2025
Patterns of sialyl-Lewis X expression predict gastric histopathology
Vargas N, Quiroga A, Chaves J, Bolaños H, Nalbantoglu I, Astaiza C, Wu Y, Sáenz J. Patterns of sialyl-Lewis X expression predict gastric histopathology. Diagnostic Pathology 2025, 20: 76. PMID: 40551130, PMCID: PMC12183862, DOI: 10.1186/s13000-025-01673-8.Peer-Reviewed Original ResearchConceptsChronic atrophic gastritisChronic non-atrophic gastritisGastric pathologyAssociated with chronic atrophic gastritisIntestinal metaplasiaProgression to gastric cancerSLex expressionPre-cancerous lesionsNon-atrophic gastritisGastric pre-cancerous lesionsHistological diagnosisPre-cancerous changesGlandular distributionAntrum biopsiesAdult patientsGastric corpusAtrophic gastritisChronic inflammationGastric cancerHistological markersHistological assessmentGastric histopathologyGastric epitheliumIntroductionGastric cancerBiopsyAssociation of Primary Language with Treatment and Outcomes in Inflammatory Bowel Disease.
Sahyoun L, Chavez V, Vasudevan J, Kogan L, Mukkamala B, Ochi M, Anand T, Ahmed Z, Tang Z, Feagins L, Gaidos J. Association of Primary Language with Treatment and Outcomes in Inflammatory Bowel Disease. Clinical And Translational Gastroenterology 2025 PMID: 40478247, DOI: 10.14309/ctg.0000000000000868.Peer-Reviewed Original ResearchCorticosteroid-free clinical remissionInflammatory bowel diseaseAdvanced therapiesClinical remissionDisease activityCohort study of adult patientsBowel diseaseStudy of adult patientsElevated fecal calprotectinBaseline disease activityPhysician global assessmentIBD disease activityRates of inflammatory bowel diseaseFecal calprotectinAdult patientsTherapy useCohort studyPrimary outcomeMultivariate analysisSecondary outcomesMulti-centerClinic visitsDisease outcomePatientsBaseline differencesPrimary Care Physician Use of Elastic Scattering Spectroscopy on Skin Lesions Suggestive of Skin Cancer
Merry S, Croghan I, Dukes K, McCormick B, Considine G, Duvall M, Thompson C, Leffell D. Primary Care Physician Use of Elastic Scattering Spectroscopy on Skin Lesions Suggestive of Skin Cancer. Journal Of Primary Care & Community Health 2025, 16: 21501319251344423. PMID: 40470593, PMCID: PMC12144386, DOI: 10.1177/21501319251344423.Peer-Reviewed Original ResearchConceptsPrimary care physiciansElastic scattering spectroscopySkin lesionsSkin cancerPredictive valueSquamous cell cancerNegative predictive valuePositive predictive valueMulticenter pivotal studyAdjunctive diagnostic deviceCell cancerPrimary care physicians' useBiopsy specimensAdult patientsPivotal studiesKeratinocyte carcinomaDiagnostic performanceSubgroup analysisPrimary care settingHistopathological analysisCancerLesionsPatientsClinical interestAge groupsDiagnostic yield of an abbreviated MRI protocol in the evaluation of dizziness in the emergency department, a single institutional experience
Shareef F, Tu L, Neupane A, Siddique Z, Joshi R, Melnick E, Wira C, Mahajan A. Diagnostic yield of an abbreviated MRI protocol in the evaluation of dizziness in the emergency department, a single institutional experience. Emergency Radiology 2025, 1-10. PMID: 40471503, DOI: 10.1007/s10140-025-02349-y.Peer-Reviewed Original ResearchAbbreviated MRI protocolDiagnostic yieldIntracranial pathologyEmergency departmentAcute findingsMRI protocolEvaluation of dizzinessMethodThis retrospective studyDetecting intracranial pathologySignificant intracranial pathologyAxial DWIAxial FLAIRProtocol MRIAbbreviated protocolSupratentorial pathologySWI sequencesMRI findingsRetrospective studyUrgent care settingsAdult patientsCentral etiologyAcute dizzinessInfratentorial siteInstitutional experienceInfarct characteristicsReal-World Treatment Patterns, Clinical Outcomes, and Costs in Patients with Higher-Risk Myelodysplastic Syndromes Across France, Germany, and the United Kingdom
Drummond M, Finelli C, Kristo F, Kelkar S, Corman S, Raina R, Ashaye A, Dalal M, Haase D. Real-World Treatment Patterns, Clinical Outcomes, and Costs in Patients with Higher-Risk Myelodysplastic Syndromes Across France, Germany, and the United Kingdom. Journal Of Blood Medicine 2025, 16: 307-319. PMID: 40585910, PMCID: PMC12206415, DOI: 10.2147/jbm.s516558.Peer-Reviewed Original ResearchHigher-risk myelodysplastic syndromesReal-world treatment patternsTreatment patternsMyelodysplastic syndromeClinical outcomesProgression to acute myeloid leukemiaProgression-free survivalMedian patient ageMedian follow-upHigh-risk diseaseFirst-line treatmentKaplan-Meier methodAcute myeloid leukemiaHealthcare resource useFollow-up post-diagnosisIPSS-R.Partial remissionTransfusion-dependentOverall survivalPatient ageMyeloid leukemiaChart reviewClinical characteristicsAdjunctive therapyAdult patientsThe UMPIRE study: A first‐in‐human multicenter trial of bilateral subscalp monitoring for epileptic seizure detection
Halliday A, Gillinder L, Lai A, Seneviratne U, Fontenot H, Cameron T, McLean K, Niemiec A, Raghupathi R, Ganguly T, Ellis C, Conrad E, Briggs R, Bulluss K, Kwan P, Perucca P, O'Brien T, McGonigal A, Gutman M, Papacostas J, Fong M, Lee A, Crompton D, Laing J, Wijayath M, Morokoff A, Murphy M, D'Souza W, Cook M. The UMPIRE study: A first‐in‐human multicenter trial of bilateral subscalp monitoring for epileptic seizure detection. Epilepsia 2025 PMID: 40445205, DOI: 10.1111/epi.18458.Peer-Reviewed Original ResearchAdverse eventsInterictal dischargesScalp video-EEG monitoringProcedure-related adverse eventsFirst-in-human studyDevice-related adverse eventsEEG recordingsScalp recordingsVideo-EEG monitoringLong-term seizure monitoringClinically relevant findingsPotential clinical utilityTemporal seizure focusScalp EEG recordingsPatient self-reportPostsurgical painHypothalamic hamartomaElectrographic seizuresAdult patientsBilateral recordingsUnilateral recordingsPatient groupPrimary outcomeSeizure frequencyLong-term EEG recordingsEfficacy of Total‐Body Irradiation‐based Intensified Myeloablative Regimens for Acute Leukemia—An International Collaborative Study
Arai Y, Brazauskas R, He N, Al‐Homsi A, Chhabra S, Battiwalla M, Yanada M, Steinberg A, Perez M, Hong S, Kanda J, Bashey A, Frangoul H, Badawy S, Verdonck L, Lazarus H, Yared J, Hashem H, Sharma A, Aljurf M, Dias A, Abid M, Wirk B, Freytes C, Zeidan A, Gergis U, Beitinjaneh A, Askar M, Pu J, Lehmann L, Rangarajan H, Wood W, Hashmi S, Yano S, Kako S, Ozawa Y, Doki N, Kanda Y, Fukuda T, Katayama Y, Ichinohe T, Tanaka J, Teshima T, Okamoto S, Atsuta Y, Saber W. Efficacy of Total‐Body Irradiation‐based Intensified Myeloablative Regimens for Acute Leukemia—An International Collaborative Study. EJHaem 2025, 6: e70061. PMID: 40438703, PMCID: PMC12118588, DOI: 10.1002/jha2.70061.Peer-Reviewed Original ResearchTreatment-related mortalityAcute lymphoblastic leukemiaAcute myeloid leukemiaHematopoietic stem cell transplantationOverall survivalConditioning regimensAllogeneic hematopoietic stem cell transplantationMyeloablative allogeneic hematopoietic stem cell transplantationConditioning regimen of cyclophosphamideMyeloablative conditioning regimensRegimen of cyclophosphamideTotal body irradiationStem cell transplantationRisk of relapseMyeloablative regimensCell transplantationAcute leukemiaLymphoblastic leukemiaMyeloid leukemiaAdult patientsCY/TBIClinical trial registrationRegimensInternational collaborative studyRelapseSpinal Cord Protection for Open Descending Thoracic and Thoracoabdominal Aorta Surgery: An STS Adult Cardiac Surgery Database Analysis
Amabile A, Bonnell L, Del Vecchio A, Basciano A, Antonios J, Kaneko T, Habib R, Di Luozzo G. Spinal Cord Protection for Open Descending Thoracic and Thoracoabdominal Aorta Surgery: An STS Adult Cardiac Surgery Database Analysis. The Annals Of Thoracic Surgery 2025 PMID: 40389192, DOI: 10.1016/j.athoracsur.2025.05.002.Peer-Reviewed Original ResearchThoracoabdominal aortic aneurysmsThoracoabdominal aortic aneurysm repairSpinal cord injuryDrain placementDTAA/TAAA repairDrain useThe Society of Thoracic Surgeons Adult Cardiac Surgery DatabaseSociety of Thoracic Surgeons Adult Cardiac Surgery DatabaseAdult Cardiac Surgery DatabaseOpen descending thoracicCardiac Surgery DatabaseSpinal cord protectionMultivariate logistic regression modelRate of spinal cord injuryArch involvementDescending thoracicPreoperative paralysisSurgery DatabaseSpinal drainAdult patientsAortic rootAortic aneurysmLogistic regression modelsSpinal injuryStudy populationDIAGNOSIS AND MANAGEMENT OF UPPER GASTROINTESTINAL INVOLVEMENT IN ADULT PATIENTS WITH CROHN’S DISEASE: A SYSTEMATIC REVIEW
Cohen N, Sror N, Naseer M, Bettenworth D, Lu C, Khedraki R, Abreu M, Atreya R, Al-Bawardy B, Connor S, d'Haens G, Dotan I, Dignass A, El Ouali S, Feagan B, Feakins R, Gearry R, Gordon I, Hedin C, Kobayashi T, Leibovitzh H, Maharshak N, Ollech J, Sebastian S, Siegmund B, Rubin D, Silverberg M, Steinwurz F, Torres J, Watermeyer G, Hernandez-Rocha C, Gurizzian P, Silfen A, Tzadok R, Falloon K, Rieder F. DIAGNOSIS AND MANAGEMENT OF UPPER GASTROINTESTINAL INVOLVEMENT IN ADULT PATIENTS WITH CROHN’S DISEASE: A SYSTEMATIC REVIEW. Clinical Gastroenterology And Hepatology 2025 PMID: 40378982, DOI: 10.1016/j.cgh.2025.03.024.Peer-Reviewed Original ResearchJoanna Briggs InstituteCrohn's diseaseSystematic reviewAnti-TNF therapyIleocolonic Crohn's diseaseFull-text reviewStandard guidanceComprehensive systematic reviewUpper GI tractQuality appraisalAbdominal painAnti-TNFSymptomatic patientsClinical presentationGastrointestinal CDSurgical managementDiagnostic modalitiesClinical characteristicsAdult patientsOutcome measuresDisease locationStudy designMedian prevalencePatientsInterventional proceduresSafety, pharmacokinetics, and efficacy of HY-072808 ointment, a novel PDE4 inhibitor, in adolescent and adult patients with mild-to-moderate AD
Yao F, He M, Wang J, Li Y, Zhang Q, Yang J, Wu J, Zhang Q, Zhou R, Zhang M, Meng L, Wu L, Chu Z, Hu W. Safety, pharmacokinetics, and efficacy of HY-072808 ointment, a novel PDE4 inhibitor, in adolescent and adult patients with mild-to-moderate AD. Expert Opinion On Investigational Drugs 2025, 34: 435-447. PMID: 40411316, DOI: 10.1080/13543784.2025.2510671.Peer-Reviewed Original ResearchConceptsMild to moderate ADAnti-atopic dermatitisAdult patientsHealthy subjectsPDE4 inhibitorsPhase I clinical trialWell-tolerated treatmentOpen-label trialDouble-blindPlacebo-controlledSafety profileAdverse eventsEASI scoreClinical developmentPharmacokinetic analysisAtopic dermatitisHealthy individualsPatientsPharmacokineticsDrug concentrationsEczema severityQuality of lifeEfficacyTrialsOintmentNational Trends of Surgical Interventions for Thumb Carpometacarpal Arthritis From 2010 to 2022
Day W, Rancu A, Halim A, Gouzoulis M, Joo P, Grauer J. National Trends of Surgical Interventions for Thumb Carpometacarpal Arthritis From 2010 to 2022. The Journal Of Hand Surgery 2025 PMID: 40314633, DOI: 10.1016/j.jhsa.2025.03.014.Peer-Reviewed Original ResearchThumb carpometacarpal arthritisSurgical optionsPatient characteristicsCarpometacarpal arthritisProsthetic arthroplastyMultivariate logistic regressionSurgical modalitiesTherapeutic IIPearlDiver databaseAdult patientsSurgical interventionCharacterize utilizationUnivariate linear regressionLRTILigament reconstructionPatientsSurgeryNonclinical factorsTendon interpositionNonclinical variablesLogistic regressionTrapeziectomyArthritisCohortArthroplastyACR Appropriateness Criteria® Acute Respiratory Illness in Immunocompetent Patients: 2024 Update
Imaging P, Batra K, Walker C, Little B, Bang T, Bartel T, Brixey A, Christensen J, Cox C, Hanak M, Khurana S, Madan R, Merchant N, Moore W, Pandya S, Sanchez L, Shroff G, Zagurovskaya M, Chung J. ACR Appropriateness Criteria® Acute Respiratory Illness in Immunocompetent Patients: 2024 Update. Journal Of The American College Of Radiology 2025, 22: s14-s35. PMID: 40409874, DOI: 10.1016/j.jacr.2025.02.014.Peer-Reviewed Original ResearchConceptsAcute respiratory illnessRespiratory illnessManagement of acute respiratory illnessesAmerican College of Radiology Appropriateness CriteriaRAND/UCLA Appropriateness Method User ManualSelf-limiting viral infectionEvidence-based guidelinesEstablished methodology principlesImmunocompetent adult patientsChronic obstructive pulmonary disease exacerbationsAppropriateness of imagingPublic health issuePeer-reviewed journalsFollow-up imagingMultidisciplinary expert panelSuspected pneumonia casesPeer-reviewed literatureGuideline developmentRecommendations AssessmentImmunocompetent patientsOccult malignancyHealth issuesExpert panelAdult patientsAppropriateness CriteriaEndovascular Stenting for Acute Ischemic Stroke Due to Cervical Artery Dissection: Nationwide Study of Stroke Recurrence
Chen H, Khunte M, Colasurdo M, Malhotra A, Gandhi D. Endovascular Stenting for Acute Ischemic Stroke Due to Cervical Artery Dissection: Nationwide Study of Stroke Recurrence. Stroke Vascular And Interventional Neurology 2025, 5 DOI: 10.1161/svin.124.001726.Peer-Reviewed Original ResearchCervical artery dissectionRate of intracranial hemorrhageNo-stent groupStent groupIntracranial hemorrhageEndovascular stentingAcute ischemic strokeArtery dissectionRate of short-term morbidityStroke recurrenceDays of follow-upSecondary end pointsShort-term morbidityRetrospective cohort studyRate of recurrent strokeRate of stroke recurrenceMaintain vessel patencyPropensity score matchingRoutine dischargeRate of routine dischargeAdult patientsRecurrence riskLogistic regression modelsOcclusive lesionsFollow-upHospital and Clinician Practice Variation in Cardiac Surgery and Postoperative Acute Kidney Injury
Mathis M, Mentz G, Cao J, Balczewski E, Janda A, Likosky D, Schonberger R, Hawkins R, Heung M, Ailawadi G, Ladhania R, Sjoding M, Kheterpal S, Singh K, Sundt T, Fitzsimons M, Shann K, Kumar V, Yarboro L, Naik B, Tibayan F, Aziz M, Mulligan M, Jelacic S, Kaneko T, Graetz T, Assi R, Mallidi H, Querejeta-Roca G, Shook D, Tsai C, Jewell E, Wanderer J, Freundlich R, Rock P, Douville N, Fisher C, Pace N, Domino K, Wagener G, King C, O'Reilly-Shah V, Bardia A, Clark D. Hospital and Clinician Practice Variation in Cardiac Surgery and Postoperative Acute Kidney Injury. JAMA Network Open 2025, 8: e258342. PMID: 40314957, PMCID: PMC12048843, DOI: 10.1001/jamanetworkopen.2025.8342.Peer-Reviewed Original ResearchConceptsAcute kidney injuryClinician-level variationAssociated with acute kidney injuryAcute kidney injury ratesCardiac surgeryIntraclass correlation coefficientAdult patientsKidney injuryCohort studyCohort study of adult patientsResuscitation practicesPostoperative acute kidney injuryOperating room practiceStudy of adult patientsAssociated with increased morbidityCardiac surgical proceduresCardiac surgical databasePractice variationRBC transfusion ratesFluid volume administrationHospital-level variationMultilevel mixed-effects modelsPatient-level characteristicsRisk-adjustment modelsHealth care costsUse of broad-spectrum antibiotics in adult cancer patients presenting to emergency department with non-neutropenic fever and/or suspected infection
Li Y, Al Maqrashi Z, Zhan L, Siddiqui Z, Jin E, Ellis P. Use of broad-spectrum antibiotics in adult cancer patients presenting to emergency department with non-neutropenic fever and/or suspected infection. Supportive Care In Cancer 2025, 33: 383. PMID: 40237926, DOI: 10.1007/s00520-025-09419-4.Peer-Reviewed Original ResearchConceptsNon-neutropenic feverBroad-spectrum antibioticsBroad-spectrum intravenous antibioticsBroad-spectrum antibiotic useCancer patientsSuspected infectionAdult cancer patientsAntibiotic useIntravenous antibioticsEmergency departmentAntibiotics prescribed to patientsMethodsA retrospective cohort studySingle-center studyProportion of patientsRetrospective cohort studyStage IV cancerMultivariate logistic regressionImprove antibiotic stewardshipSystemic treatmentSolid malignanciesGenitourinary cancersAdult patientsAntibiotic stewardshipIV cancerCohort study371 Endovascular Thrombectomy for Posterior Cerebral Artery Occlusions: 30- and 90-Day Unplanned Readmissions in the United States
Koo A, Amllay A, Kanzler M, Stogniy S, Renedo D, Sujijantarat N, Antonios J, Hebert R, Matouk C. 371 Endovascular Thrombectomy for Posterior Cerebral Artery Occlusions: 30- and 90-Day Unplanned Readmissions in the United States. Neurosurgery 2025, 71: 89-89. DOI: 10.1227/neu.0000000000003360_371.Peer-Reviewed Original ResearchEfficacy of endovascular thrombectomyPosterior cerebral artery occlusionPosterior cerebral arteryReadmitted cohortArtery occlusionEndovascular thrombectomyAcute basilar artery occlusionNationwide Readmissions Database yearsBasilar artery occlusionProportion of adverse eventsNon-readmitted cohortsNon-routine dischargeCerebral artery occlusionInpatient mortality rateAdult patientsRisk-stratifiedAdverse eventsShort-term readmissionNIHSS scorePrimary outcomeCardiac diagnosisCerebral arteryDatabase yearsPatientsIndex admissionRemoving Rehabilitation Barriers to Early Mobility in the Intensive Care Unit for Adult Patients With Femoral Arterial and Hemodialysis Catheters
Bennett K, Carbone A, Ferrante L, Cooper D, Foley B. Removing Rehabilitation Barriers to Early Mobility in the Intensive Care Unit for Adult Patients With Femoral Arterial and Hemodialysis Catheters. Journal Of Acute Care Physical Therapy 2025, 16: 49-54. DOI: 10.1097/jat.0000000000000251.Peer-Reviewed Original ResearchEdge of bedIntensive care unitBarriers to mobilityLevel of mobilityMaximum level of mobilityBed to chairCare unitMobility of patientsInterprofessional participantsInterprofessional teamTherapeutic exerciseRehabilitation barriersPractice changeNo adverse eventsEarly mobilizationProspective review of patientsBed restAdverse eventsProspective reviewAdverse event ratesHD cathetersReview of patientsAdult patientsEvent ratesStandard protocolEffect of digital adherence technologies on treatment outcomes in people with drug-susceptible tuberculosis: four pragmatic, cluster-randomised trials
Jerene D, van Kalmthout K, Levy J, Alacapa J, Deyanova N, Dube T, Mganga A, Tasca B, Bogdanov A, Efo E, Gamazina K, Garfin A, Kochanov V, Leung A, Madden N, Maraba N, McQuaid C, Mleoh L, Onjare B, Powers R, Terleiva Y, van Rest J, Gebhard A, Fielding K, Charalambous S. Effect of digital adherence technologies on treatment outcomes in people with drug-susceptible tuberculosis: four pragmatic, cluster-randomised trials. The Lancet 2025, 405: 1155-1166. PMID: 40086457, DOI: 10.1016/s0140-6736(24)02847-2.Peer-Reviewed Original ResearchDrug-susceptible tuberculosisTreatment outcomesPoor treatment outcomesPrimary outcomeDigital adherence technologiesIntervention armCluster randomised trialIntention-to-treat populationStandard of care armTuberculosis treatment outcomesDocumented treatment failureLoss to follow-upStandard of careAdherence technologiesTreatment failureTreatment startAdult patientsFollow-upPatientsTreatment statusPatient outcomesCare armTuberculosisMedicationTrialsPostoperative acute kidney injury is associated with persistent renal dysfunction: a multicentre propensity-matched cohort study
Stannard B, Epstein R, Gabel E, Nadkarni G, Ouyang Y, Lin H, Salari V, Hofer I. Postoperative acute kidney injury is associated with persistent renal dysfunction: a multicentre propensity-matched cohort study. BJA Open 2025, 14: 100384. PMID: 40129614, PMCID: PMC11930183, DOI: 10.1016/j.bjao.2025.100384.Peer-Reviewed Original ResearchPostoperative acute kidney injuryGlomerular filtration rateAcute kidney injuryRenal functionKidney injuryRates of postoperative acute kidney injuryOccurrence of postoperative acute kidney injuryAcute Kidney Injury Network classificationLong-term renal functionRetrospective propensity-matched studyCox modelPropensity-matched cohort studyPersistent renal dysfunctionIncreased hazardKaplan-Meier analysisFollow-up outpatient visitsFollow-up glomerular filtration ratePropensity-matched studyTertiary care hospitalHaemodialysis requirementRenal dysfunctionAdult patientsFiltration rateCohort studyHazard ratioReal-World Analysis of Strategies to Prevent Thrombosis and Bleeding in Adults with ALL Treated with Asparaginase
Mort J, Brighton D, Mautner B, Pierce E, Ghamsari F, Allen C, D’souza D, Patel I, Lawson J, Jackson C, Abernathy K, Yelvington B, Miller R, Dholaria B, Wolfe H, Infield J, Locke S, Shallis R, Duong V, Reed D, Walsh K, LeBlanc T, Keng M, Horton B, Chaer F. Real-World Analysis of Strategies to Prevent Thrombosis and Bleeding in Adults with ALL Treated with Asparaginase. Blood Vessels Thrombosis & Hemostasis 2025, 100065. DOI: 10.1016/j.bvth.2025.100065.Peer-Reviewed Original ResearchAcute lymphoblastic leukemiaOdds of thrombosisProphylactic anticoagulationPEG-ASPIncreased rate of thrombosisPrognosis of adult patientsAcute lymphoblastic leukemia therapyPediatric-inspired regimensPeripherally inserted central cathetersRandomized prospective studyRate of thrombosisOdds of bleedingAssociated thrombosisPegylated asparaginaseLymphoblastic leukemiaThrombotic riskRetrospective studyThrombotic eventsAdult patientsReal-world analysisProspective studyCentral cathetersBleedingMultivariate analysisAnticoagulation
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