2025
Significance of Coronary Artery Calcifications and Ischemic Electrocardiographic Changes Among Patients Undergoing Myocardial Perfusion Imaging
Kokkinidis D, Kyriakoulis I, Chui P, Agarwal R, Liu Y, Khera R, Sinusas A, Velazquez E, Miller E, Feher A. Significance of Coronary Artery Calcifications and Ischemic Electrocardiographic Changes Among Patients Undergoing Myocardial Perfusion Imaging. JACC Advances 2025, 4: 101618. PMID: 39983619, PMCID: PMC11891677, DOI: 10.1016/j.jacadv.2025.101618.Peer-Reviewed Original ResearchCoronary artery calcificationMyocardial perfusion imagingIschemic ECG changesLow event ratesECG changesNormal perfusionArtery calcificationPerfusion imagingSingle-photon emission computed tomography/computed tomographyStress ECGCAC evaluationPresence of coronary artery calcificationSuspected coronary artery diseaseMedian follow-upEvent ratesIschemic electrocardiographic changesAnalysis to patientsComposite endpoint rateCoronary artery diseaseTomography/computed tomographyPrognostic informationMACE rateFollow-upSubgroup analysisAdverse outcomesSex-Specific Clinical and Genetic Factors Associated With Adverse Outcomes in Hypertrophic Cardiomyopathy
Butters A, Arnott C, Sweeting J, Claggett B, Cuomo A, Abrams D, Ashley E, Day S, Helms A, Lampert R, Lin K, Michels M, Miller E, Olivotto I, Owens A, Parikh V, Pereira A, Rossano J, Ryan T, Saberi S, Stendahl J, Ware J, Atherton J, Semsarian C, Lakdawala N, Ho C, Ingles J. Sex-Specific Clinical and Genetic Factors Associated With Adverse Outcomes in Hypertrophic Cardiomyopathy. Circulation Genomic And Precision Medicine 2025, 18: e004641. PMID: 39851041, DOI: 10.1161/circgen.124.004641.Peer-Reviewed Original ResearchConceptsRisk of heart failureSex-specific hazard ratiosHazard ratioHypertrophic cardiomyopathyAdverse outcomesHeart failureSex interaction termsFactors associated with adverse outcomesRisk of atrial fibrillationVentricular arrhythmiasCox proportional hazards modelsSarcomeric Human Cardiomyopathy RegistryManagement of hypertrophic cardiomyopathyProportional hazards modelInvestigate sex-related differencesSex differencesHeart failure riskRisk scoreHigher heart failureModerate riskHazards modelRisk factorsCardiomyopathy RegistryDeath riskImprove outcomesCefazolin Alone Versus Cefazolin With Tobramycin or Gentamicin as Intraoperative Antibiotic Prophylaxis for Total Joint Arthroplasty
Dhodapkar M, Halperin S, Radford Z, Rubin L, Grauer J, Li M. Cefazolin Alone Versus Cefazolin With Tobramycin or Gentamicin as Intraoperative Antibiotic Prophylaxis for Total Joint Arthroplasty. Arthroplasty Today 2025, 31: 101613. PMID: 39911247, PMCID: PMC11794179, DOI: 10.1016/j.artd.2024.101613.Peer-Reviewed Original ResearchFive-year implant survivalTotal knee arthroplastyElixhauser Comorbidity IndexProphylactic cefazolinImplant survivalAdverse outcomesComorbidity indexTotal hip arthroplastyAntibiotic prophylaxis regimensIntraoperative antibiotic prophylaxisStandard prophylactic antibioticsKaplan-Meier analysisLog-rank testPerioperative adverse outcomesPostoperative adverse outcomesProsthetic joint infectionMultivariate logistic regressionAntibiotic prophylaxisProphylaxis regimensTotal knee arthroplasty patientsProphylactic antibioticsSSI ratesComplication of total knee arthroplastyJoint infectionCefazolinEfficacy and safety of anesthetic agents in awake craniotomy using monitored anesthesia care protocol: a systematic review and meta-analysis
Aghajanian S, Naeimi A, Mohammadifard F, Mohammadi I, Rajai Firouzabadi S, Baradaran Bagheri A, Khorasanizadeh M, Elsamadicy A. Efficacy and safety of anesthetic agents in awake craniotomy using monitored anesthesia care protocol: a systematic review and meta-analysis. Neurosurgical Review 2025, 48: 57. PMID: 39815114, DOI: 10.1007/s10143-025-03176-y.Peer-Reviewed Original ResearchConceptsMonitored anesthesia carePostoperative neurological deficitsNeurological deficitsAwake craniotomyClinical outcomesMeta-analysisMonitored anesthesia care protocolPooled proportion of patientsRate of postoperative neurologic deficitsRisk of neurological deficitsProportion of patientsAdverse event ratesAnesthetic agentsSystematic reviewIntraoperative seizure rateSecondary adverse outcomesImpact of anesthetic agentsTumor resectionRemifentanil usePooled proportionTense brainIntraoperative seizuresAnesthetic protocolRandomized trialsAdverse outcomesPreparing for The Silver Tsunami: The Potential for use of Big Data and Artificial Intelligence in Geriatric Anesthesia
Chu L, Kurup V. Preparing for The Silver Tsunami: The Potential for use of Big Data and Artificial Intelligence in Geriatric Anesthesia. Current Anesthesiology Reports 2025, 15: 17. DOI: 10.1007/s40140-024-00674-5.Peer-Reviewed Original ResearchBig data analyticsData analyticsMachine learningPotential of big data analyticsAdoption of MLIntegration of MLData privacyBig DataData scientistsData-driven insightsArtificial intelligenceGeriatric anesthesiaAlgorithmic biasModel interpretationML modelsPreoperative risk stratificationPredicting postoperative complicationsIntraoperative anesthesia managementPostoperative complicationsRespiratory complicationsRisk stratificationElderly patientsDataAdverse outcomesAnesthesia management
2024
Early, Individualized Recommendations for Hospitalized Patients With Acute Kidney Injury
Aklilu A, Menez S, Baker M, Brown D, Dircksen K, Dunkley K, Gaviria S, Farrokh S, Faulkner S, Jones C, Kadhim B, Le D, Li F, Makhijani A, Martin M, Moledina D, Coronel-Moreno C, O’Connor K, Shelton K, Shvets K, Srialluri N, Tan J, Testani J, Corona-Villalobos C, Yamamoto Y, Parikh C, Wilson F, Sundararajan A, Wang A, Schretlen C, Singel D, Moss E, Aune F, Iantosca G, Zou G, Chernova I, Bitzel J, Hernandez J, Lindsley J, Dane K, Orias M, Mehta P, Zassman-Isner S, Wen Y, Freeman N. Early, Individualized Recommendations for Hospitalized Patients With Acute Kidney Injury. JAMA 2024, 332: 2081-2090. PMID: 39454050, PMCID: PMC11669049, DOI: 10.1001/jama.2024.22718.Peer-Reviewed Original ResearchElectronic health recordsUsual careHealth recordsAction teamsClinicians of patientsHospitalized patientsFinal follow-upIntervention groupHealth systemStudy pharmacistsStudy physiciansMain OutcomesAssociated with adverse outcomesAcute kidney injuryRandomized clinical trialsPrimary outcomeIndividualized recommendationsNew HavenAdverse outcomesAKI detectionCareRhode IslandComposite outcomeFollow-upInterventionValidation and expansion of Baveno VII criteria for cACLD and CSPH based on liver stiffness and platelet count: Correlation with risk of hepatic decompensation and death.
Vutien P, Barnard Giustini A, Kim N, Moon A, Hsu C, Mezzacappa C, Borgerding J, Johnson K, VoPham T, Berry K, Beste L, Kaplan D, Taddei T, Ioannou G. Validation and expansion of Baveno VII criteria for cACLD and CSPH based on liver stiffness and platelet count: Correlation with risk of hepatic decompensation and death. Hepatology 2024 PMID: 39689352, DOI: 10.1097/hep.0000000000001183.Peer-Reviewed Original ResearchClinically significant portal hypertensionRisk of deathHepatic decompensationLiver stiffnessChronic liver diseasePlatelet countStratify risk of deathLiver diseaseRisk of hepatic decompensationMedian follow-upRisk of adverse outcomesSignificant portal hypertensionAssociated with risk of adverse outcomesRisk of decompensationAssociated with riskPortal hypertensionStratify riskFollow-upDecompensationAdverse outcomesCACLDPlatelet measuresPatientsPlateletDeathA Prehospital Quality Improvement Framework to Reduce Mortality and Other Harms Associated with Opioid Use Disorder
Glenn M, Crowe R, Dorsett M, Taigman M, Herring A, Mercer M, Joiner A, Venkatesh A, Davis C, Hawk K, Hern H, Carroll G, Cabañas J, D’Onofrio G, Samuels E. A Prehospital Quality Improvement Framework to Reduce Mortality and Other Harms Associated with Opioid Use Disorder. Prehospital Emergency Care 2024, ahead-of-print: 1-9. PMID: 39671519, DOI: 10.1080/10903127.2024.2428671.Peer-Reviewed Original ResearchEmergency medical servicesOpioid use disorderQI frameworkQuality improvementHarm reductionQuality improvement frameworkHarms associated with opioid useEvidence-based practiceReduce mortalityReduce overdose deathsEscalating overdose crisisImproved frameworkMedical servicesMultidisciplinary teamOverdose crisisAddiction medicinePublic healthOverdose deathsSubject matter expertsPrehospitalOpioid useQuality measuresAdverse outcomesUse disorderHarmOutcomes After Total Knee Arthroplasty in Patients With Autism: A Retrospective Database Study
Kim L, Zehner K, Halperin S, Grauer J. Outcomes After Total Knee Arthroplasty in Patients With Autism: A Retrospective Database Study. JAAOS Global Research And Reviews 2024, 8: e24.00134. PMID: 39652716, PMCID: PMC11627478, DOI: 10.5435/jaaosglobal-d-24-00134.Peer-Reviewed Original ResearchConceptsElixhauser Comorbidity IndexAdverse eventsTotal knee arthroplasty patientsKnee arthroplasty patientsKaplan-Meier survival analysisInfectious adverse eventsUrinary tract infectionHigher Elixhauser comorbidity indexTKA patientsRetrospective database studyArthroplasty patientsPerioperative precautionsTract infectionsAggregate adverse eventsPearlDiver databaseControl patientsImplant survivalMatched cohortAdverse outcomesRate of revisionComorbidity indexPatientsDatabase studySurvival analysisSpectrum disorderIntegrating Drug Target Information in Deep Learning Models to Predict the Risk of Adverse Events in Patients with Comorbid Post-Traumatic Stress Disorder and Alcohol Use Disorder
Miranda O, Qi X, Brannock M, Whitworth R, Kosten T, Ryan N, Haas G, Kirisci L, Wang L. Integrating Drug Target Information in Deep Learning Models to Predict the Risk of Adverse Events in Patients with Comorbid Post-Traumatic Stress Disorder and Alcohol Use Disorder. Biomedicines 2024, 12: 2772. PMID: 39767679, PMCID: PMC11673068, DOI: 10.3390/biomedicines12122772.Peer-Reviewed Original ResearchPost-traumatic stress disorderAlcohol use disorder patientsAlcohol use disorderComorbid post-traumatic stress disorderUse disorderOpioid use disorderStress disorderSuicidal behaviorPotential therapeutic medicationsDeep learning modelsTarget informationDisordersElectronic medical recordsLearning modelsDepressionPotential therapeutic effectsNeighborhood-level social determinants of healthUniversity of Pittsburgh Medical CenterRisk of adverse eventsNeighborhood-level social determinantsSocial determinants of healthAdverse eventsMedicationAdverse outcomesDeterminants of healthRhabdomyolysis in Severe Fever With Thrombocytopenia Syndrome: Associations With Acute Kidney Injury and Mortality
Zhang Z, Hu X, Du Q, Liu J, Chen X, Mo P, Luo M, Jiang Q, Deng L, Xiong Y. Rhabdomyolysis in Severe Fever With Thrombocytopenia Syndrome: Associations With Acute Kidney Injury and Mortality. Journal Of Medical Virology 2024, 96: e70095. PMID: 39624019, DOI: 10.1002/jmv.70095.Peer-Reviewed Original ResearchConceptsAcute kidney injuryKidney injuryRhabdomyolysis groupLaboratory parametersClinical characteristicsLevels of laboratory parametersThrombocytopenia syndromeMultivariate binary logistic regression analysisCumulative survival rateHigh viral loadMortality of patientsSevere feverBinary logistic regression analysisLogistic regression analysisAbdominal painConsecutive patientsSFTS patientsSerum levelsViral loadChest distressAdverse outcomesRhabdomyolysisSurvival ratePatientsSystem injuryImproved total shoulder arthroplasty outcomes associated with semaglutide utilization in patients with type II diabetes: A promising new addition to preoperative optimization
Seddio A, Wilhelm C, Gouzoulis M, Islam W, Vasudevan R, Halperin S, Rubin L, Medvecky M, Donohue K, Grauer J. Improved total shoulder arthroplasty outcomes associated with semaglutide utilization in patients with type II diabetes: A promising new addition to preoperative optimization. JSES International 2024 DOI: 10.1016/j.jseint.2024.10.006.Peer-Reviewed Original ResearchTotal shoulder arthroplastyBody mass indexT2DM patientsElixhauser Comorbidity IndexMultivariate analysisOdds of surgical site infectionUrinary tract infectionSurgical site infectionAcute kidney injuryType II diabetes mellitusII diabetes mellitusTract infectionsSite infectionClinical benefitPreoperative optimizationCardiac eventsKidney injuryVenous thromboembolismMetformin useAdverse eventsManagement of type II diabetes mellitusMass indexDiabetes mellitusType II diabetesAdverse outcomesPreoperative Anxiety: An Important Risk Factor of Postoperative Adverse Events and Increased Reoperation Rates in Patients Undergoing Single-Level Anterior Cervical Diskectomy and Fusion
Katsnelson B, Rancu A, Winter A, Grauer J. Preoperative Anxiety: An Important Risk Factor of Postoperative Adverse Events and Increased Reoperation Rates in Patients Undergoing Single-Level Anterior Cervical Diskectomy and Fusion. JAAOS Global Research And Reviews 2024, 8: e24.00204. PMCID: PMC11473058, DOI: 10.5435/jaaosglobal-d-24-00204.Peer-Reviewed Original ResearchRevision surgery ratesAnterior cervical diskectomyAdverse eventsACDF patientsCervical diskectomySurgery ratesSingle-level anterior cervical diskectomyAdverse outcomesPreoperative anxietyCervical spine surgeryIncreased reoperation rateAssociated with adverse eventsFusion (ACDFSingle-level ACDFPostoperative adverse eventsPrevalence of mental health disordersImportant risk factorsMultivariate regression analysisReoperation rateMental health disordersSpine surgerySurgical outcomesElixhauser Comorbidity IndexHistory of anxietySurgical proceduresThe prognostic utility of galectin-3 in patients undergoing cardiac surgery: a scoping review
Shah A, Ding Y, Walji D, Rabinovich G, Pelletier M, El-Diasty M. The prognostic utility of galectin-3 in patients undergoing cardiac surgery: a scoping review. Biomarkers 2024, 29: 485-493. PMID: 39422445, DOI: 10.1080/1354750x.2024.2415073.Peer-Reviewed Original ResearchConceptsAssociated with acute kidney injuryPostoperative atrial fibrillationGal-3 levelsLeft ventricular reverse remodelingCardiac surgeryAdverse outcomesGal-3Clinical risk prediction scorePreoperative plasma levelsVentricular reverse remodelingEuroSCORE II modelPlasma Gal-3 levelsPostoperative adverse outcomesAcute kidney injuryGalectin-3Group of patientsPredicting adverse outcomesRisk prediction scorePostoperative morbidityReverse remodelingPostoperative mortalityElectronic database searchPrognostic utilityAdult patientsKidney injuryDefining Kidney Health Dimensions and Their Associations with Adverse Outcomes in Persons with Diabetes and CKD
Peschard V, Scherzer R, Katz R, Sarnak M, Ascher S, Lash J, Schrauben S, Parikh C, Ilori T, Kimmel P, Coca S, Gutierrez O, Ramachandran V, Sondheimer J, Cheung K, Bonventre J, Levitan E, Schelling J, Taliercio J, Rao P, Greenberg J, Chen J, Estrella M, Ix J, Shlipak M. Defining Kidney Health Dimensions and Their Associations with Adverse Outcomes in Persons with Diabetes and CKD. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.2024fkhmb714. DOI: 10.1681/asn.2024fkhmb714.Peer-Reviewed Original ResearchAssociation Between Juvenile Psychotic Experiences and Problematic Gaming
Fernandes A, Biokino R, Miguel A, Machado V, Koga G, Fonseca L, Pan P, Roza T, Salum G, Passos I, Rohde L, Miguel E, Ziebold C, Gadelha A. Association Between Juvenile Psychotic Experiences and Problematic Gaming. Schizophrenia Bulletin Open 2024, 5: sgae021. PMID: 39296676, PMCID: PMC11408271, DOI: 10.1093/schizbullopen/sgae021.Peer-Reviewed Original ResearchPsychotic experiencesProblematic gamingGame addictionDSM-IVBrazilian community sampleDSM-IV diagnosisMental health conditionsCommunity samplePsychiatric disordersCross-sectional subsamplePsychiatric conditionsAssociated with significant adverse outcomesReport PEBehavioral pathwaysLevels of PESignificant adverse outcomesAssociated with PEPE scoresSociodemographic variablesAdverse outcomesBrazilian cohortDisordersParticipantsHealth conditionsLinear regression analysis35. Comparable risk of adverse events following cervicothoracic interlaminar and transforaminal epidural injections: an analysis of 1.29 million patients
Seddio A, McNamara K, Gouzoulis M, Jabbouri S, Ratnasamy P, Rubio D, Grauer J. 35. Comparable risk of adverse events following cervicothoracic interlaminar and transforaminal epidural injections: an analysis of 1.29 million patients. The Spine Journal 2024, 24: s19. DOI: 10.1016/j.spinee.2024.06.478.Peer-Reviewed Original ResearchAdverse eventsSpinal neurologic deficitsStatistically significant differenceCurrent Procedural TerminologyElixhauser Comorbidity IndexEpidural injectionAdult patientsNeurological deficitsAdverse outcomesMultivariate analysisED visitsIncidence of adverse eventsEpidural spinal injectionsTransforaminal epidural injectionsEmergency departmentTransforaminal (TFRisk of adverse eventsSignificant differenceRetrospective cohort studyMinor adverse eventsSampled adult patientsOutcome measures IncidencePotential adverse eventsSpinal injectionPatient ageMendelian randomization analysis separated the independent impact of childhood obesity and adult obesity on socioeconomic status, psychological status, and substance use
Cai J, Zhao L, Li N, Xiao Z, Huang G. Mendelian randomization analysis separated the independent impact of childhood obesity and adult obesity on socioeconomic status, psychological status, and substance use. Heliyon 2024, 10: e36835. PMID: 39263080, PMCID: PMC11388778, DOI: 10.1016/j.heliyon.2024.e36835.Peer-Reviewed Original ResearchAdult body mass indexChildhood body mass indexUnivariable Mendelian randomizationBody mass indexImpact of childhood obesityMultivariable MRPrevent adverse outcomesChildhood obesityHousehold incomeAdult obesitySocioeconomic statusPsychological statusHigher childhood body mass indexMendelian randomization analysisLower household incomeSingle nucleotide polymorphismsWell-beingHigher body mass indexSubstance useAdverse outcomesSubjective well-beingEffects of childhoodImpact of obesityMendelian randomizationRandomization analysisViews and experiences of involuntary civil commitment of people who use drugs in Massachusetts (Section 35)
Silcox J, Rapisarda S, Hughto J, Vento S, Case P, Palacios W, Zaragoza S, Shrestha S, Stopka T, Green T. Views and experiences of involuntary civil commitment of people who use drugs in Massachusetts (Section 35). Drug And Alcohol Dependence 2024, 263: 112391. PMID: 39167986, PMCID: PMC11849197, DOI: 10.1016/j.drugalcdep.2024.112391.Peer-Reviewed Original ResearchInvoluntary civil commitmentSubstance use treatmentCivil commitmentCriminal justice professionalsNegative treatment experiencesOpioid use disorderMixed-methods studyJustice professionalsUse disorderDe-criminalizationIllicit drug useSubstance useIn-depth interviewsUse treatmentMassachusetts residentsDrug usePWUDDrug treatmentPositive outcomesPublic healthParticipantsAdverse outcomesDisrupted accessSocial consequencesTreatment experienceAssociation between growth differentiation factor-15 and adverse outcomes among patients with heart failure: A systematic literature review
Javaheri A, Ozcan M, Moubarak L, Smoyer K, Rossulek M, Revkin J, Groarke J, Tarasenko L, Kosiborod M. Association between growth differentiation factor-15 and adverse outcomes among patients with heart failure: A systematic literature review. Heliyon 2024, 10: e35916. PMID: 39229539, PMCID: PMC11369438, DOI: 10.1016/j.heliyon.2024.e35916.Peer-Reviewed Original ResearchGDF-15 concentrationsGrowth differentiation factor 15Differentiation factor 15GDF-15Heart failureMultivariate analysisRenal functionComposite outcomeAdverse outcomesOptimal treatment regimensPredictors of mortalityCardiovascular-related mortalityCross-sectional studyPrognostic roleTreatment regimensClinical risk prediction modelsPoor outcomeRisk prediction modelExercise capacityEligibility criteriaPatientsPRISMA guidelinesMortalityNonfatal outcomesOutcomes
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