2025
Chronotherapeutic intervention targeting emotion regulation brain circuitry, symptoms, and suicide risk in adolescents and young adults with bipolar disorder: a pilot randomised trial
Kim J, Sankar A, Marks R, Carrubba E, Lecza B, Quatrano S, Spencer L, Constable R, Pittman B, Lebowitz E, Silverman W, Swartz H, Blumberg H. Chronotherapeutic intervention targeting emotion regulation brain circuitry, symptoms, and suicide risk in adolescents and young adults with bipolar disorder: a pilot randomised trial. BMJ Mental Health 2025, 28: e301338. PMID: 39971594, PMCID: PMC11840897, DOI: 10.1136/bmjment-2024-301338.Peer-Reviewed Original ResearchConceptsBipolar disorderEmotion regulationSuicide riskBrain circuitryChronotherapeutic interventionsEmotional face stimuliLeft amygdala responseRisk of bipolar disorderTargeting emotion regulationReduce suicide riskHigher suicide riskYoung adultsFunctional MRI dataPost-treatment improvementAmygdala responsePotential intervention targetsEmotion dysregulationMania symptomsMood episodesFace stimuliCircuitry dysfunctionRegulation therapyDaily rhythmsWeekly sessionsSelf-monitoring
2024
Amygdala response to emotional faces following acute administration of psilocybin in healthy individuals
Armand S, Larsen K, Madsen M, Ozenne B, Preller K, Knudsen G, Stenbæk D, Fisher P. Amygdala response to emotional faces following acute administration of psilocybin in healthy individuals. Neuroscience Applied 2024, 3: 103934. DOI: 10.1016/j.nsa.2023.103934.Peer-Reviewed Original ResearchPlasma psilocin levelsFunctional magnetic resonance imagingAmygdala reactivityHealthy individualsAmygdala responseMagnetic resonance imagingAcute administrationDrug intensityAcute exposureTherapeutic outcomesResonance imagingSignificant associationBrain regionsPsychedelic psilocybinPsilocybinBaselineFuture studiesSignificant changesExposureFearful facesEmotion processingResponseIndividualsAdministration
2023
Cognitive, Behavioral, and Circadian Rhythm Interventions for Insomnia Alter Emotional Brain Responses
Leerssen J, Aghajani M, Bresser T, Rösler L, Winkler A, Foster-Dingley J, Van Someren E. Cognitive, Behavioral, and Circadian Rhythm Interventions for Insomnia Alter Emotional Brain Responses. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2023, 9: 60-69. PMID: 36958474, DOI: 10.1016/j.bpsc.2023.03.007.Peer-Reviewed Original ResearchConceptsAmygdala responseSleep interventionsEmotion-related brain activityFunctional magnetic resonance imaging studyEmotional brain responsesInsomnia treatmentFunctional magnetic resonance imagingCognitive behavioral therapyMagnetic resonance imaging studyEmotional stimuliResonance imaging studyBrain mechanismsIndividual differencesPrevention of depressionCircadian interventionsBrain responsesEmotional stabilityBehavioral therapyAnxiety severityBrain activityBrain responsivenessLeft insulaInsomnia disorderHigh riskInsomnia symptoms
2022
Emotional numbing in PTSD is associated with lower amygdala reactivity to pain
Korem N, Duek O, Ben-Zion Z, Kaczkurkin AN, Lissek S, Orederu T, Schiller D, Harpaz-Rotem I, Levy I. Emotional numbing in PTSD is associated with lower amygdala reactivity to pain. Neuropsychopharmacology 2022, 47: 1913-1921. PMID: 35945274, PMCID: PMC9485255, DOI: 10.1038/s41386-022-01405-2.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderAmygdala reactivityLower amygdala reactivityHigher pain responseLower amygdala activationAltered pain perceptionAmygdala activationProcessing of painAmygdala responseEmotional numbingPain correlateMild painPain processingPain thresholdPain responsePain perceptionPainControl groupPTSD groupStress disorderRobust reductionAmygdala activityCombat controlsAmygdalaEmotional numbing symptoms
2021
Modulation of Amygdala Response by Cognitive Conflict in Adolescents with Conduct Problems and Varying Levels of CU Traits
Sebastian C, Stafford J, McCrory E, Sethi A, De Brito S, Lockwood P, Viding E. Modulation of Amygdala Response by Cognitive Conflict in Adolescents with Conduct Problems and Varying Levels of CU Traits. Research On Child And Adolescent Psychopathology 2021, 49: 1043-1054. PMID: 33728508, PMCID: PMC8222043, DOI: 10.1007/s10802-021-00787-z.Peer-Reviewed Original ResearchConceptsCallous-unemotional traitsNegative emotional stimuliAmygdala responseConduct problemsEmotional stimuliCognitive conflictTask demandsCognitive task demandsCognitive conflict tasksLow callous-unemotional traitsCP/HCUHealthy adult sampleCognitive controlEmotional facesReactive aggressionAtypical modulationConflict taskNeurocognitive responsesAffect regulationCU traitsPotential translational relevanceConflict conditionsPrefrontal areasHigh conflictAdult samples
2020
Identification of an Amygdala–Thalamic Circuit That Acts as a Central Gain Mechanism in Taste Perceptions
Veldhuizen MG, Farruggia MC, Gao X, Nakamura Y, Green BG, Small DM. Identification of an Amygdala–Thalamic Circuit That Acts as a Central Gain Mechanism in Taste Perceptions. Journal Of Neuroscience 2020, 40: 5051-5062. PMID: 32371606, PMCID: PMC7314406, DOI: 10.1523/jneurosci.2618-19.2020.Peer-Reviewed Original ResearchConceptsTaste intensity perceptionHealthy human participantsFunctional magnetic resonanceVentral posterior medial thalamusPosterior medial thalamusIntensity ratingsMedial dorsalMedial thalamusInhibitory outputInhibitory inputsPeripheral sourcesMagnetic resonanceInhibitory influenceIntensity perceptionCentral circuitsGustatory factorsIndividual variationDynamic causal modeling analysisConnectivity strengthAmygdalaMultiple tastantsGustatory systemMean intensity ratingsTaste intensity ratingsAmygdala responseAmygdala Response to Traumatic Childbirth Recall is Associated With Impaired Bonding Behaviors in Mothers With Childbirth-Related PTSD Symptoms: Preliminary Findings
Berman Z, Kaim A, Reed T, Felicione J, Hinojosa C, Oliver K, Rutherford H, Mayes L, Shin L, Dekel S. Amygdala Response to Traumatic Childbirth Recall is Associated With Impaired Bonding Behaviors in Mothers With Childbirth-Related PTSD Symptoms: Preliminary Findings. Biological Psychiatry 2020, 87: s142. DOI: 10.1016/j.biopsych.2020.02.378.Peer-Reviewed Original Research
2019
Let it be: mindful acceptance down-regulates pain and negative emotion
Kober H, Buhle J, Weber J, Ochsner KN, Wager TD. Let it be: mindful acceptance down-regulates pain and negative emotion. Social Cognitive And Affective Neuroscience 2019, 14: 1147-1158. PMID: 31989171, PMCID: PMC7057281, DOI: 10.1093/scan/nsz104.Peer-Reviewed Original ResearchConceptsMindful acceptanceEmotion regulation strategiesCognitive control systemPrefrontal control systemsMeditation-naïve participantsSelf-report measuresKinds of stimuliEmotion regulationNeutral imagesNegative emotionsAmygdala responseMindfulness trainingNegative affectAffective significanceEmotional intensityRegulation strategiesBrain processesNegative imageInitial appraisalEmotionsLateral pain systemPain systemStimuliParticipantsChronic pain
2017
Modulation of amygdala response to task-irrelevant emotion
Sebastian C, McCrory E, De Brito S, Viding E. Modulation of amygdala response to task-irrelevant emotion. Social Cognitive And Affective Neuroscience 2017, 12: 643-650. PMID: 28119506, PMCID: PMC5390695, DOI: 10.1093/scan/nsw174.Peer-Reviewed Original ResearchConceptsAmygdala responseTask demandsPerceptual inputTask performanceConflict conditionsTask-irrelevant emotional stimuliTask-irrelevant emotionFearful facial expressionsCognitive conflict tasksCognitive task performanceSlower reaction timesHigh-conflict conditionPsychophysiological interaction analysisRight amygdala responseLow-conflict conditionsMiddle frontal gyrusFunctional couplingEmotion regulationExecutive demandsEmotional informationConflict taskEmotional stimuliCognitive conflictCognitive demandsEmotional context
2015
Basolateral Amygdala Response to Food Cues in the Absence of Hunger Is Associated with Weight Gain Susceptibility
Sun X, Kroemer NB, Veldhuizen MG, Babbs AE, de Araujo IE, Gitelman DR, Sherwin RS, Sinha R, Small DM. Basolateral Amygdala Response to Food Cues in the Absence of Hunger Is Associated with Weight Gain Susceptibility. Journal Of Neuroscience 2015, 35: 7964-7976. PMID: 25995480, PMCID: PMC4438134, DOI: 10.1523/jneurosci.3884-14.2015.Peer-Reviewed Original ResearchConceptsAbsence of hungerWeight changeBasolateral amygdalaLong-term weight changeLong-term weight gainWeight gain susceptibilityGustatory inputD2 receptor densityA1 allele carriersAmygdala responseSated subjectsGhrelin levelsInitial BMILateral hypothalamusHuman hypothalamusAllele carriersReceptor densityAmygdala pathwayHealthy individualsElicit eatingDopamine signalingConfer susceptibilityWeight gainDynamic causal modelingNonhomeostatic eating
2014
A review of neuroimaging studies of race-related prejudice: does amygdala response reflect threat?
Chekroud A, Everett J, Bridge H, Hewstone M. A review of neuroimaging studies of race-related prejudice: does amygdala response reflect threat? Frontiers In Human Neuroscience 2014, 8: 179. PMID: 24734016, PMCID: PMC3973920, DOI: 10.3389/fnhum.2014.00179.Peer-Reviewed Original ResearchAmygdala activityRacial group membershipNeural correlatesHuman cognitionAmygdala responseModern psychologyOutgroup biasNeuroscientific studiesGroup membershipPervasive aspectNeural structuresPrejudiceCognitionNeural functionAmygdalaFuture directionsPotential threatPsychologyDominant interpretationCorrelatesCritical reviewThreatObserved patternsUnanswered questionsMembership
2013
Cognitive Reappraisal of Emotion: A Meta-Analysis of Human Neuroimaging Studies
Buhle JT, Silvers JA, Wager TD, Lopez R, Onyemekwu C, Kober H, Weber J, Ochsner KN. Cognitive Reappraisal of Emotion: A Meta-Analysis of Human Neuroimaging Studies. Cerebral Cortex 2013, 24: 2981-2990. PMID: 23765157, PMCID: PMC4193464, DOI: 10.1093/cercor/bht154.Peer-Reviewed Original ResearchConceptsLateral temporal cortexCognitive reappraisalEmotional respondingTemporal cortexSemantic representationEmotion regulation strategiesCognitive control regionsParietal control regionsVentromedial prefrontal cortexHuman neuroimaging studiesEmotion-related responsesCognitive controlEmotional stimuliFear extinctionAmygdala responseNegative affectRegulation strategiesNeuroimaging studiesBilateral amygdalaPrefrontal cortexAffective impactBrain regionsAttenuate activityAmygdalaReappraisalThe influence of combined cognitive plus social-cognitive training on amygdala response during face emotion recognition in schizophrenia
Hooker C, Bruce L, Fisher M, Verosky S, Miyakawa A, D'Esposito M, Vinogradov S. The influence of combined cognitive plus social-cognitive training on amygdala response during face emotion recognition in schizophrenia. Psychiatry Research 2013, 213: 99-107. PMID: 23746615, PMCID: PMC6999046, DOI: 10.1016/j.pscychresns.2013.04.001.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAmygdalaCognitive Behavioral TherapyEmotionsFacial ExpressionFemaleFunctional LateralityFunctional NeuroimagingHumansMagnetic Resonance ImagingMaleMiddle AgedPrefrontal CortexPutamenSchizophreniaSchizophrenic PsychologySocial BehaviorSocial PerceptionTherapy, Computer-AssistedTreatment OutcomeVideo GamesConceptsSocial cognition trainingSocial cognitive trainingAuditory-based cognitive trainingNeural activity increasesEmotion recognitionBehavioral improvementFunctional magnetic resonance imaging (fMRI) taskSocial cognition skillsSocial cognitive deficitsCognitive remediation studiesFace emotion recognitionFacial emotion recognitionRight medial prefrontal cortexComputer-based interventionsComputer gamesMedial prefrontal cortexEmotion perceptionCognitive trainingSocial cognitionAmygdala responseFMRI resultsSchizophrenia participantsBehavioral performanceBehavioral gainsNeural mechanismsNeural responses to fearful eyes in children with conduct problems and varying levels of callous–unemotional traits
Sebastian C, McCrory E, Dadds M, Cecil C, Lockwood P, Hyde Z, De Brito S, Viding E. Neural responses to fearful eyes in children with conduct problems and varying levels of callous–unemotional traits. Psychological Medicine 2013, 44: 99-109. PMID: 23510564, DOI: 10.1017/s0033291713000482.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingSubgenual anterior cingulate cortexImportant translational implicationsNeural responsesAnterior cingulate cortexAmygdala responseMagnetic resonance imagingFearful eyesConduct problemsTrial participantsEye conditionsCingulate cortexCortex responsesResonance imagingEvidence baseAmygdala reactivityTranslational implicationsHeterogeneous groupTD controlsEyesChildrenFear recognition deficitsNeural levelParticipantsLow levelsAccuracy and Consensus in Judgments of Trustworthiness From Faces: Behavioral and Neural Correlates
Rule N, Krendl A, Ivcevic Z, Ambady N. Accuracy and Consensus in Judgments of Trustworthiness From Faces: Behavioral and Neural Correlates. Journal Of Personality And Social Psychology 2013, 104: 409-426. PMID: 23276271, DOI: 10.1037/a0031050.Peer-Reviewed Original ResearchConceptsJudgments of trustworthinessAmygdala responseNeural correlatesStudy 4Inferences of trustworthinessSelf-reported extraversionReplicate previous researchJudgments of intelligencePerceptions of trustworthinessCheating behaviorActual cheating behaviorPerceivers' inferencesStudents' extraversionStudy 3Study 5Study 1Study 2Previous researchInterrater consensusExtraversionJudgmentStudents' scoresAmygdalaFaceStudents
2012
Amygdala Response to Preattentive Masked Fear in Children With Conduct Problems: The Role of Callous-Unemotional Traits
Viding E, Sebastian C, Dadds M, Lockwood P, Cecil C, De Brito S, McCrory E. Amygdala Response to Preattentive Masked Fear in Children With Conduct Problems: The Role of Callous-Unemotional Traits. American Journal Of Psychiatry 2012, 169: 1109-1116. PMID: 23032389, DOI: 10.1176/appi.ajp.2012.12020191.Peer-Reviewed Original ResearchConceptsHigh callous-unemotional traitsCallous-unemotional traitsLow callous-unemotional traitsConduct problemsAmygdala responseCalm facesAttention deficit hyperactivity disorderGreater amygdala responsesDifferential amygdala activityLower amygdala reactivityFindings complementMasked fearAffective processingComparison boysNeural basisAmygdala activityAmygdala reactivityConscious awarenessAmygdala involvementHyperactivity disorderNeural responsesUnemotional TraitsAmygdala hypoactivityClassification of childrenAmygdala hyperactivityAcute stress potentiates brain response to milkshake as a function of body weight and chronic stress
Rudenga KJ, Sinha R, Small DM. Acute stress potentiates brain response to milkshake as a function of body weight and chronic stress. International Journal Of Obesity 2012, 37: 309-316. PMID: 22430303, PMCID: PMC3381866, DOI: 10.1038/ijo.2012.39.Peer-Reviewed Original ResearchConceptsBody mass indexFunctional magnetic resonance imagingChronic stressOrbitofrontal cortexRight amygdalaBody weightPalatable foodAcute stressBasal cortisol levelsBrain responsesAmygdala responseMagnetic resonance imagingStress-related eatingMilkshake receiptPalatable milkshakeObese womenOverweight womenMass indexRight amygdala responseOFC responsesPotentiates responsesCortisol levelsLeft amygdalaResonance imagingVentral striatum
2011
Amygdala response to sucrose consumption is inversely related to artificial sweetener use
Rudenga KJ, Small DM. Amygdala response to sucrose consumption is inversely related to artificial sweetener use. Appetite 2011, 58: 504-507. PMID: 22178008, PMCID: PMC3289048, DOI: 10.1016/j.appet.2011.12.001.Peer-Reviewed Original Research
2010
Increased amygdala response and decreased influence of internal state on amygdala response to food in overweight compared to healthy weight individuals
Chouinard-Decorte F, Felsted J, Small D. Increased amygdala response and decreased influence of internal state on amygdala response to food in overweight compared to healthy weight individuals. Appetite 2010, 54: 639. DOI: 10.1016/j.appet.2010.04.042.Peer-Reviewed Original ResearchSex-related differences in amygdala activity influences immediate memory
Aikins DE, Anticevic A, Kiehl KA, Krystal JH. Sex-related differences in amygdala activity influences immediate memory. Neuroreport 2010, 21: 273-276. PMID: 20093991, DOI: 10.1097/wnr.0b013e328335b3f9.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmygdalaEmotionsFemaleFunctional LateralityHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMemory, Short-TermMiddle AgedNeuropsychological TestsPattern Recognition, VisualPhotic StimulationPsychomotor PerformanceRecognition, PsychologyRegression AnalysisSex CharacteristicsSex FactorsConceptsAmygdala activationImmediate memoryUnpleasant picturesImmediate recognition memoryRecognition memory testRight amygdala activationLong-term memoryFunctional magnetic resonanceUnpleasant picture viewingEmotional picturesRecognition memoryMemory testAmygdala responsePicture viewingMemoryFalse positive error rateSex differencesSex-related differencesAmygdalaError ratePictureViewingLearningMagnetic resonanceDifferences
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply