2025
Improving the Robustness of Deep-Learning Models in Predicting Hematoma Expansion from Admission Head CT.
Tran A, Karam G, Zeevi D, Qureshi A, Malhotra A, Majidi S, Murthy S, Park S, Kontos D, Falcone G, Sheth K, Payabvash S. Improving the Robustness of Deep-Learning Models in Predicting Hematoma Expansion from Admission Head CT. American Journal Of Neuroradiology 2025, ajnr.a8650. PMID: 39794133, DOI: 10.3174/ajnr.a8650.Peer-Reviewed Original ResearchFast Gradient Sign MethodDeep learning modelsRobustness of deep learning modelsAdversarial attacksAdversarial imagesAdversarial trainingSign MethodModel robustnessDeploying deep learning modelsDeep learning model performanceConvolutional neural networkImprove model robustnessAcute intracerebral hemorrhageHematoma expansionMulti-threshold segmentationReceiver operating characteristicIntracerebral hemorrhageGradient descentType attacksData perturbationNeural networkProjected GradientTraining setAntihypertensive Treatment of Acute Cerebral HemorrhageThreshold-based segmentation
2024
Radiomic Features of Acute Cerebral Hemorrhage on Non-Contrast CT Associated with Patient Survival
Zaman S, Dierksen F, Knapp A, Haider S, Karam G, Qureshi A, Falcone G, Sheth K, Payabvash S. Radiomic Features of Acute Cerebral Hemorrhage on Non-Contrast CT Associated with Patient Survival. Diagnostics 2024, 14: 944. PMID: 38732358, PMCID: PMC11083693, DOI: 10.3390/diagnostics14090944.Peer-Reviewed Original ResearchInternational Normalized RatioArea under the curveNational Institutes of Health Stroke ScaleIntracerebral hemorrhageRadiomic featuresAntihypertensive Treatment of Acute Cerebral Hemorrhage IINon-contrast head CT scanBaseline International Normalized RatioAssociated with worse survival outcomesAcute intracerebral hemorrhageSupratentorial intracerebral hemorrhageWorse survival outcomesKaplan-Meier analysisHead CT scanCox proportional hazards modelsPredictors of mortalityAcute cerebral hemorrhageReceiver Operating Characteristic (ROC) analysisFirst-order energyHigher mortality riskProportional hazards modelHealth Stroke ScaleCT radiomicsHematoma expansionPost-ICH
2023
Clinical Trial Protocol for BEACH: A Phase 2a Study of MW189 in Patients with Acute Nontraumatic Intracerebral Hemorrhage
Avadhani R, Ziai W, Thompson R, Mould W, Lane K, Nanni A, Iacobelli M, Sharrock M, Sansing L, Van Eldik L, Hanley D. Clinical Trial Protocol for BEACH: A Phase 2a Study of MW189 in Patients with Acute Nontraumatic Intracerebral Hemorrhage. Neurocritical Care 2023, 40: 807-815. PMID: 37919545, PMCID: PMC10959780, DOI: 10.1007/s12028-023-01867-2.Peer-Reviewed Original ResearchIntracerebral hemorrhageNontraumatic intracerebral hemorrhageCerebral edemaFunctional outcomeCause mortalitySymptom onsetAcute central nervous system injuryAcute spontaneous intracerebral hemorrhageEnd pointCentral nervous system injuryDays post randomizationExploratory end pointsPhase 2a studyPlacebo-controlled trialSecondary end pointsAcute brain injuryAcute intracerebral hemorrhageFuture larger trialsPhase 1 studyPerihematomal edema volumeNervous system injurySpontaneous intracerebral hemorrhageInflammatory cytokine concentrationsRate of deathClinical trial protocolResponse to: Multiple Cerebral Hemorrhages in a Patient Receiving Lecanemab and Treated with t-PA for Stroke
Sabbagh M, van Dyck C. Response to: Multiple Cerebral Hemorrhages in a Patient Receiving Lecanemab and Treated with t-PA for Stroke. New England Journal Of Medicine 2023, 388: 480-480. PMID: 36599073, DOI: 10.1056/nejmc2215907.Peer-Reviewed Original ResearchConceptsMultiple cerebral hemorrhagesAcute intracerebral hemorrhageTissue plasminogen activatorCerebral hemorrhageIntracerebral hemorrhageT-PAPlasminogen activatorHemorrhage
2020
A Pooled Analysis of Diffusion-Weighted Imaging Lesions in Patients With Acute Intracerebral Hemorrhage
Murthy SB, Cho SM, Gupta A, Shoamanesh A, Navi BB, Avadhani R, Gruber J, Li Y, Greige T, Lioutas VA, Norton C, Zhang C, Mandava P, Iadecola C, Falcone GJ, Sheth KN, Biffi A, Rosand J, Qureshi AI, Goldstein JN, Kidwell C, Awad I, Selim M, Hanley DF, Woo D, Kamel H, Ziai WC. A Pooled Analysis of Diffusion-Weighted Imaging Lesions in Patients With Acute Intracerebral Hemorrhage. JAMA Neurology 2020, 77: 1390-1397. PMID: 32687564, PMCID: PMC7372494, DOI: 10.1001/jamaneurol.2020.2349.Peer-Reviewed Original ResearchConceptsDiffusion-weighted imaging lesionsModified Rankin scoreDWI lesionsImaging lesionsAcute intracerebral hemorrhageIntracerebral hemorrhageFunctional outcomeSubgroup analysisChronic cerebral small vessel diseaseAdmission systolic blood pressureCerebral small vessel diseaseMulticenter prospective studySystolic blood pressurePoor functional outcomeSmall vessel diseaseDeep intracerebral hemorrhageBaseline hematoma volumeIndividual patient dataMixed-effects logistic regressionMixed effects regression modelsAcute sequelaeHypertensive vasculopathyRankin scoreSecondary outcomesBlood pressure
2015
Rate of Contrast Extravasation on Computed Tomographic Angiography Predicts Hematoma Expansion and Mortality in Primary Intracerebral Hemorrhage
Brouwers HB, Battey TW, Musial HH, Ciura VA, Falcone GJ, Ayres AM, Vashkevich A, Schwab K, Viswanathan A, Anderson CD, Greenberg SM, Pomerantz SR, Ortiz CJ, Goldstein JN, Gonzalez RG, Rosand J, Romero JM. Rate of Contrast Extravasation on Computed Tomographic Angiography Predicts Hematoma Expansion and Mortality in Primary Intracerebral Hemorrhage. Stroke 2015, 46: 2498-2503. PMID: 26243220, PMCID: PMC4550492, DOI: 10.1161/strokeaha.115.009659.Peer-Reviewed Original ResearchConceptsPrimary intracerebral hemorrhageHematoma expansionContrast extravasationIntracerebral hemorrhageSpot signExtravasation rateTomographic angiographyConsecutive intracerebral hemorrhage patientsML/minContrast extravasation rateAcute intracerebral hemorrhageIntracerebral hemorrhage patientsMultivariable logistic regressionRate of bleedingIntracerebral hemorrhage volumeSpot sign presenceHospital mortalityMultivariable analysisHemorrhage patientsPostcontrast CTHemorrhage volumeSemiautomated softwareMortalityLogistic regressionHemorrhage
2014
Predicting Hematoma Expansion After Primary Intracerebral Hemorrhage
Brouwers HB, Chang Y, Falcone GJ, Cai X, Ayres AM, Battey TW, Vashkevich A, McNamara KA, Valant V, Schwab K, Orzell SC, Bresette LM, Feske SK, Rost NS, Romero JM, Viswanathan A, Chou S, Greenberg SM, Rosand J, Goldstein JN. Predicting Hematoma Expansion After Primary Intracerebral Hemorrhage. JAMA Neurology 2014, 71: 158-164. PMID: 24366060, PMCID: PMC4131760, DOI: 10.1001/jamaneurol.2013.5433.Peer-Reviewed Original ResearchConceptsPrimary intracerebral hemorrhageIndependent validation cohortIntracerebral hemorrhageHematoma expansionValidation cohortHigh riskPrediction scoreUrban academic medical centerBaseline ICH volumeWarfarin sodium useProspective cohort studyAcute intracerebral hemorrhageMultivariable logistic regressionTomography angiography spot signComputed tomography angiography spot signAcademic medical centerPredictors of expansionCohort studyMultivariable analysisDevelopment cohortICH volumeC-statisticClinical trialsIndividualized treatmentMAIN OUTCOME
2013
β-Blockers associated with no class-specific survival benefit in acute intracerebral hemorrhage
Shoup JP, Winkler J, Czap A, Staff I, Fortunato G, McCullough LD, Sansing LH. β-Blockers associated with no class-specific survival benefit in acute intracerebral hemorrhage. Journal Of The Neurological Sciences 2013, 336: 127-131. PMID: 24183854, PMCID: PMC4956481, DOI: 10.1016/j.jns.2013.10.022.Peer-Reviewed Original ResearchConceptsΒ-blocker treatmentΒ-blocker useBlood pressure controlAcute intracerebral hemorrhageIntracerebral hemorrhageAdrenergic antagonistsAntihypertensive therapyPressure controlInflammation-induced injuryΒ-blocker therapyDatabase of patientsSympathetic nervous systemSpontaneous intracerebral hemorrhageAntihypertensive treatmentInpatient deathSurvival benefitImproved survivalOngoing trialsMultivariable analysisICH patientsImmune activationInpatient stayRetrospective analysisStudy populationΒ-blockers
2012
CTA Spot Sign Predicts Hematoma Expansion in Patients with Delayed Presentation After Intracerebral Hemorrhage
Brouwers HB, Falcone GJ, McNamara KA, Ayres AM, Oleinik A, Schwab K, Romero JM, Viswanathan A, Greenberg SM, Rosand J, Goldstein JN. CTA Spot Sign Predicts Hematoma Expansion in Patients with Delayed Presentation After Intracerebral Hemorrhage. Neurocritical Care 2012, 17: 421-428. PMID: 22878870, PMCID: PMC3707619, DOI: 10.1007/s12028-012-9765-2.Peer-Reviewed Original ResearchConceptsHematoma expansionSymptom onsetSpot signUnknown onset timeCTA spot signIntracerebral hemorrhageCT angiography spot signHematoma expansion ratesUnknown symptom onsetOnset timeAcute intracerebral hemorrhageMajority of patientsSymptom onset timeBackgroundHematoma expansionDelayed PresentationFollowup CTConsecutive patientsInitial CTClinical trialsNovel therapiesPatientsHemorrhageExperienced readersOnsetSigns
2011
Anti-Adrenergic Medications and Edema Development after Intracerebral Hemorrhage
Sansing LH, Messe SR, Cucchiara BL, Lyden PD, Kasner SE. Anti-Adrenergic Medications and Edema Development after Intracerebral Hemorrhage. Neurocritical Care 2011, 14: 395-400. PMID: 21264527, DOI: 10.1007/s12028-010-9498-z.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic alpha-2 Receptor AgonistsAdrenergic beta-AntagonistsAgedAntihypertensive AgentsAntioxidantsBenzenesulfonatesBlood PressureBrain EdemaCerebral HemorrhageClonidineCohort StudiesCritical CareDouble-Blind MethodDrug Therapy, CombinationFemaleFree Radical ScavengersGlasgow Coma ScaleHumansMaleMiddle AgedMultivariate AnalysisProspective StudiesTreatment OutcomeConceptsIntracerebral hemorrhageClinical outcomesBlood pressure medication useAcute intracerebral hemorrhageSympathetic nervous systemAdrenergic medicationsAntihypertensive medicationsAntihypertensive treatmentMethodsThe patientsPlacebo armBlood pressureMedication useEdema volumePerihematomal edemaEdema developmentInflammatory responseLess edemaHemorrhage volumeAdrenergic activationMedicationsNervous systemMultivariate analysisEdemaHemorrhagePatients
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