypassRinged PTFE graftEndovascular aneurysm repairKidney transplant functionFunctioning kidney transplantExternal iliac arteryRisk of ruptureSciatica symptomsAortoiliac aneurysmsAssociation between Preoperative Neutrophil-lymphocyte Ratio and All-cause Mortality in Patients Treated with Thoracic Endovascular Aortic Repair for Degenerative Thoracic Aortic Aneurysm
Kano M, Nishibe T, Dardik A, Iwahashi T, Nakano Y, Shimahara Y. Association between Preoperative Neutrophil-lymphocyte Ratio and All-cause Mortality in Patients Treated with Thoracic Endovascular Aortic Repair for Degenerative Thoracic Aortic Aneurysm. Annals Of Vascular Surgery 2024, 110: 255-264. PMID: 39341560, DOI: 10.1016/j.avsg.2024.07.110.Peer-Reviewed Original ResearchThoracic endovascular aortic repairPatients treated with thoracic endovascular aortic repairDegenerative thoracic aortic aneurysmsPreoperative neutrophil-lymphocyte ratioNeutrophil-lymphocyte ratioThoracic aortic aneurysmAll-cause mortalityEndovascular aortic repairAortic repairAortic aneurysmCut-off values of neutrophil-lymphocyte ratioOptimal cut-off values of neutrophil-lymphocyte ratioElevated preoperative neutrophil-lymphocyte ratioOverall mortalityValue of neutrophil-lymphocyte ratioOptimal cut-off valueAbsolute lymphocyte countAbsolute neutrophil countRisk of overall mortalityLikelihood of all-cause mortalityReceiver operating characteristic curveIschemic heart diseaseLymphocyte countStratify patientsNeutrophil countClinical Effectiveness of Genetic Testing Guidelines in Patients with Thoracic Aortic Aneurysms
Erez E, Acuna Higaki A, Cupo M, Phu T, Verma S, Assi R, Vallabhajosyula P. Clinical Effectiveness of Genetic Testing Guidelines in Patients with Thoracic Aortic Aneurysms. Journal Of Thoracic And Cardiovascular Surgery 2024 PMID: 39321868, DOI: 10.1016/j.jtcvs.2024.09.026.Peer-Reviewed Original ResearchFeatures of connective tissue diseaseThoracic aortic diseaseConnective tissue diseaseThoracic aortic aneurysmGenetic testing guidelinesSyndromic featuresMutation rateFamily historyVUS rateAortic aneurysmPrimary genesGenetic testingAssociated with thoracic aortic diseaseThoracic aorta diameterTesting guidelinesAorta diameterPathogen mutation rateAortic diseaseRisk stratificationSecondary genesPathogenic mutationsTissue diseaseClinical effectsVUSGenesPropensity Score Matched Comparison of EndoSuture vs Fenestrated Aortic Aneurysm Repair in Treatment of Abdominal Aortic Aneurysms With Unfavorable Neck Anatomy
Fereydooni A, Satam K, Dossabhoy S, Sorondo S, Arya S, Ullery B, Lee J. Propensity Score Matched Comparison of EndoSuture vs Fenestrated Aortic Aneurysm Repair in Treatment of Abdominal Aortic Aneurysms With Unfavorable Neck Anatomy. Journal Of Vascular Surgery 2024, 80: e87. DOI: 10.1016/j.jvs.2024.06.146.Peer-Reviewed Original ResearchThe science and practice of imaging-based screening: What the radiologist needs to know
Milch H, Haramati L. The science and practice of imaging-based screening: What the radiologist needs to know. Clinical Imaging 2024, 114: 110266. PMID: 39216274, DOI: 10.1016/j.clinimag.2024.110266.Peer-Reviewed Original ResearchScreening practicesImaging-based screeningPublic health focusScreening guidelinesOpportunistic screeningHealth focusScreening examsScreening policyFormal trainingArtery diseaseEvidence developmentColorectal cancerLeadership opportunitiesBreast cancerClinician-scientistsAbdominal aortic aneurysmCoronary artery diseaseScreeningScreening conceptCarotid artery diseaseThyroid cancerCancerPracticeAortic aneurysmLung cancerEngineered vascular grafts lend unique insight to pathophysiology of aortic aneurysms
Naegeli K, Niklason L. Engineered vascular grafts lend unique insight to pathophysiology of aortic aneurysms. Cell Stem Cell 2024, 31: 1099-1100. PMID: 39094540, DOI: 10.1016/j.stem.2024.07.002.Peer-Reviewed Original Research
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