2025
Systemic Therapies for Pediatric Alopecia Areata
Kalil L, Welch D, Heath C, Craiglow B. Systemic Therapies for Pediatric Alopecia Areata. Pediatric Dermatology 2025, 42: 36-42. PMID: 40044621, DOI: 10.1111/pde.15822.Peer-Reviewed Original ResearchConceptsAlopecia areataSystemic therapyPediatric alopecia areataAutoimmune hair loss disorderJanus kinase inhibitorsHair loss disorderComorbid atopyOral minoxidilLong-term useSystemic corticosteroidsTopical therapySystemic treatmentPediatric AACase reportAdjunctive treatmentMild diseaseKinase inhibitorsImmunomodulatory medicinesTherapyExtensive involvementAdverse effectsNarrative reviewAreataPatientsTreatmentAdvancements in the Diagnosis, Treatment, and Risk Stratification of Non-Muscle Invasive Bladder Cancer
Smani S, DuBois J, Zhao K, Sutherland R, Rahman S, Humphrey P, Hesse D, Tan W, Martin D, Lokeshwar S, Ghali F. Advancements in the Diagnosis, Treatment, and Risk Stratification of Non-Muscle Invasive Bladder Cancer. Current Oncology Reports 2025, 1-11. PMID: 39976835, DOI: 10.1007/s11912-025-01645-7.Peer-Reviewed Original ResearchNon-muscle invasive bladder cancerInvasive bladder cancerBladder cancerRisk stratificationBCG-unresponsive NMIBCEarly radical cystectomyTERT promoter mutationsHigh-risk casesLong-term outcomesNadofaragene firadenovecIntravesical therapyTransurethral resectionRadical cystectomyTreatment paradigmStratified careReduce overtreatmentProgression riskIntegration of biomarkersPromoter mutationsClinical trialsTherapeutic strategiesReviewThis reviewPersonalized treatmentAdverse effectsClinical careNav1.8, an analgesic target for nonpsychotomimetic phytocannabinoids
Ghovanloo M, Tyagi S, Zhao P, Waxman S. Nav1.8, an analgesic target for nonpsychotomimetic phytocannabinoids. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2416886122. PMID: 39835903, PMCID: PMC11789019, DOI: 10.1073/pnas.2416886122.Peer-Reviewed Original ResearchConceptsExcitation of peripheral sensory neuronsTherapeutic potential of cannabinoidsPotential of cannabinoidsPeripheral sensory neuronsVoltage-gated sodiumSpectrum of adverse effectsNociceptor excitabilityPain signalsIn vivo studiesAnalgesic targetsPain treatmentAttenuate painRepetitive firingNav1.8Sensory neuronsTreatment optionsClinical studiesInhibit excitabilityAnalgesic compoundsPainTherapeutic potentialCannabigerolProof-of-principalAdverse effectsTreatmentAnti-Amyloid Therapies for Alzheimer’s Disease and Amyloid-Related Imaging Abnormalities: Implications for the Emergency Medicine Clinician
Rech M, Carpenter C, Aggarwal N, Hwang U. Anti-Amyloid Therapies for Alzheimer’s Disease and Amyloid-Related Imaging Abnormalities: Implications for the Emergency Medicine Clinician. Annals Of Emergency Medicine 2025 PMID: 39818674, DOI: 10.1016/j.annemergmed.2024.12.002.Peer-Reviewed Original ResearchEmergency medicine cliniciansAnti-amyloid therapiesCases of dementiaEmergency department visitsAlzheimer's diseaseDepartment visitsIschemic stroke patientsStroke patientsIncreased riskAlzheimer's disease progressionCliniciansRisk of adverse effectsAnti-amyloidDisease-modifying treatmentsAmyloid-relatedNeurodegenerative disordersImaging abnormalitiesAlzheimerAdverse effectsEmergencyDementiaAmyloid-related imaging abnormalitiesTau is a receptor with low affinity for glucocorticoids and is required for glucocorticoid-induced bone loss
Fu W, Chen M, Wang K, Chen Y, Cui Y, Xie Y, Lei Z, Hu W, Sun G, Huang G, He C, Fretz J, Hettinghouse A, Liu R, Cai X, Zhang M, Chen Y, Jiang N, He M, Wiznia D, Xu H, Chen Z, Chen L, Tang K, Zhou H, Liu C. Tau is a receptor with low affinity for glucocorticoids and is required for glucocorticoid-induced bone loss. Cell Research 2025, 35: 23-44. PMID: 39743632, PMCID: PMC11701132, DOI: 10.1038/s41422-024-01016-0.Peer-Reviewed Original ResearchConceptsGC-induced osteoporosisBone lossInflammatory arthritisAdverse effects of dexamethasoneGlucocorticoid-induced bone lossHigh-dose dexamethasoneEffect of dexamethasoneFDA-approved drug librarySynthetic GCTreat inflammatory arthritisImmunosuppressive drugsPrescribed anti-inflammatoryGC receptorCombinatorial administrationSide effectsLow affinityGlucocorticoidOsteoporosisDexamethasoneReceptorsAdverse effectsBinding receptorsAnti-inflammatoryDrug libraryTau deficiencyBuprenorphine versus full agonist opioids for acute postoperative pain management: a systematic review and meta-analysis of randomized controlled trials
Hickey T, Costa G, Oliveira D, Podosek A, Abelleira A, Avila-Quintero V, De Aquino J. Buprenorphine versus full agonist opioids for acute postoperative pain management: a systematic review and meta-analysis of randomized controlled trials. Regional Anesthesia & Pain Medicine 2025, rapm-2024-106014. PMID: 39753290, DOI: 10.1136/rapm-2024-106014.Peer-Reviewed Original ResearchAcute postoperative pain managementPostoperative pain managementAcute postoperative painDuration of analgesiaPain intensityPain managementRandomized controlled trialsRisk of biasAgonist opioidsPostoperative painControlled trialsRescue analgesiaMeta-analysis of randomized controlled trialsMean duration of analgesiaRescue analgesia useLong duration of actionCochrane Central Register of Controlled TrialsSafety of buprenorphineCentral Register of Controlled TrialsMeta-analysisRegister of Controlled TrialsRandom-effects meta-analysisAdverse effectsDuration of actionCochrane Central Register
2024
Sleep and Neurodevelopment
Parsapour Z, Bemanalizadeh M, Imani V, Potenza M, Pakpour A. Sleep and Neurodevelopment. 2024, 97-108. DOI: 10.1007/978-981-97-7433-3_8.Peer-Reviewed Original ResearchSleep disordersSensory-motor abilitiesEmotion regulationAttention regulationMemory consolidationCognitive processesChildren's sleep needsMental healthNormal sleepLow-quality sleepLong-term adverse effectsSleepSleep needPotential risk factorsDisordersAdequate sleepChildhood developmentRisk factorsInfantsChildrenEarly childhood developmentAdverse effectsMemoryToddlersNeurodevelopmentThe Impact of Cannabis Use Disorder on Critical Illness
Carr Z, Strand E. The Impact of Cannabis Use Disorder on Critical Illness. 2024, 95-105. DOI: 10.1007/978-3-031-67069-5_7.Peer-Reviewed Original ResearchIntensive care unitImpacts of cannabis use disordersCannabis use disorderManagement of patientsIntensive care managementIntensive care management of patientsChronic adverse effectsCannabis useClinical evidenceCare management of patientsBotanical cannabisCannabis usageCare unitUse disorderCannabisOrgan systemsAdverse effectsPatientsDownstream effectsIntensive care unit providersMedical careCare managementPractice Advisory for Postoperative Pain Management of Cardiac Surgical Patients: A Report by Society of Cardiovascular Anesthesiologists
Makkad B, Heinke T, Sheriffdeen R, Meng M, Kachulis B, Grant M, Popescu W, Brodt J, Khatib D, Wu C, Kertai M, Bollen B. Practice Advisory for Postoperative Pain Management of Cardiac Surgical Patients: A Report by Society of Cardiovascular Anesthesiologists. Journal Of Cardiothoracic And Vascular Anesthesia 2024, 39: 770-784. PMID: 39855959, DOI: 10.1053/j.jvca.2024.10.014.Peer-Reviewed Original ResearchCardiac surgeryPostoperative pain managementPain managementManagement of cardiac surgical patientsOpioid-related adverse effectsRisk of postoperative cardiopulmonary complicationsFast-track extubationAssociated with serious adverse effectsCardiac surgical patientsPostoperative pain controlPostoperative cardiopulmonary complicationsFascial plane blocksSerious adverse effectsPractice advisoryAdverse effectsPromote early recoverySociety of Cardiovascular AnesthesiologistsNon-pharmacological therapiesPlane blockSevere painCardiopulmonary complicationsMultimodal analgesiaNeurological sequelaePain controlRegional analgesiaPrimary Treatment of Eyelid Conjunctival Melanoma with Immunotherapy: A Case Report
Weiss M, Perzia B, Sinard J, Tran T, Maeng M. Primary Treatment of Eyelid Conjunctival Melanoma with Immunotherapy: A Case Report. Ophthalmic Plastic And Reconstructive Surgery 2024, 41: e12-e15. PMID: 39240220, DOI: 10.1097/iop.0000000000002776.Peer-Reviewed Original ResearchConjunctival melanomaImmune checkpoint inhibitor regimenCombination of ipilimumabFirst-line combinationImmune checkpoint inhibitorsMonths of treatmentSystemic adverse effectsCutaneous melanoma treatmentHigher recurrence rateCheckpoint inhibitorsMucosal melanomaAdjuvant therapyDisease resolutionRecurrence rateLocal surgeryMelanoma treatmentFrequent metastasisCase reportPrimary treatmentMelanomaClinical approachIpilimumabNivolumabConjunctivalAdverse effectsThe utility of urine sodium–guided diuresis during acute decompensated heart failure
Siddiqi H, Cox Z, Stevenson L, Damman K, ter Maaten J, Bales B, Han J, Ivey-Miranda J, Lindenfeld J, Miller K, Ooi H, Rao V, Schlendorf K, Storrow A, Walsh R, Wrenn J, Testani J, Collins S. The utility of urine sodium–guided diuresis during acute decompensated heart failure. Heart Failure Reviews 2024, 29: 1161-1173. PMID: 39128947, PMCID: PMC11455821, DOI: 10.1007/s10741-024-10424-8.Peer-Reviewed Original ResearchAcute decompensated heart failureDecompensated heart failureHeart failureClinical trialsUrine sodium excretionObservational cohort studyRandomized clinical trialsAdequate decongestionDiuretic strategySodium excretionUrine chemistryCohort studyTitration strategyUrineDiuretic titrationAdverse effectsDiuresisDecongestionPatientsUsual careEvidence gapsTrialsTherapyFailureThe interactions between energy homeostasis and neurovascular plasticity
Chen B, de Launoit E, Meseguer D, Garcia Caceres C, Eichmann A, Renier N, Schneeberger M. The interactions between energy homeostasis and neurovascular plasticity. Nature Reviews Endocrinology 2024, 20: 749-759. PMID: 39054359, DOI: 10.1038/s41574-024-01021-8.Peer-Reviewed Original ResearchWestern dietLifestyle interventionNeurovascular systemCurrent obesity epidemicEnergy homeostasisStable body weightLocal neuronal networksRegulate energy balanceNeuronal networksFood intakeObesity epidemicSedentary lifestylePharmacological interventionsNeurovascular plasticityOverall healthNutritional milieuWeight lossLong-term needsCardiovascular systemBody weightEnergy expenditureAdverse effectsBrain centresLifestyleBrain vasculatureStiffening of the human proximal pulmonary artery with increasing age
Manning E, Mishall P, Ramachandra A, Hassab A, Lamy J, Peters D, Murphy T, Heerdt P, Singh I, Downie S, Choudhary G, Tellides G, Humphrey J. Stiffening of the human proximal pulmonary artery with increasing age. Physiological Reports 2024, 12: e16090. PMID: 38884325, PMCID: PMC11181131, DOI: 10.14814/phy2.16090.Peer-Reviewed Original ResearchConceptsProximal pulmonary arteriesPulmonary arteryAge-related stiffeningRight ventricular ejection fractionVentricular ejection fractionMean wall thicknessEjection fractionNo significant differenceSystemic circulationLuminal caliberDiffusing capacityArterial stiffeningIncreasing ageSignificant differenceDistensionArteryWall thicknessAdverse effectsWall strainVessel diameterCyclic biaxial strainOrgan donorsAgeMicrostructural remodelingUnderstanding how space travel affects the female reproductive system to the Moon and beyond
Mathyk B, Imudia A, Quaas A, Halicigil C, Karouia F, Avci P, Nelson N, Guzeloglu-Kayisli O, Denbo M, Sanders L, Scott R, Basar M, Guevara-Cerdán A, Strug M, Monseur B, Kayisli U, Szewczyk N, Mason C, Young S, Tasoglu S, Costes S, Beheshti A. Understanding how space travel affects the female reproductive system to the Moon and beyond. Npj Women's Health 2024, 2: 20. DOI: 10.1038/s44294-024-00009-z.Peer-Reviewed Original ResearchHypothalamic-pituitary-gonadalFemale reproductive systemEndometrial receptivityReproductive endocrinologyHealthy live birthPreimplantation embryo developmentHypothalamic-pituitary-gonadal (HPG) axisFemale reproductive healthReproductive systemOvarian folliculogenesisCircadian rhythm changesLive birthsEmbryo implantationFemale reproductive endocrinologyEffects of space travelPregnancySpace travelReproductive healthEmbryo developmentRhythm changesAdverse effectsEndocrinologySuccessful transitionEffects of spaceflightInterplanetary speciesEfficacy of laser hair removal in hidradenitis suppurativa: A systematic review and meta‐analysis
Shipman W, Williams M, Suozzi K, Eisenstein A, Dover J. Efficacy of laser hair removal in hidradenitis suppurativa: A systematic review and meta‐analysis. Lasers In Surgery And Medicine 2024, 56: 425-436. PMID: 38769894, DOI: 10.1002/lsm.23796.Peer-Reviewed Original ResearchLong-pulsed Nd:YAG laserHS disease severityHidradenitis suppurativaLaser hair removalMinimal adverse effectsTreatment optionsDisease severityMeta-analysisLaser modalitiesLong-pulse neodymium-doped yttrium aluminum garnetAdverse effectsEffective treatment optionEffects of laser hair removalChronic inflammatory conditionsSystematic reviewComprehensive literature searchStandardized mean differenceHair removalRandomized controlled trialsFollicular occlusionNeodymium-doped yttrium aluminum garnetCase seriesHair-bearing areasPainful nodulesHS pathogenesisTricyclic Antidepressants
Munoz-Acuna R, Munoz-Acuna R. Tricyclic Antidepressants. 2024, 395-396. DOI: 10.1093/med/9780197584569.003.0157.Peer-Reviewed Original ResearchTricyclic antidepressantsSide effectsReuptake of noradrenalineTreatment of choiceSpectrum of adverse effectsPotential side effectsCentral nervous systemAlpha-adrenoceptorsAcute painChronic painPerioperative considerationsSupportive treatmentPerioperative periodAbstract AntidepressantsSynaptic cleftPrescribed medicationsNervous systemTreating depressionPresynaptic terminalsAntidepressantsAdverse effectsPainMedicationTreatmentReuptakeConsidering Adverse Effects of Common Antihypertensive Medications in the ED
Wira C, Kearns T, Fleming-Nouri A, Tyrrell J, Wira C, Aydin A. Considering Adverse Effects of Common Antihypertensive Medications in the ED. Current Hypertension Reports 2024, 26: 355-368. PMID: 38687403, DOI: 10.1007/s11906-024-01304-5.Peer-Reviewed Original ResearchA retrospective cohort study describing chemotherapy-induced peripheral neuropathy in Non-Hodgkin lymphoma patients treated with EPOCH ± R: does HIV status matter?
McNally G, Aossey C, Wiczer T, Sinnott L, Lustberg M, Baiocchi R, Lustberg M. A retrospective cohort study describing chemotherapy-induced peripheral neuropathy in Non-Hodgkin lymphoma patients treated with EPOCH ± R: does HIV status matter? Leukemia & Lymphoma 2024, 65: 1110-1116. PMID: 38648546, DOI: 10.1080/10428194.2024.2340051.Peer-Reviewed Original ResearchChemotherapy-induced peripheral neuropathyIncidence of chemotherapy-induced peripheral neuropathyHIV statusPeripheral neuropathyHIV-associated non-Hodgkin's lymphomaCohort studyDose-adjusted EPOCHNon-Hodgkin's lymphomaLong-term patient outcomesRetrospective cohort studyNon-HodgkinComprehensive cancer centerCancer CenterHIVPatientsNeuropathyPatient outcomesPropensity scoreLymphomaAdverse effectsIncidenceStatusRegimenVincristineEx Vivo Immunization: A Strategy for Immunization Against SARS-CoV-2
Singh H, Nuthalapati P, Yendapalli P, Sahu D. Ex Vivo Immunization: A Strategy for Immunization Against SARS-CoV-2. 2024, 258-271. DOI: 10.1039/bk9781837672813-00258.Peer-Reviewed Original ResearchPeripheral blood mononuclear cellsNatural killer cellsCell-mediated immunityBlood mononuclear cellsEnhanced immune responseNaive lymphocytesDendritic cellsKiller cellsT cellsAntigen presentationB cellsMononuclear cellsImmune responseSARS-nCoV-2Human hostSignaling cascadesSARS-CoV-2Global pandemic coronavirus diseaseVirion particlesImmunityMass immunizationAdverse effectsCoronavirus 2Pandemic coronavirus diseaseJAK/STAT signaling pathway affects CCR5 expression in human CD4+ T cells
Wang L, Yukselten Y, Nuwagaba J, Sutton R. JAK/STAT signaling pathway affects CCR5 expression in human CD4+ T cells. Science Advances 2024, 10: eadl0368. PMID: 38507500, PMCID: PMC10954213, DOI: 10.1126/sciadv.adl0368.Peer-Reviewed Original ResearchConceptsCD4<sup>+</sup> T cellsT cellsCCR5 expressionPrimary CD4<sup>+</sup> T cellsCD4+ T cellsHuman CD4+ T cellsHuman primary CD4<sup>+</sup> T cellsGlucocorticoid-regulated kinase 1HIV cure agendaHIV co-receptorsSignaling pathwayCCR5 levelsJAK/STAT inhibitor tofacitinibViremic patientsHIV patientsHIV infectionInhibitor tofacitinibJAK/STAT signaling pathwayCCR5Co-receptorHIVProtein levelsCCR2/CCR5Adverse effectsDown-regulation
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply