2025
Diabetes Status and Long-Term Mortality and Major Amputation Outcomes Following Revascularization in Chronic Limb Threatening Ischemia
Callegari S, Romain G, Aggarwal A, Cleman J, Smolderen K, Mena-Hurtado C. Diabetes Status and Long-Term Mortality and Major Amputation Outcomes Following Revascularization in Chronic Limb Threatening Ischemia. Journal Of Vascular Surgery 2025 PMID: 40348290, DOI: 10.1016/j.jvs.2025.04.065.Peer-Reviewed Original ResearchChronic limb-threatening ischemiaLower-extremity bypassSub-hazard ratiosPeripheral vascular interventionsDM statusRisk of deathLimb-threatening ischemiaTeam-based careShared decision-makingCumulative incidenceDiabetes mellitusMedicare claims dataCumulative incidence of mortalityAll-cause mortalityType of revascularizationAmputation outcomesCare offerFine-Gray modelClaims dataCumulative incidence of deathLong-term mortalityMortality riskCox regression modelsHazard ratioDiabetes statusOutcomes of transcatheter aortic valve implantation in Africa: A systematic review and meta-analysis
Ahmed A, Safiriyu I, Kaddoura R, Mohyeldin M, Nwokeocha N, Sandeep N, Khalil H, Alhusain R, Zarich S. Outcomes of transcatheter aortic valve implantation in Africa: A systematic review and meta-analysis. International Journal Of Cardiology 2025, 429: 133139. PMID: 40074042, DOI: 10.1016/j.ijcard.2025.133139.Peer-Reviewed Original ResearchTranscatheter aortic valve implantationOutcomes of transcatheter aortic valve implantationAll-cause mortalityAortic valve implantationAdverse eventsValve implantationIn-hospital all-cause mortalitySevere aortic stenosisMeta-analysisProcedural success rateTranscatheter aortic valve implantation outcomesStandard of careSurgical riskAortic stenosisPooled proportionProcedural successFollow-upObservational studyInterquartile rangeNational registryMortality rateGrey literatureHealthcare systemSuccess rateConfidence intervalsIMPACT OF TUMOR STAGE IN PATIENTS WITH BCG-UNRESPONSIVE NMIBC WHO UNDERGO UPFRONT RADICAL CYSTECTOMY: A LARGE MULTI-INSTITUTIONAL STUDY
Annapureddy D, Taylor J, Howard J, Tan W, McElree I, Davaro F, Yim K, Harrington S, Dyer E, Black A, Kanabur P, Roumiguié M, Lerner S, Black P, Raman J, Preston M, Steinberg G, Huang W, Li R, Packiam V, O'Donnell M, Kamat A, Woldu S, Lotan Y. IMPACT OF TUMOR STAGE IN PATIENTS WITH BCG-UNRESPONSIVE NMIBC WHO UNDERGO UPFRONT RADICAL CYSTECTOMY: A LARGE MULTI-INSTITUTIONAL STUDY. Urologic Oncology Seminars And Original Investigations 2025, 43: 81. DOI: 10.1016/j.urolonc.2024.12.204.Peer-Reviewed Original ResearchBCG-unresponsive NMIBCNon-muscle invasive bladder cancerCarcinoma in situImpact of tumor stageBCG-unresponsiveRadical cystectomyUpfront RCCancer-specific mortalityOncological outcomesTumor stageT1 patientsAll-cause mortalityTA patientsPathological outcomesPapillary diseaseHigh risk of recurrenceBCG-unresponsive diseaseClinical stage tumorsUpfront radical cystectomyClinical tumor stageNode-positive diseaseCompare oncologic outcomesInvasive bladder cancerT1 stage tumorsKaplan-Meier methodIMPROVED OUTCOMES IN BCG-UNRESPONSIVE BLADDER CANCER PATIENTS WITH NON-INVASIVE DISEASE UNDERGOING BLADDER SPARING THERAPY COMPARED TO T1 DISEASE: RESULTS FROM AN INTERNATIONAL COHORT
Annapureddy D, Taylor J, Howard J, Tan W, McElree I, Davaro F, Yim K, Harrington S, Dyer E, Black A, Kanabur P, Roumiguié M, Lerner S, Black P, Raman J, Preston M, Steinberg G, Huang W, Li R, Packiam V, O'Donnell M, Kamat A, Woldu S, Lotan Y. IMPROVED OUTCOMES IN BCG-UNRESPONSIVE BLADDER CANCER PATIENTS WITH NON-INVASIVE DISEASE UNDERGOING BLADDER SPARING THERAPY COMPARED TO T1 DISEASE: RESULTS FROM AN INTERNATIONAL COHORT. Urologic Oncology Seminars And Original Investigations 2025, 43: 80-81. DOI: 10.1016/j.urolonc.2024.12.203.Peer-Reviewed Original ResearchBCG-unresponsive NMIBCNon-muscle invasive bladder cancerBladder sparing therapyAll-cause mortalityOncological outcomesRadical cystectomyCancer-specific mortalityNon-invasive diseaseBCG-unresponsiveBladder cancerPathological outcomesT1 diseaseT1 patientsCIS patientsMedian timeProgression to muscle-invasive bladder cancerBCG-unresponsive NMIBC patientsImpact of pathological stageImpact of tumor stageInternational cohortMuscle-invasive bladder cancerAssociated with significant morbiditySingle-institution seriesHeterogeneous group of patientsCompare oncologic outcomesImpact of Transcatheter or Surgical Aortic Valve Performance on 5-Year Outcomes in Patients at ≥ Intermediate Risk
Yakubov S, Van Mieghem N, Oh J, Ito S, Grubb K, O’Hair D, Forrest J, Gada H, Mumtaz M, Deeb G, Tang G, Rovin J, Jain R, Windecker S, Skelding K, Kleiman N, Chetcuti S, Dedrick A, Boatman S, Popma J, Reardon M. Impact of Transcatheter or Surgical Aortic Valve Performance on 5-Year Outcomes in Patients at ≥ Intermediate Risk. Journal Of The American College Of Cardiology 2025 DOI: 10.1016/j.jacc.2025.02.009.Peer-Reviewed Original ResearchBioprosthetic valve dysfunctionRandomized controlled trialsRandomized controlled trial patientsClinical outcomesAssociated with increased 5-year all-cause mortalityWorsening heart failureContinued Access StudyAll-cause mortalityPost hoc analysisPooled randomized controlled trialsIntermediate riskPivotal trialsPrimary endpointAortic valve performanceValve dysfunctionSurgery patientsHeart failureValve diseaseTAVI patientsSupra-annularSurgeryCardiovascular mortalityClinical importancePatientsControlled trialsThe sex differences in diseases progression and prognosis among persons with HIV and HBV coinfection
Yang R, Chen Q, Jiao F, Yu X, Xiong Y. The sex differences in diseases progression and prognosis among persons with HIV and HBV coinfection. Scientific Reports 2025, 15: 4018. PMID: 39893294, PMCID: PMC11787304, DOI: 10.1038/s41598-025-88530-2.Peer-Reviewed Original ResearchConceptsCD4+ T-lymphocyte countT lymphocyte countsEnd-stage-liver diseaseFIB-4 scoreHBV coinfectionFIB-4HBV DNADecline of HBV DNA levelsDisease progressionLong-term surveillance periodRisk factorsPrevalence of liver cirrhosisHBV co-infectionMultivariate logistic regression analysisHBV DNA levelsProgression of liver diseaseIndependent risk factorLiver disease progressionLiver fibrosis levelsAll-cause mortalityMultivariate logistic regressionLogistic regression analysisMale groupSex differencesFemale groupCardiovascular disease, bone fracture, and all-cause mortality risks among postmenopausal women by arthritis and veteran status: A multistate Markov transition analysis
Beydoun H, Beydoun M, Weiss J, Brunner R, Mishra N, Ding M, Wactawski-Wende J, Gradidge P, Liu S, Tsai J. Cardiovascular disease, bone fracture, and all-cause mortality risks among postmenopausal women by arthritis and veteran status: A multistate Markov transition analysis. GeroScience 2025, 1-18. PMID: 39875753, DOI: 10.1007/s11357-025-01527-7.Peer-Reviewed Original ResearchNon-veteransVeteran statusCardiovascular diseaseRelationship of arthritisNon-veteran womenWomen's Health InitiativePostmenopausal womenPrevalence of arthritisAll-cause mortalityBone fracturesAssociated with cardiovascular diseaseAssociated with greater probabilityMultistate Markov modelHealth initiativesAnalyzed longitudinal dataPrevalent arthritisMortality riskMilitary veteransVeteransFracture riskStudy objectiveGreater probabilityCox modelWomenLongitudinal dataP-1950. An estimate of pediatric lives saved due to non-pharmacologic interventions during the early COVID-19 pandemic
Faust J, Chen A, Renton B, Du C, Li S, Lin Z, Krumholz H. P-1950. An estimate of pediatric lives saved due to non-pharmacologic interventions during the early COVID-19 pandemic. Open Forum Infectious Diseases 2025, 12: ofae631.2109. PMCID: PMC11778407, DOI: 10.1093/ofid/ofae631.2109.Peer-Reviewed Original ResearchAll-causeICD-10 classificationPediatric deathsCDC WONDERMedical mortalityConfidence intervalsExcess mortalityMedical deathsICD-10Age groupsPandemic mitigation measuresCOVID-19 pandemicNon-pharmacological interventionsChildren aged 0Residents aged 0All-cause mortalityAll-cause excess mortalityChildren aged 1US childrenCOVID-19 pandemic periodExcess deathsPediatric mortalityChildhood mortalityAged 0COVID-19Predictors of late recurrence of colorectal cancer (CRC) among older long-term survivors using claims-based evidence.
Yasin F, Westvold S, Long J, Fan J, Hyslop T, Leeds I, Cecchini M, Gross C, Dinan M. Predictors of late recurrence of colorectal cancer (CRC) among older long-term survivors using claims-based evidence. Journal Of Clinical Oncology 2025, 43: 66-66. DOI: 10.1200/jco.2025.43.4_suppl.66.Peer-Reviewed Original ResearchCRC-specific mortalityAll-cause mortalityCancer diagnosisColorectal cancerLong-term CRC survivorsNon-cancer related conditionsNon-metastatic colorectal cancerSEER-MedicareRisk of all-cause mortalityRecurrence of colorectal cancerColon cancerSEER-Medicare populationYear 5CRC survivorsSEER-Medicare databaseSurvivorship careRectal cancerFollow-up accountsColorectal cancer recurrenceMultiple co-morbiditiesMedicare claimsRetrospective cohort studyFine-Gray modelEstimate cumulative incidencePrimary risk factorOutcomes of chronic limb-threatening ischemia revascularization in patients with chronic kidney disease in the BEST-CLI trial
Malas M, Hamouda M, Farber A, Menard M, Conte M, Rosenfield K, Strong M, Doros G, Powell R, Mena-Hurtado C, Gasper W, Schermerhorn M, Allievi S, Smolderen K, Dake M, Rymer J, Tuttle K. Outcomes of chronic limb-threatening ischemia revascularization in patients with chronic kidney disease in the BEST-CLI trial. Journal Of Vascular Surgery 2025, 81: 945-956.e3. PMID: 39846933, DOI: 10.1016/j.jvs.2024.12.128.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAmputation, SurgicalChronic Limb-Threatening IschemiaEndovascular ProceduresFemaleGlomerular Filtration RateHumansIschemiaKidneyLimb SalvageMaleMiddle AgedPeripheral Arterial DiseaseProspective StudiesRenal DialysisRenal Insufficiency, ChronicRisk AssessmentRisk FactorsSeverity of Illness IndexTime FactorsTreatment OutcomeVascular Surgical ProceduresConceptsChronic limb-threatening ischemiaChronic kidney diseaseDialysis-dependent patientsBEST-CLIChronic kidney disease stagePrimary trial outcomeRisk of amputationAssociated with lower mortalityEndovascular therapyAll-cause mortalityHigh risk of poor outcomesRisk of poor outcomesEndovascular revascularizationKidney diseaseBEST-CLI trialOutcomes of lower extremity revascularizationAssociated with better survivalMultivariate Cox regression analysisBest Surgical TherapyIncreased reintervention rateStage 4 CKD patientsRisk of reinterventionGroup C patientsAdverse limb eventsChronic kidney disease severityA Bayesian Interpretation of CABANA and Other Randomized Controlled Trials for Catheter Ablation in Patients With Atrial Fibrillation
Nogueira A, Felix N, Kalil F, Tramujas L, Godoi A, Miyawaki I, Bellavia A, Moura F, Cardoso R, d'Avila A, Fernandes G. A Bayesian Interpretation of CABANA and Other Randomized Controlled Trials for Catheter Ablation in Patients With Atrial Fibrillation. Journal Of Cardiovascular Electrophysiology 2025, 36: 617-624. PMID: 39834105, DOI: 10.1111/jce.16552.Peer-Reviewed Original ResearchConceptsBayesian analysisTreatment effect distributionAdverse cardiovascular outcomesAll-cause mortalityCardiovascular outcomesRandomized controlled trialsFrequentist estimatorsCatheter ablationMedical therapyAtrial fibrillationBayesian interpretationImpact of catheter ablationControlled trialsAnalysis of randomized controlled trialsProbability distributionAtrial fibrillation patientsReduce adverse cardiovascular outcomesImpact of ablationEffective distributionRandom-effects modelBayes' theoremTrial-level dataProbabilistic understandingSurvival outcomesFibrillation patientsMortality, Hepatic Decompensation, and Cardiovascular Outcomes in Lean vs. Non-lean MASLD Cirrhosis: A Veterans Affairs Cohort Study
Njei B, Mezzacappa C, John B, Serper M, Kaplan D, Taddei T, Mahmud N. Mortality, Hepatic Decompensation, and Cardiovascular Outcomes in Lean vs. Non-lean MASLD Cirrhosis: A Veterans Affairs Cohort Study. Digestive Diseases And Sciences 2025, 70: 802-813. PMID: 39779587, PMCID: PMC11839701, DOI: 10.1007/s10620-024-08764-4.Peer-Reviewed Original ResearchConceptsNon-lean individualsAll-cause mortalityMajor adverse cardiovascular eventsIncreased risk of all-cause mortalityRisk of all-cause mortalityVeterans Health AdministrationRisk of hepatic decompensationPrevalence of diabetesRisk of cardiovascular mortalityHepatic decompensationHigher mortality riskCardiovascular-related mortalityCox proportional hazards modelsCohort study of patientsCardiovascular outcomesIncident major adverse cardiovascular eventsRetrospective cohort study of patientsProportional hazards modelNon-HispanicRetrospective cohort studyCompeting risk regressionHealth AdministrationMultivariate Cox proportional hazards modelLean individualsAssessed associationsThe Association between All-cause Mortality and Obstructive Sleep Apnea in Adults: A U-Shaped Curve.
Azarian M, Ramezani A, Sharafkhaneh A, Maghsoudi A, Kryger M, Thomas R, Westover M, Razjouyan J. The Association between All-cause Mortality and Obstructive Sleep Apnea in Adults: A U-Shaped Curve. Annals Of The American Thoracic Society 2025 PMID: 39746198, DOI: 10.1513/annalsats.202407-755oc.Peer-Reviewed Original ResearchApnea-hypopnea indexAll-cause mortalitySleep apneaBody mass indexAssociated with apnea-hypopnea indexApnea hypopnea index categoriesInterpretation of sleep studiesOdds ratioOdds of all-cause mortalityObstructive sleep apneaSeverity of SAAll-cause mortality ratesElixhauser Comorbidity IndexSleep studiesPropensity-matchedMass indexSevere SAComorbidity indexAll-causeMortality rateMortalityEffects of ageApneaLogistic regressionAge groupsLiver Fibrosis and Cardiovascular Events
Nso N, Bookani K, Trimingham M, Orji R, Njei B, Balasubramanian S, Pursnani A. Liver Fibrosis and Cardiovascular Events. Southern Medical Journal 2025, 118: 19-25. PMID: 39753232, DOI: 10.14423/smj.0000000000001769.Peer-Reviewed Original ResearchConceptsLiver fibrosis scoresNonalcoholic fatty liver diseaseRisk of cardiovascular eventsNAFLD fibrosis scoreCardiovascular eventsAll-cause mortalityFibrosis scoreLiver fibrosisSystematic reviewFibrosis-4Noninvasive liver fibrosis scoresLiver diseaseCardiovascular mortalityHigh risk of cardiovascular eventsNonalcoholic fatty liver disease fibrosis scoreRelevant prospective studiesSeverity of liver fibrosisNational Institutes of Health toolCardiovascular diseaseHigher liver fibrosis scoresSpectrum of cardiovascular diseasesFibrosis-4 scoreSeverity of fibrosisCardiovascular event occurrenceChronic liver disease
2024
Validation and epidemiologic definition of the novel steatotic liver disease nomenclature in a national United States cohort with cirrhosis
Mezzacappa C, Ochoa-Allemant P, Serper M, Taddei T, John B, Kaplan D, Mahmud N. Validation and epidemiologic definition of the novel steatotic liver disease nomenclature in a national United States cohort with cirrhosis. Clinical Gastroenterology And Hepatology 2024 PMID: 39689774, DOI: 10.1016/j.cgh.2024.10.035.Peer-Reviewed Original ResearchAlcohol-associated liver diseaseCardiometabolic risk factorsAlcohol use disorderSteatotic liver diseaseLiver diseaseLow high-density lipoproteinChild-Turcotte-Pugh classIncidence rateIncident hepatocellular carcinomaIncreased alcohol intakeAlcohol useClinically relevant definitionAll-cause mortalityHigher hazard of mortalityNational cohort of veteransUnited States cohortCohort of veteransAcute cardiac eventsHigh-density lipoproteinHazard of mortalityHazardous alcohol useAlcohol intakeCardiac eventsAlcohol exposureHepatocellular carcinomaImpact of a multicomponent strategy including decentralized molecular testing for tuberculosis on mortality: planned analysis of a cluster-randomized trial in Uganda
Katamba A, Mochizuki T, Nalugwa T, Nantale M, Oyuku D, Nabwire S, Babirye D, Musinguzi J, Nakawesa A, Nekesa I, Turyahabwe S, Joloba M, Dowdy D, Moore D, Davis J, Shete P, Adams K, Reza T, Fielding K, Cattamanchi A. Impact of a multicomponent strategy including decentralized molecular testing for tuberculosis on mortality: planned analysis of a cluster-randomized trial in Uganda. EClinicalMedicine 2024, 78: 102953. PMID: 39659443, PMCID: PMC11629260, DOI: 10.1016/j.eclinm.2024.102953.Peer-Reviewed Original ResearchCommunity health centersCluster randomized trialHealth centersPragmatic cluster randomized trialMulticomponent strategiesSix-month mortality riskSecondary outcomesPan African Clinical Trials RegistryCluster-level analysisPatient-level covariatesAll-cause mortalityClinical Trials RegistryIntervention armSub-group analysisTB careMortality risk analysisRoutine careVital statusTrial armsMagnitude of effectPresumptive TBRate ratiosProximal outcomesTrial participantsUS National InstitutesClonal hematopoiesis of indeterminate potential is associated with increased risk of immune checkpoint inhibitor myocarditis in a prospective study of a cardio-oncology cohort
Jaber Chehayeb R, Singh J, Matute-Martinez C, Chen N, Guajardo A, Lin D, Jayakrishnan R, Christofides A, Leveille E, Im Y, Biancon G, VanOudenhove J, Ibrahim E, Ardasheva A, Jha A, Hwa J, Halene S, Kwan J. Clonal hematopoiesis of indeterminate potential is associated with increased risk of immune checkpoint inhibitor myocarditis in a prospective study of a cardio-oncology cohort. Cardio-Oncology 2024, 10: 84. PMID: 39587635, PMCID: PMC11590368, DOI: 10.1186/s40959-024-00289-z.Peer-Reviewed Original ResearchImmune checkpoint inhibitor myocarditisImmune checkpoint inhibitorsImmune checkpoint inhibitor useICI-myocarditisIndeterminate potentialProspective studyImmune checkpoint inhibitor therapyCancer therapyClonal hematopoiesis of indeterminate potentialCancer treated with immunotherapyIncreased T cell activationObstructive coronary artery diseaseMultivariate competing risk analysisCardiotoxic cancer therapyRisks Cox regressionAssociated with increased riskIncreased all-cause mortalityPatient co-morbiditiesRisk of cardiomyopathyT cell activationCompeting risk analysisCoronary artery calcificationCoronary artery diseaseAll-cause mortalityHeart failure patientsMachine Learning-Based Prediction of Death and Hospitalization in Patients With Implantable Cardioverter Defibrillators
Rosman L, Lampert R, Wang K, Gehi A, Dziura J, Salmoirago-Blotcher E, Brandt C, Sears S, Burg M. Machine Learning-Based Prediction of Death and Hospitalization in Patients With Implantable Cardioverter Defibrillators. Journal Of The American College Of Cardiology 2024, 85: 42-55. PMID: 39570241, DOI: 10.1016/j.jacc.2024.09.006.Peer-Reviewed Original ResearchImplantable cardioverter-defibrillatorYear of device implantationAll-cause mortalityCardiac resynchronization therapyDeath/HF hospitalizationValidation cohortHeart failureDevice implantationTime of ICD implantationArea under the receiver-operating characteristic curveMedian follow-upReceiver-operating characteristic curvePredicting all-cause mortalityImplantable cardioverter-defibrillator patientsVeterans Health AdministrationPersonalized risk estimatesImplantable cardioverter defibrillatorResynchronization therapyBaseline demographicsICD implantationTraining cohortTrajectories of individual patientsProspective studyComposite outcomeContinuum of riskAnticoagulation Therapy for Venous Thromboembolism in the Pediatric Population: A Systematic Review and Meta-Analysis
Azzam M, Kawtharany H, Monagle P, Bercovitz R, Hamarsha Q, Alkhader A, Abou Zeid H, Mansour R, Patel P, Tabak C, Baghdadi S, Betensky M, Bhat R, Biss T, Branchford B, Brandao L, Chan A, Faustino E, Jaffray J, Jones S, Kerlin B, Kucine N, Kumar R, Male C, Pelland-Marcotte M, Raffini L, Raulji C, Sartain S, Takemoto C, Tarango C, Van Ommen H, Velez-Yanguas M, Vesely S, Wiernikowski J, Williams S, Wilson H, Woods G, Zia A, Mustafa R. Anticoagulation Therapy for Venous Thromboembolism in the Pediatric Population: A Systematic Review and Meta-Analysis. Blood 2024, 144: 1257-1257. DOI: 10.1182/blood-2024-212150.Peer-Reviewed Original ResearchRisk of biasCertainty of evidenceVenous thromboembolismPediatric patientsThrombus resolutionAll-cause mortalityThrombus recurrenceAC therapyAnticoagulant therapyAbsolute effectEvents of all-cause mortalityPediatric populationSystematic reviewNon-randomized Studies of InterventionsManagement of venous thromboembolismMeta-analysisStudies of interventionsConcerns related to riskNon-randomized observational studyNon-randomized studiesRecommendations AssessmentThrombus progressionBleeding eventsBleeding riskPortal hypertensionThe Burden of All-Cause Mortality Following Influenza-Associated Hospitalizations: Influenza Hospitalization Surveillance Network, 2010–2019
O’Halloran A, Millman A, Holstein R, Olsen S, Cummings C, Chai S, Kirley P, Alden N, Yousey-Hindes K, Meek J, Openo K, Fawcett E, Ryan P, Leegwater L, Henderson J, McMahon M, Lynfield R, Angeles K, Bleecker M, McGuire S, Spina N, Tesini B, Gaitan M, Lung K, Shiltz E, Thomas A, Talbot H, Schaffner W, Hill M, Reed C, Garg S. The Burden of All-Cause Mortality Following Influenza-Associated Hospitalizations: Influenza Hospitalization Surveillance Network, 2010–2019. Clinical Infectious Diseases 2024, 80: e43-e45. PMID: 39495002, PMCID: PMC11912969, DOI: 10.1093/cid/ciae547.Peer-Reviewed Original ResearchInfluenza-associated hospitalizationsInfluenza-associated deathsIn-hospitalInfluenza Hospitalization Surveillance NetworkClinical characteristics of patientsHospital dischargeLaboratory-confirmed influenzaImpact of influenzaCharacteristics of patientsAll-cause mortalityMedical conditionsDied in-hospitalFluSurv-NETInfluenza hospitalizationsPost-discharge outcomesClinical characteristicsDeath certificatesOlder patientsPost-dischargeMedian daysPost-discharge deathsInfluenzaPatientsDays post-dischargeCardiovascular disease
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply